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David A. Boothman
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Journal Articles

Abstract 3432: Zinc metallochaperones for mutant p53 reactivation in cancer therapeutics

Xin Yu, Bing Na, Saif Zaman, Tracy Withers, John Gilleran, Alan J. Blayney, Anthony F. Bencivenga, Adam R. Blanden, Yue Liu, David A. Boothman, Stewart N. Loh, S. David Kimball, Shridar Ganesan, Darren R. Carpizo
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3432.
https://doi.org/10.1158/1538-7445.AM2020-3432
Published: 15 August 2020
View article titled, Abstract 3432: Zinc metallochaperones for mutant p53 reactivation in cancer therapeutics
Journal Articles

Abstract 5169: Tissue analysis of NAD(P)H: quinone oxidoreductase (NQO1) and catalase expression in patients with germ cell tumors (GCT)

Neda Hashemi Sadraei, Nabil Adra, Constance Temm, Kenneth A. Kesler, Muhammad T. Idrees, David A. Boothman, Lawrence Einhorn
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5169.
https://doi.org/10.1158/1538-7445.AM2020-5169
Published: 15 August 2020
View article titled, Abstract 5169: Tissue analysis of NAD(P)H: quinone oxidoreductase (NQO1) and catalase expression in patients with germ cell tumors (GCT)
Journal Articles

Abstract B39: NQO1 as a therapeutic target for atypical teratoid/ rhabdoid tumor

Julia C. Meade, Zachary R. Moore, Sarai H. Stuart, Agnieszka Cholka, Richard L. Boriack, Jingying Xu, Anat Erdreich-Epstein, Dinesh Rakheja, David A. Boothman, James F. Amatruda, Theodore W. Laetsch
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B39.
https://doi.org/10.1158/1538-7445.PEDCA15-B39
Published: 04 April 2016
View article titled, Abstract B39: NQO1 as a therapeutic target for atypical teratoid/ rhabdoid tumor
Journal Articles

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

Miao Wang, Mary Topalovski, Jason E. Toombs, Christopher M. Wright, Zachary R. Moore, David A. Boothman, Hiromi Yanagisawa, Huamin Wang, Agnieszka Witkiewicz, Diego H. Castrillon, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5058–5069.
https://doi.org/10.1158/0008-5472.CAN-15-0744
Published: 30 November 2015
View article titled, Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Abstract 1613: β-lapachone: a novel targeted therapy for atypical teratoid rhabdoid tumors (ATRTs)

Zachary R. Moore, Sarai Stuart, Agnieszka Cholka, Ashwin Venkataraman, Jingying Xu, Anat Erdreich-Epstein, Dinesh Rakheja, David A. Boothman, James F. Amatruda, Theodore W. Laetsch
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1613.
https://doi.org/10.1158/1538-7445.AM2015-1613
Published: 01 August 2015
View article titled, Abstract 1613: β-lapachone: a novel targeted therapy for atypical teratoid rhabdoid tumors (ATRTs)
Journal Articles

Abstract 1679: Inhibiting KRAS-reprogrammed glutamine metabolism sensitizes pancreatic cancer to NQO1-bioactivatable drugs

Gaurab Chakrabarti, David A. Boothman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1679.
https://doi.org/10.1158/1538-7445.AM2014-1679
Published: 01 October 2014
View article titled, Abstract 1679: Inhibiting KRAS-reprogrammed glutamine metabolism sensitizes pancreatic cancer to NQO1-bioactivatable drugs
Journal Articles

Abstract 1760: Tumor-specific targeting of the NAD metabolome with β-lapachone and NamPT inhibition

Zachary Moore, David A. Boothman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1760.
https://doi.org/10.1158/1538-7445.AM2014-1760
Published: 01 October 2014
View article titled, Abstract 1760: Tumor-specific targeting of the NAD metabolome with β-lapachone and NamPT inhibition
Journal Articles

Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers

Xiumei Huang, Zachary Moore, Xiuquan Luo, Gaurab Chakrabarti, Mariya Ilcheva, Rolf Brekken, Sandeep Burma, Jinming Gao, Ralph Deberardinis, William Bornmann, Paul Hergenrother, David A. Boothman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 787.
https://doi.org/10.1158/1538-7445.AM2014-787
Published: 01 October 2014
View article titled, Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers
Journal Articles

Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer.

Xiuquan Luo, Longshan Li, Xiumei Huang, Lifen Cao, Zachary Moore, Ralph Deberardinis, Rolf Brekken, Stanton Gerson, Lili Liu, David A. Boothman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3344.
https://doi.org/10.1158/1538-7445.AM2013-3344
Published: 15 April 2013
View article titled, Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer.
Journal Articles

Abstract 4614: β-lapachone suppresses glucose metabolism in a NQO1-dependent, tumor-selective manner.

Xiuquan Luo, Malina Patel, Longshan Li, Ralph Deberardinis, David A. Boothman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4614.
https://doi.org/10.1158/1538-7445.AM2013-4614
Published: 15 April 2013
View article titled, Abstract 4614: β-lapachone suppresses glucose metabolism in a NQO1-dependent, tumor-selective manner.
Journal Articles

Abstract 589: NQO1-dependent anticancer action with combination β-lapachone and ionizing radiation in the head and neck cancer.

