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David B. Solit
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Journal Articles

Abstract 3544: OncoKB™, MSK’s precision oncology knowledge base: 2023 updates

Sarah P. Suehnholz, Moriah Nissan, Hongxin Zhang, Ritika Kundra, Calvin Lu, Amanda Dhaneshwar, Nicole Fernandez, Benjamin Preiser, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Aijazuddin Syed, A. Rose Brannon, Ross Levine, Ahmet Dogan, Alexander Drilon, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3544.
https://doi.org/10.1158/1538-7445.AM2024-3544
Published: 22 March 2024
View article titled, Abstract 3544: OncoKB™, MSK’s precision oncology knowledge base: 2023 updates
Journal Articles

Abstract 1757: Pan-cancer analysis identifies signatures of HRD-positivity in germline BRCA1/2 mutated non-BRCA associated cancers

Daniel M. Muldoon, Miika Mehine, Samuel Tischfield, A. Rose Brannon, Marc Ladanyi, Zsofia K. Stadler, David B. Solit, Alexander Drilon, Michael F. Berger, Yonina Murciano-Goroff, Chaitanya Bandlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1757.
https://doi.org/10.1158/1538-7445.AM2024-1757
Published: 22 March 2024
View article titled, Abstract 1757: Pan-cancer analysis identifies signatures of HRD-positivity in germline BRCA1/2 mutated non-BRCA associated cancers
Journal Articles

Abstract 4632: Lineage plasticity as a determinant of antibody-drug conjugate target expression in urothelial bladder cancer

Jiaqian Luo, Sizhi P. Gao, Fengshen Kuo, Gamze Gokturk Ozcan, Merve Basar, Florestan Koll, Jacob E. Tallman, Syed M. Alam, Carissa E. Chu, Ziyu Chen, Eugene J. Pietzak, Gopakumar Iyer, Jonathan E. Rosenberg, David B. Solit, Hikmat Al-Ahmadie
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4632.
https://doi.org/10.1158/1538-7445.AM2024-4632
Published: 22 March 2024
View article titled, Abstract 4632: Lineage plasticity as a determinant of antibody-drug conjugate target expression in urothelial bladder cancer
Journal Articles

Abstract 3703: Utility of circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) for prognosis of patients with recurrent high grade glioma

Bridget M. Holle, Subhiksha Nandakumar, Christoph Kreitzer, Timothy Song, Marlene Tartaro, Charli Ann J. Hertz, Johnathan Rafailov, Carl Campos, Anne S. Reiner, Robert Young, Alicia Meng, Luca Pasquini, A. Rose Brannon, Nicholas D. Socci, Maria E. Arcila, David B. Solit, Michael F. Berger, Nikolaus Schultz, Ingo K. Mellinghoff, Alexandra M. Miller
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3703.
https://doi.org/10.1158/1538-7445.AM2024-3703
Published: 22 March 2024
View article titled, Abstract 3703: Utility of circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) for prognosis of patients with recurrent high grade glioma
Journal Articles

Abstract 889: Machine learning-enhanced targeted versus whole-exome sequencing as a guide to cancer care

Hyung Jun Woo, Shweta S. Chavan, Aphrothiti J. Hanrahan, Allison L. Richards, Anne Marie Noronha, Ahmet Zehir, Alexander Drilon, Michael F. Berger, David B. Solit, Mark T. Donoghue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 889.
https://doi.org/10.1158/1538-7445.AM2024-889
Published: 22 March 2024
View article titled, Abstract 889: Machine learning-enhanced targeted versus whole-exome sequencing as a guide to cancer care
Journal Articles

Abstract 6129: Emerging disparities in the clinical actionability landscape for patients with inferred African ancestry

Kanika Arora, Sarah P. Suehnholz, Hongxin Zhang, Ritika Kundra, Subhiksha Nandakumar, Moriah Nissan, A. Rose Brannon, Chaitanya Bandlamudi, Marc Ladanyi, Alexander Drilon, David B. Solit, Nikolaus Schultz, Michael F. Berger, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6129.
https://doi.org/10.1158/1538-7445.AM2024-6129
Published: 22 March 2024
View article titled, Abstract 6129: Emerging disparities in the clinical actionability landscape for patients with inferred African ancestry
Journal Articles

Abstract 4366: Loss of EP300 triggers IL-1α signaling and subsequent activation of the IL-6/JAK/STAT3 axis to drive oncogenesis in bladder cancer

