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Constantine A. Stratakis
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Journal Articles

Abstract 412: Blockade of beta-catenin pathway combined with Aurora kinase activity inhibition enhances antitumor effects in adrenocortical cancer cells

Andrea G. Maria, Kleiton S. Borges, Regia C. Lira, Carolina H. Thome, Annabel Berthon, Ludivine Drougat, Fabio R. Faucz, Vitor M. Faca, Luiz G. Tone, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 412.
https://doi.org/10.1158/1538-7445.AM2021-412
Published: 01 July 2021
View article titled, Abstract 412: Blockade of beta-catenin pathway combined with Aurora kinase activity inhibition enhances antitumor effects in adrenocortical cancer cells
Journal Articles

Abstract 2239: Macronodular adrenal hyperplasia due to mutations in ARMC5: New mutations in humans and modeling in zebrafish

Fabio R. Faucz, Mihail Zilbermint, Guillaume Assié, Maya B. Lodish, Eva Szarek, Giampaolo Trivellin, Annabel Berthon, Ninet Sinaii, Rossella Libé, Stéphanie Espiard, Ludivine Drougat, Bruno Ragazzon, Benjamin Feldman, Jerome Bertherat, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2239.
https://doi.org/10.1158/1538-7445.AM2014-2239
Published: 01 October 2014
View article titled, Abstract 2239: Macronodular adrenal hyperplasia due to mutations in ARMC5: New mutations in humans and modeling in zebrafish
Journal Articles

Abstract 568: Few Carney's Triad patients have mutations in two subunits of the succinate dehydrogenase enzyme (SDHB, SDHC)

Sosipatros A. Boikos, Paraskevi Xekouki, Fabio R. Faucz, Karel Pacak, Margarita Raygada, Karen Adams, Evan Szarek, Evan Ball, Su Young Kim, Elena Fumagalli, Lee J. Helman, J Aidan Carney, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 568.
https://doi.org/10.1158/1538-7445.AM2014-568
Published: 01 October 2014
View article titled, Abstract 568: Few Carney's Triad patients have mutations in two subunits of the succinate dehydrogenase enzyme (SDHB, SDHC)
Journal Articles

Abstract 3854: Novel hematopoietic neoplasms in prkar2a- deficient mice.

Emmanouil Saloustros, Paraskevi Salpea, Lina Gugglioti, Kittman Tsang, Anelia Horvath, Maria Nesterova, Chen-Feng Qi, Herbert C. Morse, III, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3854.
https://doi.org/10.1158/1538-7445.AM2013-3854
Published: 15 April 2013
View article titled, Abstract 3854: Novel hematopoietic neoplasms in prkar2a- deficient mice.
Journal Articles

Abstract 2963: Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.

Paul S. Meltzer, J. Keith Killian, Su Young Kim, Markku Miettinen, Carly Smith, Maria Tsokos, Martha Quezado, William I. Smith, Mona S. Jahromi, Robert L. Walker, Jerzy Lasota, Brandy Klotzle, Zengfeng Wang, Laura Jones, Yuelin Zhu, Yonghong Wang, Joshua J. Waterfall, Marina Bibikova, Maureen J. O'Sullivan, Constantine A. Stratakis, Joshua D. Schiffman, Jian-Bing Fan, Lee Helman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2963.
https://doi.org/10.1158/1538-7445.AM2013-2963
Published: 15 April 2013
View article titled, Abstract 2963: Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.
Journal Articles

Abstract 2736: Genetic deletion of the prkar1a in the endocrine pancreas promotes neuroendocrine carcinogenesis.

