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Journal Articles

Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Riccardo Muzzioli, Brittany E. Jewell, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, JIngjing Liu, Xingzhi Song, Jianhua Zhang, Albert R. Klekers, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0555
Published: 01 December 2023
View article titled, Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
Open the PDF for Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity in another window
Includes: Supplementary data
Journal Articles

Metabolomic rewiring promotes endocrine therapy resistance in breast cancer

Songyeon Ahn, Jun Hyoung. Park, Sandra L. Grimm, Danthasinghe Waduge Badrajee Piyarathna, Tagari Samanta, Vasanta Putluri, Dereck Mezquita, Suzanne A.W. Fuqua, Nagireddy Putluri, Cristian Coarfa, Benny Abraham. Kaipparettu
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0184
Published: 31 October 2023
View article titled, Metabolomic rewiring promotes endocrine therapy resistance in breast cancer
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Includes: Supplementary data
Journal Articles

Abstract A008: Elucidating the effects of the Alzheimer's disease associated gene BIN1 on cancer tumorigenesis

Collin McColl, Darlene Skapura, Elisa Echartea, Jenny Deng, Cristian Coarfa, Salma Kaochar, Brian Simons, Aleksandra Rusin
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A008.
https://doi.org/10.1158/1538-7445.PRCA2023-A008
Published: 02 June 2023
View article titled, Abstract A008: Elucidating the effects of the Alzheimer's disease associated gene BIN1 on cancer tumorigenesis
Journal Articles

Abstract B069: SPOP loss places the prostate luminal epithelial cells at a selective disadvantage

Kinza Rizwan, Darlene Skapura, Cammy Mason, Cristian Coarfa, Nicholas Mitsiades, Damian Young, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B069.
https://doi.org/10.1158/1538-7445.PRCA2023-B069
Published: 02 June 2023
View article titled, Abstract B069: SPOP loss places the prostate luminal epithelial cells at a selective disadvantage
Journal Articles

Abstract 1705: SPOP: An essential gene for normal and prostate tumor cells

Kinza Rizwan, Darlene Skapura, Cammy Mason, Cristian Coarfa, Nicholas Mitsiades, Damian Young, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1705.
https://doi.org/10.1158/1538-7445.AM2023-1705
Published: 04 April 2023
View article titled, Abstract 1705: <em>SPOP</em>: An essential gene for normal and prostate tumor cells
Journal Articles

Abstract 4852: Metabolomic rewiring in endocrine therapy resistant estrogen receptor positive breast cancer

Songyeon Ahn, Junhyoung Park, Sandra L. Grimm, Badrajee WB Piyarathna, Nagireddy Putluri, Gokul Das, Cristian Coarfa, Benny A. Kaipparettu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4852.
https://doi.org/10.1158/1538-7445.AM2023-4852
Published: 04 April 2023
View article titled, Abstract 4852: Metabolomic rewiring in endocrine therapy resistant estrogen receptor positive breast cancer
Journal Articles

Abstract 442: Developing a lipogenesis inhibitor for prostate cancer

Dallin Lowder, Jin Na Shin, Maria E. Ruiz-Echartea, Darlene Skapura, Jenny Deng, Aleksandra Rusin, Christel Davis, Erik Ehli, Cristian Coarfa, Michael Ittmann, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 442.
https://doi.org/10.1158/1538-7445.AM2023-442
Published: 04 April 2023
View article titled, Abstract 442: Developing a lipogenesis inhibitor for prostate cancer
Journal Articles

Abstract 3406: GATA2 a novel potential therapeutic target for treatment of neuroendocrine prostate cancer

Amit K. Dash, Maria Elisa Ruiz Echartea, Darlene Skapura, Karen Berman de Ruiz, Jenny Jianmin Deng, Cristian Coarfa, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3406.
https://doi.org/10.1158/1538-7445.AM2023-3406
Published: 04 April 2023
View article titled, Abstract 3406: GATA2 a novel potential therapeutic target for treatment of neuroendocrine prostate cancer
Journal Articles

MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET

Ankit Srivastava, Cristina Tommasi, Dane Sessions, Angela Mah, Tomas Bencomo, Jasmine M. Garcia, Tiffany Jiang, Michael Lee, Joseph Y. Shen, Lek Wei Seow, Audrey Nguyen, Kimal Rajapakshe, Cristian Coarfa, Kenneth Y. Tsai, Vanessa Lopez-Pajares, Carolyn S. Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3143–3157.
https://doi.org/10.1158/0008-5472.CAN-22-0047
Published: 02 September 2022
View article titled, MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
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Includes: Supplementary data
Journal Articles

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

Jacob E. Berchuck, Elio Adib, Sarah Abou Alaiwi, Amit K. Dash, Jin Na Shin, Dallin Lowder, Collin McColl, Patricia Castro, Ryan Carelli, Elisa Benedetti, Jenny Deng, Matthew Robertson, Sylvan C. Baca, Connor Bell, Heather M. McClure, Talal El Zarif, Matthew P. Davidsohn, Gitanjali Lakshminarayanan, Kinza Rizwan, Darlene G. Skapura, Sandra L. Grimm, Christel M. Davis, Erik A. Ehli, Kaitlin M. Kelleher, Ji-Heui Seo, Nicholas Mitsiades, Cristian Coarfa, Mark M. Pomerantz, Massimo Loda, Michael Ittmann, Matthew L. Freedman, Salma Kaochar
Journal: Cancer Research
Cancer Res (2022) 82 (16): 2848–2859.
https://doi.org/10.1158/0008-5472.CAN-21-3552
Published: 16 August 2022
View article titled, The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response
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Includes: Supplementary data
Journal Articles

Abstract 2379: Gender-specific metabolome in bladder cancer: Role of EPHX2 in bladder cancer

Mohammed Khurshidul Hassan, Roshan Borkar, Karthik Reddy Kami Reddy, Danthasinghe Waduge Badrajee Piyarathna, Chandra Shekar Amara, Allison Bellman, ChandraShekar R. Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Roni J. Bollag, Martha K. Terris, Leomar Y. Ballester, Yair Lotan, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2379.
https://doi.org/10.1158/1538-7445.AM2022-2379
Published: 15 June 2022
View article titled, Abstract 2379: Gender-specific metabolome in bladder cancer: Role of EPHX2 in bladder cancer
Journal Articles

Abstract 6047: Identification of a 13 gene signature to predict survival in localized osteosarcoma

Tajhal D. Patel, Kshiti Dholakia, Tanmay R. Gandhi, Rupa S. Kanchi, Sandra L. Grimm, Chenlian Fu, Jason T. Yustein, Cristian Coarfa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6047.
https://doi.org/10.1158/1538-7445.AM2022-6047
Published: 15 June 2022
View article titled, Abstract 6047: Identification of a 13 gene signature to predict survival in localized osteosarcoma
Journal Articles

Abstract PD1-07: Mutant ESR1 receptors antagonize the tumor suppressor function of androgen receptors

Sandra L. Grimm, Guowei Gu, Sarah K. Herzog, Thomas L. Gonzalez, Hangqing Lin, Amanda R. Beyer, Yassine Rechoum, Tasneem Bawa-Khalfe, Ashfia F. Khan, Lili Du, W. Fraser Symmans, Ralf Kittler, Cristian Coarfa, Suzanne A.W. Fuqua
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-07.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-07
Published: 15 February 2022
View article titled, Abstract PD1-07: Mutant <em>ESR1</em> receptors antagonize the tumor suppressor function of androgen receptors
Journal Articles

Abstract P5-05-06: Metformin concentration is a deciding factor of its pro- or anti-tumor function in triple negative breast cancer

