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Cynthia Hawkins
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Journal Articles

Abstract 2421: Targeted and low-pass whole genome sequencing of cerebrospinal fluid circulating tumor DNA for the diagnosis and monitoring of pediatric, adolescent and young adult CNS tumors

Ian Burns, Liana Nobre, Yoshiko Nakano, Michelle Ku, Monique Johnson, Javal Sheth, Logine Negm, Chantel Cacciotti, Mansuba Rana, Richard Yuditskiy, Andrew Bondoc, Robert Siddaway, Uri Tabori, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2421.
https://doi.org/10.1158/1538-7445.AM2024-2421
Published: 22 March 2024
View article titled, Abstract 2421: Targeted and low-pass whole genome sequencing of cerebrospinal fluid circulating tumor DNA for the diagnosis and monitoring of pediatric, adolescent and young adult CNS tumors
Journal Articles

Abstract 1451: Replication repair deficient mouse models provide insights into gliomagenesis and response to immunotherapy

Zoya Aamir, Melissa Galati, Emma Gattoni, Owen Crump, Nuno M. Nunes, Anirban Das, Nicholas Fernandez, Nicholas Fernandez, Angel K. Wong, Jerome Fortin, Lucie Stengs, Vanessa Bianchi, Melissa Edwards, Logine Negm, Cynthia Hawkins, David Malkin, Sean Egan, Uri Tabori
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1451.
https://doi.org/10.1158/1538-7445.AM2024-1451
Published: 22 March 2024
View article titled, Abstract 1451: Replication repair deficient mouse models provide insights into gliomagenesis and response to immunotherapy
Journal Articles

Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Guillaume Bourque, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Paul Moorehead, Michael F. Moran, Daniel A. Morgenstern, Sapna Oberoi, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, Stephanie Villeneuve, James A. Whitlock, David Malkin, on behalf of the PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4509.
https://doi.org/10.1158/1538-7445.AM2023-4509
Published: 04 April 2023
View article titled, Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program
Journal Articles

Correction: PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William Stanford, Michael D. Taylor, Gelareh Zadeh, James T. Rutka
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4695.
https://doi.org/10.1158/0008-5472.CAN-22-3445
Published: 16 December 2022
View article titled, Correction: PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
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Journal Articles

Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Michael F. Moran, Daniel A. Morgenstern, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2022-5224
Published: 15 June 2022
View article titled, Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada
Journal Articles

Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Thierry Alcindor, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Abha Gupta, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael F. Moran, Daniel A. Morgenstern, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 636.
https://doi.org/10.1158/1538-7445.AM2021-636
Published: 01 July 2021
View article titled, Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Abstract 1165: Complementary diagnostics for precision targeting of cellular pathways

Robert Siddaway, Liana Nobre, Monique Johnson, Scott Milos, Scott Ryall, Javal Sheth, Uri Tabori, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1165.
https://doi.org/10.1158/1538-7445.AM2021-1165
Published: 01 July 2021
View article titled, Abstract 1165: Complementary diagnostics for precision targeting of cellular pathways
Journal Articles

Abstract PO052: Uncovering the evolution of Glioblastoma proteome landscape from primary to the recurrent stage for development of novel diagnostic and predictive biomarkers

Nazanin Tatari, Shahbaz Khan, Julie Livingstone, Chitra Venugopal, Jennifer Chan, Cynthia Hawkins, John Provias, Jian-Qiang Lu, Kjetil Ask, Thomas Kislinger, Sheila Singh
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO052.
https://doi.org/10.1158/1538-7445.TME21-PO052
Published: 01 March 2021
View article titled, Abstract PO052: Uncovering the evolution of Glioblastoma proteome landscape from primary to the recurrent stage for development of novel diagnostic and predictive biomarkers
Journal Articles

Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Jason N. Berman, Jennifer A. Chan, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael Moran, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5413.
https://doi.org/10.1158/1538-7445.AM2020-5413
Published: 15 August 2020
View article titled, Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Abstract A35: From map to model: Genetic evolution of diffuse intrinsic pontine glioma provides the framework for accurate tumor modeling

Evan Lubanszky, Scott Ryall, Robert Siddaway, Byunjin Kim, Taylor Bridge, Sanja Pajovic, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): A35.
https://doi.org/10.1158/1538-7445.CAMODELS2020-A35
Published: 02 June 2020
View article titled, Abstract A35: From map to model: Genetic evolution of diffuse intrinsic pontine glioma provides the framework for accurate tumor modeling
Journal Articles

Abstract 2226: Validation of a liquid biopsy tool to identify point mutations in pediatric brain tumor patients

