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Daryl C. Drummond
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Journal Articles

Abstract 2491: Engineering and preclinical activity of MM-201, a best-in-class TRAIL receptor agonist

Andrew J. Sawyer, Sara Ghassemifar, Christina Wong, Jennifer Richards, Stephanie Grabow, James Suchy, Alexander Koshkaryev, Maja Razlog, Eric Tam, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2491.
https://doi.org/10.1158/1538-7445.AM2019-2491
Published: 01 July 2019
View article titled, Abstract 2491: Engineering and preclinical activity of MM-201, a best-in-class TRAIL receptor agonist
Journal Articles

Abstract 3270: Mechanism of action of a novel agonist TNFR2 antibody that induces co-stimulation of T cells and promotes robust anti-tumor immunity

Ross B. Fulton, Adam Camblin, James F. Sampson, Jennifer Richards, Christina Wong, Alexander Koshkaryev, Lia Luus, Yang Jiao, Lihui Xu, Violette Paragas, Maja Razlog, Marco Muda, Eric M. Tam, Daryl C. Drummond, Andreas Raue
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3270.
https://doi.org/10.1158/1538-7445.AM2019-3270
Published: 01 July 2019
View article titled, Abstract 3270: Mechanism of action of a novel agonist TNFR2 antibody that induces co-stimulation of T cells and promotes robust anti-tumor immunity
Journal Articles

Abstract 700: Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancer

Sara Ghassemifar, Yasmin Hashambhoy-Ramsay, Haluk Yuzugullu, Tamara Utermark, Violette Paragas, Tim Maiwald, Lia Luus, Maja Razlog, Hannah Hudson, Diane Chai, Birgit Schoeberl, C. Patrick Reynolds, Peter Sorger, Andrew J. Sawyer, Daryl C. Drummond, Eric Tam
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 700.
https://doi.org/10.1158/1538-7445.AM2019-700
Published: 01 July 2019
View article titled, Abstract 700: Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancer
Journal Articles

Abstract 555: A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity

James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 555.
https://doi.org/10.1158/1538-7445.AM2019-555
Published: 01 July 2019
View article titled, Abstract 555: A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity
Journal Articles

Abstract CT146: Plasma pharmacokinetics of liposomal irinotecan (nal-IRI) in pediatric oncology patients with recurrent or refractory solid tumors: South Plains Oncology Consortium Study 2012-001

Paul D. Harker-Murray, William H. Meyer, Patrick Leavey, Min H. Kang, Hwangeui Cho, Bambang S. Adiwijaya, Jonathan B. Fitzgerald, J Marc Pipas, Daryl C. Drummond, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT146.
https://doi.org/10.1158/1538-7445.AM2017-CT146
Published: 01 July 2017
View article titled, Abstract CT146: Plasma pharmacokinetics of liposomal irinotecan (nal-IRI) in pediatric oncology patients with recurrent or refractory solid tumors: South Plains Oncology Consortium Study 2012-001
Journal Articles

Abstract 4711: Immunomodulatory effects of an EphA2-targeted docetaxel antibody-directed nanotherapeutic and synergistic combination with PD-1 inhibitor

Andrew J. Sawyer, Anne-Sophie Dugast, Lia Luus, Zhaohua Richard Huang, Suresh K. Tipparaju, Dmitri B. Kirpotin, Daryl C. Drummond, Walid S. Kamoun
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4711.
https://doi.org/10.1158/1538-7445.AM2017-4711
Published: 01 July 2017
View article titled, Abstract 4711: Immunomodulatory effects of an EphA2-targeted docetaxel antibody-directed nanotherapeutic and synergistic combination with PD-1 inhibitor
Journal Articles

Abstract 3096: Mechanisms of synergy of carboplatin and an EphA2-targeted docetaxel antibody-directed nanotherapeutic

Walid S. Kamoun, Andrew J. Sawyer, Christine Pien, Alexander Koshkaryev, Lia Luus, Samantha Merrigan, Gang Sun, Sergey Kozin, Zhaohua Richard Huang, Suresh K. Tipparaju, Dmitri B. Kirpotin, Hannah Xu, Vasileios Askoxylakis, Patrick C. Reynolds, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3096.
https://doi.org/10.1158/1538-7445.AM2017-3096
Published: 01 July 2017
View article titled, Abstract 3096: Mechanisms of synergy of carboplatin and an EphA2-targeted docetaxel antibody-directed nanotherapeutic
Journal Articles