Long Shan Li, Srilakshmi Reddy, Jinming Gao, David A. Boothman, Baran Sumer, John S. Yordy
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 589.
https://doi.org/10.1158/1538-7445.AM2013-589
Published: 15 April 2013
View article titled, Abstract 589: NQO1-dependent anticancer action with combination β-lapachone and ionizing radiation in the head and neck cancer.
Journal Articles

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

Xiumei Huang, Ying Dong, Erik A. Bey, Jessica A. Kilgore, Joseph S. Bair, Long-Shan Li, Malina Patel, Elizabeth I. Parkinson, Yiguang Wang, Noelle S. Williams, Jinming Gao, Paul J. Hergenrother, David A. Boothman
Journal: Cancer Research
Cancer Res (2012) 72 (12): 3038–3047.
https://doi.org/10.1158/0008-5472.CAN-11-3135
Published: 14 June 2012
View article titled, An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
Open the PDF for An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis in another window
Includes: Supplementary data
Journal Articles

Abstract 5369: Prostate cancer radiosensitization through PARP-1 hyperactivation

Ying Dong, Erik A. Bey, Longshan Li, David A. Boothman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5369.
https://doi.org/10.1158/1538-7445.AM2011-5369
Published: 15 April 2011
View article titled, Abstract 5369: Prostate cancer radiosensitization through PARP-1 hyperactivation
Journal Articles

Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 Hyperactivation

Ying Dong, Erik A. Bey, Long-Shan Li, Wareef Kabbani, Jingsheng Yan, Xian-Jin Xie, Jer-Tsong Hsieh, Jinming Gao, David A. Boothman
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8088–8096.
https://doi.org/10.1158/0008-5472.CAN-10-1418
Published: 13 October 2010
View article titled, Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 Hyperactivation
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Includes: Supplementary data
Journal Articles

β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy

Elvin Blanco, Erik A. Bey, Chalermchai Khemtong, Su-Geun Yang, Jagadeesh Setti-Guthi, Huabing Chen, Chase W. Kessinger, Kevin A. Carnevale, William G. Bornmann, David A. Boothman, Jinming Gao
Journal: Cancer Research
Cancer Res (2010) 70 (10): 3896–3904.
https://doi.org/10.1158/0008-5472.CAN-09-3995
Published: 12 May 2010
View article titled, β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy
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Includes: Supplementary data
Journal Articles

Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring K-RAS Mutations

Georgia Konstantinidou, Erik A. Bey, Andrea Rabellino, Katja Schuster, Michael S. Maira, Adi F. Gazdar, Augusto Amici, David A. Boothman, Pier Paolo Scaglioni
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7644–7652.
https://doi.org/10.1158/0008-5472.CAN-09-0823
Published: 01 October 2009
View article titled, Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring <em>K-RAS</em> Mutations
Open the PDF for Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring <em>K-RAS</em> Mutations in another window
Includes: Supplementary data
Journal Articles

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Bipasha Mukherjee, Brian McEllin, Cristel V. Camacho, Nozomi Tomimatsu, Shyam Sirasanagandala, Suraj Nannepaga, Kimmo J. Hatanpaa, Bruce Mickey, Christopher Madden, Elizabeth Maher, David A. Boothman, Frank Furnari, Webster K. Cavenee, Robert M. Bachoo, Sandeep Burma
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4252–4259.
https://doi.org/10.1158/0008-5472.CAN-08-4853
Published: 15 May 2009
View article titled, EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma
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Journal Articles

RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF-κB–Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN

Seongmi Park, Dawen Zhao, Kimmo J. Hatanpaa, Bruce E. Mickey, Debabrata Saha, David A. Boothman, Michael D. Story, Eric T. Wong, Sandeep Burma, Maria-Magdalena Georgescu, Vivek M. Rangnekar, Sandili S. Chauncey, Amyn A. Habib
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4107–4111.
https://doi.org/10.1158/0008-5472.CAN-09-0474
Published: 15 May 2009
View article titled, RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF-κB–Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN
Open the PDF for RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF-κB–Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN in another window
Includes: Supplementary data
Journal Articles

The Receptor Interacting Protein 1 Inhibits p53 Induction through NF-κB Activation and Confers a Worse Prognosis in Glioblastoma

Seongmi Park, Kimmo J. Hatanpaa, Yang Xie, Bruce E. Mickey, Christopher J. Madden, Jack M. Raisanen, Deepti B. Ramnarain, Guanghua Xiao, Debabrata Saha, David A. Boothman, Dawen Zhao, Robert M. Bachoo, Russell O. Pieper, Amyn A. Habib
Journal: Cancer Research
Cancer Res (2009) 69 (7): 2809–2816.
https://doi.org/10.1158/0008-5472.CAN-08-4079
Published: 01 April 2009
View article titled, The Receptor Interacting Protein 1 Inhibits p53 Induction through NF-κB Activation and Confers a Worse Prognosis in Glioblastoma
Open the PDF for The Receptor Interacting Protein 1 Inhibits p53 Induction through NF-κB Activation and Confers a Worse Prognosis in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

In vivo Off-Resonance Saturation Magnetic Resonance Imaging of αvβ3-Targeted Superparamagnetic Nanoparticles

Chalermchai Khemtong, Chase W. Kessinger, Jimin Ren, Erik A. Bey, Su-Geun Yang, Jagadeesh Setti Guthi, David A. Boothman, A. Dean Sherry, Jinming Gao
Journal: Cancer Research
Cancer Res (2009) 69 (4): 1651–1658.
https://doi.org/10.1158/0008-5472.CAN-08-3231
Published: 12 February 2009
View article titled, <em>In vivo</em> Off-Resonance Saturation Magnetic Resonance Imaging of α<sub>v</sub>β<sub>3</sub>-Targeted Superparamagnetic Nanoparticles
Open the PDF for <em>In vivo</em> Off-Resonance Saturation Magnetic Resonance Imaging of α<sub>v</sub>β<sub>3</sub>-Targeted Superparamagnetic Nanoparticles in another window
Includes: Supplementary data