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Cynthia Wetmore
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Journal Articles

Abstract B065: A phase 1 study of abemaciclib, a CDK 4/6 inhibitor, with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

Thomas Cash, Dolly Aguilera, Zhulin He, Melissa Schink, Amanda Sykes, Celine Pitou, Erin Connelly, Bree Eaton, Natia Esiashvili, Ross Mangum, Margaret E. Macy, Robert C. Castellino, Jason Fangusaro, Tobey J. MacDonald, Cynthia Wetmore, Lindsey Hoffman
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B065.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B065
Published: 05 September 2024
View article titled, Abstract B065: A phase 1 study of abemaciclib, a CDK 4/6 inhibitor, with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)
Journal Articles

Abstract CT250: A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer

Aung Naing, Margaret Callahan, Brian A. Costello, Brendan Curti, Evan Hall, Aaron Hansen, Georgina V. Long, Anthony M. Joshua, Cynthia Wetmore, Andrew Weickhardt
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT250.
https://doi.org/10.1158/1538-7445.AM2022-CT250
Published: 15 June 2022
View article titled, Abstract CT250: A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer
Journal Articles

Abstract OT2-01-02: First in human phase 1 dose escalation and expansion study of the safety and pharmacokinetics of the oral CDK7 inhibitor XL102 as a single-agent and in combination therapy in patients with inoperable locally advanced or metastatic solid tumors, including breast cancer

Amita Patnaik, Minal Barve, Manali Bhave, Vivek Subbiah, Sumandeep Atwal, Keerti Sharma, Christian Scheffold, Cynthia Wetmore, Geoffrey Shapiro
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT2-01-02.
https://doi.org/10.1158/1538-7445.SABCS21-OT2-01-02
Published: 15 February 2022
View article titled, Abstract OT2-01-02: First in human phase 1 dose escalation and expansion study of the safety and pharmacokinetics of the oral CDK7 inhibitor XL102 as a single-agent and in combination therapy in patients with inoperable locally advanced or metastatic solid tumors, including breast cancer
Journal Articles

Abstract 3047: Spatial heterogeneity in diffuse intrinsic pontine gliomas treated with a PDGFR inhibitor

Sasi Arunachalam, Samuel W. Brady, Xiaotu Ma, Karol Szlachta, Heather Mulder, John Easton, Christopher L. Tinkle, Cynthia Wetmore, Suzanne J. Baker, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3047.
https://doi.org/10.1158/1538-7445.AM2021-3047
Published: 01 July 2021
View article titled, Abstract 3047: Spatial heterogeneity in diffuse intrinsic pontine gliomas treated with a PDGFR inhibitor
Journal Articles

Abstract CT030: STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions

Ami V. Desai, Garrett M. Brodeur, Jennifer Foster, Suzanne Shusterman, Amit J. Sabnis, Magaret Macy, Cynthia Wetmore, Ellen Basu, Zachary Hornby, Vanessa Esquibel, Edna Chow Maneval, Pratik S. Multani, Elizabeth Fox
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT030.
https://doi.org/10.1158/1538-7445.AM2017-CT030
Published: 01 July 2017
View article titled, Abstract CT030: STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions
Journal Articles

Abstract PR03: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

Alexander K. Diaz, Gang Wu, Barbara S. Paugh, Yongjin Li, Xiaoyan Zhu, Sherri Rankin, Chunxu Qu, Xiang Chen, Junyuan Zhang, John Easton, Michael Edmonson, Charles Lu, Panduka Nagahawatte, Erin Hedlund, Michael Rusch, Stanley Pounds, Tong Lin, Arzu Onar-Thomas, Robert Huether, Richard Kriwacki, Matthew Parker, Pankaj Gupta, Jared Becksfort, Lei Wei, Heather L. Mulder, Kristy Boggs, Bhavin Vadodaria, Donald Yergeau, Kerri Ochoa, Robert S. Fulton, Lucinda S. Fulton, Chris Jones, Alberto Broniscer, Cynthia Wetmore, Amar Gajjar, Li Ding, Elaine R. Mardis, Richard K. Wilson, James R. Downing, David W. Ellison, Jinghui Zhang, Suzanne J. Baker, For the St Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): PR03.
https://doi.org/10.1158/1538-7445.PEDCAN-PR03
Published: 09 October 2014
View article titled, Abstract PR03: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Journal Articles

Abstract A58: GLI1 mediates oncogenic KRAS-induced transformation in pancreatic ductal adenocarcinoma.

Lisa Mills, Ronald Marler, Marta Herreros-Villanueva, Lizhi Zhang, Fergus Couch, Cynthia Wetmore, Martin E. Fernandez-Zapico
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A58.
https://doi.org/10.1158/1538-7445.PANCA2012-A58
Published: 03 April 2014
View article titled, Abstract A58: GLI1 mediates oncogenic KRAS-induced transformation in pancreatic ductal adenocarcinoma.
Journal Articles

Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

Barbara S. Paugh, Xiaoyan Zhu, Chunxu Qu, Raelene Endersby, Alexander K. Diaz, Junyuan Zhang, Dorine A. Bax, Diana Carvalho, Rui M. Reis, Arzu Onar-Thomas, Alberto Broniscer, Cynthia Wetmore, Jinghui Zhang, Chris Jones, David W. Ellison, Suzanne J. Baker
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6219–6229.
https://doi.org/10.1158/0008-5472.CAN-13-1491
Published: 14 October 2013
View article titled, Novel Oncogenic <em>PDGFRA</em> Mutations in Pediatric High-Grade Gliomas
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Includes: Supplementary data
Journal Articles

Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells

Leah E. Colvin Wanshura, Katherine E. Galvin, Hong Ye, Martin E. Fernandez-Zapico, Cynthia Wetmore
Journal: Cancer Research
Cancer Res (2011) 71 (15): 5336–5345.
https://doi.org/10.1158/0008-5472.CAN-10-2633
Published: 28 July 2011
View article titled, Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells
Open the PDF for Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 7: Snail1 promotes proliferation and induces N-Myc in medulloblastoma cells

Leah E. Colvin Wanshura, Hong Ye, Katherine E. Galvin, Cynthia Wetmore
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 7.
https://doi.org/10.1158/1538-7445.AM10-7
Published: 15 April 2010
View article titled, Abstract 7: Snail1 promotes proliferation and induces N-Myc in medulloblastoma cells
Journal Articles

Abrogation of G1 arrest in murine brain tumor derived stem-like cells afer ionizing radiation.

Andrew Foy, Hong Ye, Cynthia Wetmore
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4595.
Published: 01 May 2008
View article titled, Abrogation of G1 arrest in murine brain tumor derived stem-like cells afer ionizing radiation.
Journal Articles

Cellular and molecular consequences of Patched haploinsufficiency: Perturbation of cell cycle and signal transduction pathways in the developing cerebellum

Jennifer M. Leonard, Karen Baskerville, Ye Hong, Michael McKinney, Cynthia Wetmore
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1088–1089.
Published: 01 May 2005
View article titled, Cellular and molecular consequences of Patched haploinsufficiency: Perturbation of cell cycle and signal transduction pathways in the developing cerebellum
Journal Articles

A Molecular Fingerprint for Medulloblastoma

Youngsoo Lee, Heather L. Miller, Patricia Jensen, Roberto Hernan, Michele Connelly, Cynthia Wetmore, Frederique Zindy, Martine F. Roussel, Tom Curran, Richard J. Gilbertson, Peter J. McKinnon
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5428–5437.
Published: 18 September 2003
View article titled, A Molecular Fingerprint for Medulloblastoma
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Includes: Supplementary data
Journal Articles

Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma

Wen Qing Yang, Donna Senger, Huong Muzik, Zhong Qiao Shi, Denise Johnson, Penny M. A. Brasher, N. Barry Rewcastle, Mark Hamilton, Jim Rutka, Johannes Wolff, Cynthia Wetmore, Tom Curran, Patrick W. K. Lee, Peter A. Forsyth
Journal: Cancer Research
Cancer Res (2003) 63 (12): 3162–3172.
Published: 15 June 2003
View article titled, Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma
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Journal Articles

Mouse Embryos Cloned from Brain Tumors

Leyi Li, Michele C. Connelly, Cynthia Wetmore, Tom Curran, James I. Morgan
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2733–2736.
Published: 01 June 2003
View article titled, Mouse Embryos Cloned from Brain Tumors
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Journal Articles

Loss of p53 but not ARF Accelerates Medulloblastoma in Mice Heterozygous for patched

Cynthia Wetmore, Derek E. Eberhart, Tom Curran
Journal: Cancer Research
Cancer Res (2001) 61 (2): 513–516.
Published: 01 January 2001
View article titled, Loss of <em>p53</em> but not <em>ARF</em> Accelerates Medulloblastoma in Mice Heterozygous for <em>patched</em>
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Journal Articles

The Normal patched Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of patched

Cynthia Wetmore, Derek E. Eberhart, Tom Curran
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2239–2246.
Published: 01 April 2000
View article titled, The Normal <em>patched</em> Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of <em>patched</em>
Open the PDF for The Normal <em>patched</em> Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of <em>patched</em> in another window