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Journal Articles

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

Open Access
Catriona A. Ford, Dana Koludrovic, Patricia P. Centeno, Mona Foth, Elpida Tsonou, Nikola Vlahov, Nathalie Sphyris, Kathryn Gilroy, Courtney Bull, Colin Nixon, Bryan Serrels, Alison F. Munro, John C. Dawson, Neil O. Carragher, Valeria Pavet, David C. Hornigold, Philip D. Dunne, Julian Downward, Heidi C.E. Welch, Simon T. Barry, Owen J. Sansom, Andrew D. Campbell
Journal: Cancer Research
Cancer Res (2025) 85 (4): 808–824.
https://doi.org/10.1158/0008-5472.CAN-23-2814
Published: 17 February 2025
View articletitled, Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma
Open the PDF for Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma in another window
Includes: Supplementary data
Journal Articles

KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition

Open Access
Sigrid K. Fey, Arafath K. Najumudeen, Dale M. Watt, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Rosalin J. Simpson, Kathy McLay, Rosanna Upstill-Goddard, David Chang, William Clark, Colin Nixon, Joanna L. Birch, Simon T. Barry, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Journal: Cancer Research
Cancer Res (2025) 85 (2): 251–262.
https://doi.org/10.1158/0008-5472.CAN-23-2709
Published: 15 January 2025
View articletitled, KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition
Open the PDF for KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 6806: Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden

Free
Alistair S. McLaren, Rana Fetit, Mark White, Megan L. Mills, Tamsin Lannagan, John Falconer, Xabier Cortes-Lavaud, Kathryn Gilroy, Rachel Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J. Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, Jim C. Norman, Leo M. Carlin, Andrew D. Campbell, Owen J. Sansom, Colin W. Steele
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6806.
https://doi.org/10.1158/1538-7445.AM2024-6806
Published: 22 March 2024
View articletitled, Abstract 6806: Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden
Journal Articles

Abstract A028: Multiomic modelling of pancreatic IPMN stroma reveals distinct tertiary lymphoid structure distribution: Mapping the transcriptomic landscape via regional bulk, single-cell and subcellular approaches

Free
Andrew J. Cameron, Assya Legrini, Colin S. Wood, Craig Nourse, Yoana Doncheva, Claire Kennedy Dietrich, Colin Nixon, Jennifer Hay, Fraser Duthie, Pawel Herzyk, Jennifer Morton, Nigel B. Jamieson
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A028.
https://doi.org/10.1158/1538-7445.PANCA2023-A028
Published: 16 January 2024
View articletitled, Abstract A028: Multiomic modelling of pancreatic IPMN stroma reveals distinct tertiary lymphoid structure distribution: Mapping the transcriptomic landscape via regional bulk, single-cell and subcellular approaches
Journal Articles

Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Open Access
Colin S. Wood, Kathryn A.F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S.D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1329–1344.
https://doi.org/10.1158/0008-5472.CAN-22-2794
Published: 14 April 2023
View articletitled, Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
Open the PDF for Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases in another window
Includes: Supplementary data
Journal Articles

SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Available to Purchase
Rafael S. Martinez, Mark J. Salji, Linda Rushworth, Chara Ntala, Giovanny Rodriguez Blanco, Ann Hedley, William Clark, Paul Peixoto, Eric Hervouet, Elodie Renaude, Sonia H.Y. Kung, Laura C.A. Galbraith, Colin Nixon, Sergio Lilla, Gillian M. MacKay, Ladan Fazli, Luke Gaughan, David Sumpton, Martin E. Gleave, Sara Zanivan, Arnaud Blomme, Hing Y. Leung
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3664–3678.
https://doi.org/10.1158/0008-5472.CAN-20-3694
Published: 01 July 2021
View articletitled, SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer
Open the PDF for SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Free
Nicholas Rooney, Susan M. Mason, Laura McDonald, J. Henry M. Däbritz, Kirsteen J. Campbell, Ann Hedley, Steven Howard, Dimitris Athineos, Colin Nixon, William Clark, Joshua D.G. Leach, Owen J. Sansom, Joanne Edwards, Ewan R. Cameron, Karen Blyth
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (11): 2325–2339.
https://doi.org/10.1158/0008-5472.CAN-19-3870
Published: 02 June 2020
View articletitled, RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome
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Includes: Supplementary data
Journal Articles

Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer

Free
Rachana Patel, Elspeth A. Brzezinska, Peter Repiscak, Imran Ahmad, Ernest Mui, Meiling Gao, Arnaud Blomme, Victoria Harle, Ee Hong Tan, Gaurav Malviya, Agata Mrowinska, Carolyn J. Loveridge, Linda K. Rushworth, Joanne Edwards, Chara Ntala, Colin Nixon, Ann Hedley, Gillian Mackay, Saverio Tardito, Owen J. Sansom, Hing Y. Leung
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (3): 576–590.
https://doi.org/10.1158/0008-5472.CAN-19-1684
Published: 03 February 2020
View articletitled, Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer
Open the PDF for Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response

Free
Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom, Jurre J. Kamphorst
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (2): 175–188.
https://doi.org/10.1158/0008-5472.CAN-19-0644
Published: 15 January 2020
View articletitled, Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
Open the PDF for Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response in another window
Includes: Supplementary data
Journal Articles

Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis

Free
Carolyn J. Loveridge, Ernest J. Mui, Rachana Patel, Ee Hong Tan, Imran Ahmad, Michelle Welsh, Julie Galbraith, Ann Hedley, Colin Nixon, Karen Blyth, Owen Sansom, Hing Y. Leung
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (12): 3158–3168.
https://doi.org/10.1158/0008-5472.CAN-16-2565
Published: 14 June 2017
View articletitled, Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis
Open the PDF for Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis in another window
Includes: Supplementary data