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Journal Articles

Abstract 1333: A novel and highly efficient biomimetic capture approach for the isolation and characterization of circulating metastatic cancer cell clusters from lung cancer patients

Kourosh Kouhmareh, Erika Martin, Darren Finlay, Anukriti Bhadada, Francisco Downey, Jeff A. Allen, Peter Teriete
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1333.
https://doi.org/10.1158/1538-7445.AM2023-1333
Published: 04 April 2023
View article titled, Abstract 1333: A novel and highly efficient biomimetic capture approach for the isolation and characterization of circulating metastatic cancer cell clusters from lung cancer patients
Journal Articles

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma

Jessica M. Rusert, Edwin F. Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Sameerah Wahab, Yoko T. Udaka, Darren Finlay, Huriye Seker-Cin, Brendan Reardon, Susanne Gröbner, Jonathan Serrano, Jonas Ecker, Lin Qi, Mari Kogiso, Yuchen Du, Patricia A. Baxter, Jacob J. Henderson, Michael E. Berens, Kristiina Vuori, Till Milde, Yoon-Jae Cho, Xiao-Nan Li, James M. Olson, Iris Reyes, Matija Snuderl, Terence C. Wong, David P. Dimmock, Shareef A. Nahas, Denise Malicki, John R. Crawford, Michael L. Levy, Eliezer M. Van Allen, Stefan M. Pfister, Pablo Tamayo, Marcel Kool, Jill P. Mesirov, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5393–5407.
https://doi.org/10.1158/0008-5472.CAN-20-1655
Published: 02 December 2020
View article titled, Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
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Includes: Supplementary data
Journal Articles

Abstract 2405: Inhibitor of apoptosis protein antagonists as novel targeted chemotherapeutic agents for acute myeloid leukemia

Darren Finlay, Nicole Bata, Allison Limpert, Dominik Heimann, Peter Teriete, Carol Burian, James Mason, Nicholas D. Cosford, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2405.
https://doi.org/10.1158/1538-7445.AM2020-2405
Published: 15 August 2020
View article titled, Abstract 2405: Inhibitor of apoptosis protein antagonists as novel targeted chemotherapeutic agents for acute myeloid leukemia
Journal Articles

Abstract 1434: Loss of PTEN confers resistance to neddylation inhibition through TOP2A in glioblastoma

Brett Taylor, Shayesteh Ferdosi, Nanyun Tang, Rita Bybee, George Reid, Lauren Hartman, Darren Finlay, Kristiina Vuori, Matthew Lee, Sen Peng, Frank Furnari, Harshil Dhruv, Michael Berens
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1434.
https://doi.org/10.1158/1538-7445.AM2020-1434
Published: 15 August 2020
View article titled, Abstract 1434: Loss of PTEN confers resistance to neddylation inhibition through TOP2A in glioblastoma
Journal Articles

Abstract 3529: Detection of genomic structural variations associated with drug sensitivities and resistance in AML using novel whole genome imaging

Darren Finlay, Rabi Murad, Karl Hong, Joyce Lee, Andy Pang, Chi-Yu Lai, Carol Burian, James Mason, Alex Hastie, Jun Yin, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3529.
https://doi.org/10.1158/1538-7445.AM2020-3529
Published: 15 August 2020
View article titled, Abstract 3529: Detection of genomic structural variations associated with drug sensitivities and resistance in AML using novel whole genome imaging
Journal Articles

Abstract 3426: A synthetic lethality approach to eradicate AML via synergistic activation of pro-apoptotic p53 by MDM2 and BET inhibitors

Sha Li, Anne Latif, Ashley Newcombe, Kathryn Gilroy, Neil Robertson, Xue Lei, Darren Finlay, Helen Stewart, Karina Barbosa, Brian Higgins, Tim Chevassut, Xu Huang, Mhairi Copland, Karen Keeshan, Ani Deshpande, Peter Adams
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3426.
https://doi.org/10.1158/1538-7445.AM2020-3426
Published: 15 August 2020
View article titled, Abstract 3426: A synthetic lethality approach to eradicate AML via synergistic activation of pro-apoptotic p53 by MDM2 and BET inhibitors
Journal Articles

Abstract LB-110: Proteasome addiction a new therapeutic opportunity to treat PTEN-deficient brain tumors

Jorge A. Benitez, Darren Finlay, Alexandre Rosa-Campos, Jianhui Ma, Tomoyuki Koga, Kristiina Vuori, Frank Furnari
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-110.
https://doi.org/10.1158/1538-7445.AM2019-LB-110
Published: 01 July 2019
View article titled, Abstract LB-110: Proteasome addiction a new therapeutic opportunity to treat PTEN-deficient brain tumors
Journal Articles

Abstract 3550: microRNA-211 promotes aggressive melanoma growth in vivo by epigenetic modification, and contributes to BRAFV600E inhibitor resistance via ERK5 signaling

