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FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

Claudia Tonelli, Astrid Deschênes, Victoria A. Gaeth, Amanda Jensen, Nandan Vithlani, Melissa A. Yao, Zhen Zhao, Youngkyu Park, David A. Tuveson

Cancer Res OF1–OF18.

https://doi.org/10.1158/0008-5472.CAN-24-4576

Published: 06 May 2025

View articletitled, FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

Includes: Supplementary data

Journal Articles

Abstract 1165: The landscape of molecular targets across 665 next-generation cancer models in the human cancer models initiative identifies opportunities for improved therapy and overcoming resistance

Cancer Res (2025) 85 (8_Supplement_1): 1165.

https://doi.org/10.1158/1538-7445.AM2025-1165

Published: 21 April 2025

View articletitled, Abstract 1165: The landscape of molecular targets across 665 next-generation cancer models in the human cancer models initiative identifies opportunities for improved therapy and overcoming resistance

Journal Articles

Abstract 5998: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Cancer Res (2025) 85 (8_Supplement_1): 5998.

https://doi.org/10.1158/1538-7445.AM2025-5998

Published: 21 April 2025

View articletitled, Abstract 5998: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Journal Articles

Abstract 3882: Patterns of genomic patient-model conservation and evolution in the Human Cancer Models Initiative (HCMI) next-generation cancer model resource

Cancer Res (2025) 85 (8_Supplement_1): 3882.

https://doi.org/10.1158/1538-7445.AM2025-3882

Published: 21 April 2025

View articletitled, Abstract 3882: Patterns of genomic patient-model conservation and evolution in the Human Cancer Models Initiative (HCMI) next-generation cancer model resource

Journal Articles

Abstract 6358: Single cell transcriptional dynamics in the HCMI cancer model collection

Cancer Res (2025) 85 (8_Supplement_1): 6358.

https://doi.org/10.1158/1538-7445.AM2025-6358

Published: 21 April 2025

View articletitled, Abstract 6358: Single cell transcriptional dynamics in the HCMI cancer model collection

Journal Articles

Abstract 4005: Integrative clinical and molecular characterization of an international community resource of organoid models of human cancer

Cancer Res (2025) 85 (8_Supplement_1): 4005.

https://doi.org/10.1158/1538-7445.AM2025-4005

Published: 21 April 2025

View articletitled, Abstract 4005: Integrative clinical and molecular characterization of an international community resource of organoid models of human cancer

Journal Articles

Abstract 6608: Integrating HCMI models and tumors with CCLE and TCGA: Advancing cancer modeling and precision oncology

Cancer Res (2025) 85 (8_Supplement_1): 6608.

https://doi.org/10.1158/1538-7445.AM2025-6608

Published: 21 April 2025

View articletitled, Abstract 6608: Integrating HCMI models and tumors with CCLE and TCGA: Advancing cancer modeling and precision oncology

Journal Articles

Abstract B025: Integrative clinical and molecular analysis of 665 next-generation in vitro cancer models generated by the the Human Cancer Models Initiative (HCMI) for advancing precision medicine and functional drug discovery

Cancer Res (2025) 85 (5_Supplement): B025.

https://doi.org/10.1158/1538-7445.GENFUNC25-B025

Published: 11 March 2025

View articletitled, Abstract B025: Integrative clinical and molecular analysis of 665 next-generation in vitro cancer models generated by the the Human Cancer Models Initiative (HCMI) for advancing precision medicine and functional drug discovery

Journal Articles

Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Cancer Res (2024) 84 (18): 2968–2984.

https://doi.org/10.1158/0008-5472.CAN-23-3419

Published: 16 September 2024

View articletitled, Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Includes: Supplementary data

Journal Articles

Abstract C008: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Amber N. Habowski, Dennis Plenker, Hardik Patel, Caitlin Tsang, Luce St. Surin, Fatim Kouassi, Deepthi Budagavi, Grainne M O'Kane, Stephanie Ramotar, Kenneth H Yu, Faiyaz Notta, Andrew Aguirre, Brian Wolpin, Dan Laheru, Daniel A King, Elizabeth M Jaffee, Jennifer J Knox, David A Tuveson

Cancer Res (2024) 84 (17_Supplement_2): C008.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C008

Published: 15 September 2024

View articletitled, Abstract C008: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Journal Articles

Abstract C093: Dysregulated spliceosomal components promote pancreatic cancer progression

Ledong Wan, Kuan-Ting Lin, Mohammad A. Rahman, Yuma Ishigami, Alexander J. Kral, Dillon Voss, Zhikai Wang, Mads A. Jensen, John E. Wilkinson, Youngkyu Park, David A. Tuveson, Adrian R. Krainer

Cancer Res (2024) 84 (2_Supplement): C093.

https://doi.org/10.1158/1538-7445.PANCA2023-C093

Published: 16 January 2024

View articletitled, Abstract C093: Dysregulated spliceosomal components promote pancreatic cancer progression

Journal Articles

Abstract B040: Neural control of cancer-associated fibroblasts in PDAC

Jeremy Nigri, Wenjun Lan, Sangeeta S Chavan, Youngkyu Park, Jeremy Borniger, Kevin J Tracey, David A Tuveson

Cancer Res (2024) 84 (2_Supplement): B040.

https://doi.org/10.1158/1538-7445.PANCA2023-B040

Published: 16 January 2024

View articletitled, Abstract B040: Neural control of cancer-associated fibroblasts in PDAC

Journal Articles

AACR Cancer Centers Alliance: Fostering Collaboration and Innovation to Advance Lifesaving Scientific Discoveries for Patients

Carlos L. Arteaga, John L. Cleveland, Margaret Foti, Ruben A. Mesa, Louis M. Weiner, Cheryl L. Willman, David A. Tuveson

Cancer Res (2023) 83 (21): 3504–3506.

https://doi.org/10.1158/0008-5472.CAN-23-2803

Published: 01 November 2023

View articletitled, AACR Cancer Centers Alliance: Fostering Collaboration and Innovation to Advance Lifesaving Scientific Discoveries for Patients

Journal Articles

Correction: Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Pascal Belleau, Astrid Deschênes, Nyasha Chambwe, David A. Tuveson, Alexander Krasnitz

Cancer Res (2023) 83 (2): 347.

https://doi.org/10.1158/0008-5472.CAN-22-3926

Published: 18 January 2023

View articletitled, Correction: Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Journal Articles

Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Pascal Belleau, Astrid Deschênes, Nyasha Chambwe, David A. Tuveson, Alexander Krasnitz

Cancer Res (2023) 83 (1): 49–58.

https://doi.org/10.1158/0008-5472.CAN-22-0682

Published: 04 January 2023

View articletitled, Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Includes: Supplementary data

Journal Articles

Abstract A007: Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs

Cancer Res (2022) 82 (22_Supplement): A007.

https://doi.org/10.1158/1538-7445.PANCA22-A007

Published: 15 November 2022

View articletitled, Abstract A007: Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs

Journal Articles

Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Giuseppina Caligiuri, Jennifer S. Thalappillil, Mojdeh Shakiba, Sandeep Nadella, Juliene Hinds, Elise Courtois, William F. Flynn, Brinda Alagesan, Georgi N. Yordanov, Benjamin Kaminow, Paul Robson, Pedro A. Perez-Mancera, Jonathan Preall, Alexander Dobin, Youngku Park, David A. Tuveson

Cancer Res (2022) 82 (22_Supplement): C084.

https://doi.org/10.1158/1538-7445.PANCA22-C084

Published: 15 November 2022

View articletitled, Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Journal Articles

Abstract 1572: FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression

Payton D. Stevens, Emily Sall, Alex Zhong, Galen Hostetter, Zachary Madaj, Jennifer Thalappillil, Alexander Dobin, Youngkyu Park, David A. Tuveson, Bart O. Williams

Cancer Res (2022) 82 (12_Supplement): 1572.

https://doi.org/10.1158/1538-7445.AM2022-1572

Published: 15 June 2022

View articletitled, Abstract 1572: FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression

Journal Articles

Abstract 6081: The transcription factor SPDEF promotes the survival of mucinous pancreatic ductal adenocarcinoma of the classical subtype

Claudia Tonelli, Georgi N. Yordanov, Yuan Hao, Astrid Deschênes, Erin Brosnan, Abishek Doshi, Youngkyu Park, Jonathan Preall, David A. Tuveson

Cancer Res (2022) 82 (12_Supplement): 6081.

https://doi.org/10.1158/1538-7445.AM2022-6081

Published: 15 June 2022

View articletitled, Abstract 6081: The transcription factor SPDEF promotes the survival of mucinous pancreatic ductal adenocarcinoma of the classical subtype

Journal Articles

Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

Jennifer S. Thalappillil, Giuseppina Caligiuri, Sandeep Nadella, Brinda Alagesan, Georgi N. Yordanov, Mojdeh Shakiba, Benjamin Kaminow, Juliene Hinds, Pedro A. Perez-Mancera, Jonathan Preall, Alexander Dobin, Youngkyu Park, David A. Tuveson

Cancer Res (2022) 82 (12_Supplement): 3647.

https://doi.org/10.1158/1538-7445.AM2022-3647

Published: 15 June 2022

View articletitled, Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

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FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

Abstract 1165: The landscape of molecular targets across 665 next-generation cancer models in the human cancer models initiative identifies opportunities for improved therapy and overcoming resistance

Abstract 5998: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Abstract 3882: Patterns of genomic patient-model conservation and evolution in the Human Cancer Models Initiative (HCMI) next-generation cancer model resource

Abstract 6358: Single cell transcriptional dynamics in the HCMI cancer model collection

Abstract 4005: Integrative clinical and molecular characterization of an international community resource of organoid models of human cancer

Abstract 6608: Integrating HCMI models and tumors with CCLE and TCGA: Advancing cancer modeling and precision oncology

Abstract B025: Integrative clinical and molecular analysis of 665 next-generation in vitro cancer models generated by the the Human Cancer Models Initiative (HCMI) for advancing precision medicine and functional drug discovery

Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

Abstract C008: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Abstract C093: Dysregulated spliceosomal components promote pancreatic cancer progression

Abstract B040: Neural control of cancer-associated fibroblasts in PDAC

AACR Cancer Centers Alliance: Fostering Collaboration and Innovation to Advance Lifesaving Scientific Discoveries for Patients

Correction: Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Genetic Ancestry Inference from Cancer-Derived Molecular Data across Genomic and Transcriptomic Platforms

Abstract A007: Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs

Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Abstract 1572: FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression

Abstract 6081: The transcription factor SPDEF promotes the survival of mucinous pancreatic ductal adenocarcinoma of the classical subtype

Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

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