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Dafna Bar-Sagi
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Journal Articles

Abstract A022: Novel nanoparticle delivery of toll like receptor agonists alters the tumor immune landscape and improves response to standard of care therapy in preclinical PDAC models

Nathan Beals, Anthony Sorrentino, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A022.
https://doi.org/10.1158/1538-7445.PANCA2023-A022
Published: 16 January 2024
View article titled, Abstract A022: Novel nanoparticle delivery of toll like receptor agonists alters the tumor immune landscape and improves response to standard of care therapy in preclinical PDAC models
Journal Articles

Abstract A018: Exercise stimulates anti-tumoral immunity in metastatic PDAC

Mansour E. Riachi, Carolina G. Alcantara Hirsch, Erica Ma, Beny Shapiro, Ammar Javed, Christopher L. Wolfgang, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A018.
https://doi.org/10.1158/1538-7445.PANCA2023-A018
Published: 16 January 2024
View article titled, Abstract A018: Exercise stimulates anti-tumoral immunity in metastatic PDAC
Journal Articles

Abstract C027: Perioperative immune perturbations of the metastatic microenvironment in a murine PDAC orthotopic resection model

Anthony Sorrentino, Carolina Alcantara-Hirsch, Beny Shapiro, Erica Ma, Ammar Javed, Christopher Wolfgang, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C027.
https://doi.org/10.1158/1538-7445.PANCA2023-C027
Published: 16 January 2024
View article titled, Abstract C027: Perioperative immune perturbations of the metastatic microenvironment in a murine PDAC orthotopic resection model
Journal Articles

Abstract C091: Harnessing proteostatic vulnerabilities in pancreatic cancer

Sandra Vogt, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C091.
https://doi.org/10.1158/1538-7445.PANCA2023-C091
Published: 16 January 2024
View article titled, Abstract C091: Harnessing proteostatic vulnerabilities in pancreatic cancer
Journal Articles

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

Erika Y. Faraoni, Kanchan Singh, Vidhi Chandra, Olivereen Le Roux, Yulin Dai, Ismet Sahin, Baylee J. O'Brien, Lincoln N. Strickland, Le Li, Emily Vucic, Amanda N. Warner, Melissa Pruski, Trent Clark, George Van Buren, Nirav C. Thosani, John S. Bynon, Curtis J. Wray, Dafna Bar-Sagi, Kyle L. Poulsen, Lana A. Vornik, Michelle I. Savage, Shizuko Sei, Altaf Mohammed, Zhongming Zhao, Powel H. Brown, Tingting Mills, Holger K. Eltzschig, Florencia McAllister, Jennifer M. Bailey-Lundberg
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1111–1127.
https://doi.org/10.1158/0008-5472.CAN-22-2553
Published: 04 April 2023
View article titled, CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Open the PDF for CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity

Justine Habault, Jeffrey A. Schneider, Susan Ha, Rachel Ruoff, Joseph Puccini, Dafna Bar-Sagi, Kwok-Kin Wong, Amina Zoubeidi, Frank Claessens, David R. Wise, Susan K. Logan, Kent Kirshenbaum, Michael J. Garabedian
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3441.
https://doi.org/10.1158/1538-7445.AM2023-3441
Published: 04 April 2023
View article titled, Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity
Journal Articles

Abstract IA002: Contextual determinants of pancreatic tumorigenesis

Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): IA002.
https://doi.org/10.1158/1538-7445.PANCA22-IA002
Published: 15 November 2022
View article titled, Abstract IA002: Contextual determinants of pancreatic tumorigenesis
Journal Articles

Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis

Paul E. Oberstein, Osama Rahma, Nina Beri, Amy Stoll-D'Astice, Emily A. Kawaler, Igor Dolgalev, Gregor Werba, Victoire Cardo-Ruffino, Naïma Böllenrücher, Andressa Dias Costa, Saloney Nazeer, Matthew Squires, Jonathan Nowak, Dafna Bar-Sagi, Brian Wolpin, Diane M Simeone, Stephanie K Dougan
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR005.
https://doi.org/10.1158/1538-7445.PANCA22-PR005
Published: 15 November 2022
View article titled, Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis
Journal Articles

