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Journal Articles

Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Stephen T. Keir, Heng Liu, Justin T. Low, Christopher J. Pirozzi, Nathan Reynolds, Eric S. Lipp, Annick Desjardins, Henry S. Friedman, Mustafa Khasraw, Darell D. Bigner, David M. Ashley, Matthew S. Waitkus

Cancer Res (2023) 83 (7_Supplement): 4924.

https://doi.org/10.1158/1538-7445.AM2023-4924

Published: 04 April 2023

View article titled, Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Journal Articles

Abstract 2073: Childhood vaccine-specific CD4⁺T cell recall coordinates antitumor type I and II immunity

Michael Clavon Brown, Zachary P. Mckay, Yuanfan Yang, Darell D. Bigner, Smita K. Nair, Matthias Gromeier

Cancer Res (2022) 82 (12_Supplement): 2073.

https://doi.org/10.1158/1538-7445.AM2022-2073

Published: 15 June 2022

View article titled, Abstract 2073: Childhood vaccine-specific CD4+T cell recall coordinates antitumor type I and II immunity

Journal Articles

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Cancer Res (2019) 79 (13): 3383–3394.

https://doi.org/10.1158/0008-5472.CAN-18-1010

Published: 01 July 2019

View article titled, MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Includes: Supplementary data

Journal Articles

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Cancer Res (2018) 78 (1): 256–264.

https://doi.org/10.1158/0008-5472.CAN-17-0469

Published: 02 January 2018

View article titled, Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Includes: Supplementary data

Journal Articles

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1^R132H-Induced Metabolic Liabilities

Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan

Cancer Res (2018) 78 (1): 36–50.

https://doi.org/10.1158/0008-5472.CAN-17-1352

Published: 02 January 2018

View article titled, Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

Includes: Supplementary data

Journal Articles

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Rui Yang, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, Bill H. Diplas, Matthew S. Waitkus, Paula K. Greer, Huishan Zhu, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan

Cancer Res (2017) 77 (22): 6097–6108.

https://doi.org/10.1158/0008-5472.CAN-17-1018

Published: 14 November 2017

View article titled, Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Includes: Supplementary data

Journal Articles

Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors

Fang Li, Xinjian Liu, John H. Sampson, Darell D. Bigner, Chuan-Yuan Li

Cancer Res (2016) 76 (17): 5143–5150.

https://doi.org/10.1158/0008-5472.CAN-16-0171

Published: 31 August 2016

View article titled, Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors

Includes: Supplementary data

Journal Articles

Abstract A08: IGF1R as a key target in high risk, metastatic medulloblastoma

Matthew N. Svalina, Ken Kikuchi, Jinu Abraham, Sangeet Lal, Monika A. Davare, Jennifer L. Peckham, Yoon-Jae Cho, Melanie Jackson, Daniel J. Guillaume, Nathan R. Selden, Darell D. Bigner, Kellie J. Nazemi, Sarah C. Green, Christopher L. Corless, Sakir Gultekin, Brian P. Rubin, Randall Woltjer, Charles Keller

Cancer Res (2015) 75 (23_Supplement): A08.

https://doi.org/10.1158/1538-7445.BRAIN15-A08

Published: 09 December 2015

View article titled, Abstract A08: IGF1R as a key target in high risk, metastatic medulloblastoma

Journal Articles

Abstract 2435A: Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes

Stephen T. Keir, B. Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Madan M. Kwatra, Henry S. Friedman, Darell D. Bigner

Cancer Res (2015) 75 (15_Supplement): 2435A.

https://doi.org/10.1158/1538-7445.AM2015-2435A

Published: 01 August 2015

View article titled, Abstract 2435A: Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes

Journal Articles

Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Christopher J. Pirozzi, Catherine Y. Wang, Austin B. Carpenter, Huishan Zhu, Paula K. Greer, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan

Cancer Res (2014) 74 (19_Supplement): 63.

https://doi.org/10.1158/1538-7445.AM2014-63

Published: 01 October 2014

View article titled, Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Journal Articles

Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation

Changcun Guo, Lee H. Chen, Yafen Huang, Chun-chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner, Yiping He

Cancer Res (2014) 74 (19_Supplement): LB-82.

https://doi.org/10.1158/1538-7445.AM2014-LB-82

Published: 01 October 2014

View article titled, Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation

Journal Articles

Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes

Stephen T. Keir, B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, Darell D. Bigner

Cancer Res (2014) 74 (19_Supplement): 838.

https://doi.org/10.1158/1538-7445.AM2014-838

Published: 01 October 2014

View article titled, Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes

Journal Articles

Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts.

