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Clinton F. Stewart
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Journal Articles

Abstract 1358: Model-based evaluation of pegfilgrastim effects on chemotherapy-induced neutropenia in infants with CNS tumors

Olivia Campagne, Abigail Davis, Santhosh A. Upadhyaya, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1358.
https://doi.org/10.1158/1538-7445.AM2021-1358
Published: 01 July 2021
View article titled, Abstract 1358: Model-based evaluation of pegfilgrastim effects on chemotherapy-induced neutropenia in infants with CNS tumors
Journal Articles

Abstract 1357: Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas

Elizabeth Grace Gibson, Nicholas S. Selvo, Olivia Campagne, Amar Gajjar, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1357.
https://doi.org/10.1158/1538-7445.AM2021-1357
Published: 01 July 2021
View article titled, Abstract 1357: Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas
Journal Articles

Abstract 3031: Characterization of gemcitabine triphosphate formation in mice to aid in the development of a translational tumor model

Elizabeth G. Gibson, Abi Davis, Bo Zhong, Olivia Campagne, Martine F. Roussel, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3031.
https://doi.org/10.1158/1538-7445.AM2020-3031
Published: 15 August 2020
View article titled, Abstract 3031: Characterization of gemcitabine triphosphate formation in mice to aid in the development of a translational tumor model
Journal Articles

Abstract 4927: Plasma and CNS pharmacokinetics of the CHK-1 inhibitor prexasertib (LY-2606368) in mice bearing orthotopic group 3 medulloblastoma

Anil Maharaj, Abigail Davis, Bo Zhong, Martine F. Roussel, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4927.
https://doi.org/10.1158/1538-7445.AM2018-4927
Published: 01 July 2018
View article titled, Abstract 4927: Plasma and CNS pharmacokinetics of the CHK-1 inhibitor prexasertib (LY-2606368) in mice bearing orthotopic group 3 medulloblastoma
Journal Articles

Abstract A33: An individualized predictive 3D model of tumor response to topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma

Abbas Shirinifard, Suresh Thiagarajan, Yogesh T. Patel, Abigail D. Davis, Megan O. Jacus, Jessica Roberts, Clinton F. Stewart, András Sablauer
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): A33.
https://doi.org/10.1158/1538-7445.EPSO16-A33
Published: 16 January 2017
View article titled, Abstract A33: An individualized predictive 3D model of tumor response to topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma
Journal Articles

Abstract 2708: Development of an individualized 3D transport model of topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma

Abbas Shirinifard, Suresh Thiagarajan, Yogesh T. Patel, Abigail D. Davis, Megan O. Jacus, Stacy L. Throm, Jessica Roberts, Vinay Daryani, Clinton F. Stewart, András Sablauer.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2708.
https://doi.org/10.1158/1538-7445.AM2016-2708
Published: 15 July 2016
View article titled, Abstract 2708: Development of an individualized 3D transport model of topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma
Journal Articles

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

Marie Morfouace, Satish Cheepala, Sadhana Jackson, Yu Fukuda, Yogesh T. Patel, Soghra Fatima, Daisuke Kawauchi, Anang A. Shelat, Clinton F. Stewart, Brian P. Sorrentino, John D. Schuetz, Martine F. Roussel
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (18): 3879–3889.
https://doi.org/10.1158/0008-5472.CAN-15-0030
Published: 14 September 2015
View article titled, ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Open the PDF for ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 4519: Development of a whole body physiologically-based pharmacokinetic (PBPK) model with individualized tumor compartment for topotecan (TPT) in mice bearing neuroblastoma (NB)

Yogesh T. Patel, Megan O. Jacus, Abbas Shirinifard, Abigail D. Davis, Suresh Thiagarajan, Stacy L. Throm, Vinay M. Daryani, Andras Sablauer, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4519.
https://doi.org/10.1158/1538-7445.AM2015-4519
Published: 01 August 2015
View article titled, Abstract 4519: Development of a whole body physiologically-based pharmacokinetic (PBPK) model with individualized tumor compartment for topotecan (TPT) in mice bearing neuroblastoma (NB)
Journal Articles