Abstract B060: Investigating the role of ERphagy in pancreatic cancer

Sandra L. Vogt, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B060.
https://doi.org/10.1158/1538-7445.PANCA22-B060
Published: 15 November 2022
View article titled, Abstract B060: Investigating the role of ERphagy in pancreatic cancer
Journal Articles

Abstract 6142: Gain-of-function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy

Despina Siolas, Emily Vucic, Emma Kurz, Cristina Hajdu, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6142.
https://doi.org/10.1158/1538-7445.AM2022-6142
Published: 15 June 2022
View article titled, Abstract 6142: Gain-of-function p53<sup>R172H</sup> mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy
Journal Articles

Abstract LT005: Tumor-intrinsic gain of function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment that promotes resistance to immunotherapy

Despina Siolas, Emily Vucic, Emma Kurz, Cristina Hajdu, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): LT005.
https://doi.org/10.1158/1538-7445.TME21-LT005
Published: 01 March 2021
View article titled, Abstract LT005: Tumor-intrinsic gain of function p53<sup>R172H</sup> mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment that promotes resistance to immunotherapy
Journal Articles

Abstract PR-005: Tumor intrinsic p53 mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy

Despina Siolas, Emily Vucic, Emma Kurz, Cristina Hajdu, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-005.
https://doi.org/10.1158/1538-7445.PANCA20-PR-005
Published: 13 November 2020
View article titled, Abstract PR-005: Tumor intrinsic p53 mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy
Journal Articles

Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

Shipra Das, Beny Shapiro, Emily A. Vucic, Sandra Vogt, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2020) 80 (5): 1088–1101.
https://doi.org/10.1158/0008-5472.CAN-19-2080
Published: 02 March 2020
View article titled, Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer
Open the PDF for Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2797: Accumulation of neutrophils in the tumor microenvironment promotes resistance to immunotherapy in pancreatic cancer

Despina Siolas, Emily Vucic, Jane Cullis, Mark Choi, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2797.
https://doi.org/10.1158/1538-7445.AM2019-2797
Published: 01 July 2019
View article titled, Abstract 2797: Accumulation of neutrophils in the tumor microenvironment promotes resistance to immunotherapy in pancreatic cancer
Journal Articles

Abstract 3001: Accurins are endocytosed by KRAS-mutant cells via macropinocytosis

Jane E. Cullis, Laura Taylor, Susan Low, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3001.
https://doi.org/10.1158/1538-7445.AM2016-3001
Published: 15 July 2016
View article titled, Abstract 3001: Accurins are endocytosed by KRAS-mutant cells via macropinocytosis
Journal Articles

Abstract IA21: Ras oncogene in cancer pathogenesis and therapy

Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): IA21.
https://doi.org/10.1158/1538-7445.FBCR15-IA21
Published: 07 April 2016
View article titled, Abstract IA21: Ras oncogene in cancer pathogenesis and therapy
Journal Articles

Abstract LB-224: Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer

Jane E. Cullis, Despina Siolas, Anirban Maitra, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-224.
https://doi.org/10.1158/1538-7445.AM2015-LB-224
Published: 01 August 2015
View article titled, Abstract LB-224: Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer
Journal Articles

Abstract A12: Establishing in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDA) utilizing both acinar and ductal lineages

Jesse Handler, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A12.
https://doi.org/10.1158/1538-7445.PANCA2014-A12
Published: 30 June 2015
View article titled, Abstract A12: Establishing in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDA) utilizing both acinar and ductal lineages
Journal Articles

Abstract B62: The role of B regulatory cells in pancreatic cancer

Yuliya Pylayeva-Gupta, Jesse S. Handler, Cristina Hajdu, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B62.
https://doi.org/10.1158/1538-7445.PANCA2014-B62
Published: 30 June 2015
View article titled, Abstract B62: The role of B regulatory cells in pancreatic cancer
Journal Articles

Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer

Cosimo Commisso, Craig Ramirez, Rengin Soydaner-Azeloglu, David L. Bajor, Robert H. Vonderheide, Dafna Bar-Sagi
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): PR08.
https://doi.org/10.1158/1538-7445.PANCA2014-PR08
Published: 30 June 2015
View article titled, Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer