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David A. Orlando
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Journal Articles

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Open Access
Bharti Garg, Sohini Khan, Asimina S. Courelli, Ponmathi Panneerpandian, Deepa Sheik Pran Babu, Evangeline S. Mose, Kevin Christian Montecillo Gulay, Shweta Sharma, Divya Sood, Alexander T. Wenzel, Alexei Martsinkovskiy, Nirakar Rajbhandari, Jay Patel, Dawn Jaquish, Edgar Esparza, Katelin Jaque, Neetu Aggarwal, Guillem Lambies, Anthony D’Ippolito, Kathryn Austgen, Brian Johnston, David A. Orlando, Gun Ho Jang, Steven Gallinger, Elliot Goodfellow, Pnina Brodt, Cosimo Commisso, Pablo Tamayo, Jill P. Mesirov, Hervé Tiriac, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1049–1063.
https://doi.org/10.1158/0008-5472.CAN-24-0744
Published: 14 March 2025
View articletitled, MICAL2 Promotes Pancreatic Cancer Growth and Metastasis
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Includes: Supplementary data
Journal Articles

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7

Free
Shanhu Hu, Jason J. Marineau, Nisha Rajagopal, Kristin B. Hamman, Yoon Jong Choi, Darby R. Schmidt, Nan Ke, Liv Johannessen, Michael J. Bradley, David A. Orlando, Sydney R. Alnemy, Yixuan Ren, Stephane Ciblat, Dana K. Winter, Anzhelika Kabro, Kevin T. Sprott, J. Graeme Hodgson, Christian C. Fritz, John P. Carulli, Emmanuelle di Tomaso, Eric R. Olson
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3479–3491.
https://doi.org/10.1158/0008-5472.CAN-19-0119
Published: 01 July 2019
View articletitled, Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
Open the PDF for Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 in another window
Includes: Supplementary data
Journal Articles

Abstract B1-60: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers

Free
David A. Orlando, Michael R. McKeown, Mei Wei Chen, Cindy Collins, Matthew G. Guenther, Christian C. Fritz
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B1-60.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B1-60
Published: 15 November 2015
View articletitled, Abstract B1-60: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers
Journal Articles

Abstract A1-69: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers

Free
David A. Orlando, Michael R. McKeown, Mei Wei Chen, Cindy Collins, Matthew G. Guenther, Christian C. Fritz
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A1-69.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A1-69
Published: 15 November 2015
View articletitled, Abstract A1-69: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers
Journal Articles

Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies

Free
Matthew G Guenther, David A Orlando, Matthew L Eaton, Cindy A Collins, Mei Wei Chen, Sneha Solanki, Jakob Loven, Christian C Fritz, Eric R Olson
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P1-06-04.
https://doi.org/10.1158/1538-7445.SABCS14-P1-06-04
Published: 01 May 2015
View articletitled, Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies