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Journal Articles

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Cancer Res (2025) 85 (6): 1049–1063.

https://doi.org/10.1158/0008-5472.CAN-24-0744

Published: 14 March 2025

View article titled, MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Includes: Supplementary data

Journal Articles

Abstract A033: Mapping age-specific biomarker dynamics in pancreatic ductal adenocarcinoma

Priyanka Gupta, Karen Duong-Polk, Rabi Murad, Cosimo Commisso

Cancer Res (2024) 84 (17_Supplement_2): A033.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A033

Published: 15 September 2024

View article titled, Abstract A033: Mapping age-specific biomarker dynamics in pancreatic ductal adenocarcinoma

Journal Articles

Abstract A069: Development of an AAV-mediated GEM model to investigate the impact of age on pancreatic tumorigenesis

Karen XD Duong-Polk, Madelaine Neff, Cosimo Commisso

Cancer Res (2024) 84 (17_Supplement_2): A069.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A069

Published: 15 September 2024

View article titled, Abstract A069: Development of an AAV-mediated GEM model to investigate the impact of age on pancreatic tumorigenesis

Journal Articles

Abstract B058: Rewiring CD8⁺ T cell responses to PD-1 immune checkpoint blockade in PDAC via the inhibitory receptor PSGL-1

Jennifer L Hope, Yijuan Zhang, Hannah A. F. Hetrick, Evelyn S. Sanchez Hernandez, Gabriele Romano, Sreeja Roy, Michelle Lin, Ashley B Palete, Swetha Maganti, Dennis C Otero, Katelyn T Byrne, Cosimo Commisso, Linda M Bradley

Cancer Res (2024) 84 (17_Supplement_2): B058.

https://doi.org/10.1158/1538-7445.PANCREATIC24-B058

Published: 15 September 2024

View article titled, Abstract B058: Rewiring CD8<sup>+</sup> T cell responses to PD-1 immune checkpoint blockade in PDAC via the inhibitory receptor PSGL-1

Journal Articles

Abstract C044: PI5P4Kα regulates cell fitness through iron homeostasis in pancreatic cancer

Gurpreet Kaur Arora, Ryan Loughran, Kyanh Ly, Cheska Marie Galapate, Alicia Llorente, Taylor R Anderson, Chantal Pauli, David A Scott, Yoav Altman, Cosimo Commisso, Brooke M Emerling

Cancer Res (2024) 84 (17_Supplement_2): C044.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C044

Published: 15 September 2024

View article titled, Abstract C044: PI5P4Kα regulates cell fitness through iron homeostasis in pancreatic cancer

Journal Articles

Abstract C041: Emerging role of P2X receptors as Golgi pH regulators in pancreatic cancer

Cheska Marie Galapate, Koen Galenkamp, Charles Fisher, Susanne Heynen-Genel, Cosimo Commisso

Cancer Res (2024) 84 (17_Supplement_2): C041.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C041

Published: 15 September 2024

View article titled, Abstract C041: Emerging role of P2X receptors as Golgi pH regulators in pancreatic cancer

Journal Articles

Abstract PR-19: Cell polarity proteins as novel regulators of macropinocytosis

Guillem Lambies Barjau, Szu-Wei Lee, Karen Duong-Polk Duong-Polk, David Dawson, Cheska Marie Galapate, Swetha Maganti, Cosimo Commisso

Cancer Res (2024) 84 (17_Supplement_2): PR-19.

https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-19

Published: 15 September 2024

View article titled, Abstract PR-19: Cell polarity proteins as novel regulators of macropinocytosis

Journal Articles

Abstract 4452: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Ambroise Manceau, Koen M. Galenkamp, Cheska M. Galapate, Cosimo Commisso

Cancer Res (2024) 84 (6_Supplement): 4452.

https://doi.org/10.1158/1538-7445.AM2024-4452

Published: 22 March 2024

View article titled, Abstract 4452: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Journal Articles

Abstract 3155: Metabolic stress induces an intrinsic inflammatory CAF phenotype that regulates stromal architecture in pancreatic cancer

Yijuan Zhang, Swetha Maganti, Jennifer Hope, Li Lin, Cheska Marie Galapate, Florent Carrette, Linda Bradley, Cosimo Commisso

Cancer Res (2024) 84 (6_Supplement): 3155.

https://doi.org/10.1158/1538-7445.AM2024-3155

Published: 22 March 2024

View article titled, Abstract 3155: Metabolic stress induces an intrinsic inflammatory CAF phenotype that regulates stromal architecture in pancreatic cancer

Journal Articles

Abstract 1359: Rewiring CD8⁺T cell responses to PD-1 immune checkpoint blockade in PDAC by preventing terminal exhaustion via the inhibitory receptor PSGL-1

Jennifer L. Hope, Yijuan Zhang, Hannah A. Hetrick, Gabriele Romano, Sreeja Roy, Michelle Lin, Ashley B. Palete, Swetha Maganti, Dennis C. Otero, Cosimo Commisso, Linda M. Bradley

Cancer Res (2024) 84 (6_Supplement): 1359.

https://doi.org/10.1158/1538-7445.AM2024-1359

Published: 22 March 2024

View article titled, Abstract 1359: Rewiring CD8<sup>+</sup>T cell responses to PD-1 immune checkpoint blockade in PDAC by preventing terminal exhaustion via the inhibitory receptor PSGL-1

Journal Articles

Abstract 372: Cell polarity proteins as novel regulators of macropinocytosis in pancreatic cancer

Guillem Lambies Barjau, Szu-Wei Lee, Cosimo Commisso

Cancer Res (2024) 84 (6_Supplement): 372.

https://doi.org/10.1158/1538-7445.AM2024-372

Published: 22 March 2024

View article titled, Abstract 372: Cell polarity proteins as novel regulators of macropinocytosis in pancreatic cancer

Journal Articles

Abstract A096: PIKfyve as a potential therapeutic target in pancreatic cancer

Shea Grenier, Cheska Galapate, Yijuan Zhang, Gurpreet Arora, Steven Olson, Brooke Emerling, Cosimo Commisso

Cancer Res (2024) 84 (2_Supplement): A096.

https://doi.org/10.1158/1538-7445.PANCA2023-A096

Published: 16 January 2024

View article titled, Abstract A096: PIKfyve as a potential therapeutic target in pancreatic cancer

Journal Articles

Abstract B013: Effect of aging on pancreatic cancer progression

Deepika Bhullar, Swetha Maganti, Yijuan Zhang, Cheska Marie Galapate, Rabi Murad, Peter D. Adams, Cosimo Commisso

Cancer Res (2024) 84 (2_Supplement): B013.

https://doi.org/10.1158/1538-7445.PANCA2023-B013

Published: 16 January 2024

View article titled, Abstract B013: Effect of aging on pancreatic cancer progression

Journal Articles

Abstract B088: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Ambroise Manceau, Koen M.O. Galenkamp, Cheska M. Galapate, Cosimo Commisso

Cancer Res (2024) 84 (2_Supplement): B088.

https://doi.org/10.1158/1538-7445.PANCA2023-B088

Published: 16 January 2024

View article titled, Abstract B088: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Journal Articles

Abstract A051: PSGL-1-deficiency promotes pancreatic ductal adenocarcinoma tumor control and synergy with immune checkpoint blockade

Jennifer L. Hope, Yijuan Zhang, Hannah A. Faso, Sreeja Roy, Michelle Lin, Ashley B. Palete, Swetha Maganti, Dennis C. Otero, Cosimo Commisso, Linda M. Bradley

Cancer Res (2024) 84 (2_Supplement): A051.

https://doi.org/10.1158/1538-7445.PANCA2023-A051

Published: 16 January 2024

View article titled, Abstract A051: PSGL-1-deficiency promotes pancreatic ductal adenocarcinoma tumor control and synergy with immune checkpoint blockade

Journal Articles

Abstract C044: Macropinocytic stress reprograms cancer-associated fibroblasts and enhances therapeutic responses in pancreatic cancer

Yijuan Zhang, Swetha Maganti, Jennifer Hope, Li Ling, Cheska Marie Galapate, Florent Carrette, Linda Bradley, Cosimo Commisso

Cancer Res (2024) 84 (2_Supplement): C044.

https://doi.org/10.1158/1538-7445.PANCA2023-C044

Published: 16 January 2024

View article titled, Abstract C044: Macropinocytic stress reprograms cancer-associated fibroblasts and enhances therapeutic responses in pancreatic cancer

Journal Articles

Abstract PO-130: Macropinocytosis at the nexus of crosstalk in the pancreatic tumor microenvironment

Yijuan Zhang, M. Victoria Recouvreux, Michael Jung, Koen Galencamp, Yunbo Li, Olga Zagnitko, David Scott, Andrew Lowy, Cosimo Commisso

Cancer Res (2021) 81 (22_Supplement): PO-130.

https://doi.org/10.1158/1538-7445.PANCA21-PO-130

Published: 15 November 2021

View article titled, Abstract PO-130: Macropinocytosis at the nexus of crosstalk in the pancreatic tumor microenvironment

Journal Articles

Abstract IA-005: Metabolic Stress in Pancreatic Cancer Progression and Therapy

Cosimo Commisso

Cancer Res (2021) 81 (22_Supplement): IA-005.

https://doi.org/10.1158/1538-7445.PANCA21-IA-005

Published: 15 November 2021

View article titled, Abstract IA-005: Metabolic Stress in Pancreatic Cancer Progression and Therapy

Journal Articles

Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer

Cosimo Commisso, Craig Ramirez, Rengin Soydaner-Azeloglu, David L. Bajor, Robert H. Vonderheide, Dafna Bar-Sagi

Cancer Res (2015) 75 (13_Supplement): PR08.

https://doi.org/10.1158/1538-7445.PANCA2014-PR08

Published: 30 June 2015

View article titled, Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer

Journal Articles

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Jurre J. Kamphorst, Michel Nofal, Cosimo Commisso, Sean R. Hackett, Wenyun Lu, Elda Grabocka, Matthew G. Vander Heiden, George Miller, Jeffrey A. Drebin, Dafna Bar-Sagi, Craig B. Thompson, Joshua D. Rabinowitz

Cancer Res (2015) 75 (3): 544–553.

https://doi.org/10.1158/0008-5472.CAN-14-2211

Published: 01 February 2015

View article titled, Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Includes: Supplementary data

NARROW

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Abstract A033: Mapping age-specific biomarker dynamics in pancreatic ductal adenocarcinoma

Abstract A069: Development of an AAV-mediated GEM model to investigate the impact of age on pancreatic tumorigenesis

Abstract B058: Rewiring CD8⁺ T cell responses to PD-1 immune checkpoint blockade in PDAC via the inhibitory receptor PSGL-1

Abstract C044: PI5P4Kα regulates cell fitness through iron homeostasis in pancreatic cancer

Abstract C041: Emerging role of P2X receptors as Golgi pH regulators in pancreatic cancer

Abstract PR-19: Cell polarity proteins as novel regulators of macropinocytosis

Abstract 4452: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Abstract 3155: Metabolic stress induces an intrinsic inflammatory CAF phenotype that regulates stromal architecture in pancreatic cancer

Abstract 1359: Rewiring CD8⁺T cell responses to PD-1 immune checkpoint blockade in PDAC by preventing terminal exhaustion via the inhibitory receptor PSGL-1

Abstract 372: Cell polarity proteins as novel regulators of macropinocytosis in pancreatic cancer

Abstract A096: PIKfyve as a potential therapeutic target in pancreatic cancer

Abstract B013: Effect of aging on pancreatic cancer progression

Abstract B088: The macropinosome: Uncovering the molecular anatomy of an oncogene-driven organelle

Abstract A051: PSGL-1-deficiency promotes pancreatic ductal adenocarcinoma tumor control and synergy with immune checkpoint blockade

Abstract C044: Macropinocytic stress reprograms cancer-associated fibroblasts and enhances therapeutic responses in pancreatic cancer

Abstract PO-130: Macropinocytosis at the nexus of crosstalk in the pancreatic tumor microenvironment

Abstract IA-005: Metabolic Stress in Pancreatic Cancer Progression and Therapy

Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

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