1-20 of 43
David A. Largaespada
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 6011: Methylation profiling reveals the role of PRC2 in regulating DNA methylome changes in malignant peripheral nerve sheath tumors

Christopher M. Stehn, Minu Bhunia, Kyle B. Williams, Alex T. Larsson, David A. Largaespada
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6011.
https://doi.org/10.1158/1538-7445.AM2023-6011
Published: 04 April 2023
View article titled, Abstract 6011: Methylation profiling reveals the role of PRC2 in regulating DNA methylome changes in malignant peripheral nerve sheath tumors
Journal Articles

Abstract 1615: Developing a novel model of neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors using induced pluripotent stem cells

Garrett M. Draper, Daniel Panken, Mahathi Patchava, Wendy Hudson, Kyle B. Williams, David A. Largaespada
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1615.
https://doi.org/10.1158/1538-7445.AM2022-1615
Published: 15 June 2022
View article titled, Abstract 1615: Developing a novel model of neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors using induced pluripotent stem cells
Journal Articles

Abstract 1614: Creation of malignant peripheral nerve sheath tumor models deficient for polycomb repressive complex 2 and identification of therapeutic vulnerabilities

Kyle B. Williams, Alex Larsson, Justin Tibbits, Christopher L. Moertel, David A. Largaespada
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1614.
https://doi.org/10.1158/1538-7445.AM2022-1614
Published: 15 June 2022
View article titled, Abstract 1614: Creation of malignant peripheral nerve sheath tumor models deficient for polycomb repressive complex 2 and identification of therapeutic vulnerabilities
Journal Articles

Abstract 3026: Sex differences in the genomic profiles of medulloblastoma subtypes

Rachel M. Moss, Natali Sorajja, Lauren J. Mills, Christopher L. Moertel, Logan G. Spector, David A. Largaespada, Lindsay A. Williams
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3026.
https://doi.org/10.1158/1538-7445.AM2021-3026
Published: 01 July 2021
View article titled, Abstract 3026: Sex differences in the genomic profiles of medulloblastoma subtypes
Journal Articles

Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST

Katherine E. Chaney, Melissa R. Perrino, Leah J. Kershner, Ami V. Patel, Jianqiang Wu, Kwangmin Choi, Tilat A. Rizvi, Eva Dombi, Sara Szabo, David A. Largaespada, Nancy Ratner
Journal: Cancer Research
Cancer Res (2020) 80 (21): 4720–4730.
https://doi.org/10.1158/0008-5472.CAN-19-1429
Published: 03 November 2020
View article titled, <em>Cdkn2a</em> Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST
Open the PDF for <em>Cdkn2a</em> Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST in another window
Includes: Supplementary data
Journal Articles

Abstract 2582: Dose-dependent NRASG12V-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line

Morito Kurata, Marie L. Antony, Klara E. Noble, Susan K. Rathe, Haruka Hirakouchi, Kouhei Yamamoto, Masanobu Kitagawa, Zohar Sachs, David A. Largaespada
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2582.
https://doi.org/10.1158/1538-7445.AM2020-2582
Published: 15 August 2020
View article titled, Abstract 2582: Dose-dependent <em>NRAS<sup>G12V</sup></em>-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line
Journal Articles

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia

Karen Sachs, Aaron L. Sarver, Klara E. Noble-Orcutt, Rebecca S. LaRue, Marie Lue Antony, Daniel Chang, Yoonkyu Lee, Connor M. Navis, Alexandria L. Hillesheim, Ian R. Nykaza, Ngoc A. Ha, Conner J. Hansen, Fatma K. Karadag, Rachel J. Bergerson, Michael R. Verneris, Matthew M. Meredith, Matthew L. Schomaker, Michael A. Linden, Chad L. Myers, David A. Largaespada, Zohar Sachs
Journal: Cancer Research
Cancer Res (2020) 80 (3): 458–470.
https://doi.org/10.1158/0008-5472.CAN-18-2932
Published: 03 February 2020
View article titled, Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia
Open the PDF for Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Pauline J. Beckmann, Jon D. Larson, Alex T. Larsson, Jason P. Ostergaard, Sandra Wagner, Eric P. Rahrmann, Ghaidan A. Shamsan, George M. Otto, Rory L. Williams, Jun Wang, Catherine Lee, Barbara R. Tschida, Paramita Das, Adrian M. Dubuc, Branden S. Moriarity, Daniel Picard, Xiaochong Wu, Fausto J. Rodriguez, Quincy Rosemarie, Ryan D. Krebs, Amy M. Molan, Addison M. Demer, Michelle M. Frees, Anthony E. Rizzardi, Stephen C. Schmechel, Charles G. Eberhart, Robert B. Jenkins, Robert J. Wechsler-Reya, David J. Odde, Annie Huang, Michael D. Taylor, Aaron L. Sarver, David A. Largaespada
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (5): 905–917.
https://doi.org/10.1158/0008-5472.CAN-18-1261
Published: 01 March 2019
View article titled, <em>Sleeping Beauty</em> Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors
Open the PDF for <em>Sleeping Beauty</em> Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract LB-197: Transposon mutagenesis and CRISPR/Cas9 screening reveal pathways driving peripheral nerve sheath tumor development and maintenance

German L. Velez Reyes, Nicholas Koes, Gabriel Kaufmann, Esther Ryu, David A. Largaespada
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-197.
https://doi.org/10.1158/1538-7445.AM2018-LB-197
Published: 01 July 2018
View article titled, Abstract LB-197: Transposon mutagenesis and CRISPR/Cas9 screening reveal pathways driving peripheral nerve sheath tumor development and maintenance
Journal Articles

Abstract 2264: RNA sequencing based analysis of transposon-induced tumors reveals novel insights into cancer pathogenesis and progression

