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Abstract 2049: A novel, rapid, sensitive, and reproducible in vivo platform to assess efficacy and toxicity of bispecific antibodies

Jiwon Yang, Jing Jiao, Kyle Draheim, Danying Cai, Michael A. Brehm, Leonard D. Shultz, Dale L. Greiner, Mingshan Cheng, James G. Keck

Cancer Res (2022) 82 (12_Supplement): 2049.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2049

Published: 15 June 2022

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Journal Articles

Abstract 2875: Development of a new tumor-bearing humanized mouse model to evaluate the efficacy and toxicity of bispecific T cell engagers

Guoxiang Yang, Li-Chin Yao, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Danying Cai, MIngshan Cheng, James G. Keck

Cancer Res (2022) 82 (12_Supplement): 2875.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2875

Published: 15 June 2022

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Journal Articles

Abstract 1338: Humanized mouse model for in vivo evaluation of bispecific antibody efficacy

Li-Chin Yao, James G. Keck, Danying cai

Cancer Res (2022) 82 (12_Supplement): 1338.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1338

Published: 15 June 2022

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Abstract 2816: A novel in vivo model to simultaneously assess efficacy and toxicity of chimeric antigen receptor T-cell immunotherapy

Jiwon Yang, Won Lee, Jing Jiao, Danying Cai, Heather Gustafson, Rebecca Gardner, Mingshan Cheng, James G. Keck

Cancer Res (2022) 82 (12_Supplement): 2816.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2816

Published: 15 June 2022

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Journal Articles

Abstract 3354: Preclinical evaluation of potential cytokine release syndrome and efficacy of a BCMA-CD3 bispecific antibody for the treatment of multiple myeloma in humanized mice

Jing Jiao, Danying Cai, Li-Chin Yao, Kyle Draheim, Hongyuan Yang, Mingshan Cheng, James Keck

Cancer Res (2020) 80 (16_Supplement): 3354.

DOI: https://doi.org/10.1158/1538-7445.AM2020-3354

Published: 15 August 2020

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Journal Articles

Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology

Li-Chin Yao, Mingshan Cheng, Danying Cai, Leonard D. Shultz, James G. Keck

Cancer Res (2020) 80 (16_Supplement): 3320.

DOI: https://doi.org/10.1158/1538-7445.AM2020-3320

Published: 15 August 2020

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Abstract 4512: Mouse model for in vivo evaluation of efficacy and potential cytokine release syndrome of chimeric antigen receptor (CAR) T cell therapy

Jing Jiao, Chunting Ye, Danying Cai, Mingshan Cheng, James Keck

Cancer Res (2020) 80 (16_Supplement): 4512.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4512

Published: 15 August 2020

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Journal Articles

Abstract 5632: PBMC-humanized mouse model for the assessment of cytokine release syndrome caused by checkpoint and bispecific immunotherapy

Danying Cai, Jing Jiao, Chunting Ye, Hongyuan Yang, Mingshan Cheng, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, James G. Keck

Cancer Res (2020) 80 (16_Supplement): 5632.

DOI: https://doi.org/10.1158/1538-7445.AM2020-5632

Published: 15 August 2020

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Journal Articles

Abstract 584: TGN1412 induces dose and time dependent human cytokines in a humanized PBMC mouse model for cytokine release syndrome

Hongyuan Yang, Jing Jiao, Danying Cai, Mingshan Cheng, Michael Brehm, Dale Grainer, Leonard Shultz, James Keck

Cancer Res (2020) 80 (16_Supplement): 584.

DOI: https://doi.org/10.1158/1538-7445.AM2020-584

Published: 15 August 2020

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Journal Articles

Abstract 5186: Human stem cell humanized mouse model for in vivo evaluation of bispecific antibody efficacy and drug-induced cytokine release

Li-Chin Yao, Danying Cai, Roberta Aliperta, Allison Colthart, Werner Meier, Mingshan Cheng, James G. Keck

Cancer Res (2020) 80 (16_Supplement): 5186.

DOI: https://doi.org/10.1158/1538-7445.AM2020-5186

Published: 15 August 2020

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Journal Articles

Abstract LB-050: Patient-derived tumor xenografts in humanized NSG mice: a model to study immune responses in cancer therapy

Minan Wang, James G. Keck, Mingshan Cheng, Danying Cai, Leonard Shultz, Karolina Palucka, Jacques Banchereau, Carol Bult, Rick Huntress

Cancer Res (2015) 75 (15_Supplement): LB-050.