James A. Rodrigues, Jiaqian Luo, Amanda R. Sabel, Ziyu Chen, Xinran Tang, Fengshen Kuo, Hikmat Al-Ahmadie, Kwanghee Kim, Eugene Pietzak, Gopa Iyer, David B. Solit, Sizhi P. Gao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4366.
https://doi.org/10.1158/1538-7445.AM2024-4366
Published: 22 March 2024
View article titled, Abstract 4366: Loss of <em>EP300</em> triggers IL-1α signaling and subsequent activation of the IL-6/JAK/STAT3 axis to drive oncogenesis in bladder cancer
Journal Articles

Abstract 1202: Signatures of selection for biallelic inactivation in tumor suppressor genes across cancer types

Mark R. Zucker, Maria A. Perry, Arielle Elkrief, Anton Safonov, Rohit Thummalapalli, Samuel I. Gould, Debyani Chakravarty, Rose Brannon, Marc Ladanyi, Pedram Razavi, Mark T. Donoghue, Yonina R. Murciano-Goroff, Francisco J. Sánchez-Rivera, Yuan Chen, Ronglai Shen, Sarat Chandarlapaty, David B. Solit, Nikolaus Schultz, Michael F. Berger, Adam J. Schoenfeld, Jason Chang, Ed Reznik, Chaitanya Bandlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2024-1202
Published: 22 March 2024
View article titled, Abstract 1202: Signatures of selection for biallelic inactivation in tumor suppressor genes across cancer types
Journal Articles

Correction: ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer

Tomasz B. Owczarek, Takashi Kobayashi, Ricardo Ramirez, Lijie Rong, Anna M. Puzio-Kuter, Gopa Iyer, Min Yuen Teo, Francisco Sánchez-Vega, Jingqiang Wang, Nikolaus Schultz, Tian Zheng, David B. Solit, Hikmat A. Al-Ahmadie, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1159.
https://doi.org/10.1158/0008-5472.CAN-23-0518
Published: 04 April 2023
View article titled, Correction: ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer
Open the PDF for Correction: ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer in another window
Journal Articles

Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort

Alexis M. Jones, Aphrothiti J. Hanrahan, Moriah H. Nissan, Sebastien Monette, Ziyu Chen, Wenhuo Hu, Sandra Misale, Isabell Schulze, Naresh Vasani, Cailian Liu, Xia Yang, Mohsen Abu-Akeel, Elisa de Stanchina, Nikolaus Schultz, Michael F. Berger, Neal Rosen, Taha Merghoub, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2.
https://doi.org/10.1158/1538-7445.AM2023-2
Published: 04 April 2023
View article titled, Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort
Journal Articles

Abstract 330: EP300 loss drives tumorigenesis in bladder cancer via activation of IL-6/JAK/STAT3 signaling

Sizhi P. Gao, James A. Rodrigues, Amanda R. Sabel, Jiaqian Luo, Chen Ziyu, Xinran Tang, Eduardo A. Mascareno, Naryan Rustgi, Hikmat Al-Ahmadie, Kwanghee Kim, Eugene J. Pietzak, Gopakumar V. Iyer, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 330.
https://doi.org/10.1158/1538-7445.AM2023-330
Published: 04 April 2023
View article titled, Abstract 330: <em>EP300</em> loss drives tumorigenesis in bladder cancer via activation of IL-6/JAK/STAT3 signaling
Journal Articles

Abstract 930: Treatment patterns and overall survival among men with metastatic castration-resistant prostate cancer harboring DDR mutations

David B. Solit, Niharika B. Mettu, Shannon J. McCall, Mallika Dhawan, Priyanka J. Bobbili, Maral DerSarkissian, Jasmina Ivanova, Bhakti Arondekar, Jane Chang, Alexander Niyazov, Jocelyn Lee, Risha Huq, Michelle Green, Michelle Turski, Aruna Muthukumar, Tracy Guo, Mei Sheng Duh, William K. Oh
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 930.
https://doi.org/10.1158/1538-7445.AM2023-930
Published: 04 April 2023
View article titled, Abstract 930: Treatment patterns and overall survival among men with metastatic castration-resistant prostate cancer harboring DDR mutations
Journal Articles

Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models

Ziyu Chen, Xinran Tang, Eliyahu Havasov, Andrew Mcpherson, Carissa Chu, John R. Christin, Michael F. Berger, Nikolaus D. Schultz, Elisa de Stanchina, Michael M. Shen, Hikmat Al-Ahmadie, Kwanghee Kim, Gopa Iyer, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5931.
https://doi.org/10.1158/1538-7445.AM2023-5931
Published: 04 April 2023
View article titled, Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models
Journal Articles