Abstract 2075: Differential tissue clearance results in improved therapeutic index for irinotecan liposome injection (ONIVYDE) when combined with the PARP inhibitor veliparib in preclinical cervical tumors

Alexander Koshkaryev, Jonathan Fitzgerald, Jaeyeon Kim, Ashish Kalra, Walid Kamoun, Sarah Blanchette, Lia Luus, Stephan Klinz, Ozan Alkan, Tad Kornaga, Susan Bates, Yves Pommier, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2075.
https://doi.org/10.1158/1538-7445.AM2016-2075
Published: 15 July 2016
View article titled, Abstract 2075: Differential tissue clearance results in improved therapeutic index for irinotecan liposome injection (ONIVYDE) when combined with the PARP inhibitor veliparib in preclinical cervical tumors
Journal Articles

Abstract 2069: Activity of an EphA2-targeted docetaxel nanoliposome in pancreatic patient-derived models as monotherapy and in combination with gemcitabine

Daryl C. Drummond, Ninfa L. Straubinger, Tista Roy Chaudhuri, Michael Moser, Walid S. Kamoun, Lia Luus, Zhaohua Richard Huang, Suresh Tipparaju, Bryan Gillard, Carl Morrison, Elizabeth Repasky, Dmitri B. Kirpotin, Robert M. Straubinger
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2069.
https://doi.org/10.1158/1538-7445.AM2016-2069
Published: 15 July 2016
View article titled, Abstract 2069: Activity of an EphA2-targeted docetaxel nanoliposome in pancreatic patient-derived models as monotherapy and in combination with gemcitabine
Journal Articles

Abstract 871: Nanoliposomal targeting of ephrin receptor A2 (EphA2): Preclinical in vitro and in vivo rationale

Walid S. Kamoun, Lia Luus, Christine Pien, Tad Kornaga, Shinji Oyama, Zhaohua Richard Huang, Suresh Tipparaju, Dmitri B. Kirpotin, James D. Marks, Alexander Koshkaryev, Melissa Geddie, Lihui Xu, Alexey Lugovosky, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 871.
https://doi.org/10.1158/1538-7445.AM2016-871
Published: 15 July 2016
View article titled, Abstract 871: Nanoliposomal targeting of ephrin receptor A2 (EphA2): Preclinical in vitro and in vivo rationale
Journal Articles

Abstract 3912: MM-310, a novel EphA2-targeted docetaxel nanoliposome

Dmitri B. Kirpotin, Suresh Tipparaju, Zhaohua Richard Huang, Walid S. Kamoun, Christine Pien, Tad Kornaga, Shinji Oyama, Ken Olivier, James D. Marks, Alexander Koshkaryev, Sarah S. Schihl, Gerald Fetterly, Birgit Schoeberl, Charles Noble, Mark Hayes, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3912.
https://doi.org/10.1158/1538-7445.AM2016-3912
Published: 15 July 2016
View article titled, Abstract 3912: MM-310, a novel EphA2-targeted docetaxel nanoliposome
Journal Articles

Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer

Daniel F. Gaddy, Helen Lee, Nancy Paz, Shannon C. Leonard, Ashish Kalra, Ninfa L. Straubinger, Robert M. Straubinger, Bryan M. Gillard, Michael T. Moser, Daryl C. Drummond, Stephan G. Klinz, Bart S. Hendriks, Jonathan B. Fitzgerald
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4830.
https://doi.org/10.1158/1538-7445.AM2016-4830
Published: 15 July 2016
View article titled, Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer
Journal Articles

Abstract 750: Nanoliposomal targeting of Ephrin receptor A2 (EphA2): Clinical translation

Walid S. Kamoun, Shinji Oyama, Tad Kornaga, Theresa Feng, Lia Luus, Minh T. Pham, Dmitri B. Kirpotin, James D. Marks, Melissa Geddie, Lihui Xu, Alexey A. Lugovskoy, Monica Murphy, Carl Morrisson, Daryl C. Drummond
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 750.
https://doi.org/10.1158/1538-7445.AM2016-750
Published: 15 July 2016
View article titled, Abstract 750: Nanoliposomal targeting of Ephrin receptor A2 (EphA2): Clinical translation
Journal Articles

Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion

Ashish V. Kalra, Jaeyeon Kim, Stephan G. Klinz, Nancy Paz, Jason Cain, Daryl C. Drummond, Ulrik B. Nielsen, Jonathan B. Fitzgerald
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (23): 7003–7013.
https://doi.org/10.1158/0008-5472.CAN-14-0572
Published: 30 November 2014
View article titled, Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion
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Includes: Supplementary data
Journal Articles

Abstract 3972: Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewings family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression

Min H. Kang, Michael M. Song, Monish Makena, Joo-Sang Lee, Connor P. Hall, Ashly Hindle, Winford Ko, Nancy Paz, Jonathan Fitzgerald, Daryl C. Drummond, Timothy J. Triche, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3972.
https://doi.org/10.1158/1538-7445.AM2014-3972
Published: 01 October 2014
View article titled, Abstract 3972: Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewings family tumor xenografts is associated with high exposure of tumor to drug and high <em>SLFN11</em> expression
Journal Articles

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

Dmitri B. Kirpotin, Daryl C. Drummond, Yi Shao, M. Refaat Shalaby, Keelung Hong, Ulrik B. Nielsen, James D. Marks, Christopher C. Benz, John W. Park
Journal: Cancer Research
Cancer Res (2006) 66 (13): 6732–6740.
https://doi.org/10.1158/0008-5472.CAN-05-4199
Published: 03 July 2006
View article titled, Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models
Open the PDF for Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models in another window
Journal Articles

Development of a Highly Active Nanoliposomal Irinotecan Using a Novel Intraliposomal Stabilization Strategy

Daryl C. Drummond, Charles O. Noble, Zexiong Guo, Keelung Hong, John W. Park, Dmitri B. Kirpotin
Journal: Cancer Research
Cancer Res (2006) 66 (6): 3271–3277.
https://doi.org/10.1158/0008-5472.CAN-05-4007
Published: 15 March 2006
View article titled, Development of a Highly Active Nanoliposomal Irinotecan Using a Novel Intraliposomal Stabilization Strategy
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Journal Articles

Novel Nanoliposomal CPT-11 Infused by Convection-Enhanced Delivery in Intracranial Tumors: Pharmacology and Efficacy

Charles O. Noble, Michal T. Krauze, Daryl C. Drummond, Yoji Yamashita, Ryuta Saito, Mitchel S. Berger, Dmitri B. Kirpotin, Krystof S. Bankiewicz, John W. Park
Journal: Cancer Research
Cancer Res (2006) 66 (5): 2801–2806.
https://doi.org/10.1158/0008-5472.CAN-05-3535
Published: 01 March 2006
View article titled, Novel Nanoliposomal CPT-11 Infused by Convection-Enhanced Delivery in Intracranial Tumors: Pharmacology and Efficacy
Open the PDF for Novel Nanoliposomal CPT-11 Infused by Convection-Enhanced Delivery in Intracranial Tumors: Pharmacology and Efficacy in another window
Journal Articles

Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs In vivo

Christoph Mamot, Daryl C. Drummond, Charles O. Noble, Verena Kallab, Zexiong Guo, Keelung Hong, Dmitri B. Kirpotin, John W. Park
Journal: Cancer Research
Cancer Res (2005) 65 (24): 11631–11638.
https://doi.org/10.1158/0008-5472.CAN-05-1093
Published: 15 December 2005
View article titled, Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs <em>In vivo</em>
Open the PDF for Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs <em>In vivo</em> in another window
Journal Articles

Development of a highly stable liposomal irinotecan with low toxicity and potent antitumor efficacy

Daryl C. Drummond, Charles O. Noble, IV, Zexiong Guo, Mark E. Hayes, Keelung Hong, John W. Park, Dmitri B. Kirpotin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 330.
Published: 01 May 2005
View article titled, Development of a highly stable liposomal irinotecan with low toxicity and potent antitumor efficacy