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David B. Solit
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Journal Articles

Abstract 3410: Identifying potential mechanisms of resistance to erdafitinib (erda) via longitudinal analysis of circulating tumor (ct)-DNA of patients (pts) with advanced/metastatic urothelial cancer (mUC)

Brendan J. Guercio, Michal Sarfaty, Min Yuen Teo, Samuel A. Funt, Chung-Han Lee, David H. Aggen, Neha Ratna, Ashley M. Regazzi, Ziyu Chen, Michael Lattanzi, Hikmat A. Al-Ahmadie, A. Rose Brannon, Michael F. Berger, David B. Solit, Jonathan E. Rosenberg, Dean F. Bajorin, Gopa Iyer
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3410.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3410
Published: 15 June 2022
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Journal Articles

Abstract 1189: OncoKB, MSK’s precision oncology knowledge base

Sarah P. Suehnholz, Moriah Nissan, Hongxin Zhang, Ritika Kundra, Calvin Lu, Benjamin Xu, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Ahmet Zehir, Aijaz Syed, Julia E. Rudolph, Ross L. Levine, Ahmet Dogan, Jianjiong Gao, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1189.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1189
Published: 15 June 2022
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Journal Articles

Abstract 1596: Genomic heterogeneity as a barrier to precision oncology in urothelial cancer

Ziyu Chen, Timothy N. Clinton, Soonbum Park, Andrew T. Lenis, Mark Donoghue, Jonathan E. Rosenberg, Bajorin F. Dean, Min Y. Teo, Bernard H. Bochner, Irina Ostrovnaya, Eugene J. Pietzak, Gopakumar V. Iyer, Sizhi Gao, Wenhuo Hu, Michael M. Shen, Michael F. Berger, Hikmat A. Al-Ahmadie, Corinne T. Abate-Shen, David B. Solit
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1596.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1596
Published: 15 June 2022
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Journal Articles

Abstract OT2-23-01: A Phase 1b/2a, open-label platform study to evaluate mirdametinib in combination with fulvestrant in ER+ metastatic breast cancers harboring MAPK-activating mutations

Ezra Y. Rosen, Payal Patel, Nenad Sarapa, Badreddin Edris, Alexia Iasonos, Komal Jhaveri, Pedram Razavi, Mark Robson, Alexander Drilon, Michael F. Berger, David B. Solit, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT2-23-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT2-23-01
Published: 15 February 2022
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Journal Articles

BRAF Mutations: The Discovery of Allele- and Lineage-Specific Differences

Aphrothiti J. Hanrahan, David B. Solit
Journal: Cancer Research
Cancer Res (2022) 82 (1): 12–14.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3377
Published: 04 January 2022
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Journal Articles

Novel Mouse Models of Bladder Cancer Identify a Prognostic Signature Associated with Risk of Disease Progression

Soonbum Park, Lijie Rong, Tomasz B. Owczarek, Matteo Di Bernardo, Rivka L. Shoulson, Chee-Wai Chua, Jaime Y. Kim, Amir Lankarani, Prithi Chakrapani, Talal Syed, James M. McKiernan, David B. Solit, Michael M. Shen, Hikmat A. Al-Ahmadie, Cory Abate-Shen
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5161–5175.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1254
Published: 15 October 2021
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2834: Integration of genomic and clinical data from 25,000 patients identifies molecular determinants of metastatic potential and organotropisms

Bastien Nguyen, Christopher Fong, Renzo DiNatale, Anisha Luthra, Subhiksha Nandakumar, Henry Walch, Walid K. Chatila, Arjun Rajanna, David B. Solit Solit, Michael F. Berger, Ahmet Zehir, Jianjiong Gao, Francisco Sanchez-Vega, Nikolaus Schultz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2834.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2834
Published: 01 July 2021
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Journal Articles

Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer

Aphrothiti J. Hanrahan, Brooke E. Sylvester, Matthew T. Chang, Arijh Elzein, Jianjiong Gao, Weiwei Han, Ye Liu, Dong Xu, Sizhi P. Gao, Alexander N. Gorelick, Alexis M. Jones, Amber J. Kiliti, Moriah H. Nissan, Clare A. Nimura, Abigail N. Poteshman, Zhan Yao, Yijun Gao, Wenhuo Hu, Hannah C. Wise, Elena I. Gavrila, Alexander N. Shoushtari, Shakuntala Tiwari, Agnes Viale, Omar Abdel-Wahab, Taha Merghoub, Michael F. Berger, Neal Rosen, Barry S. Taylor, David B. Solit
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4233–4243.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-0865
Published: 02 October 2020
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Includes: Supplementary data
Journal Articles

Abstract 1122: Germline mutation prevalence in young adults with cancer

Zsofia K. Stadler, Anna Maio, Angelika Padunan, Yelena Kemel, Erin Salo-Mullen, Margaret Sheehan, Kimeisha Belanfanti, Prince R. Tejada, Ozge Birsoy, Diana Mandelker, Liying Zhang, Jesse Galle, Darren Feldman, Laura Boucai, Julia Glade Bender, Anna Piotrowski, Carol Aghajanian, Karen A. Cadoo, Maria I. Carlo, Michael Walsh, Yelena Janjigian, Eileen O'Reilly, Lisa M. DeAngelis, David B. Solit, Barry Taylor, Andrea Cercek, William Tap, Mark E. Robson, Michael F. Berger, Kenneth Offit, Luis A. Diaz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1122.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1122
Published: 15 August 2020
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Journal Articles

Abstract 3208: OncoKB, a precision oncology knowledgebase

Sarah Suehnholz, Hongxin Zhang, Moriah Nissan, Ritika Kundra, Jing Su, Lindsay LaFave, Kinisha Gala, Chad Vanderbilt, Maria Arcila, Marc Ladanyi, Michael Berger, Ahmet Zehir, Julia E. Rudolph, Paul Sabbatini, Ross Levine, Ahmet Dogan, Jianjiong Gao, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3208.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3208
Published: 15 August 2020
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Journal Articles

Abstract 1308: CDK12 alterations define a distinct molecular subtype of prostate cancers with unique genomic and clinical characteristics

Bastien Nguyen, Jose Mauricio Mota, Subhiksha Nandakumar, Konrad H. Stopsack, Emily Weg, Dana Rathkopf, Michael J. Morris, Howard Scher, Philip W. Kantoff, Anuradha Gopalan, Dmitriy Zamarin, David B. Solit, Nikolaus Schultz, Wassim Abida
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1308.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1308
Published: 15 August 2020
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Journal Articles

Abstract P1-19-08: Neratinib + trastuzumab + fulvestrant for HER2-mutant, hormone receptor-positive, metastatic breast cancer: Updated results from the phase 2 SUMMIT ‘basket’ trial

Hans Wildiers, Valentina Boni, Cristina Saura, Mafalda Oliveira, Komal Jhaveri, Helen Won, François-Clément Bidard, Adam M Brufsky, Mark E Burkard, Andrés Cervantes, Carlos Fernández-Martos, Barbara Haley, Sherene Loi, Iben Spanggaard, Stefano Panni, Janice Lu, Melanie E Dujka, Feng Xu, Sonia Macia, Lisa D Eli, Alshad S Lalani, Sarina Piha-Paul, Funda Meric-Bernstam, David B Solit, David M Hyman
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-19-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P1-19-08
Published: 15 February 2020
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Journal Articles

Abstract P2-10-01: The genomic landscape of breast cancer in African American women

Cristian Serna-Tamayo, Joshua Z Drago, Carlos Dos Anjos, Joshua Herbert, Fresia Pareja, Shanu Modi, Komal Jhaveri, Chau Dang, David B Solit, Larry Norton, Mauricio Scaltriti, Jorge S Reis-Filho, Sarat Chandarlapaty, Mark E. Robson, Pedram Razavi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-10-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-10-01
Published: 15 February 2020
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Journal Articles

Abstract P4-17-01: Genomic profiling of primary and metastatic breast cancer in men

Joshua Z Drago, Cristian Serna-Tamayo, Carlos H Dos Anjos, David N Brown, Shanu Modi, Komal Jhaveri, David B Solit, Tiffany A Traina, Sarat Chandarlapaty, Jorge S Reis-Filho, Mark E Robson, Ayca Gucalp, Pedram Razavi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-17-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P4-17-01
Published: 15 February 2020
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Journal Articles

Abstract 2934: AKT mutant allele-specific activation dictates pharmacologic sensitivities

Tripti Shrestha Bhattarai, Tambudzai Shamu, Swati Patel, Alexander Gorelick, Matthew T. Chang, Elena I. Gavrila, JianJong Gao, Mark T. Donoghue, Paul S. Gao, Tara Soumerai, Wassim Abida, Lilian M. Smyth, David M. Hyman, David B. Solit, Barry S. Taylor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2934.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2934
Published: 01 July 2019
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Abstract 1752: BRCA-mediated tumorigenesis is origin and cell-type dependent

Philip Jonsson, Michael L. Cheng, Chaitanya Bandlamudi, Preethi Srinivasan, Shweta S. Chavan, Noah D. Friedman, Ezra Y. Rosen, Allison L. Richards, Nancy Bouvier, S. Duygu Selcuklu, Craig Bielski, Wassim Abida, Ahmet Zehir, Nikolaus Schultz, Mark T. Donoghue, Jose Baselga, Kenneth Offit, Marc Ladanyi, Eileen M. O’Reilly, Howard I. Scher, Zsofia K. Stadler, Mark E. Robson, David M. Hyman, Michael F. Berger, David B. Solit, Barry S. Taylor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1752.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1752
Published: 01 July 2019
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Journal Articles

Abstract 929: Paired tumor and cfDNA in patients with HER2-mutant solid tumors treated with neratinib reveals convergence of multiple on-target resistance mechanisms: Results from the SUMMIT "Basket" Trial

Helen H. Won, S. Duygu Selcuklu, Sarina A. Piha-Paul, Cristina Saura, Jordi Rodon, Ingrid A. Mayer, Sherene Loi, Geoffrey I. Shapiro, Janice Lu, Adam Brufsky, Catherine Zimel, Myra Melcer, Maurizio Scaltriti, Lisa D. Eli, Richard E. Cutler, Jr., Alshad S. Lalani, Richard P. Bryce, Carlos Arteaga, Funda Meric-Bernstam, Michael F. Berger, David B. Solit, Alison Schram, David M. Hyman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 929.
DOI: https://doi.org/10.1158/1538-7445.AM2019-929
Published: 01 July 2019
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Journal Articles

Abstract LB-304: Oncologic therapy for solid tumors alters the risk of clonal hematopoiesis

Kelly Bolton, Ryan Ptashkin, Lior Braunstein, Teng Gao, Sean M. Devlin, Daniel Kelly, Catherine Coombs, Minal Patel, Matahi Moarii, Elsa Bernard, Antonin Berthon, Laura Boucai, Dominik Glodzik, Axel Martin, Zsofia Stadler, Michael Walsh, Diana Mandelker, Akshar Patel, Jessica Schulman, Gunes Gundem, Aijazuddin Syed, Maria Arcila, David B. Solit, Mark E. Robson, Marc Ladanyi, Choonsik Lee, John Philip, Dean Bajorin, Montserrat Garcia-Closas, Stuart Gardos, David Hyman, Martin Tallman, Mariko Yabe, Kenneth Offit, Howard Scher, Virginia Klimek, Luis Diaz, Nilanjan Chatterjee, Michael F. Berger, Lindsay Morton, Ross Levine, Ahmet Zehir, Elli Papaemmanuil
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-304.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-304
Published: 01 July 2019
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Abstract 1672: Clinical validation of a genomics-based classifier to predict tissue of origin from targeted tumor sequencing

Youyun Zheng, Alexander V. Penson, Niedzica Camacho, Evan Biederstedt, Ahmet Zehir, Cyriac Kandoth, Aijazuddin Syed, Anna M. Varghese, Hikmat A. Al-Ahmadie, Nikolaus Schultz, Marc Ladanyi, David B. Solit, David S. Klimstra, David Hyman, Barry Taylor, Michael F. Berger
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1672.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1672
Published: 01 July 2019
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Abstract 729: Zygosity, lineage, and penetrance dictate the role of germline pathogenicity in tumorigenesis

Chaitanya Bandlamudi, Preethi Srinivasan, Philip Jonsson, Yelena M. Kemel, Shweta S. Chavan, Allison L. Richards, Alex Penson, Craig M. Bielski, Chris Fong, Aijazuddin Syed, Gowtham Jayakumaran, Meera Prasad, Jason Hwee, Nikolaus Schultz, Semanti Mukherjee, Vijai Joseph, Diana Mandelkar, Ozge Birsoy, Liying Zhang, Jinru Shia, Ahmet Zehir, Marc Ladanyi, David M. Hyman, Kenneth Offit, Mark E. Robson, David B. Solit, Zsofia K. Stadler, Michael F. Berger, Barry S. Taylor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 729.
DOI: https://doi.org/10.1158/1538-7445.AM2019-729
Published: 01 July 2019
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