Bongyong Lee, Anupama Sahoo, Junko Sawada, Dimitrios G. Zisoulis, John Marchica, Sanjay Sahoo, Fabiana I Alves De Lima Layng, Darren Finlay, Joseph Mazar, Piyush Joshi, Masanobu Komatsu, Kristiina Vuori, Garth Powis, Petrus R. de Jong, Animesh Ray, Ranjan J. Perera
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3550.
https://doi.org/10.1158/1538-7445.AM2019-3550
Published: 01 July 2019
View article titled, Abstract 3550: microRNA-211 promotes aggressive melanoma growth <em>in vivo</em> by epigenetic modification, and contributes to BRAFV600E inhibitor resistance via ERK5 signaling
Journal Articles

Abstract 881: Identifying the context of vulnerability to MLN4924 in glioblastoma (GBM)

Leena Chaudhuri, Rita L. Bybee, Lauren K. Hartman, Sen Peng, Darren Finlay, Kristiina Vuori, Michael E. Berens, Harshil D. Dhruv
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 881.
https://doi.org/10.1158/1538-7445.AM2018-881
Published: 01 July 2018
View article titled, Abstract 881: Identifying the context of vulnerability to MLN4924 in glioblastoma (GBM)
Journal Articles

Abstract 1177: Targeting NEDD8 to uncover an exceptional responder molecular subtype in glioblastoma

Lauren K. Hartman, Darren Finlay, Peiwen Pan, Seungchan Kim, Gil Speyer, Jeff Kiefer, Harshil Dhruv, Kristiina Vuori, Michael Berens
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1177.
https://doi.org/10.1158/1538-7445.AM2017-1177
Published: 01 July 2017
View article titled, Abstract 1177: Targeting NEDD8 to uncover an exceptional responder molecular subtype in glioblastoma
Journal Articles

Abstract 1142: Novel target discovery for glioblastoma using chemical biology fingerprinting

Darren Finlay, Pedro Aza-Blanc, Harshil Dhruv, Alexey Eroshkin, Craig Hauser, Jeff Kiefer, Seungchan Kim, Tao Long, Robert G. Oshima, Sen Peng, Gil Speyer, Michael Berens, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1142.
https://doi.org/10.1158/1538-7445.AM2017-1142
Published: 01 July 2017
View article titled, Abstract 1142: Novel target discovery for glioblastoma using chemical biology fingerprinting
Journal Articles

Abstract 4671: Identification of novel drugs for glioblastoma using chemical biology fingerprinting

Darren Finlay, Harshil Dhruv, Lisa Evers, Sen Peng, Jeff Kiefer, Seungchan Kim, Jeffrey Raizer, Michael Berens, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4671.
https://doi.org/10.1158/1538-7445.AM2015-4671
Published: 01 August 2015
View article titled, Abstract 4671: Identification of novel drugs for glioblastoma using chemical biology fingerprinting
Journal Articles

Critical Role for Caspase-8 in Epidermal Growth Factor Signaling

Darren Finlay, Amy Howes, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5023–5029.
https://doi.org/10.1158/0008-5472.CAN-08-3731
Published: 15 June 2009
View article titled, Critical Role for Caspase-8 in Epidermal Growth Factor Signaling
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Journal Articles

Combination treatment of rapamycin and low dose irradiation causes cell death in human cancer cells cultured as 3-D spheroids

Amy Howes, Darren Finlay, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4182.
Published: 01 May 2008
View article titled, Combination treatment of rapamycin and low dose irradiation causes cell death in human cancer cells cultured as 3-D spheroids
Journal Articles

Novel Noncatalytic Role for Caspase-8 in Promoting Src-Mediated Adhesion and Erk Signaling in Neuroblastoma Cells

Darren Finlay, Kristiina Vuori
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11704–11711.
https://doi.org/10.1158/0008-5472.CAN-07-1906
Published: 18 December 2007
View article titled, Novel Noncatalytic Role for Caspase-8 in Promoting Src-Mediated Adhesion and Erk Signaling in Neuroblastoma Cells
Open the PDF for Novel Noncatalytic Role for Caspase-8 in Promoting Src-Mediated Adhesion and Erk Signaling in Neuroblastoma Cells in another window
Includes: Supplementary data
Journal Articles

Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Brooke Helfer, Bernard C. Boswell, Darren Finlay, Angel Cipres, Kristiina Vuori, Tae Bong Kang, David Wallach, Andrea Dorfleutner, Jill M. Lahti, Daniel C. Flynn, Steven M. Frisch
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4273–4278.
https://doi.org/10.1158/0008-5472.CAN-05-4183
Published: 17 April 2006
View article titled, Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions
Open the PDF for Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions in another window
Includes: Supplementary data