DOI: https://doi.org/10.1158/1538-7445.AM2015-LB-050

Published: 01 August 2015

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Journal Articles

Abstract 3246: Synthesis and biochemical characterization of novel analogues of ezatiostat hydrochloride (TLK199, Telintra®)

Danying Cai, Mingshan Cheng, James G. Keck, Edgardo Laborde, Robert W. Macsata

Cancer Res (2011) 71 (8_Supplement): 3246.

DOI: https://doi.org/10.1158/1538-7445.AM2011-3246

Published: 15 April 2011

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Journal Articles

Abstract #1764: In vivo characterization and mechanism of action of orally active Aurora kinase/VEGFR inhibitors

Li Fang, Angela Sho, Nancy Hsu, Natalia Aurrecoechea, Louise Robinson, Reyna Simon, Andrew Kelson, Edgardo Laborde, Mingshan Cheng, James Keck, Danying Cai

Cancer Res (2009) 69 (9_Supplement): 1764.

Published: 01 May 2009

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Journal Articles

Identification and characterization of novel tyrosine kinase inhibitors targeting vascular endothelial growth factor receptor 2

Shu Chi Hsu, Li Fang, Nancy Hsu, Natalia Aurrecoechea, Reyna Simon, Komath Damodaran, Paul Beroza, Lidia Sambucetti, James Keck, Danying Cai

Cancer Res (2008) 68 (9_Supplement): 1439.

Published: 01 May 2008

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Journal Articles

Induction of apoptosis by TLK199 in human leukemia cells

Mary Stofega, Shu Chi Hsu, Jason Chew, Gail Brown, James Keck, Azra Raza, Danying Cai

Cancer Res (2008) 68 (9_Supplement): 2270.

Published: 01 May 2008

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Journal Articles

GST P1-1 polymorphisms do not affect the rate of TELCYTA™ (TLK286) prodrug activation.

Danying Cai, Jason Chew, Jonathan Wray, Vinita Kumar, Steven Danko, Lidia Sambucetti, Reinaldo Gomez, James G. Keck

Cancer Res (2004) 64 (7_Supplement): 883.

Published: 01 April 2004

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NARROW

Abstract 2049: A novel, rapid, sensitive, and reproducible in vivo platform to assess efficacy and toxicity of bispecific antibodies

Abstract 2875: Development of a new tumor-bearing humanized mouse model to evaluate the efficacy and toxicity of bispecific T cell engagers

Abstract 1338: Humanized mouse model for in vivo evaluation of bispecific antibody efficacy

Abstract 2816: A novel in vivo model to simultaneously assess efficacy and toxicity of chimeric antigen receptor T-cell immunotherapy

Abstract 3354: Preclinical evaluation of potential cytokine release syndrome and efficacy of a BCMA-CD3 bispecific antibody for the treatment of multiple myeloma in humanized mice

Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology

Abstract 4512: Mouse model for in vivo evaluation of efficacy and potential cytokine release syndrome of chimeric antigen receptor (CAR) T cell therapy

Abstract 5632: PBMC-humanized mouse model for the assessment of cytokine release syndrome caused by checkpoint and bispecific immunotherapy

Abstract 584: TGN1412 induces dose and time dependent human cytokines in a humanized PBMC mouse model for cytokine release syndrome

Abstract 5186: Human stem cell humanized mouse model for in vivo evaluation of bispecific antibody efficacy and drug-induced cytokine release

Abstract LB-050: Patient-derived tumor xenografts in humanized NSG mice: a model to study immune responses in cancer therapy

Abstract 3246: Synthesis and biochemical characterization of novel analogues of ezatiostat hydrochloride (TLK199, Telintra®)

Abstract #1764: In vivo characterization and mechanism of action of orally active Aurora kinase/VEGFR inhibitors

Identification and characterization of novel tyrosine kinase inhibitors targeting vascular endothelial growth factor receptor 2

Induction of apoptosis by TLK199 in human leukemia cells

GST P1-1 polymorphisms do not affect the rate of TELCYTA™ (TLK286) prodrug activation.

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