Abstract 6585: OncoKB, MSK’s precision oncology knowledge base

Sarah P. Suehnholz, Moriah Nissan, Hongxin Zhang, Ritika Kundra, Calvin Lu, Amanda Dhaneshwar, Nicole Fernandez, Stephanie Carrero, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Aijazuddin Syed, Rose Brannon, Ross Levine, Ahmet Dogan, Ezra Rosen, Alexander Drilon, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6585.
https://doi.org/10.1158/1538-7445.AM2023-6585
Published: 04 April 2023
View article titled, Abstract 6585: OncoKB, MSK’s precision oncology knowledge base
Journal Articles

Abstract 1176: Quantitative integration of PIK3CA hotspots and paralogy identifies occult oncogenic mutants in PIK3CD

Arijh Elzein, Alexander N. Gorelick, Ino de Bruijn, Barry S. Taylor, Aphrothiti J. Hanrahan, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1176.
https://doi.org/10.1158/1538-7445.AM2023-1176
Published: 04 April 2023
View article titled, Abstract 1176: Quantitative integration of PIK3CA hotspots and paralogy identifies occult oncogenic mutants in PIK3CD
Journal Articles

Abstract 472: HER2 as a therapeutic target in bladder cancer

Xinran Tang, Ziyu Chen, Jasmine Thomas, Karan Nagar, John Christin, Naryan Rustgi, Sizhi Gao, Carissa Chu, Elisa De Stanchina, Michael F. Berger, Jonathan A. Coleman, Michael M. Shen, Hikmat A. Al-Ahmadie, Gopakumar V. Iyer, Kwanghee Kim, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 472.
https://doi.org/10.1158/1538-7445.AM2023-472
Published: 04 April 2023
View article titled, Abstract 472: HER2 as a therapeutic target in bladder cancer
Journal Articles

Abstract 5214: Expanding the spectrum of germline-driven cancers by leveraging population-scale targeted tumor and normal sequencing

Miika Mehine, Rebecca Caeser, Yelena Kemel, Daniel Muldoon, Sebastià Franch-Expósito, A. Rose Brannon, Aijazuddin Syed, Ozge Ceyhan-Birsoy, Maksym Misyura, Panieh Terraf, David B. Solit, Marc Ladanyi, Kenneth Offit, Zsofia K. Stadler, Diana L. Mandelker, Yonina R. Murciano-Goroff, Charles M. Rudin, Michael F. Berger, Chaitanya Bandlamudi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5214.
https://doi.org/10.1158/1538-7445.AM2023-5214
Published: 04 April 2023
View article titled, Abstract 5214: Expanding the spectrum of germline-driven cancers by leveraging population-scale targeted tumor and normal sequencing
Journal Articles

Abstract 1053: Circulating tumor DNA from cerebrospinal fluid (CSF) allows for characterization and monitoring of glioma patients

Subhiksha Nandakumar, Christoph Kreitzer, Charli Ann Hertz, Johnathan Rafailov, Timothy Song, Nicholas D. Socci, A. Rose Brannon, Maria E. Arcila, David B. Solit, Michael F. Berger, Nikolaus Schultz, Ingo K. Mellinghoff, Alexandra M. Miller
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1053.
https://doi.org/10.1158/1538-7445.AM2023-1053
Published: 04 April 2023
View article titled, Abstract 1053: Circulating tumor DNA from cerebrospinal fluid (CSF) allows for characterization and monitoring of glioma patients
Journal Articles

KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Hong Qiu, Vladimir Makarov, Jennifer K. Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V. Iyer, Hannah Wise, Daniel Kim, Varna Thayaparan, Daniel J. Lindner, Georges-Pascal Haber, Angela H. Ting, Bing Ren, Timothy A. Chan, Vivek Arora, David B. Solit, Byron H. Lee
Journal: Cancer Research
Cancer Res (2023) 83 (6): 814–829.
https://doi.org/10.1158/0008-5472.CAN-22-1444
Published: 15 March 2023
View article titled, KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer
Open the PDF for KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract P4-02-01: Efficacy of HER2 ADCs against HER2 inhibitor resistance alterations in the PI3K and MAPK pathways in HER2-positive breast cancer

Emanuela Ferraro, Anton Safonov, Yuan Chen, Charlie White, Antonio Marra, Mehnaj Ahmed, Barbara Acevedo, Chau T Dang, Shanu Modi, David B. Solit, Larry Norton, Mark E. Robson, Jorge Reis-Filho, Sarat Chandarlapaty, Pedram Razavi
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-02-01.
https://doi.org/10.1158/1538-7445.SABCS22-P4-02-01
Published: 01 March 2023
View article titled, Abstract P4-02-01: Efficacy of HER2 ADCs against HER2 inhibitor resistance alterations in the PI3K and MAPK pathways in HER2-positive breast cancer