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Daniel D. Von Hoff
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Journal Articles

Abstract B012: Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer: initial results of safety and feasibility of the medically supervised ketogenic diet

Gayle S Jameson, Erkut Borazanci, Diana L Hanna, Caroline GP Roberts, Meredith S Pelster, Richard C Frank, Angela T Alistar, Julia E Wiedmeier-Nutor, Sandra D Algaze, Brandon Fell, Sarah J Hallberg, Denise J Roe, Betsy C Wertheim, Derek Cridebring, Joshua D Rabinowitz, Stephen Gately, Daniel D Von Hoff, Drew W Rasco
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B012.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B012
Published: 15 September 2024
View article titled, Abstract B012: Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer: initial results of safety and feasibility of the medically supervised ketogenic diet
Journal Articles

Abstract 5957: Development of a selective, oral ATP-competitive CDK9 inhibitor, BLX-3030, for treatment of pancreatic cancer

Yesenia Barrera-Millan, Zhaoliang Li, Hariprasad Vankayalapati, David J. Bearss, Daniel D. Von Hoff, Haiyong Han
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5957.
https://doi.org/10.1158/1538-7445.AM2024-5957
Published: 22 March 2024
View article titled, Abstract 5957: Development of a selective, oral ATP-competitive CDK9 inhibitor, BLX-3030, for treatment of pancreatic cancer
Journal Articles

Abstract 2688: Inhibition of CDK7 using small molecule inhibitor, TGN-1062, augments the effect of cisplatin treatment in head and neck PDX models

Trason Thode, Alexis Weston, Serina Ng, Shelby Rheinschmidt, Tithi Ghosh Halder, Sydney Adamson, Kate Gutowsky, Brian Durbin, Raffaella Soldi, Mohan Kaadige, Srinivas Kasibhatla, Haiyong Han, Justin Moser, Vincent Chung, Joseph Chao, Victoria Villaflor, Daniel D. Von Hoff, Sunil Sharma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2688.
https://doi.org/10.1158/1538-7445.AM2023-2688
Published: 04 April 2023
View article titled, Abstract 2688: Inhibition of CDK7 using small molecule inhibitor, TGN-1062, augments the effect of cisplatin treatment in head and neck PDX models
Journal Articles

Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL

Russell Moser, James Annis, Olga Nikolova, Cliff Whatcott, Kay Gurley, Eduardo Mendez, Kim Moran-Jones, Craig Dorrell, Rosalie C. Sears, Calvin Kuo, Haiyong Han, Andrew Biankin, Carla Grandori, Daniel D. Von Hoff, Christopher J. Kemp
Journal: Cancer Research
Cancer Res (2022) 82 (18): 3375–3393.
https://doi.org/10.1158/0008-5472.CAN-21-4222
Published: 16 September 2022
View article titled, Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL
Open the PDF for Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL in another window
Includes: Supplementary data
Journal Articles

Abstract CT549: Randomized Phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer

Diana Hanna, Gayle S. Jameson, Drew W. Rasco, Angela Alistar, Richard C. Frank, Anthony B. El-Khoueiry, Julia E. Wiedmeier, Caroline Roberts, Brandon Fell, Sarah Hallberg, Denise Roe, Derek Cridebring, Joshua Rabinowitz, Stephen Thomas Gately, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT549.
https://doi.org/10.1158/1538-7445.AM2022-CT549
Published: 15 June 2022
View article titled, Abstract CT549: Randomized Phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer
Journal Articles

Abstract PO-010: Detection of early tissue changes on historical CT scans in the regions of the pancreas gland that subsequently develop adenocarcinoma using quantitative textural analysis and fat fraction analysis

Ronald L. Korn, Daniel D. Von Hoff, Andre Burkett, Dominic Zygadlo, Taylor Brodie, Kathleen Panak, Sweta Rajan, Derek Cridebring, Michael J. Demeure
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-010.
https://doi.org/10.1158/1538-7445.PANCA21-PO-010
Published: 15 November 2021
View article titled, Abstract PO-010: Detection of early tissue changes on historical CT scans in the regions of the pancreas gland that subsequently develop adenocarcinoma using quantitative textural analysis and fat fraction analysis
Journal Articles