Emily T. Camilleri, Pauli J. Beckmann, Jon D. Larson, Morito Kurata, Jingmin Shu, Emily Pope, Wendy A. Hudson, Nuri A. Temiz, Susan K. Rathe, Rebecca S. LaRue, Anne E. Sarver, Milcah C. Scott, Jyotika Varshney, Jaime F. Modiano, Branden S. Moriarity, Aaron L. Sarver, Somasekar Seshagiri, David A. Largaespada
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2264.
https://doi.org/10.1158/1538-7445.AM2018-2264
Published: 01 July 2018
View article titled, Abstract 2264: RNA sequencing based analysis of transposon-induced tumors reveals novel insights into cancer pathogenesis and progression
Journal Articles

Abstract 5183: Using transposon elements to elucidate the genetic mechanisms of HCC-associated lung metastases

Lilian H. Lo, Amy P. Chiu, Xiao-Xiao Li, Barbara R. Tschida, Dewi K. Rowlands, David A. Largaespada, Vincent W. Keng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5183.
https://doi.org/10.1158/1538-7445.AM2018-5183
Published: 01 July 2018
View article titled, Abstract 5183: Using transposon elements to elucidate the genetic mechanisms of HCC-associated lung metastases
Journal Articles

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma

Milcah C. Scott, Nuri A. Temiz, Anne E. Sarver, Rebecca S. LaRue, Susan K. Rathe, Jyotika Varshney, Natalie K. Wolf, Branden S. Moriarity, Timothy D. O'Brien, Logan G. Spector, David A. Largaespada, Jaime F. Modiano, Subbaya Subramanian, Aaron L. Sarver
Journal: Cancer Research
Cancer Res (2018) 78 (2): 326–337.
https://doi.org/10.1158/0008-5472.CAN-17-0576
Published: 15 January 2018
View article titled, Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma
Open the PDF for Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma in another window
Includes: Supplementary data
Journal Articles

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors

Barbara R. Tschida, Nuri A. Temiz, Timothy P. Kuka, Lindsey A. Lee, Jesse D. Riordan, Carlos A. Tierrablanca, Robert Hullsiek, Sandra Wagner, Wendy A. Hudson, Michael A. Linden, Khalid Amin, Pauline J. Beckmann, Rachel A. Heuer, Aaron L. Sarver, Ju Dong Yang, Lewis R. Roberts, Joseph H. Nadeau, Adam J. Dupuy, Vincent W. Keng, David A. Largaespada
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6576–6588.
https://doi.org/10.1158/0008-5472.CAN-17-2281
Published: 30 November 2017
View article titled, <em>Sleeping Beauty</em> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Open the PDF for <em>Sleeping Beauty</em> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML

Rebecca S. LaRue, Klara E. Noble-Orcutt, Conner Hansen, Ngoc Ha, David A. Largaespada, Zohar Sachs
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3339.
https://doi.org/10.1158/1538-7445.AM2016-3339
Published: 15 July 2016
View article titled, Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML
Journal Articles

Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers

Barbara R. Tschida, N. Alpay Temiz, Ju D. Yang, Vincent W. Keng, David A. Largaespada
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 63.
https://doi.org/10.1158/1538-7445.AM2016-63
Published: 15 July 2016
View article titled, Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers
Journal Articles

Abstract 1097: The miR-17-92 microRNA cluster plays a crucial role in osteosarcoma progression

Jyotika Varshney, Nicholas J. Slipek, John Osborne, Adrian Chang, Anne E. Sarver, Ingrid Cornax, Gerry M. O’Sullivan, Subbaya Subramanian, David A. Largaespada
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1097.
https://doi.org/10.1158/1538-7445.AM2016-1097
Published: 15 July 2016
View article titled, Abstract 1097: The miR-17-92 microRNA cluster plays a crucial role in osteosarcoma progression
Journal Articles

Abstract A36: Validation of candidate cancer genes using the CRISPR system

Natalie Wolf, Branden Smeester, Madison Weg, David A. Largaespada, Branden Scott Moriarity
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): A36.
https://doi.org/10.1158/1538-7445.PEDCA15-A36
Published: 04 April 2016
View article titled, Abstract A36: Validation of candidate cancer genes using the CRISPR system
Journal Articles

Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma

Miller Huang, Lauren K. McHenry, Matthew L. Miller, Grace E. Kim, Branden S. Moriarity, Yuichiro Miyaoka, Marianne E. Bronner, David A. Largaespada, Bruce R. Conklin, Hanlee P. Ji, John M. Maris, Katherine K. Matthay, William A. Weiss
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3230.
https://doi.org/10.1158/1538-7445.AM2015-3230
Published: 01 August 2015
View article titled, Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma
Journal Articles

Abstract A14: A forward genetic screen for genes that cooperate with PTEN in lung cancer development

Timothy K. Starr, Raha Allaei, M. Gerard O'Sullivan, Aaron L. Sarver, Adam J. Dupuy, Nancy A. Jenkins, Neal G. Copeland, David A. Largaespada
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A14.
https://doi.org/10.1158/0008-5472.FBCR09-A14
Published: 28 October 2014
View article titled, Abstract A14: A forward genetic screen for genes that cooperate with PTEN in lung cancer development
Journal Articles

Abstract 929: Identification of ZBTB20 as a novel oncogene associated with the gender bias occurrence of hepatocellular carcinoma

Vincent W. Keng, Barbara R. Tschida, Timothy P. Kuka, Branden S. Moriarity, Jason B. Bell, David A. Largaespada
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 929.
https://doi.org/10.1158/1538-7445.AM2014-929
Published: 01 October 2014
View article titled, Abstract 929: Identification of ZBTB20 as a novel oncogene associated with the gender bias occurrence of hepatocellular carcinoma