Abstract 4526: Age dependent disposition of cyclophosphamide (CTX) and metabolites in infants ≤ 1 year old with brain tumors

Vinay M. Daryani, Thandranese S. Owens, K. Elaine Harstead, Yogesh T. Patel, David C. Turner, Stacy L. Throm, John C. Panetta, Amar Gajjar, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4526.
https://doi.org/10.1158/1538-7445.AM2015-4526
Published: 01 August 2015
View article titled, Abstract 4526: Age dependent disposition of cyclophosphamide (CTX) and metabolites in infants ≤ 1 year old with brain tumors
Journal Articles

Abstract 1496: Quantification of tumor blood perfusion of an orthotopic mouse model of neuroblastoma using nonlinear contrast-enhanced ultrasound imaging

Suresh Thiagarajan, Abbas Shirinifard, Megan O. Jacus, Abigail D. Davis, Yogesh T. Patel, Stacy L. Throm, Vinay Daryani, Clinton F. Stewart, András Sablauer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1496.
https://doi.org/10.1158/1538-7445.AM2015-1496
Published: 01 August 2015
View article titled, Abstract 1496: Quantification of tumor blood perfusion of an orthotopic mouse model of neuroblastoma using nonlinear contrast-enhanced ultrasound imaging
Journal Articles

Abstract B12: Synergistic anticancer activity of Aurora A kinase and MDM2 antagonists in melanoma

Anna E. Vilgelm, Jeff S. Pawlikowski, Yan Liu, E. Hawkins Oriana, A. Davis Tyler, Kevin P. Weller, Linda W. Horton, Colt M. McClain, Gregory D. Ayers, David Turner, David C. Essaka, Clinton F. Stewart, Jeffrey A. Sosman, Mark C. Kelley, Jeffrey A. Ecsedy, Jeffrey N. Johnston, Ann Richmond
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): B12.
https://doi.org/10.1158/1538-7445.MEL2014-B12
Published: 16 July 2015
View article titled, Abstract B12: Synergistic anticancer activity of Aurora A kinase and MDM2 antagonists in melanoma
Journal Articles

Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells

Anna E. Vilgelm, Jeff S. Pawlikowski, Yan Liu, Oriana E. Hawkins, Tyler A. Davis, Jessica Smith, Kevin P. Weller, Linda W. Horton, Colt M. McClain, Gregory D. Ayers, David C. Turner, David C. Essaka, Clinton F. Stewart, Jeffrey A. Sosman, Mark C. Kelley, Jeffrey A. Ecsedy, Jeffrey N. Johnston, Ann Richmond
Journal: Cancer Research
Cancer Res (2015) 75 (1): 181–193.
https://doi.org/10.1158/0008-5472.CAN-14-2405
Published: 04 January 2015
View article titled, Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Open the PDF for Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4645: Clofarabine, a potent anticancer compound with limited penetration in an orthotopic murine model of ependymoma

Yogesh T. Patel, Megan O. Jacus, Abigail D. Davis, Pradeep Vuppala, Jason D. Dapper, Burgess B. Freeman, Nidal Boulos, Stacy L. Throm, Richard J. Gilbertson, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4645.
https://doi.org/10.1158/1538-7445.AM2014-4645
Published: 01 October 2014
View article titled, Abstract 4645: Clofarabine, a potent anticancer compound with limited penetration in an orthotopic murine model of ependymoma
Journal Articles

Abstract 2749: Gemcitabine (GEM), a drug with clinical activity against pediatric solid tumors, demonstrates satisfactory CNS penetration in a preclinical murine medulloblastoma (MB) model.

David C. Turner, Burgess B. Freeman, Megan O. Jacus, Marie Morfouace, Stacy L. Throm, Pradeep K. Vuppala, Martine Roussel, Amar Gajjar, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2749.
https://doi.org/10.1158/1538-7445.AM2013-2749
Published: 15 April 2013
View article titled, Abstract 2749: Gemcitabine (GEM), a drug with clinical activity against pediatric solid tumors, demonstrates satisfactory CNS penetration in a preclinical murine medulloblastoma (MB) model.
Journal Articles

Abstract 3365: Population pharmacokinetics of oxaliplatin: An analysis across human development in infants, children and adults.

Mina Nikanjam, Clinton F. Stewart, Chris H. Takimoto, Timothy W. Synold, Edmund V. Capparelli
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3365.
https://doi.org/10.1158/1538-7445.AM2013-3365
Published: 15 April 2013
View article titled, Abstract 3365: Population pharmacokinetics of oxaliplatin: An analysis across human development in infants, children and adults.
Journal Articles

Abstract 2742: Cerebral microdialysis for simultaneous sampling of crenolanib (PDGFR inhibitor) and erlotinib (EGFR inhibitor) in mouse models of glioma

Mohamed Elmeliegy, Stacy L. Throm, Fan Wang, Feng Bai, Abhijit Ramachandran, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2742.
https://doi.org/10.1158/1538-7445.AM2012-2742
Published: 15 April 2012
View article titled, Abstract 2742: Cerebral microdialysis for simultaneous sampling of crenolanib (PDGFR inhibitor) and erlotinib (EGFR inhibitor) in mouse models of glioma
Journal Articles

Abstract 4759: Integrated in vitro and in vivo screening of tumor and normal neural stem cells identifies potential new treatments of ependymoma

Jennifer M. Atkinson, Anang A. Shelat, Tanya A. Kranenburg, Angel M. Carcaboso, Alexander Arnold, Karen D. Wright, Robert A. Johnson, Helen Poppleton, Kumarasamypet M. Mohankumar, Paul Gibson, Timothy N. Phoenix, Liqin Zhu, Yiai Tong, Christopher Eden, Amar Gajjar, Clinton F. Stewart, R.Kip Guy, Richard J. Gilbertson
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4759.
https://doi.org/10.1158/1538-7445.AM2011-4759
Published: 15 April 2011
View article titled, Abstract 4759: Integrated in vitro and in vivo screening of tumor and normal neural stem cells identifies potential new treatments of ependymoma
Journal Articles

Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas

Angel M. Carcaboso, Mohamed A. Elmeliegy, Jun Shen, Stephen J. Juel, Ziwei M. Zhang, Christopher Calabrese, Lorraine Tracey, Christopher M. Waters, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2010) 70 (11): 4499–4508.
https://doi.org/10.1158/0008-5472.CAN-09-4264
Published: 01 June 2010
View article titled, Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
Open the PDF for Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas in another window
Includes: Supplementary data
Journal Articles

Abstract 2758: Population pharmacokinetics of cyclophosphamide in infants and young children

Michael Tagen, John C. Panetta, Amar Gajjar, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2758.
https://doi.org/10.1158/1538-7445.AM10-2758
Published: 15 April 2010
View article titled, Abstract 2758: Population pharmacokinetics of cyclophosphamide in infants and young children
Journal Articles

Abstract 1663: A tyrosine kinase inhibitor enhances topotecan penetration of orthotopic glioma xenografts

Angel M. Carcaboso, Mohamed A. Elmeliegy, Jun Shen, Stephen J. Juel, Ziwei M. Zhang, Christopher Calabrese, Lorraine Tracey, Christopher M. Waters, Clinton F. Stewart
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1663.
https://doi.org/10.1158/1538-7445.AM10-1663
Published: 15 April 2010
View article titled, Abstract 1663: A tyrosine kinase inhibitor enhances topotecan penetration of orthotopic glioma xenografts