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Daniel A. Haber
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Journal Articles

Abstract CT073: Efficacy of novel oral SERD elacestrant in fulvestrant-refractory hormone receptor-positive (HR+) breast cancer: a translational investigation

Taronish D. Dubash, Aditya Bardia, Brian Chirn, Brittany A. Reeves, Joseph A. LiCausi, Risa Burr, Ben S. Wittner, Sumit Rai, Hitisha Patel, Teeru Bihani, Heike Arlt, Francois-Clement Bidard, Virginia G. Kaklamani, Philippe Aftimos, Javier Cortés, Simona Scartoni, Monica Binaschi, Nassir Habboubi, A. John Iafrate, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT073.
https://doi.org/10.1158/1538-7445.AM2023-CT073
Published: 14 April 2023
View article titled, Abstract CT073: Efficacy of novel oral SERD elacestrant in fulvestrant-refractory hormone receptor-positive (HR+) breast cancer: a translational investigation
Journal Articles

Abstract 771: Mechanisms of genetic predisposition to multifocal lung cancer

Risa Burr, Ignaty Leshchiner, Christina L. Costantino, Martin Blohmer, Tilak Sundaresan, Justin Cha, Karsen Seeger, Sara Guay, Brian P. Danysh, Ira Gore, Raquel A. Jacobs, Kara Slowik, Filippo Utro, Kahn Rhrissorrakrai, Chaya Levovitz, Jaimie L. Barth, Taronish Dubash, Brian Chirn, Laxmi Parida, Lecia V. Sequist, Mari Mino-Kenudson, Kamila Naxerova, Shyamala Maheswaran, Gad Getz, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 771.
https://doi.org/10.1158/1538-7445.AM2023-771
Published: 04 April 2023
View article titled, Abstract 771: Mechanisms of genetic predisposition to multifocal lung cancer
Journal Articles

Abstract IA010: Hypomethylation of immune-related loci contribute to prostate tumorigenesis

Daniel A. Haber, Hongshan Guo, Ben S. Wittner, Joanna A Vuille, Michael S. Lawrence, Chin-Lee Wu, Mehmet Toner, David T. Miyamoto, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): IA010.
https://doi.org/10.1158/1538-7445.METASTASIS22-IA010
Published: 15 January 2023
View article titled, Abstract IA010: Hypomethylation of immune-related loci contribute to prostate tumorigenesis
Journal Articles

Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition

Nezihi Murat Karabacak, Yu Zheng, Taronish D. Dubash, Risa Burr, Douglas S. Micalizzi, Ben S. Wittner, Maoxuan Lin, Devon F. Wiley, Valentine Comaills, Erin Emmons, Kira L. Niederhoffer, Uyen Ho, Jacob Ukleja, Dante Che, Hannah Stowe, Linda T. Nieman, Wilhelm Haas, Shannon L. Stott, Michael S. Lawrence, David T. Ting, David T. Miyamoto, Daniel A. Haber, Mehmet Toner, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1084–1097.
https://doi.org/10.1158/0008-5472.CAN-21-2609
Published: 15 March 2022
View article titled, Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition
Open the PDF for Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract P1-18-22: AKT inhibition in combination with endocrine therapy and a CDK4/6 inhibitor (CDK4/6i) in patients with hormone receptor positive (HR+)/HER2 negative metastatic breast cancer (MBC) and prior CDK4/6i exposure: A translational investigation

Seth A. Wander, Douglas S. Micalizzi, Taronish Dubash, Dejan Juric, Laura M. Spring, Neelima Vidula, Jennifer Keenan, Maureen Beeler, Elene Viscosi, Dante Che, Elizabeth L. Fisher, Rachel A. Hepp, Beverly Moy, Steven J. Isakoff, Leif W. Ellisen, Jeffrey G. Supko, Shyamala Maheswaran, Daniel A. Haber, Aditya Bardia
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-18-22.
https://doi.org/10.1158/1538-7445.SABCS21-P1-18-22
Published: 15 February 2022
View article titled, Abstract P1-18-22: AKT inhibition in combination with endocrine therapy and a CDK4/6 inhibitor (CDK4/6i) in patients with hormone receptor positive (HR+)/HER2 negative metastatic breast cancer (MBC) and prior CDK4/6i exposure: A translational investigation
Journal Articles

Abstract PD2-03: Association between co-existing genomic alterations and abemaciclib benefit in patients with metastatic hormone receptor-positive breast cancer with ESR1 mutations following disease progression on prior endocrine therapy plus palbociclib or ribociclib

