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Daniel C. Chan
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Journal Articles

Abstract 3047: Sensitization of prostate cancer to chemo-radiation by ribosomal protein S6 inhibition

Suleman S. Hussain, Carolina B. Livi, Nikos Papanikolaou, Daniel C. Chan, Rita Ghosh, Addanki P. Kumar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3047.
https://doi.org/10.1158/1538-7445.AM2016-3047
Published: 15 July 2016
View article titled, Abstract 3047: Sensitization of prostate cancer to chemo-radiation by ribosomal protein S6 inhibition
Journal Articles

Abstract 1797: Downregulation of ribosomal protein S6 overcomes radioresistance in prostate cancer

Suleman S. Hussain, Paul Rivas, Roble G. Bedolla, Nikos Papanikolaou, Robert L. Reddick, Brad H. Pollock, Daniel C. Chan, Rita Ghosh, Addanki P. Kumar
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1797.
https://doi.org/10.1158/1538-7445.AM2015-1797
Published: 01 August 2015
View article titled, Abstract 1797: Downregulation of ribosomal protein S6 overcomes radioresistance in prostate cancer
Journal Articles

Abstract 4836: Immune-tolerance due to aberrant expression of Natural Killer-Cell Immunoglobulin-like Receptors (KIRs) on cancer cells and enhanced cancer-platelet interactions

Daniel C. Chan, Zhiyong Zhang, Di Zheng, Tiffany Chan, Mary Berg, Kathryn Horwitz, Natalie Ahn, Lewis Lanier, Paul Bunn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4836.
https://doi.org/10.1158/1538-7445.AM2014-4836
Published: 01 October 2014
View article titled, Abstract 4836: Immune-tolerance due to aberrant expression of Natural Killer-Cell Immunoglobulin-like Receptors (KIRs) on cancer cells and enhanced cancer-platelet interactions
Journal Articles

Abstract 4626: Evaluating the pharmacodynamics and pharmacokinetic effects of MM-398, a nanoliposomal irinotecan (nal-IRI) in subcutaneous xenograft tumor models of human squamous cell carcinoma and small cell lung cancers

Daniel C. Chan, Ashish Kalra, Zhiyong Zhang, Nancy Paz, Dmitri Kirpotin, Daryl Drummond, Ulrik Nielsen, Paul A. Bunn, Jonathan Fitzgerald
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4626.
https://doi.org/10.1158/1538-7445.AM2014-4626
Published: 01 October 2014
View article titled, Abstract 4626: Evaluating the pharmacodynamics and pharmacokinetic effects of MM-398, a nanoliposomal irinotecan (nal-IRI) in subcutaneous xenograft tumor models of human squamous cell carcinoma and small cell lung cancers
Journal Articles

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition

Matias Casás-Selves, Jihye Kim, Zhiyong Zhang, Barbara A. Helfrich, Dexiang Gao, Christopher C. Porter, Hannah A. Scarborough, Paul A. Bunn, Jr., Daniel C. Chan, Aik Choon Tan, James DeGregori
Journal: Cancer Research
Cancer Res (2012) 72 (16): 4154–4164.
https://doi.org/10.1158/0008-5472.CAN-11-2848
Published: 14 August 2012
View article titled, Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
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Includes: Supplementary data
Journal Articles

Abstract 1941: Development of novel NSAID conjugated molecules for lung cancer therapy

Daniel C. Chan, Lajos Gera, Zhiyong Zhang, Di Zheng, Robert Hodges, John Stewart, Paul Bunn
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1941.
https://doi.org/10.1158/1538-7445.AM2012-1941
Published: 15 April 2012
View article titled, Abstract 1941: Development of novel NSAID conjugated molecules for lung cancer therapy
Journal Articles

Abstract 1357: Role of Natural Killer-cell Immunoglobulin-like receptors KIR2DL1 and KIR3DL1 in immune resistance

