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Journal Articles

Abstract 1134: The tumor suppressor activity of miR-300 is detrimental for leukemia development but required for leukemia stem cell maintenance

Giovannino Silvestri, Lorenzo Stramucci, Justin Ellis, Jason Harb, Paolo Neviani, Bin Zhang, Klara Srutova, Gabriel Pineda, Catriona Jamieson, Bruno Calabretta, Fabio Stagno, Paolo Vigneri, Georgios Nteliopoulos, Philippa May, Alistar Reid, Ramiro Garzon, Denis-Claude Roy, Martin Guimond, Peter Hokland, Michael Deininger, Garrett Fitzgerald, Chris Harman, Francesco Dazzi, Dragana Milojkovic, Jane Apperley, Guido Marcucci, Jianfei Qi, Katerina Machova-Polakova, Xiaoxuan Fan, Maria Baer, Rossana Trotta, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1134.
https://doi.org/10.1158/1538-7445.AM2018-1134
Published: 01 July 2018
View article titled, Abstract 1134: The tumor suppressor activity of miR-300 is detrimental for leukemia development but required for leukemia stem cell maintenance
Journal Articles

Abstract 834: FLT3 inhibitors and PP2A-activating drugs synergistically induce cytotoxicity in AML cells with FLT3-ITD through enhanced Pim-1 and Myc proteasomal degradation

Mario Scarpa, Shivani Kapoor, Sikemi Ibikunle, Andre Rush, Patrick R. Baldwin, Danilo Perrotti, Maria R. Baer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 834.
https://doi.org/10.1158/1538-7445.AM2018-834
Published: 01 July 2018
View article titled, Abstract 834: FLT3 inhibitors and PP2A-activating drugs synergistically induce cytotoxicity in AML cells with FLT3-ITD through enhanced Pim-1 and Myc proteasomal degradation
Journal Articles

Abstract 4736: Bone marrow microenvironment-induced miR-300 expression impairs natural killer cell proliferation and antitumor activity

Rossana Trotta, Giovannino Silvestri, Lorenzo Stramucci, Martin Guimond, Guido Marcucci, Xiaoxuan Fan, Maria R. Baer, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4736.
https://doi.org/10.1158/1538-7445.AM2018-4736
Published: 01 July 2018
View article titled, Abstract 4736: Bone marrow microenvironment-induced miR-300 expression impairs natural killer cell proliferation and antitumor activity
Journal Articles

Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML

Rossana Trotta, Giovannino Silvestri, Lorenzo Stramucci, Justin J. Ellis, Justine Yu, Jason J. Harb, Paolo Neviani, Guido Marcucci, Klara Srutova, Polakova K. Machova, Denis-Claude Roy, Peter Hokland, Michael Deininger, Ravi Bhatia, Carlo Gambacorti-Passerini, Dragana Milojkovic, Alistair Reid, Jane Apperley, Ferenc Livak, Jianfei Qi, Maria R. Baer, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 951.
https://doi.org/10.1158/1538-7445.AM2016-951
Published: 15 July 2016
View article titled, Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML
Journal Articles

Abstract 3454: Bcl-xL anti-apoptotic network is dispensable for emergence and maintenance of CML but required for disease progression, and represents an alternative target for halting survival of blast crisis CML progenitors.

Jason Harb, Paolo Neviani, Justin E. Ellis, Gregory J. Ferenchak, Brenda I. Chyla, Peter Hokland, Denis Claude Roy, Michael A. Caligiuri, Guido Marcucci, Claudia S. Huettner, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3454.
https://doi.org/10.1158/1538-7445.AM2013-3454
Published: 15 April 2013
View article titled, Abstract 3454: Bcl-xL anti-apoptotic network is dispensable for emergence and maintenance of CML but required for disease progression, and represents an alternative target for halting survival of blast crisis CML progenitors.
Journal Articles

Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia .

Somayeh S. Tarighat, Kiran Mahasenan, Danilo Perrotti, Ramiro Garzon, Michael Caligiuri, Chenglong Li, William Blum, Guido Marcucci, Robert A. Baiocchi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1128.
https://doi.org/10.1158/1538-7445.AM2013-1128
Published: 15 April 2013
View article titled, Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia .
Journal Articles

Abstract 3839: Nuclear export (karyopherin) inhibitors: A novel therapeutic strategy for treating Philadelphia-positive (Ph+) acute leukemias

Christopher Walker, Joshua J. Oaks, Ramasamy Santhanam, Paolo Neviani, Jason G. Harb, Carolyn Paisie, Guido Marcucci, Yosef Landesman, Sharon Shacham, Michael Kauffman, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3839.
https://doi.org/10.1158/1538-7445.AM2012-3839
Published: 15 April 2012
View article titled, Abstract 3839: Nuclear export (karyopherin) inhibitors: A novel therapeutic strategy for treating Philadelphia-positive (Ph<sup>+</sup>) acute leukemias
Journal Articles

Abstract CT-06: The combination of bortezomib (BOR) and decitabine (DEC): A phase I trial in patients (pts) with acute myeloid leukemia (AML) targeting FLT3 expression

Sebastian Schwind, William Blum, Shujun Liu, Somayeh Samadzadeh Tarighat, Susan Geyer, Rebecca Klisovic, Ann-Kathrin Eisfeld, Alison Walker, Susan Whitman, Santhanam Ramasamy, Yue-Zhong Wu, Samson Jacob, Michael Caligiuri, Michael Grever, Danilo Perrotti, John Byrd, Clara Bloomfield, Ramiro Garzon, Guido Marcucci
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): CT-06.
https://doi.org/10.1158/1538-7445.AM2012-CT-06
Published: 15 April 2012
View article titled, Abstract CT-06: The combination of bortezomib (BOR) and decitabine (DEC): A phase I trial in patients (pts) with acute myeloid leukemia (AML) targeting FLT3 expression
Journal Articles

Abstract 1111: Synthetic microRNA (miR)-181a nanoparticles (NP) target RAS and sensitize cells to daunorubicin (DNR) in acute myeloid leukemia (AML)

Xiaomeng Huang, Schwind Sebastian, Ann-Kathrin Eisfeld, Yan Jin, Bo Yu, Christopher Hickey, Jiuxia Pang, Santhanam Ramasamy, Kenneth Chan, Danilo Perrotti, Natarajan Muthusamy, John Byrd, William Blum, Clara Bloomfield, Shujun Liu, Ramiro Garzon, Robert Lee, Ly Lee, Guido Marcucci
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1111.
https://doi.org/10.1158/1538-7445.AM2012-1111
Published: 15 April 2012
View article titled, Abstract 1111: Synthetic <em>microRNA (miR)-181a</em> nanoparticles (NP) target RAS and sensitize cells to daunorubicin (DNR) in acute myeloid leukemia (AML)
Journal Articles

Abstract 119: AR42, a histone deacetylase inhibitor (HDACI), increases microRNA (miR)-29b and sensitizes cells to decitabine (DAC) treatment: A novel epigenetic-targeting approach in acute myeloid leukemia (AML)

Alice S. Mims, Alison R. Walker, Pia Hoellerbauer, Xiaomeng Huang, Kenneth K. Chan, Rebecca B. Klisovic, Danilo Perrotti, Michael A. Caligiuri, John C. Byrd, Ching-Shih Chen, William Blum, Ramiro Garzon, Sebastian Schwind, Guido Marcucci
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 119.
https://doi.org/10.1158/1538-7445.AM2012-119
Published: 15 April 2012
View article titled, Abstract 119: AR42, a histone deacetylase inhibitor (HDACI), increases microRNA (miR)-29b and sensitizes cells to decitabine (DAC) treatment: A novel epigenetic-targeting approach in acute myeloid leukemia (AML)
Journal Articles

Abstract LB-109: BCR-ABL1 kinase activity but not its expression is dispensable for Ph+ quiescent stem cell survival which depends on the PP2A-controlled Jak2 activation and is sensitive to FTY720 treatment

Paolo Neviani, Jason Harb, Joshua Oaks, Christopher Walker, Ramasamy Santhanam, Carolyn Paisie, Anna Eiring, Bin Zhang, Bastianella Perazzona, Y Ma, Charlene Mao, Guido Marcucci, Tessa Holyoake, Stefano Volinia, Jorge Cortes, Michael Caligiuri, Claudia Huettner, Robert Bittman, Ching-Shih Chen, Ralph Arlinghaus, Peter Hokland, Denis-Claude Roy, Ravi Bhatia, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-109.
https://doi.org/10.1158/1538-7445.AM2011-LB-109
Published: 15 April 2011
View article titled, Abstract LB-109: BCR-ABL1 kinase activity but not its expression is dispensable for Ph+ quiescent stem cell survival which depends on the PP2A-controlled Jak2 activation and is sensitive to FTY720 treatment
Journal Articles

Abstract 2014: Modulation of DNA methyltransferases in leukemia cells by curcumin and its associated anti-leukemia activities

Zhongfa Liu, Hongyan Wang, Lai-chu Wu, Zhiliang Xie, Liping Du, Xiaokui Mo, Ming Chiu, Danilo Perrotti, Michael Grever, John C. Byrd, Shujun Liu, Guido Marcucci, Kenneth K. Chan
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2014.
https://doi.org/10.1158/1538-7445.AM2011-2014
Published: 15 April 2011
View article titled, Abstract 2014: Modulation of DNA methyltransferases in leukemia cells by curcumin and its associated anti-leukemia activities
Journal Articles

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

Kathryn G. Roberts, Amanda M. Smith, Fiona McDougall, Helen Carpenter, Martin Horan, Paolo Neviani, Jason A. Powell, Daniel Thomas, Mark A. Guthridge, Danilo Perrotti, Alistair T.R. Sim, Leonie K. Ashman, Nicole M. Verrills
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5438–5447.
https://doi.org/10.1158/0008-5472.CAN-09-2544
Published: 30 June 2010
View article titled, Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT<sup>+</sup> Cancers
Open the PDF for Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT<sup>+</sup> Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells

Houda Alachkar, Shujun Liu, Sebastian Schwind, Heiko Becker, Klaus H. Metzeler, Christopher Hickey, Jiuxia Pang, Susan P. Whitman, Kenneth K. Chan, Ramiro Garzon, David M. Lucas, Danilo Perrotti, Lai-Chu Wu, Michael R. Grever, A D. Kinghorn, Guido Marcucci
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3558.
https://doi.org/10.1158/1538-7445.AM10-3558
Published: 15 April 2010
View article titled, Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and <em>miR-155</em> levels in <em>FLT3</em>-ITD positive Acute Myeloid Leukemia (AML) cells
Journal Articles

Abstract 1950: Suppression of RISC-independent decoy and RISC-mediated RNA-pairing activities of microRNA-328 is required for maturation-arrest and enhanced survival of blast crisis CML progenitors

Anna M. Eiring, Jason Harb, Paolo Neviani, Joshua J. Oaks, Shujun Liu, Riccardo Spizzo, Sebastian Schwind, Ramasamy Santhanam, Christopher Hickey, Heiko Becker, Jason C. Chandler, Raul Andino, Jorge Cortes, Peter Hokland, Claudia S. Huettner, Ravi Bhatia, Denis C. Roy, Stephen Liebhaber, Michael A. Caligiuri, Guido Marcucci, Ramiro Garzon, Carlo M. Croce, George A. Calin, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1950.
https://doi.org/10.1158/1538-7445.AM10-1950
Published: 15 April 2010
View article titled, Abstract 1950: Suppression of RISC-independent decoy and RISC-mediated RNA-pairing activities of microRNA-328 is required for maturation-arrest and enhanced survival of blast crisis CML progenitors
Journal Articles

Abstract #1075: PP2A induction by FTY720 inhibits survival and self-renewal of CD34+/CD38- CML stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL-independent signals.

Paolo Neviani, Ramasamy Santhanam, Yihui Ma, Bin Zhang, Hsiaoyin Mao, Stefano Volinia, Guido Marcucci, Ching-Shih Chen, Jorge Cortes, Claudia Huettner, Steffen Koschmieder, Peter Hokland, Ravi Bhatia, Denis Roy, Michael Caligiuri, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1075.
Published: 01 May 2009
View article titled, Abstract #1075: PP2A induction by FTY720 inhibits survival and self-renewal of CD34+/CD38- CML stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL-independent signals.
Journal Articles

Abstract #3644: Reactivation of PP2A as a treatment strategy for c-KIT+ core-binding factor acute myeloid leukemia

Kathryn Roberts, Amanda Smith, Helen Carpenter, Ramasamy Santhanam, Alistair Sim, Leonie Ashman, Danilo Perrotti, Nicole Verrills
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3644.
Published: 01 May 2009
View article titled, Abstract #3644: Reactivation of PP2A as a treatment strategy for c-KIT<sup>+</sup> core-binding factor acute myeloid leukemia
Journal Articles

Metastasis suppressor 1 is a target gene of BCR/ABL in leukemic stem cells

Mirle Schemionek, Christian Elling, Shuchi Agrawal, Martin Stehling, Claudia Huettner, Ulrich Steidl, Daniel Tenen, Ashley Hamilton, Tessa Holyoake, Danilo Perrotti, Thomas Buchner, Wolfgang Berdel, Hubert Serve, Carsten Muller-Tidow, Steffen Koschmieder
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 869.
Published: 01 May 2008
View article titled, Metastasis suppressor 1 is a target gene of BCR/ABL in leukemic stem cells
Journal Articles

The proteasome inhibitor bortezomib alters epigenetic profiling through impairing Sp1/NF-kB-dependent DNA methyltransferase activity in acute myeloid leukemia

Shujun Liu, Jiuxia Pang, Zhongfa Liu, Zhiliang Xie, Jianhua Yu, Haiming Ding, Lenguyen Huynh, Rebecca B. Klisovic, Robert A. Baiocchi, Ramiro Garzon, Danilo Perrotti, Kenneth K. Chan, Lai-Chu Wu, William Blum, Guido Marcucci
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2622.
Published: 01 May 2008
View article titled, The proteasome inhibitor bortezomib alters epigenetic profiling through impairing Sp1/NF-kB-dependent DNA methyltransferase activity in acute myeloid leukemia
Journal Articles

MicroRNAs act as decoy molecules to restore granulocytic maturation of differentiation-arrested BCR/ABL+ myeloid progenitors

Anna Eiring, Paolo Neviani, George Calin, Denis Roy, Carlo Croce, Danilo Perrotti
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1494.
Published: 01 May 2008
View article titled, MicroRNAs act as decoy molecules to restore granulocytic maturation of differentiation-arrested BCR/ABL<sup>+</sup> myeloid progenitors