Jamie O Brett, Taronish D Dubash, Andrzej Niemierko, Veronica Mariotti, Leslie SL Kim, Jing Xi, Apurva Pandey, Siobhan Dunne, Azadeh Nasrazadani, Maxwell R Lloyd, Laura M Spring, Douglas Micalizzi, Maristela Onozato, Dante Che, Adam Brufsky, Kevin M Kalinsky, Cynthia X Ma, Joyce O’Shaughnessy, Hyo S Han, A. John Iafrate, Shyamala Maheswaran, Daniel A Haber, Aditya Bardia, Seth A Wander
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-03.
https://doi.org/10.1158/1538-7445.SABCS21-PD2-03
Published: 15 February 2022
View article titled, Abstract PD2-03: Association between co-existing genomic alterations and abemaciclib benefit in patients with metastatic hormone receptor-positive breast cancer with ESR1 mutations following disease progression on prior endocrine therapy plus palbociclib or ribociclib
Journal Articles

Abstract 2473: NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation

Hongshan Guo, Gabriel Golczer, Shyamala Maheswaran, Michael S. Lawrence, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2473.
https://doi.org/10.1158/1538-7445.AM2021-2473
Published: 01 July 2021
View article titled, Abstract 2473: <em>NR4A1</em> suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation
Journal Articles

Abstract 1053: A large cellular screen charting the landscape of synergistic drug combinations in lung cancer

Nishanth Ulhas Nair, Adam Friedman, Patricia Greninger, Avinash D. Sahu, Ellen Murchie, Giovanna Stein Crowther, Joe McClanaghan, Joo Sang Lee, Daniel A. Haber, Jeffrey Engelman, Eytan Ruppin, Cyril Benes
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1053.
https://doi.org/10.1158/1538-7445.AM2021-1053
Published: 01 July 2021
View article titled, Abstract 1053: A large cellular screen charting the landscape of synergistic drug combinations in lung cancer
Journal Articles

Translational Regulation of Cancer Metastasis

Douglas S. Micalizzi, Richard Y. Ebright, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2021) 81 (3): 517–524.
https://doi.org/10.1158/0008-5472.CAN-20-2720
Published: 01 February 2021
View article titled, Translational Regulation of Cancer Metastasis
Open the PDF for Translational Regulation of Cancer Metastasis in another window
Journal Articles

Abstract 6073: The lipogenic regulator SREBP induces Transferrin in circulating melanoma cells, suppressing their susceptibility to ferroptosis

Xin Hong, Whijae Roh, Ryan J. Sullivan, Keith H. Wong, Ben S. Wittner, HongShan Guo, Taronish D. Dubash, Moshe Sade-Feldman, Ben K. Wesley, Genevieve M. Boland, Dieuwke L. Marvin, Todd Bonesteel, Chenyue Lu, Elad Horwitz, François Aguet, Samuel S. Freeman, Katherine Calhoun, Michelle K. Jewett, Linda T. Nieman, Nir Hacohen, Anders M. Näär, David T. Ting, Mehmet Toner, Shannon L. Stott, Gad Getz, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6073.
https://doi.org/10.1158/1538-7445.AM2020-6073
Published: 15 August 2020
View article titled, Abstract 6073: The lipogenic regulator <em>SREBP</em> induces <em>Transferrin</em> in circulating melanoma cells, suppressing their susceptibility to ferroptosis
Journal Articles

Abstract P4-01-06: Elacestrant (RAD1901) inhibits growth of ex vivo cultured circulating tumor cells derived from hormone receptor-positive metastatic breast cancer (mBC) patients including those harboring ESR1 mutations

Taronish Dorab Dubash, Aditya Bardia, Brittany A Reeves, Brian Chirn, Annamaria Szabolcs, Ben S Wittner, John Iafrate, David Ting, Hitisha K Patel, Teeru Bihani, Mehmet Toner, Daniel A Haber, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-01-06.
https://doi.org/10.1158/1538-7445.SABCS19-P4-01-06
Published: 15 February 2020
View article titled, Abstract P4-01-06: Elacestrant (RAD1901) inhibits growth of ex vivo cultured circulating tumor cells derived from hormone receptor-positive metastatic breast cancer (mBC) patients including those harboring ESR1 mutations
Journal Articles

Abstract 2972: Co-clinical trial of olaparib and temozolomide in SCLC PDX models uncovers new biomarkers of sensitivity

Benjamin J. Drapkin, Julie George, Marcello Stanzione, Beow Y. Yeap, Mari Mino-Kenudson, Camilla L. Christensen, Ruben Dries, Sarah Phat, Jun Zhong, David T. Myers, Joseph A. Licausi, Tilak Sundaresan, Marina Kem, Nima Abedpour, Leica V. Sequist, Alice T. Shaw, Aaron N. Hata, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber, Martin Peifer, Roman K. Thomas, Anna F. Farago, Nicholas J. Dyson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2972.
https://doi.org/10.1158/1538-7445.AM2018-2972
Published: 01 July 2018
View article titled, Abstract 2972: Co-clinical trial of olaparib and temozolomide in SCLC PDX models uncovers new biomarkers of sensitivity
Journal Articles