Liana Nobre, Michal Zapotocky, Monique Johnson, Jonathan Wasserman, Oussama Abla, Jim Whitlock, Uri Tabori, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2226.
https://doi.org/10.1158/1538-7445.AM2019-2226
Published: 01 July 2019
View article titled, Abstract 2226: Validation of a liquid biopsy tool to identify point mutations in pediatric brain tumor patients
Journal Articles

CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma

Lisa Liang, Ludivine Coudière-Morrison, Nazanin Tatari, Margaret Stromecki, Agnes Fresnoza, Christopher J. Porter, Marc R. Del Bigio, Cynthia Hawkins, Jennifer A. Chan, Timothy C. Ryken, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4745–4759.
https://doi.org/10.1158/0008-5472.CAN-18-0027
Published: 14 August 2018
View article titled, CD271<sup>+</sup> Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma
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Journal Articles

Abstract 1184: Clonal evolution of diffuse intrinsic pontine glioma

Scott T. Ryall, Robert Siddaway, Arun Ramani, Andrei Turinsky, Michael Brudno, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1184.
https://doi.org/10.1158/1538-7445.AM2018-1184
Published: 01 July 2018
View article titled, Abstract 1184: Clonal evolution of diffuse intrinsic pontine glioma
Journal Articles

Abstract 1477: The interactomes of H3.1 and H3.3 reveal novel interactions, and associations with histone chaperones

Scott Milos, Robert Siddaway, Sanja Pajovic, Eric Campos, Brian Raught, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1477.
https://doi.org/10.1158/1538-7445.AM2018-1477
Published: 01 July 2018
View article titled, Abstract 1477: The interactomes of H3.1 and H3.3 reveal novel interactions, and associations with histone chaperones
Journal Articles

Abstract 1351: Alternative splicing of neurofibromin 1 is associated with elevated MAPK activity and poor prognosis in glioma

Robert Siddaway, Arun Ramani, Man Yu, Michael Brudno, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1351.
https://doi.org/10.1158/1538-7445.AM2017-1351
Published: 01 July 2017
View article titled, Abstract 1351: Alternative splicing of neurofibromin 1 is associated with elevated MAPK activity and poor prognosis in glioma
Journal Articles

Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas

Sriram Venneti, Jill Bayliss, Piali Mukherjee, Chao Lu, Siddhant Jain, Chan Chung, Daniel Martinez, Benjamin Sabari, Ashley Margol, Pooja Panwalkar, Abhijit Paroloia, Melike Pekmezci, Richard Mc Eachin, Marcin Cieslik, Benita Tamrazi, Benjamin Garcia, Gaspare La Rocca, Mariarita Santi, Peter Lewis, Cynthia Hawkins, Ari Melnick, C David Allis, Craig B. Thompson, Arul Chinnaiyan, Alexander R. Judkins
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3863.
https://doi.org/10.1158/1538-7445.AM2017-3863
Published: 01 July 2017
View article titled, Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas
Journal Articles

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William L. Stanford, Michael D. Taylor, Gelareh Zadeh, James T. Rutka
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4708–4719.
https://doi.org/10.1158/0008-5472.CAN-15-3079
Published: 15 August 2016
View article titled, PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
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Includes: Supplementary data
Journal Articles

Abstract 2789: Investigating the role of DNA methylation in pediatric choroid plexus tumors

Malgorzata Pienkowska, Sanaa Choufani, Andrei Turinsky, Diana Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard Gilbertson, David Malkin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2789.
https://doi.org/10.1158/1538-7445.AM2016-2789
Published: 15 July 2016
View article titled, Abstract 2789: Investigating the role of DNA methylation in pediatric choroid plexus tumors
Journal Articles

JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma

Tiffany Sin Yu Chan, Cynthia Hawkins, Jonathan R. Krieger, C. Jane McGlade, Annie Huang
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2802–2812.
https://doi.org/10.1158/0008-5472.CAN-15-2194
Published: 01 May 2016
View article titled, JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Open the PDF for JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract B12: H3-K27M is a negative prognostic marker in high- and low-grade pediatric thalamic glioma

Scott Ryall, Pawel Buczkowicz, Anthony Arnoldo, Rahul Krishnatry, Matthew Mistry, Joshua Rubin, Paul Steinbok, Uri Tabori, Cynthia Hawkins
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): B12.
https://doi.org/10.1158/1538-7445.CHROMEPI15-B12
Published: 14 January 2016
View article titled, Abstract B12: H3-K27M is a negative prognostic marker in high- and low-grade pediatric thalamic glioma