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Cynthia A. Zahnow
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Journal Articles

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V. Anekal, Paula D.L.M. Montero Llopis, Clement N. David, Jeffery L. Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A. Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E. Hawkins, Christopher Ponne, Quan Le, Geoffrey I. Shapiro, Madeleine E. Lemieux, Kyle P. Eagen, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3956–3973.
https://doi.org/10.1158/0008-5472.CAN-23-1475
Published: 01 December 2023
View article titled, EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
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Includes: Supplementary data
Journal Articles

DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Meghan Travers, Stephen M. Brown, Matthew Dunworth, Cassandra E. Holbert, Karla R. Wiehagen, Kurtis E. Bachman, Jackson R. Foley, Meredith L. Stone, Stephen B. Baylin, Robert A. Casero, Jr., Cynthia A. Zahnow
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3445–3454.
https://doi.org/10.1158/0008-5472.CAN-18-4018
Published: 01 July 2019
View article titled, DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer
Open the PDF for DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer

Hanghang Zhang, Somnath Pandey, Meghan Travers, Jittasak Khowsathit, George Morton, Hongxing Sum, Carlos A. Barrero, Carmen Merali, Yasuyuki Okamoto, Takahiro Sato, Judit Garriga, Natarajan V. Bhanu, Johayra Simithy, Bela Patel, Jozef Madzo, Noël Raynal, Benjamin A. Garcia, Marlene A. Jacobson, Salim Merali, Yi Zhang, Wayne Childers, Magid Abou-Gharbia, John Karanicolas, Stephen B. Baylin, Cynthia A. Zahnow, Jaroslav Jelinek, Xavier Graña, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2952.
https://doi.org/10.1158/1538-7445.AM2018-2952
Published: 01 July 2018
View article titled, Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer
Journal Articles

Abstract 1002: An epigenetic strategy to degrade the estrogen receptor in breast cancer

Huili Li, Foteinos-Ioannis Dimitrakopoulos, Meredith Stone, Lauren Murphy, Stephen Baylin, Cynthia A. Zahnow
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1002.
https://doi.org/10.1158/1538-7445.AM2017-1002
Published: 01 July 2017
View article titled, Abstract 1002: An epigenetic strategy to degrade the estrogen receptor in breast cancer
Journal Articles

Abstract 4045: Decreased Fanconi anemia gene expression contributes to efficacy of PARP and DNMT inhibitor combination therapy in triple negative breast cancer

Lena J. McLaughlin, Huili Li, Pratik Nagaria, Stephen B. Baylin, Cynthia A. Zahnow, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4045.
https://doi.org/10.1158/1538-7445.AM2017-4045
Published: 01 July 2017
View article titled, Abstract 4045: Decreased Fanconi anemia gene expression contributes to efficacy of PARP and DNMT inhibitor combination therapy in triple negative breast cancer
Journal Articles

Abstract 4019: Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy

Katherine B. Chiappinelli, Meredith L. Stone, Michael J. Topper, Lauren Murphy, Pamela L. Strissel, Reiner Strick, Cynthia A. Zahnow, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4019.
https://doi.org/10.1158/1538-7445.AM2016-4019
Published: 15 July 2016
View article titled, Abstract 4019: Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy
Journal Articles

Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation

Michelle P. Vaz, Stephen Y. Hwang, Ashwini Patil, Jillian Phallen, Lauren Murphy, Cynthia A. Zahnow, Victor E. Velculescu, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2773.
https://doi.org/10.1158/1538-7445.AM2016-2773
Published: 15 July 2016
View article titled, Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation
Journal Articles

Combining Epigenetic and Immunotherapy to Combat Cancer

Katherine B. Chiappinelli, Cynthia A. Zahnow, Nita Ahuja, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (7): 1683–1689.
https://doi.org/10.1158/0008-5472.CAN-15-2125
Published: 31 March 2016
View article titled, Combining Epigenetic and Immunotherapy to Combat Cancer
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Journal Articles

Abstract B20: Malignant transformation initiates a stochastic DNA methylation alteration pattern distinct from that in senescence