Jun Hyoung Park, Dongya Jia, Sukjin Yang, Kwang Hwa Jung, Abha Tiwari, Debasmita Dutta, Meron Ghidey, Nagireddy Putluri, Cristian Coarfa, Chad Creighton, José N. Onuchic, Benny A Kaipparettu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-05-06.
https://doi.org/10.1158/1538-7445.SABCS21-P5-05-06
Published: 15 February 2022
View article titled, Abstract P5-05-06: Metformin concentration is a deciding factor of its pro- or anti-tumor function in triple negative breast cancer
Journal Articles

A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis

Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I.J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4441–4454.
https://doi.org/10.1158/0008-5472.CAN-21-1112
Published: 01 September 2021
View article titled, A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Abstract 2042: A cytoskeletal function for PBRM1: reading methylated microtubules to maintain genomic stability

Menuka Karki, Rahul Jangid, Ramakrishnan Anish, Riyad N. Seervai, Jean-Philippe Bertocchio, Takashi Hotta, Pavlos Msaouel, Sung Y. Jung, Sandra L. Grimm, Cristian Coarfa, Bernard E. Weissman, Ryoma Ohi, Kristen J. Verhey, Courtney H. Hodges, Ruhee Dere, In Young Park, B. V. Venkataram Prasad, W. Kimryn Rathmell, Cheryl L. Walker, Durga N. Tripathi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2042.
https://doi.org/10.1158/1538-7445.AM2021-2042
Published: 01 July 2021
View article titled, Abstract 2042: A cytoskeletal function for PBRM1: reading methylated microtubules to maintain genomic stability
Journal Articles

Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer

Fei Yue, Weiyu Jiang, Amy T Ku, Adelaide IJ Young, Weijie Zhang, Eric P Souto, Yankun Gao, Zhihan Yu, Yi Wang, Chad J Creighton, Chandandeep Nagi, Tao Wang, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H.-F. Zhang, Qingyun Liu, Xia Lin, Yi Li
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD15-03.
https://doi.org/10.1158/1538-7445.SABCS20-PD15-03
Published: 15 February 2021
View article titled, Abstract PD15-03: LGR4 engages a wnt-independent mechanism to enhance EGFR signaling and promote metastasis of triple-negative breast cancer
Journal Articles

Abstract PD8-09: Androgen and ESR1 mutant receptors mechanistically collaborate for overexpression of genes associated with poor outcomes in ER-positive metastatic breast cancer

Suzanne Fuqua, Thomas L Gonzalez, Guowei Gu, Sarah Herzog, Yassine Rechoum, Amanda Beyer, David Edwards, Hangqing Lin, BAsil Paul, Ralf Kittler, Nancy Weigel, Sandra Grimm, Cristian Coarfa, Tasneem Bawa-Khalfe
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD8-09.
https://doi.org/10.1158/1538-7445.SABCS20-PD8-09
Published: 15 February 2021
View article titled, Abstract PD8-09: Androgen and ESR1 mutant receptors mechanistically collaborate for overexpression of genes associated with poor outcomes in ER-positive metastatic breast cancer
Journal Articles

Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma

Atreyi Dasgupta, Laura Sierra, Susan V. Tsang, Lyazat Kurenbekova, Tajhal Patel, Kimal Rajapakse, Ryan L. Shuck, Nino Rainusso, Yosef Landesman, Thaddeus Unger, Cristian Coarfa, Jason T. Yustein
Journal: Cancer Research
Cancer Res (2021) 81 (1): 199–212.
https://doi.org/10.1158/0008-5472.CAN-20-0854
Published: 04 January 2021
View article titled, Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma
Open the PDF for Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4501: RNA seq analysis reveals altered immune specific gene signature in African American bladder cancer

Karthik reddy kami reddy, Balasubramanyam Karanam, Cristian Coarfa, Yair Lotan, Roni J. Bollag, Martha K. Terris, Nagireddy Putluri
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4501.
https://doi.org/10.1158/1538-7445.AM2020-4501
Published: 15 August 2020
View article titled, Abstract 4501: RNA seq analysis reveals altered immune specific gene signature in African American bladder cancer