Abstract LB-144: Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

Xin Hong, Ryan J. Sullivan, Mark Kalinich, Tanya Kwan, Shiwei Pan, Joseph A. LiCausi, John D. Milner, Linda T. Nieman, Ben S. Wittner, Uyen Ho, Tianqi Chen, Ravi Kapur, Don Lawrence, Keith T. Flaherty, Lecia V. Sequist, Sridhar Ramaswamy, David T. Miyamoto, Michael Lawrence, Anita Giobbie-Hurder, Mehmet Toner, Kurt J. Isselbacher, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-144.
https://doi.org/10.1158/1538-7445.AM2018-LB-144
Published: 01 July 2018
View article titled, Abstract LB-144: Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy
Journal Articles

Abstract 210: Uncovering a novel layer of complexity in the architecture of pancreatic cancer

Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, Sandra Misale, Murat Karabacak, Linda Nieman, Shyamala Maheswaran, Daniel A. Haber, Andrew L. Warshaw, Carlos Fernandez-Del Castillo, Cristina R. Ferrone, Wilhelm Haas, Martin Aryee, David T. Ting
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 210.
https://doi.org/10.1158/1538-7445.AM2018-210
Published: 01 July 2018
View article titled, Abstract 210: Uncovering a novel layer of complexity in the architecture of pancreatic cancer
Journal Articles

Abstract 1734: Absolute quantification of circulating tumor cell RNA enables high specificity detection of hepatocellular carcinoma

Mark Kalinich, Irun Bhan, Tanya T. Kwan, David T. Miyamoto, Sarah Javaid, Joseph A. LiCausi, John D. Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A. Weitz, Lecia V. Sequist, David P. Ryan, Raymond Chung, Andrew X. Zhu, Kurt J. Isselbacher, David T. Ting, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1734.
https://doi.org/10.1158/1538-7445.AM2017-1734
Published: 01 July 2017
View article titled, Abstract 1734: Absolute quantification of circulating tumor cell RNA enables high specificity detection of hepatocellular carcinoma
Journal Articles

Abstract 4953: Single cell signaling analysis reveals circulating tumor cell markers of drug susceptibility and tumor heterogeneity

N Murat Karabacak, Yu Zheng, Erin Emmons, Michael Koulopoulos, Daniel A. Haber, Mehmet Toner, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4953.
https://doi.org/10.1158/1538-7445.AM2017-4953
Published: 01 July 2017
View article titled, Abstract 4953: Single cell signaling analysis reveals circulating tumor cell markers of drug susceptibility and tumor heterogeneity
Journal Articles

Abstract CT048: Phase 1/2 study of olaparib tablets and temozolomide in patients with small cell lung cancer (SCLC) following failure of prior chemotherapy

Anna F. Farago, Benjamin J. Drapkin, Allison Charles, Beow Yeap, Rebecca S. Heist, Christopher G. Azzoli, David M. Jackman, David A. Barbie, Edwin Choy, Lecia V. Sequist, Shyamala Maheswaran, Daniel A. Haber, Aaron N. Hata, Nicholas Dyson, Alice T. Shaw
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT048.
https://doi.org/10.1158/1538-7445.AM2017-CT048
Published: 01 July 2017
View article titled, Abstract CT048: Phase 1/2 study of olaparib tablets and temozolomide in patients with small cell lung cancer (SCLC) following failure of prior chemotherapy
Journal Articles

Abstract SY24-01: High-throughput CTC detection for noninvasive cancer monitoring

Shyamala Maheswaran, Mark Kalinich, Irun Bhan, David Miyamoto, Yu Zheng, Xin Hong, Tanya Todorova Kwan, Ravi Kapur, Lecia Sequist, Ryan Sullivan, Aditya Bardia, Richard Lee, David Ting, Mehmet Toner, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): SY24-01.
https://doi.org/10.1158/1538-7445.AM2017-SY24-01
Published: 01 July 2017
View article titled, Abstract SY24-01: High-throughput CTC detection for noninvasive cancer monitoring
Journal Articles

Abstract 1410: Proliferation during epithelial-to-mesenchymal transition induces genomic instability

Valentine Comaills, Lilian Kabeche, Robert Morris, Min Yu, Marissa Wells Madden, Joseph A. LiCausi, Nicola Aceto, Yu Zheng, David T. Miyamoto, Sridhar Ramaswamy, Lee Zou, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1410.
https://doi.org/10.1158/1538-7445.AM2017-1410
Published: 01 July 2017
View article titled, Abstract 1410: Proliferation during epithelial-to-mesenchymal transition induces genomic instability
Journal Articles

Abstract 2679: Induction of β-globin protects circulating tumor cells from oxidative stress during dissemination

Yu Zheng, David T. Miyamoto, Ben S. Wittner, James P. Sullivan, Nicola Aceto, Nicole Vincent Jordan, Min Yu, Nezihi Murat Karabacak, Valentine Comaills, Robert Morris, Rushil Desai, Niyati Desai, Erin Emmons, Richard J. Lee, Chin-Lee Wu, Lecia V. Sequist, Wilhelm Haas, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2679.
https://doi.org/10.1158/1538-7445.AM2016-2679
Published: 15 July 2016
View article titled, Abstract 2679: Induction of β-globin protects circulating tumor cells from oxidative stress during dissemination