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Journal Articles

Gprc5a Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor

Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Taoyan Men, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8917–8926.
https://doi.org/10.1158/0008-5472.CAN-10-0518
Published: 31 October 2010
View articletitled, Gprc5a Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor
Open the PDF for Gprc5a Deletion Enhances the Transformed Phenotype in Normal and Malignant Lung Epithelial Cells by Eliciting Persistent Stat3 Signaling Induced by Autocrine Leukemia Inhibitory Factor in another window
Includes: Supplementary data
Journal Articles

Abstract 2466: Tobacco carcinogen-enhanced lung tumorigenesis in Gprc5a knockout mice recapitulates human lung cancer development

Junya Fujimoto, Humam N. Kadara, Qingguo Tao, Taoyan Men, Carolyn van Pelt, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2466.
https://doi.org/10.1158/1538-7445.AM10-2466
Published: 15 April 2010
View articletitled, Abstract 2466: Tobacco carcinogen-enhanced lung tumorigenesis in Gprc5a knockout mice recapitulates human lung cancer development
Journal Articles

Abstract 4995: Loss of the lung-specific tumor suppressor Gprc5a causes persistent activation of Stat3 leading to increased survival signaling in normal and malignant lung epithelial cells

Yulong Chen, Jiong Deng, Junya Fujimoto, Humam Kadara, Xiaofeng Ye, Taoyan Men, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4995.
https://doi.org/10.1158/1538-7445.AM10-4995
Published: 15 April 2010
View articletitled, Abstract 4995: Loss of the lung-specific tumor suppressor Gprc5a causes persistent activation of Stat3 leading to increased survival signaling in normal and malignant lung epithelial cells
Journal Articles

Abstract #1437: Gene expression signatures of tumor suppressor Gprc5a loss in murine lung cells predict poor survival in human lung adenocarcinomas

Humam Kadara, Junya Fujimoto, Taoyan Men, Dafna Lotan, Xiaofeng Ye, Ju-Seog Lee, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1437.
Published: 01 May 2009
View articletitled, Abstract #1437: Gene expression signatures of tumor suppressor Gprc5a loss in murine lung cells predict poor survival in human lung adenocarcinomas
Journal Articles

Abstract #5347: The lung tumor suppressor GPRC5A inhibits activation of NF-\#954;B in human non-small cell lung adenocarcinoma cells

Jiong Deng, Junya Fujimoto, Xiao-Feng Ye, Tao-Yan Men, Xiao-Feng Lin, Yu-Long Chen, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5347.
Published: 01 May 2009
View articletitled, Abstract #5347: The lung tumor suppressor GPRC5A inhibits activation of NF-\#954;B in human non-small cell lung adenocarcinoma cells
Journal Articles

Involvement of Rac in Fenretinide-Induced Apoptosis

Humam Kadara, Eiji Tahara, Hyun-Jung Kim, Dafna Lotan, Jeffrey Myers, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4416–4423.
https://doi.org/10.1158/0008-5472.CAN-08-0031
Published: 02 June 2008
View articletitled, Involvement of Rac in Fenretinide-Induced Apoptosis
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Journal Articles

Differential effects of 4HPR on gene expression and apoptosis in normal and malignant cells of the head and neck despite induction of reactive oxygen species in both cell types

Humam Kadara, Hyun Jung Kim, Eiji Tahara, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2282A.
Published: 01 May 2008
View articletitled, Differential effects of 4HPR on gene expression and apoptosis in normal and malignant cells of the head and neck despite induction of reactive oxygen species in both cell types
Journal Articles

Targeting cap-dependent translation: chemoprevention potential in oral carcinogenesis

Nitin Chakravarti, Ludovic Lacroix, Do-Jun Yoon, Jerry Shay, Jeffrey Myers, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4653.
Published: 01 May 2008
View articletitled, Targeting cap-dependent translation: chemoprevention potential in oral carcinogenesis
Journal Articles

Evidence for the involvement of NF-κB and inflammation in the promotion of lung carcinogenesis in the Gprc5a knockout mouse model

Jiong Deng, Xiaofeng Ye, Junya Fujimoto, Qingguo Tao, Taoyan Men, Carolyn Van Pelt, Xiaofeng Lin, Yulong Chen, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4725.
Published: 01 May 2008
View articletitled, Evidence for the involvement of NF-κB and inflammation in the promotion of lung carcinogenesis in the Gprc5a knockout mouse model
Journal Articles

Differential Rac-mediated generation of reactive oxygen species increases sensitivity of metastatic cancer cells to the proapoptotic synthetic retinoid 4HPR relative to their primary cancer cell counterparts

Humam Kadara, Eiji Tahara, Hyun-Jung Kim, Dafna Lotan, Jeffrey Myers, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4591.
Published: 01 May 2007
View articletitled, Differential Rac-mediated generation of reactive oxygen species increases sensitivity of metastatic cancer cells to the proapoptotic synthetic retinoid 4HPR relative to their primary cancer cell counterparts
Journal Articles

Inhibition of cell growth in head and neck premalignant and malignant cells by curcumin in eIF4E-dependent manner

Nitin Chakravarti, Humam Kadara, Ludovic Lacroix, Do-Jun Yoon, Jerry Shay, Jeffrey Myers, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5342.
Published: 01 May 2007
View articletitled, Inhibition of cell growth in head and neck premalignant and malignant cells by curcumin in eIF4E-dependent manner
Journal Articles

The expression of GPRC5A in cultured normal and malignant cells is modulated by endogenous retinoids in serum

Xiaofeng Ye, Jiong Deng, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1652.
Published: 01 May 2007
View articletitled, The expression of GPRC5A in cultured normal and malignant cells is modulated by endogenous retinoids in serum
Journal Articles

Inhibition of lung cancer cell growth by the putative tumor suppressor gene KLF6 through activation of PKC α pathway and inhibition of PI3Kinase pathway

Eiji Tahara, Humam Kadara, Ludovic Lacroix, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3677.
Published: 01 May 2007
View articletitled, Inhibition of lung cancer cell growth by the putative tumor suppressor gene KLF6 through activation of PKC α pathway and inhibition of PI3Kinase pathway
Journal Articles

Identification of biomarkers for human lung carcinogenesis by analysis of transcriptomes of cell lines representing different stages of lung carcinogenesis

Ludovic Lacroix, Eiji Tahara, Carmen Behrens, Humam Kadara, Dafna Lotan, Ignacio Wistuba, Reuben Lotan
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2956.
Published: 01 May 2007
View articletitled, Identification of biomarkers for human lung carcinogenesis by analysis of transcriptomes of cell lines representing different stages of lung carcinogenesis
Journal Articles

Involvement of Mitochondrial and Akt Signaling Pathways in Augmented Apoptosis Induced by a Combination of Low Doses of Celecoxib and N-(4-Hydroxyphenyl) Retinamide in Premalignant Human Bronchial Epithelial Cells

Claudia P. Schroeder, Humam Kadara, Dafna Lotan, Jong K. Woo, Ho-Young Lee, Waun Ki Hong, Reuben Lotan
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9762–9770.
https://doi.org/10.1158/0008-5472.CAN-05-4124
Published: 03 October 2006
View articletitled, Involvement of Mitochondrial and Akt Signaling Pathways in Augmented Apoptosis Induced by a Combination of Low Doses of Celecoxib and N-(4-Hydroxyphenyl) Retinamide in Premalignant Human Bronchial Epithelial Cells
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Journal Articles

Differential expression of the orphan G-protein coupled receptor GPCR5A in human cancers and its induction by retinoic acid and fenretinide

Qingguo Tao, Xiaofeng Ye, Yijun Cheng, Ludovic Lacroix, Li Mao, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 595–596.
Published: 15 April 2006
View articletitled, Differential expression of the orphan G-protein coupled receptor GPCR5A in human cancers and its induction by retinoic acid and fenretinide
Journal Articles

The pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide activates the endoplasmic reticulum stress pathway in 22B human head and neck cancer cells

Humam N. Kadara, Ludovic Lacroix, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 158–159.
Published: 15 April 2006
View articletitled, The pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide activates the endoplasmic reticulum stress pathway in 22B human head and neck cancer cells
Journal Articles

Molecular cloning of two novel murine retinoic acid-inducible orphan G-protein-coupled receptors (mGPRC5B and mGPRC5C), their expression in adult mouse tissues and embryos, and their induction by retinoic acid during embryonal carcinoma cell differentiation

Qingguo Tao, Dafna Lotan, Reuben Lotan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 457.
Published: 01 May 2005
View articletitled, Molecular cloning of two novel murine retinoic acid-inducible orphan G-protein-coupled receptors (mGPRC5B and mGPRC5C), their expression in adult mouse tissues and embryos, and their induction by retinoic acid during embryonal carcinoma cell differentiation
Journal Articles

Overexpression of Retinoic Acid Receptor β in Head and Neck Squamous Cell Carcinoma Cells Increases Their Sensitivity to Retinoid-induced Suppression of Squamous Differentiation by Retinoids

Haisu Wan, Nobuhiko Oridate, Dafna Lotan, Waun K. Hong, Reuben Lotan
Journal: Cancer Research
Cancer Res (1999) 59 (14): 3518–3526.
Published: 15 July 1999
View articletitled, Overexpression of Retinoic Acid Receptor β in Head and Neck Squamous Cell Carcinoma Cells Increases Their Sensitivity to Retinoid-induced Suppression of Squamous Differentiation by Retinoids
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Journal Articles

Carcinoembryonic Antigen and Other Glycoconjugates Act as Ligands for Galectin-3 in Human Colon Carcinoma Cells

David W. Ohannesian, Dafna Lotan, Peter Thomas, J. Milburn Jessup, Minoru Fukuda, Hans-Joachim Gabius, Reuben Lotan
Journal: Cancer Research
Cancer Res (1995) 55 (10): 2191–2199.
Published: 01 May 1995
View articletitled, Carcinoembryonic Antigen and Other Glycoconjugates Act as Ligands for Galectin-3 in Human Colon Carcinoma Cells
Open the PDF for Carcinoembryonic Antigen and Other Glycoconjugates Act as Ligands for Galectin-3 in Human Colon Carcinoma Cells in another window