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David A. Greenhalgh
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Journal Articles

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

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Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R. Croft, Martin J. Drysdale, Mathew J. Garnett, Kathryn Gill, Christopher Gray, David A. Greenhalgh, James A.M. Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDonald, Lynn McGarry, Heather McKinnon, Carol McMenemy, Mokdad Mezna, Nicolas A. Morrice, June Munro, Gregory Naylor, Nicola Rath, Alexander W. Schüttelkopf, Mairi Sime, Michael F. Olson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (8): 2096–2114.
https://doi.org/10.1158/0008-5472.CAN-17-2870
Published: 12 April 2018
View articletitled, Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
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Includes: Supplementary data
Journal Articles

Abstract 930: Inducible ROCK 2/rasHa cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible ROCK 2/PTEN loss fails to achieve benign papilloma

Free
Siti F. Masre, Michael S. Samuel, Michael F. Olson, David A. Greenhalgh
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 930.
https://doi.org/10.1158/1538-7445.AM2014-930
Published: 01 October 2014
View articletitled, Abstract 930: Inducible ROCK 2/rasHa cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible ROCK 2/PTEN loss fails to achieve benign papilloma
Journal Articles

PTEN Loss Promotes rasHa-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways

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Denggao Yao, Claire L. Alexander, Jean A. Quinn, Michael J. Porter, Hong Wu, David A. Greenhalgh
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1302–1312.
https://doi.org/10.1158/0008-5472.CAN-05-2341
Published: 01 February 2006
View articletitled, PTEN Loss Promotes rasHa-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways
Open the PDF for PTEN Loss Promotes rasHa-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways in another window
Includes: Supplementary data
Journal Articles

Cooperation between fos activation and inducible, conditional PTEN knockout elicits benign keratoacanthomas and reprogrammes terminal differentiation in transgenic mouse epidermis

Free
David A. Greenhalgh, Claire L. Alexander, Denggao Yao, Jean A. Quin, Hong Wu
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1272.
Published: 01 April 2004
View articletitled, Cooperation between fos activation and inducible, conditional PTEN knockout elicits benign keratoacanthomas and reprogrammes terminal differentiation in transgenic mouse epidermis
Journal Articles

Paradoxical Tumor Inhibitory Effect of p53 Loss in Transgenic Mice Expressing Epidermal-targeted v-rasHa, v-fos, or Human Transforming Growth Factor α

Free
David A. Greenhalgh, Xiao-Jing Wang, Lawrence A. Donehower, Dennis R. Roop
Journal: Cancer Research
Cancer Res (1996) 56 (19): 4413–4423.
Published: 01 October 1996
View articletitled, Paradoxical Tumor Inhibitory Effect of p53 Loss in Transgenic Mice Expressing Epidermal-targeted v-rasHa, v-fos, or Human Transforming Growth Factor α
Open the PDF for Paradoxical Tumor Inhibitory Effect of p53 Loss in Transgenic Mice Expressing Epidermal-targeted v-rasHa, v-fos, or Human Transforming Growth Factor α in another window
Journal Articles

Cooperation between v-fos and v-rasHA Induces Autonomous Papillomas in Transgenic Epidermis but not Malignant Conversion

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David A. Greenhalgh, Maria I. Quintanilla, Christine C. Orengo, Jennifer L. Barber, Joshua N. Eckhardt, Joseph A. Rothnagel, Dennis R. Roop
Journal: Cancer Research
Cancer Res (1993) 53 (21): 5071–5075.
Published: 01 November 1993
View articletitled, Cooperation between v-fos and v-rasHA Induces Autonomous Papillomas in Transgenic Epidermis but not Malignant Conversion
Open the PDF for Cooperation between v-fos and v-rasHA Induces Autonomous Papillomas in Transgenic Epidermis but not Malignant Conversion in another window
Journal Articles

Development of Murine Epidermal Cell Lines Which Contain an Activated rasHa Oncogene and Form Papillomas in Skin Grafts on Athymic Nude Mouse Hosts

Free
James E. Strickland, David A. Greenhalgh, Aneta Koceva-Chyla, Henry Hennings, Clara Restrepo, Michael Balaschak, Stuart H. Yuspa
Journal: Cancer Research
Cancer Res (1988) 48 (1): 165–169.
Published: 01 January 1988
View articletitled, Development of Murine Epidermal Cell Lines Which Contain an Activated rasHa Oncogene and Form Papillomas in Skin Grafts on Athymic Nude Mouse Hosts
Open the PDF for Development of Murine Epidermal Cell Lines Which Contain an Activated rasHa Oncogene and Form Papillomas in Skin Grafts on Athymic Nude Mouse Hosts in another window