Emmanouil Saloustros, Maria Tsokos, Paraskevi Salpea, Matthew Starost, Sisi Liu, Li Guang, Maria Nesterova, Eva Szarek, Mehboob A. Hussain, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2736.
https://doi.org/10.1158/1538-7445.AM2013-2736
Published: 15 April 2013
View article titled, Abstract 2736: Genetic deletion of the prkar1a in the endocrine pancreas promotes neuroendocrine carcinogenesis.
Journal Articles

Abstract 954: COX-2 inhibition reduces bone tumor growth in animal models:A role for celecoxib treatment in cAMP/protein kinase A-induced tumors

Emmanouil Saloustros, Edward Mertz, Maria Nesterova, Meg Keil, Anelia Horvath, Kiran Nadella, Kenn Holmbeck, Sisi Liu, Vince Mandas, Kapil Shikha, Sergey Leikin, Pamela Robey, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2012-954
Published: 15 April 2012
View article titled, Abstract 954: COX-2 inhibition reduces bone tumor growth in animal models:A role for celecoxib treatment in cAMP/protein kinase A-induced tumors
Journal Articles

Functional Phosphodiesterase 11A Mutations May Modify the Risk of Familial and Bilateral Testicular Germ Cell Tumors

Anelia Horvath, Larissa Korde, Mark H. Greene, Rossella Libe, Paulo Osorio, Fabio Rueda Faucz, Marie Laure Raffin-Sanson, Kit Man Tsang, Limor Drori-Herishanu, Yianna Patronas, Elaine F. Remmers, Maria Eleni Nikita, Jason Moran, Joseph Greene, Maria Nesterova, Maria Merino, Jerome Bertherat, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5301–5306.
https://doi.org/10.1158/0008-5472.CAN-09-0884
Published: 01 July 2009
View article titled, Functional Phosphodiesterase 11A Mutations May Modify the Risk of Familial and Bilateral Testicular Germ Cell Tumors
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Includes: Supplementary data
Journal Articles

MicroRNA Signature of Primary Pigmented Nodular Adrenocortical Disease: Clinical Correlations and Regulation of Wnt Signaling

Dimitrios Iliopoulos, Eirini I. Bimpaki, Maria Nesterova, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3278–3282.
https://doi.org/10.1158/0008-5472.CAN-09-0155
Published: 15 April 2009
View article titled, MicroRNA Signature of Primary Pigmented Nodular Adrenocortical Disease: Clinical Correlations and Regulation of <em>Wnt</em> Signaling
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Includes: Supplementary data
Journal Articles

Protein Kinase A Effects of an Expressed PRKAR1A Mutation Associated with Aggressive Tumors

Elise Meoli, Ioannis Bossis, Laure Cazabat, Manos Mavrakis, Anelia Horvath, Sotiris Stergiopoulos, Miriam L. Shiferaw, Glawdys Fumey, Karine Perlemoine, Michael Muchow, Audrey Robinson-White, Frank Weinberg, Maria Nesterova, Yianna Patronas, Lionel Groussin, Jérôme Bertherat, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2008) 68 (9): 3133–3141.
https://doi.org/10.1158/0008-5472.CAN-08-0064
Published: 01 May 2008
View article titled, Protein Kinase A Effects of an Expressed <em>PRKAR1A</em> Mutation Associated with Aggressive Tumors
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Includes: Multimedia, Supplementary data
Journal Articles

Targeted Deletion of Prkar1a Reveals a Role for Protein Kinase A in Mesenchymal-to-Epithelial Transition

Kiran S. Nadella, Georgette N. Jones, Anthony Trimboli, Constantine A. Stratakis, Gustavo Leone, Lawrence S. Kirschner
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2671–2677.
https://doi.org/10.1158/0008-5472.CAN-07-6002
Published: 15 April 2008
View article titled, Targeted Deletion of <em>Prkar1a</em> Reveals a Role for Protein Kinase A in Mesenchymal-to-Epithelial Transition
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Includes: Supplementary data
Journal Articles

Somatic loss of heterozigosity or allelic imbalance at Succinate-dehydrogenase B, C and D loci in sporadic GISTs

Barbara Ferrando, Patrizia Pappi, Lisa Bonello, Giuseppe Matullo, Rosy Rosas, Giorgio Inghirami, Mauro Papotti, Constantine A Stratakis, Barbara Pasini
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3654.
Published: 01 May 2007
View article titled, Somatic loss of heterozigosity or allelic imbalance at Succinate-dehydrogenase B, C and D loci in sporadic GISTs
Journal Articles

Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of PDE11A Sequence Variants That Are Frequent in the Population

Anelia Horvath, Christoforos Giatzakis, Audrey Robinson-White, Sosipatros Boikos, Elizabeth Levine, Kurt Griffin, Erica Stein, Virginia Kamvissi, Payal Soni, Ioannis Bossis, Wouter de Herder, J. Aidan Carney, Jérôme Bertherat, Peter K. Gregersen, Elaine F. Remmers, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2006) 66 (24): 11571–11575.
https://doi.org/10.1158/0008-5472.CAN-06-2914
Published: 18 December 2006
View article titled, Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of <em>PDE11A</em> Sequence Variants That Are Frequent in the Population
Open the PDF for Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of <em>PDE11A</em> Sequence Variants That Are Frequent in the Population in another window
Includes: Supplementary data
Journal Articles

PRKAR1A Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes

Audrey J. Robinson-White, Wolfgang W. Leitner, Eiman Aleem, Philipp Kaldis, Ioannis Bossis, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2006) 66 (21): 10603–10612.
https://doi.org/10.1158/0008-5472.CAN-06-2200
Published: 01 November 2006
View article titled, <em>PRKAR1A</em> Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes
Open the PDF for <em>PRKAR1A</em> Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes in another window
Includes: Supplementary data
Journal Articles

Autoantibody Cancer Biomarker: Extracellular Protein Kinase A

Maria V. Nesterova, Natalie Johnson, Christopher Cheadle, Susan E. Bates, Sridhar Mani, Constantine A. Stratakis, Islam Kahn, Rishab K. Gupta, Yoon S. Cho-Chung
Journal: Cancer Research
Cancer Res (2006) 66 (18): 8971–8974.
https://doi.org/10.1158/0008-5472.CAN-06-1049
Published: 18 September 2006
View article titled, Autoantibody Cancer Biomarker: Extracellular Protein Kinase A
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Journal Articles

A Mouse Model for the Carney Complex Tumor Syndrome Develops Neoplasia in Cyclic AMP–Responsive Tissues

Lawrence S. Kirschner, Donna F. Kusewitt, Ludmila Matyakhina, William H. Towns, II, J. Aidan Carney, Heiner Westphal, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2005) 65 (11): 4506–4514.
https://doi.org/10.1158/0008-5472.CAN-05-0580
Published: 01 June 2005
View article titled, A Mouse Model for the Carney Complex Tumor Syndrome Develops Neoplasia in Cyclic AMP–Responsive Tissues
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Journal Articles

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors

Kurt J. Griffin, Lawrence S. Kirschner, Ludmila Matyakhina, Sotirios Stergiopoulos, Audrey Robinson-White, Sara Lenherr, Frank D. Weinberg, Edward Claflin, Elise Meoli, Yoon S. Cho-Chung, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2004) 64 (24): 8811–8815.
https://doi.org/10.1158/0008-5472.CAN-04-3620
Published: 16 December 2004
View article titled, Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors
Open the PDF for Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors in another window
Includes: Supplementary data
Journal Articles

Molecular and Functional Analysis of PRKAR1A and its Locus (17q22–24) in Sporadic Adrenocortical Tumors: 17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity

Jerome Bertherat, Lionel Groussin, Fabiano Sandrini, Ludmila Matyakhina, Thalia Bei, Sotirios Stergiopoulos, Theocharis Papageorgiou, Isabelle Bourdeau, Lawrence S. Kirschner, Caroline Vincent-Dejean, Karine Perlemoine, Christine Gicquel, Xavier Bertagna, Constantine A. Stratakis
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5308–5319.
Published: 18 September 2003
View article titled, Molecular and Functional Analysis of <em>PRKAR1A</em> and its Locus (17q22–24) in Sporadic Adrenocortical Tumors: <subtitle>17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity</subtitle>
Open the PDF for Molecular and Functional Analysis of <em>PRKAR1A</em> and its Locus (17q22–24) in Sporadic Adrenocortical Tumors: <subtitle>17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity</subtitle> in another window