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Darren Orton
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Journal Articles

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells

Free
Annamil Alvarez-Trotta, William Guerrant, Luisana Astudillo, Mohini Lahiry, Giulia Diluvio, Elena Shersher, Hugo Kaneku, David J. Robbins, Darren Orton, Anthony J. Capobianco
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (12): 3347–3357.
https://doi.org/10.1158/0008-5472.CAN-20-3611
Published: 15 June 2021
View articletitled, Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Open the PDF for Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells in another window
Includes: Supplementary data
Journal Articles

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

Free
Luisana Astudillo, Thiago G. Da Silva, Zhiqiang Wang, Xiaoqing Han, Ke Jin, Jeffrey VanWye, Xiaoxia Zhu, Kelly Weaver, Taiji Oashi, Pedro E.M. Lopes, Darren Orton, Leif R. Neitzel, Ethan Lee, Ralf Landgraf, David J. Robbins, Alexander D. MacKerell, Jr, Anthony J. Capobianco
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3593–3603.
https://doi.org/10.1158/0008-5472.CAN-16-0061
Published: 14 June 2016
View articletitled, The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Open the PDF for The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

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Bin Li, Dennis Liang Fei, Colin A. Flaveny, Nadia Dahmane, Valérie Baubet, Zhiqiang Wang, Feng Bai, Xin-Hai Pei, Jezabel Rodriguez-Blanco, Brian Hang, Darren Orton, Lu Han, Baolin Wang, Anthony J. Capobianco, Ethan Lee, David J. Robbins
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4811–4821.
https://doi.org/10.1158/0008-5472.CAN-14-0317
Published: 01 September 2014
View articletitled, Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Open the PDF for Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened in another window
Includes: Supplementary data