Wenbing Xie, Yang W. Zhang, Li-Xia Pan, Fillipe Carvlho, Byung-Hak Kang, Limin Xia, Lauren Murphy, Cynthia A. Zahnow, Stephen B. Baylin, Hari Easwaran
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): B20.
https://doi.org/10.1158/1538-7445.CHROMEPI15-B20
Published: 14 January 2016
View article titled, Abstract B20: Malignant transformation initiates a stochastic DNA methylation alteration pattern distinct from that in senescence
Journal Articles

Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

Katherine B. Chiappinelli, Pamela L. Strissel, Alexis Desrichard, Huili Li, Christine Henke, Benjamin Akman, Alexander Hein, Neal S. Rote, Leslie M. Cope, Alexandra Snyder, Vladimir Makarov, Sadna Budhu, Jedd Wolchok, Cynthia A. Zahnow, Taha Mergoub, Timothy A. Chan, Reiner Strick, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): B32.
https://doi.org/10.1158/1538-7445.CHROMEPI15-B32
Published: 14 January 2016
View article titled, Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
Journal Articles

Abstract NG07: Immunomodulatory and tumor cell killing effects of the demethylating agent 5-azacytidine in ovarian cancer

Katherine B. Chiappinelli, Pamela Strissel, Ray-Whay Chiu Yen, Huili Li, Meredith L. Stone, Lauren Murphy, Benjamin Akman, Cynthia A. Zahnow, Reiner Strick, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): NG07.
https://doi.org/10.1158/1538-7445.AM2015-NG07
Published: 01 August 2015
View article titled, Abstract NG07: Immunomodulatory and tumor cell killing effects of the demethylating agent 5-azacytidine in ovarian cancer
Journal Articles

Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer.

Roisin M. Connolly, Rachel C. Jankowitz, Cynthia A. Zahnow, Zhe Zhang, Michelle A. Rudek, Stacie C. Jeter, Shannon Slater, Penny Powers, Antonio C. Wolff, John Fetting, Adam M. Brufsky, Richard Piekarz, Nita Ahuja, George Somlo, Augustin Garcia, Steven Baylin, Nancy E. Davidson, Vered Stearns
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4666.
https://doi.org/10.1158/1538-7445.AM2013-4666
Published: 15 April 2013
View article titled, Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer.
Journal Articles

Abstract 995: Transient low doses of DNA demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

Hsing-Chen Tsai, Huili Li, Leander Van Neste, Yi Cai, Carine Robert, Feyruz V. Rassool, James J. Shin, Kirsten M. Harbom, Robert Beaty, Emmanouil Pappou, James Harris, Ray-Whay Chiu Yen, Nita Ahuja, Malcolm V. Brock, Vered Stearns, David Feller-Kopman, Yi-Chun Lin, Alana L. Welm, Jean-Pierre Issa, Il Minn, William Matsui, Yoon-Young Jang, Saul J. Sharkis, Stephen B. Baylin, Cynthia A. Zahnow
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 995.
https://doi.org/10.1158/1538-7445.AM2012-995
Published: 15 April 2012
View article titled, Abstract 995: Transient low doses of DNA demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
Journal Articles

Abstract LB-88: Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor response

Hsing-Chen Tsai, Leander Van Neste, Huili Li, Yi Cai, Carine Robert, James J. Shin, Emmanouil Pappou, Ray-Whay Yen, IL Minn, Nita Ahuja, Malcolm V. Brock, Feyruz V. Rassool, Yoon-Young Jang, Saul J. Sharkis, William Matsui, Cynthia A. Zahnow, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-88.
https://doi.org/10.1158/1538-7445.AM10-LB-88
Published: 15 April 2010
View article titled, Abstract LB-88: Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor response
Journal Articles

A Role for CCAAT/Enhancer Binding Protein β-Liver-enriched Inhibitory Protein in Mammary Epithelial Cell Proliferation

Cynthia A. Zahnow, Robert D. Cardiff, Rodolfo Laucirica, Daniel Medina, Jeffrey M. Rosen
Journal: Cancer Research
Cancer Res (2001) 61 (1): 261–269.
Published: 01 January 2001
View article titled, A Role for CCAAT/Enhancer Binding Protein β-Liver-enriched Inhibitory Protein in Mammary Epithelial Cell Proliferation
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