Daniel C. Chan, Zhiyong Zhang, Hong Wang, Xiaomei Sui, Tiffany T. Chan, Natalie Ahn, Lewis L. Lanier, Paul A. Bunn
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1357.
https://doi.org/10.1158/1538-7445.AM10-1357
Published: 15 April 2010
View article titled, Abstract 1357: Role of Natural Killer-cell Immunoglobulin-like receptors KIR2DL1 and KIR3DL1 in immune resistance
Journal Articles

Abstract 5439: Characterization of the class 1 histone deacetylase inhibitor entinostat in EGFRi acquired resistance models and in combination with cetuximab in NSCLC

Daniel C. Chan, Samir E. Witta, Di Zheng, Veronika Franekova, Xiaomei Sui, Peter Ordentlich, Paul A. Bunn, Fred R. Hirsch
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5439.
https://doi.org/10.1158/1538-7445.AM10-5439
Published: 15 April 2010
View article titled, Abstract 5439: Characterization of the class 1 histone deacetylase inhibitor entinostat in EGFRi acquired resistance models and in combination with cetuximab in NSCLC
Journal Articles

Cross-talk between G Protein–Coupled Receptor and Epidermal Growth Factor Receptor Signaling Pathways Contributes to Growth and Invasion of Head and Neck Squamous Cell Carcinoma

Sufi Mary Thomas, Neil E. Bhola, Qing Zhang, Sarah C. Contrucci, Abbey L. Wentzel, Maria L. Freilino, William E. Gooding, Jill M. Siegfried, Daniel C. Chan, Jennifer Rubin Grandis
Journal: Cancer Research
Cancer Res (2006) 66 (24): 11831–11839.
https://doi.org/10.1158/0008-5472.CAN-06-2876
Published: 18 December 2006
View article titled, Cross-talk between G Protein–Coupled Receptor and Epidermal Growth Factor Receptor Signaling Pathways Contributes to Growth and Invasion of Head and Neck Squamous Cell Carcinoma
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Journal Articles

Combination of antioxidants prevent the development of PIN in Noble rats

Rita Ghosh, Daniel C. Chan, Dean A. Troyer, Addanki P. Kumar
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 162.
Published: 15 April 2006
View article titled, Combination of antioxidants prevent the development of PIN in Noble rats
Journal Articles

Head and neck squamous cell carcinoma express receptors for PGE2 and bradykinin that transactivate the EGFR signaling axis increasing tumor invasion and proliferation

Sufi M. Thomas, Qing Zhang, Shailaja Kalyankrishna, Abbey Wentzel, Maria Freilino, Chris Gubish, William E. Gooding, Jill M. Siegfried, Daniel C. Chan, Jennifer R. Grandis
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1131.
Published: 15 April 2006
View article titled, Head and neck squamous cell carcinoma express receptors for PGE2 and bradykinin that transactivate the EGFR signaling axis increasing tumor invasion and proliferation
Journal Articles

Preclinical studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancers.

Daniel C. Chan, Victor Chen, Barbara Helfrich, Zhiyong Zhang, Fred Hirsch, Doreen Ma, Paul Bunn, Jr.
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1278.
Published: 15 April 2006
View article titled, Preclinical studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancers.
Journal Articles

In vitro and in vivo mechanisms of action for the antitumor activity of the microtubule destabilizing agent ENMD-1198 include inhibition of HIF-1α, NF-κB and Stat3

Patricia A. Burke, Xiaoru Chen, Cassandra L. Waters, Glenn M. Swartz, Steven J. Strawn, Zhiyong Zhang, Daniel C. Chan, Theresa M. Lavallee
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 116.
Published: 15 April 2006
View article titled, In vitro and in vivo mechanisms of action for the antitumor activity of the microtubule destabilizing agent ENMD-1198 include inhibition of HIF-1α, NF-κB and Stat3
Journal Articles

Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines

Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio Sugita, Zeng Chan, Anna Baron, Wilbur Franklin, Harry A. Drabkin, Luc Girard, Adi F. Gazdar, John D. Minna, Paul A. Bunn, Jr.
Journal: Cancer Research
Cancer Res (2006) 66 (2): 944–950.
https://doi.org/10.1158/0008-5472.CAN-05-1988
Published: 19 January 2006
View article titled, Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
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Journal Articles

Prostaglandin E2 and Bradykinin contribute to head and neck squamous cell carcinoma carcinogenesis via EGFR dependent and independent mechanisms.

Sufi M. Thomas, Abbey L. Wentzel, Qing Zhang, Maria L. Freilino, Daniel C. Chan, William E. Gooding, Jill M. Siegfried, Jennifer R. Granids
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 39.
Published: 01 May 2005
View article titled, Prostaglandin E2 and Bradykinin contribute to head and neck squamous cell carcinoma carcinogenesis via EGFR dependent and independent mechanisms.
Journal Articles

2-Methoxyestradiol (2-ME2, Panzem®) inhibited orthotopic lung tumors in athymic nude rats

Daniel C. Chan, Tom L. Zhao, Lajos Gera, Glenn Swartz, Paul Bunn, Jr., William E. Fogler
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 690–691.
Published: 01 April 2004
View article titled, 2-Methoxyestradiol (2-ME2, Panzem®) inhibited orthotopic lung tumors in athymic nude rats
Journal Articles

Development of novel nonpeptide molecules for lung cancer therapy.

Daniel C. Chan, Lajos Gera, Barbara Helfrich, Tom L. Zhao, Jie Yang, Ralphe Nemenoff, John Stewart, Paul Bunn, Jr
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 476.
Published: 01 April 2004
View article titled, Development of novel nonpeptide molecules for lung cancer therapy.
Journal Articles

Synergistic Effects of New Chemopreventive Agents and Conventional Cytotoxic Agents against Human Lung Cancer Cell Lines

Ariel F. Soriano, Barbara Helfrich, Daniel C. Chan, Lynn E. Heasley, Paul A. Bunn, Jr., Ting-Chao Chou
Journal: Cancer Research
Cancer Res (1999) 59 (24): 6178–6184.
Published: 15 December 1999
View article titled, Synergistic Effects of New Chemopreventive Agents and Conventional Cytotoxic Agents against Human Lung Cancer Cell Lines
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Journal Articles

Paclitaxel Enhances in Vitro Radiosensitivity of Squamous Carcinoma Cell Lines of the Head and Neck

Charles E. Leonard, Daniel C. Chan, T-C. Chou, Rita Kumar, Paul A. Bunn
Journal: Cancer Research
Cancer Res (1996) 56 (22): 5198–5204.
Published: 01 November 1996
View article titled, Paclitaxel Enhances <em>in Vitro</em> Radiosensitivity of Squamous Carcinoma Cell Lines of the Head and Neck
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Journal Articles

Elevated DT-diaphorase Activity and Messenger RNA Content in Human Non-Small Cell Lung Carcinoma: Relationship to the Response of Lung Tumor Xenografts to Mitomycin C

Alvin M. Malkinson, David Siegel, Gerald L. Forrest, Adi F. Gazdar, Herbert K. Oie, Daniel C. Chan, Paul A. Bunn, Mack Mabry, Donald J. Dykes, Steadman D. Harrison, Jr., David Ross
Journal: Cancer Research
Cancer Res (1992) 52 (17): 4752–4757.
Published: 01 September 1992
View article titled, Elevated DT-diaphorase Activity and Messenger RNA Content in Human Non-Small Cell Lung Carcinoma: Relationship to the Response of Lung Tumor Xenografts to Mitomycin C
Open the PDF for Elevated DT-diaphorase Activity and Messenger RNA Content in Human Non-Small Cell Lung Carcinoma: Relationship to the Response of Lung Tumor Xenografts to Mitomycin C in another window