Abstract PO-015: A phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with previously untreated metastatic pancreatic cancer (MPC)

Gayle S. Jameson, Erkut H. Borazanci, Daniel D. Von Hoff, Joshua D. Rabinowitz, Michael S. Gordon, Sarah D. LeGrand, Courtney Snyder, Karen Ansaldo, Denise J. Roe, Haiyong Han
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-015.
https://doi.org/10.1158/1538-7445.PANCA21-PO-015
Published: 15 November 2021
View article titled, Abstract PO-015: A phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with previously untreated metastatic pancreatic cancer (MPC)
Journal Articles

Abstract PR-002: A phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC)

Erkut Borazanci, Gayle S. Jameson, Sunil Sharma, Frank Tsai, Ronald L. Korn, Lana Caldwell, Karen Ansaldo, David T. Ting, Denise Roe, Anna Bermudez, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PR-002.
https://doi.org/10.1158/1538-7445.PANCA21-PR-002
Published: 15 November 2021
View article titled, Abstract PR-002: A phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC)
Journal Articles

Abstract PO-054: A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP)

Nebojsa Skorupan, Mehwish I. Ahmad, Seth M. Steinberg, Jane B. Trepel, Derek Cridebring, Haiyong Han, Daniel D. Von Hoff, Christine Alewine
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-054.
https://doi.org/10.1158/1538-7445.PANCA21-PO-054
Published: 15 November 2021
View article titled, Abstract PO-054: A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP)
Journal Articles

Abstract 3121: Characterization of nab-paclitaxel resistant and gemcitabine resistant BxPC3 and MIA PaCa-2 pancreatic cancer cells

Danielle M. Arias, John Collins, Pawan Noel, Daniel D. Von Hoff, Haiyong Han
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3121.
https://doi.org/10.1158/1538-7445.AM2021-3121
Published: 01 July 2021
View article titled, Abstract 3121: Characterization of nab-paclitaxel resistant and gemcitabine resistant BxPC3 and MIA PaCa-2 pancreatic cancer cells
Journal Articles

Abstract 1254: Preclinical studies with TGN-1062, a selective and reversible small molecule inhibitor of CDK7

Ryan L. Rodriguez del Villar, Trason G. Thode, Alexis Weston, Serina Ng, Raffaella Soldi, Mohan Kaadige, Srinivas Kasibhatla, Vincent Chung, Joseph Chao, Daniel D. Von Hoff, Sunil Sharma
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1254.
https://doi.org/10.1158/1538-7445.AM2021-1254
Published: 01 July 2021
View article titled, Abstract 1254: Preclinical studies with TGN-1062, a selective and reversible small molecule inhibitor of CDK7
Journal Articles

Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas

Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham, William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M. Grandgenett, Michael A. Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C. Hernandez, Jennifer L. Leiting, Ronald M. Evans, Tamas Ordog, Mark J. Truty, Mitesh J. Borad, Tannishtha Reya, Daniel D. Von Hoff, Martin E. Fernandez-Zapico, Michael T. Barrett
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (20): 4324–4334.
https://doi.org/10.1158/0008-5472.CAN-20-0078
Published: 15 October 2020
View article titled, Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
Open the PDF for Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas in another window
Includes: Supplementary data
Journal Articles

Abstract 5221: Development of TGN-1076, a selective and reversible small molecule inhibitor of CDK7

Trason Thode, Zhaoliang Li, Alexis Weston, Srikanta Dana, Sherin Daniel Ampanattu, Raffaella Soldi, Mohan Rao Kaadige, Hariprasad Vankayalapti, Vincent Chung, Joseph Chao, Daniel D Von Hoff, Sunil Sharma
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5221.
https://doi.org/10.1158/1538-7445.AM2020-5221
Published: 15 August 2020
View article titled, Abstract 5221: Development of TGN-1076, a selective and reversible small molecule inhibitor of CDK7
Journal Articles

Abstract CT147: Phase 1 dose escalation of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors

Alison Schram, Erkut Borazanci, Irene Brana, Maria Vieito Villar, Elena Garralda, Anna Spreafico, Marc Oliva, Nehal Lakhani, Robert Wasserman, Kimberly Hoffmann, Robin Hallett, Judit Anido, Dorotea Maetzel, Patricia Giblin, Enda Moran, Adrianne Kelly, Joan Seoane, Daniel D. Von Hoff, Lillian Siu, Josep Tabernero
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT147.
https://doi.org/10.1158/1538-7445.AM2020-CT147
Published: 15 August 2020
View article titled, Abstract CT147: Phase 1 dose escalation of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors
Journal Articles

Abstract B27: A phase Ib/II trial of high-dose (HD) ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC)

Gayle S. Jameson, Erkut H. Borazanci, Joshua Rabinowitz, Karen Ansaldo, Sarah LeGrand, David Propper, Courtney Snyder, Michael Gordon, Denise Roe, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B27.
https://doi.org/10.1158/1538-7445.PANCA19-B27
Published: 13 December 2019
View article titled, Abstract B27: A phase Ib/II trial of high-dose (HD) ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC)
Journal Articles

Abstract B24: Gastrointestinal microbiome changes in stage IV pancreatic cancer patients treated with pembrolizumab with or without paricalcitol on the Stand Up to Cancer (SU2C) Pancreas Catalyst Trial

Sarah K. Highlander, Vincent Chung, Angela T. Alistar, Erkut Borazanci, Gayle Jameson, Talima Pearson, Nina A. Cantafio, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B24.
https://doi.org/10.1158/1538-7445.PANCA19-B24
Published: 13 December 2019
View article titled, Abstract B24: Gastrointestinal microbiome changes in stage IV pancreatic cancer patients treated with pembrolizumab with or without paricalcitol on the Stand Up to Cancer (SU2C) Pancreas Catalyst Trial
Journal Articles

Abstract A29: Bicompartmental regulation of disease-related gene networks by histone deacetylase inhibition curbs pancreatic cancer progression

Gaoyang Liang, Nasun Hah, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Cory Fraser, Ester Banayo, Senada Bashi, Yang Dai, Mara Sherman, Christopher Liddle, Ruth T. Yu, Tony Hunter, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A29.
https://doi.org/10.1158/1538-7445.PANCA19-A29
Published: 13 December 2019
View article titled, Abstract A29: Bicompartmental regulation of disease-related gene networks by histone deacetylase inhibition curbs pancreatic cancer progression
Journal Articles

Abstract A37: Mapping super-enhancer signatures in pancreatic ductal adenocarcinoma, cancer-associated fibroblasts and their targeting by epigenetic inhibitors

Pawan Noel, Shaimaa Hussein, Kenian Chen, Daniel D. Von Hoff, Yin Lin, Haiyong Han
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A37.
https://doi.org/10.1158/1538-7445.PANCA19-A37
Published: 13 December 2019
View article titled, Abstract A37: Mapping super-enhancer signatures in pancreatic ductal adenocarcinoma, cancer-associated fibroblasts and their targeting by epigenetic inhibitors
Journal Articles

Abstract 282: Minnelide improves the efficacy of the nab-paclitaxel plus gemcitabine plus cisplatin chemotherapy in mouse models of PDAC

Liang Ng, Pawan Noel, Stephanie Mou, Daniel D. Von Hoff, Haiyong Han
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 282.
https://doi.org/10.1158/1538-7445.AM2019-282
Published: 01 July 2019
View article titled, Abstract 282: Minnelide improves the efficacy of the nab-paclitaxel plus gemcitabine plus cisplatin chemotherapy in mouse models of PDAC
Journal Articles

Abstract CT152: A Phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC)

Erkut H. Borazanci, Gayle Jameson, Ronald Lee Korn, Lana Caldwell, Karen Ansaldo, Kristin Hendrickson, Katie Marceau, Kevin Gosselin, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT152.
https://doi.org/10.1158/1538-7445.AM2019-CT152
Published: 01 July 2019
View article titled, Abstract CT152: A Phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC)