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Journal Articles

Abstract LB191: A genome-wide CRISPR-based functional screen uncovers the KLF4-Survivin/BIRC5 signaling pathways as a key regulator of cell fate following endoplasmic reticulum stress: Implications for tumor growth and therapeutic targeting

Nektaria M. Leli, Hengxi Liu, Souvik Dey, Lauren Brady, Carlo Salas Salinas, Victoria Wu, Spiros Tastsoglou, Giorgos Skoufos, Ioannis Verginadis, Ilias Karagounis, Artemis G. Hatzigeorgiou, Constantinos Koumenis

Cancer Res (2024) 84 (7_Supplement): LB191.

https://doi.org/10.1158/1538-7445.AM2024-LB191

Published: 05 April 2024

View article titled, Abstract LB191: A genome-wide CRISPR-based functional screen uncovers the KLF4-Survivin/BIRC5 signaling pathways as a key regulator of cell fate following endoplasmic reticulum stress: Implications for tumor growth and therapeutic targeting

Journal Articles

Abstract 6036: Flash proton radiotherapy mitigates radiation-induced salivary gland dysfunction and oral mucositis in mice

Priyanka Chowdhury, Anastasia Velalopoulou, Ioannis Verginadis, George Morcos, Michele Kim, James Metz, Lei Dong, Alexander Lin, Constantinos Koumenis

Cancer Res (2024) 84 (6_Supplement): 6036.

https://doi.org/10.1158/1538-7445.AM2024-6036

Published: 22 March 2024

View article titled, Abstract 6036: Flash proton radiotherapy mitigates radiation-induced salivary gland dysfunction and oral mucositis in mice

Journal Articles

Abstract 6022: Investigating the mechanisms behind salivary gland tissue sparing in response to ultra-high dose-rate FLASH proton radiotherapy

George S. Morcos, Priyanka Chowdhury, Michele M. Kim, Khayrullo Shoniyozov, James Metz, Lei Dong, Constantinos Koumenis

Cancer Res (2024) 84 (6_Supplement): 6022.

https://doi.org/10.1158/1538-7445.AM2024-6022

Published: 22 March 2024

View article titled, Abstract 6022: Investigating the mechanisms behind salivary gland tissue sparing in response to ultra-high dose-rate FLASH proton radiotherapy

Journal Articles

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

Renzo Perales-Linares, Nektaria Maria Leli, Hesham Mohei, Silvia Beghi, Osvaldo D. Rivera, Nektarios Kostopoulos, Andrea Giglio, Subin S. George, Mireia Uribe-Herranz, Francesca Costabile, Stefano Pierini, Sergei Pustylnikov, Giorgos Skoufos, Yoseph Barash, Artemis G. Hatzigeorgiou, Constantinos Koumenis, Amit Maity, Michael T. Lotze, Andrea Facciabene

Cancer Res (2023) 83 (21): 3562–3576.

https://doi.org/10.1158/0008-5472.CAN-22-2499

Published: 01 November 2023

View article titled, Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

Includes: Supplementary data

Journal Articles

Abstract 217: A novel class of dimeric quinacrine compounds induce DNA damage and increase the anticancer activity of radiation

Ilias V. Karagounis, Jayashree Karar, Christoforos Thomas, Constantinos Koumenis, Jeffrey Winkler, Ravi Amaravadi, Amit Maity

Cancer Res (2022) 82 (12_Supplement): 217.

https://doi.org/10.1158/1538-7445.AM2022-217

Published: 15 June 2022

View article titled, Abstract 217: A novel class of dimeric quinacrine compounds induce DNA damage and increase the anticancer activity of radiation

Journal Articles

Abstract 144: Survivin, a novel mediator of the UPR identified by a functional genome wide CRISPR/Cas9 based knock out screen

Nektaria Maria Leli, Souvik Dey, Lauren Brady, Carlo Salas Salinas, Jerome Lin, Giorgos Skoufos, Ioannis Verginadis, Artemis Chatzigeorgiou, Constantinos Koumenis

Cancer Res (2022) 82 (12_Supplement): 144.

https://doi.org/10.1158/1538-7445.AM2022-144

Published: 15 June 2022

View article titled, Abstract 144: Survivin, a novel mediator of the UPR identified by a functional genome wide CRISPR/Cas9 based knock out screen

Journal Articles

Abstract 4188: CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells

Samuel I. Kim, Charu Arora, Ioannis I. Verginadis, Christopher R. Cassella, Nune Markosyan, Constantinos Koumenis, Robert H. Vonderheide, Katelyn T. Byrne

Cancer Res (2022) 82 (12_Supplement): 4188.

https://doi.org/10.1158/1538-7445.AM2022-4188

Published: 15 June 2022

View article titled, Abstract 4188: CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells

Journal Articles

Abstract 3178: A stromal integrated stress response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumor progression

Cancer Res (2022) 82 (12_Supplement): 3178.

https://doi.org/10.1158/1538-7445.AM2022-3178

Published: 15 June 2022

View article titled, Abstract 3178: A stromal integrated stress response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumor progression

Journal Articles

Abstract 3320: Single-cell RNA sequencing analysis and transgenic mouse models reveal differential effects of flash vs. standard proton radiotherapy on gastrointestinal tissues and tumors

Ioannis I. Verginadis, Clara Morral Martinez, Tristan Lim, Priyanka Chowdhury, Giorgos Skoufos, Michele M. Kim, Anastasia Velalopoulou, Denisa Goia, Leo Luo, Caitlin J. Foley, Zachary J. Reitman, Andrea R. Daniel, Eric Diffenderfer, Lei Dong, James Metz, David G. Kirsch, Andy Minn, Constantinos Koumenis

Cancer Res (2022) 82 (12_Supplement): 3320.

https://doi.org/10.1158/1538-7445.AM2022-3320

Published: 15 June 2022

View article titled, Abstract 3320: Single-cell RNA sequencing analysis and transgenic mouse models reveal differential effects of flash vs. standard proton radiotherapy on gastrointestinal tissues and tumors

Journal Articles

Abstract 3304: Gene expression profiling of full-thickness skin after FLASH proton radiotherapy

Anastasia Velalopoulou, Ilias V. Karagounis, Giorgos Skoufos, Ioannis I. Verginadis, Michele Kim, Khayrullo Shoniyozov, Artemis G. Hatzigeorgiou, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith A. Cengel, Amit Maity, Theresa M. Busch

Cancer Res (2022) 82 (12_Supplement): 3304.

https://doi.org/10.1158/1538-7445.AM2022-3304

Published: 15 June 2022

View article titled, Abstract 3304: Gene expression profiling of full-thickness skin after FLASH proton radiotherapy

Journal Articles

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Cancer Res (2021) 81 (18): 4808–4821.

https://doi.org/10.1158/0008-5472.CAN-21-1500

Published: 15 September 2021

View article titled, FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Includes: Supplementary data

Journal Articles

Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer

Christoforos Thomas, Ilias V. Karagounis, Ratnesh K. Srivastava, Nicholas Vrettos, Fotis Nikolos, Noëlle Francois, Menggui Huang, Siliang Gong, Qi Long, Sushil Kumar, Constantinos Koumenis, Savitri Krishnamurthy, Naoto T. Ueno, Rumela Chakrabarti, Amit Maity

Cancer Res (2021) 81 (9): 2399–2414.

https://doi.org/10.1158/0008-5472.CAN-20-2743

Published: 01 May 2021

View article titled, Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer

Includes: Supplementary data

Journal Articles

Abstract 6509: Hypofractionated radiotherapy as a vaccine in combination with the TLR7/8 agonist resiquimod leads to significant abscopal tumor response and persistence antitumor immunity

Ilias V. Karagounis, Stefano Pierini, Noëlle François, Christoforos Thomas, Xiaowei Xu, Constantinos Koumenis, Andrea Facciabene, Amit Maity

Cancer Res (2020) 80 (16_Supplement): 6509.

https://doi.org/10.1158/1538-7445.AM2020-6509

Published: 15 August 2020

View article titled, Abstract 6509: Hypofractionated radiotherapy as a vaccine in combination with the TLR7/8 agonist resiquimod leads to significant abscopal tumor response and persistence antitumor immunity

Journal Articles

Abstract PD7-02: Estrogen receptor β suppresses metastasis of inflammatory breast cancer by regulating signaling that promotes cytoskeleton remodeling

Christoforos Thomas, Ilias Karagounis, Ratnesh Srivastava, Sushil Kumar, Noelle Francois, Fotis Nikolos, Igor Bado, Hann-Hsiang Chao, Constantinos Koumenis, Savitri Krishnamurthy, Naoto T Ueno, Rumela Chakrabarti, Amit Maity

Cancer Res (2020) 80 (4_Supplement): PD7-02.

https://doi.org/10.1158/1538-7445.SABCS19-PD7-02

Published: 15 February 2020

View article titled, Abstract PD7-02: Estrogen receptor β suppresses metastasis of inflammatory breast cancer by regulating signaling that promotes cytoskeleton remodeling

Journal Articles

Abstract LB-116: Combination of a cell cycle checkpoint kinase inhibitor and ionizing radiation leads to abscopal tumor response through increased CD8+ infiltration

Ilias V. Karagounis, Hann-Hsiang Chao, Christoforos Tomas, Constantinos Koumenis, Amit Maity

Cancer Res (2019) 79 (13_Supplement): LB-116.

https://doi.org/10.1158/1538-7445.AM2019-LB-116

Published: 01 July 2019

View article titled, Abstract LB-116: Combination of a cell cycle checkpoint kinase inhibitor and ionizing radiation leads to abscopal tumor response through increased CD8+ infiltration

Journal Articles

Abstract 1998: Transcriptome analysis of hypoxic head and neck cancer cells uncovers intron retention in EIF2B5 as a mechanism to reduce protein synthesis

Lauren K. Brady, Hejia Wang, Caleb Radens, Milan Radovich, Amit Maity, Cristina Ivan, Mircea Ivan, Yoseph Barash, Constantinos Koumenis

Cancer Res (2017) 77 (13_Supplement): 1998.

https://doi.org/10.1158/1538-7445.AM2017-1998

Published: 01 July 2017

View article titled, Abstract 1998: Transcriptome analysis of hypoxic head and neck cancer cells uncovers intron retention in EIF2B5 as a mechanism to reduce protein synthesis

Journal Articles

Abstract 4500: Inhibition of PERK by small molecule inhibitors enhances the response to ionizing radiation in vitro and animal tumor models

Ioannis Verginadis, Joel Encarnación, Souvik Dey, Constantinos Koumenis

Cancer Res (2017) 77 (13_Supplement): 4500.

https://doi.org/10.1158/1538-7445.AM2017-4500

Published: 01 July 2017

View article titled, Abstract 4500: Inhibition of PERK by small molecule inhibitors enhances the response to ionizing radiation in vitro and animal tumor models

Journal Articles

Abstract 5863: Identifying the radiosensitizing effects of PARP inhibitor in ovarian cancer

Yue Bi, Ioannis Verginadis, Souvik Dey, linlang Guo, Lilie Lin, Yanfang Zheng, Constantinos Koumenis

Cancer Res (2017) 77 (13_Supplement): 5863.

https://doi.org/10.1158/1538-7445.AM2017-5863

Published: 01 July 2017

View article titled, Abstract 5863: Identifying the radiosensitizing effects of PARP inhibitor in ovarian cancer

Journal Articles

Abstract 1247: Identifying novel regulators of the Unfolded Protein Response (UPR) by genome-scale CRISPR-Cas9 knockout screens

Nektaria Maria Leli, Souvik Dey, Lauren Brady, Constantinos Koumenis

Cancer Res (2017) 77 (13_Supplement): 1247.

https://doi.org/10.1158/1538-7445.AM2017-1247

Published: 01 July 2017

View article titled, Abstract 1247: Identifying novel regulators of the Unfolded Protein Response (UPR) by genome-scale CRISPR-Cas9 knockout screens

Journal Articles

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors

Ioannis I. Verginadis, Rahul Kanade, Brett Bell, Sravya Koduri, Edgar Ben-Josef, Constantinos Koumenis

Cancer Res (2017) 77 (4): 908–917.

https://doi.org/10.1158/0008-5472.CAN-16-2724

Published: 14 February 2017

View article titled, A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors

Includes: Multimedia, Supplementary data

NARROW

Abstract LB191: A genome-wide CRISPR-based functional screen uncovers the KLF4-Survivin/BIRC5 signaling pathways as a key regulator of cell fate following endoplasmic reticulum stress: Implications for tumor growth and therapeutic targeting

Abstract 6036: Flash proton radiotherapy mitigates radiation-induced salivary gland dysfunction and oral mucositis in mice

Abstract 6022: Investigating the mechanisms behind salivary gland tissue sparing in response to ultra-high dose-rate FLASH proton radiotherapy

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

Abstract 217: A novel class of dimeric quinacrine compounds induce DNA damage and increase the anticancer activity of radiation

Abstract 144: Survivin, a novel mediator of the UPR identified by a functional genome wide CRISPR/Cas9 based knock out screen

Abstract 4188: CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells

Abstract 3178: A stromal integrated stress response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumor progression

Abstract 3320: Single-cell RNA sequencing analysis and transgenic mouse models reveal differential effects of flash vs. standard proton radiotherapy on gastrointestinal tissues and tumors

Abstract 3304: Gene expression profiling of full-thickness skin after FLASH proton radiotherapy

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer

Abstract 6509: Hypofractionated radiotherapy as a vaccine in combination with the TLR7/8 agonist resiquimod leads to significant abscopal tumor response and persistence antitumor immunity

Abstract PD7-02: Estrogen receptor β suppresses metastasis of inflammatory breast cancer by regulating signaling that promotes cytoskeleton remodeling

Abstract LB-116: Combination of a cell cycle checkpoint kinase inhibitor and ionizing radiation leads to abscopal tumor response through increased CD8+ infiltration

Abstract 1998: Transcriptome analysis of hypoxic head and neck cancer cells uncovers intron retention in EIF2B5 as a mechanism to reduce protein synthesis

Abstract 4500: Inhibition of PERK by small molecule inhibitors enhances the response to ionizing radiation in vitro and animal tumor models

Abstract 5863: Identifying the radiosensitizing effects of PARP inhibitor in ovarian cancer

Abstract 1247: Identifying novel regulators of the Unfolded Protein Response (UPR) by genome-scale CRISPR-Cas9 knockout screens

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors

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