Stephen T. Keir, Martin A. Roskoski, Michael Kragh, Mikkel W. Pederson, Helle J. Jacobsen, Ivan D. Horak, Henry S. Friedman, Darell D. Bigner

Cancer Res (2013) 73 (8_Supplement): 4322.

https://doi.org/10.1158/1538-7445.AM2013-4322

Published: 15 April 2013

View article titled, Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts.

Journal Articles

Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Stephen T. Keir, Martin A. Roskoski, Sabrina Wagner, Ralph Tiedt, Darell D. Bigner, Henry S. Friedman

Cancer Res (2013) 73 (8_Supplement): 2079.

https://doi.org/10.1158/1538-7445.AM2013-2079

Published: 15 April 2013

View article titled, Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Journal Articles

Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

Genglin Jin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B. Ahmed Rasheed, Rui Yang, Giselle Y. Lopez, Yiping He, Roger E. McLendon, Darell D. Bigner, Hai Yan

Cancer Res (2013) 73 (2): 496–501.

https://doi.org/10.1158/0008-5472.CAN-12-2852

Published: 16 January 2013

View article titled, Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

Includes: Supplementary data

Journal Articles

Abstract 2732: Internalization of the dual-specific immunotoxin D2C7-(scdsFv)-PE38KDEL in malignant glioma cell lines

Chris J. Hedegaard, Charles N. Pegram, Darell D. Bigner, Hans S. Poulsen

Cancer Res (2012) 72 (8_Supplement): 2732.

https://doi.org/10.1158/1538-7445.AM2012-2732

Published: 15 April 2012

View article titled, Abstract 2732: Internalization of the dual-specific immunotoxin D2C7-(scdsFv)-PE38KDEL in malignant glioma cell lines

Journal Articles

Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem

Matthew Wortham, Genglin Jin, Julia Lailai Sun, Darell D. Bigner, Hai Yan

Cancer Res (2012) 72 (8_Supplement): 3352.

https://doi.org/10.1158/1538-7445.AM2012-3352

Published: 15 April 2012

View article titled, Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem

Journal Articles

Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome

Hai Yan, Zachary J. Reitman, Genglin Jin, Ivan Spasojevic, Yiping He, Darell D. Bigner, Edward D. Karoly, Jian Yang, Kenneth W. Kinzler, Bert Vogelstein

Cancer Res (2011) 71 (8_Supplement): LB-257.

https://doi.org/10.1158/1538-7445.AM2011-LB-257

Published: 15 April 2011

View article titled, Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome

Journal Articles

Abstract 5611: Interleukin-2 receptor α (IL-2R α/CD25)-specific antibodies eliminate regulatory T-cells (TRegs) and enhance tumor-specific immune responses

John H. Sampson, Gary E. Archer, Robert Schmittling, James E. Herndon, April D. Coan, David A. Reardon, James Verdenburgh, Annick Desjardins, Anjelika Dechkovskaia, Sharon McGehee-Norman, Denise Lally-Goss, Beth A. Perry, Allan Friedman, Henry S. Friedman, Darell D. Bigner, Duane A. Mitchell

Cancer Res (2010) 70 (8_Supplement): 5611.

https://doi.org/10.1158/1538-7445.AM10-5611

Published: 15 April 2010

View article titled, Abstract 5611: Interleukin-2 receptor α (IL-2R α/CD25)-specific antibodies eliminate regulatory T-cells (TRegs) and enhance tumor-specific immune responses

Journal Articles

Abstract 233: OTX2 copy number gain is a driver event in Shh-independent medulloblastomas

Matthew Wortham, David C. Adamson, Qun Shi, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan

Cancer Res (2010) 70 (8_Supplement): 233.

https://doi.org/10.1158/1538-7445.AM10-233

Published: 15 April 2010

View article titled, Abstract 233: OTX2 copy number gain is a driver event in Shh-independent medulloblastomas

NARROW

Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Abstract 2073: Childhood vaccine-specific CD4⁺T cell recall coordinates antitumor type I and II immunity

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1^R132H-Induced Metabolic Liabilities

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors

Abstract A08: IGF1R as a key target in high risk, metastatic medulloblastoma

Abstract 2435A: Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes

Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation

Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes

Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts.

Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

Abstract 2732: Internalization of the dual-specific immunotoxin D2C7-(scdsFv)-PE38KDEL in malignant glioma cell lines

Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem

Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome

Abstract 5611: Interleukin-2 receptor α (IL-2R α/CD25)-specific antibodies eliminate regulatory T-cells (TRegs) and enhance tumor-specific immune responses

Abstract 233: OTX2 copy number gain is a driver event in Shh-independent medulloblastomas

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