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Clint Mitchell
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Journal Articles

Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death in vitro and in vivo

Hossein A. Hamed, Clint Mitchell, Paul Dent, Adly Yacoub, Gary Tye, Mary Danielle Bareford
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5383.
https://doi.org/10.1158/1538-7445.AM2011-5383
Published: 15 April 2011
View article titled, Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy Allegood, Dieter Häussinger, Roland Reinehr, Andrew Larner, Sarah Spiegel, Paul B. Fisher, Christina Voelkel-Johnson, Besim Ogretmen, Steven Grant, Paul Dent
Journal: Cancer Research
Cancer Res (2010) 70 (15): 6313–6324.
https://doi.org/10.1158/0008-5472.CAN-10-0999
Published: 28 July 2010
View article titled, Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca<sup>2+</sup>-<em>De novo</em> Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway
Open the PDF for Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca<sup>2+</sup>-<em>De novo</em> Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway in another window
Includes: Supplementary data
Journal Articles

PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Adly Yacoub, Hossein A. Hamed, Jeremy Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Ogretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, Paul Dent
Journal: Cancer Research
Cancer Res (2010) 70 (3): 1120–1129.
https://doi.org/10.1158/0008-5472.CAN-09-4043
Published: 31 January 2010
View article titled, PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in <em>mda</em>-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells
Open the PDF for PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in <em>mda</em>-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells in another window
Includes: Supplementary data
Journal Articles

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien, Sarah Spiegel
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6915–6923.
https://doi.org/10.1158/0008-5472.CAN-09-0664
Published: 31 August 2009
View article titled, Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts
Open the PDF for Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts in another window
Includes: Supplementary data
Journal Articles

Abstract #1849: Knock down of BCL-2 family protein expression enhances HDACI+sorafenib toxicity in tumor cells.

Aditi Martin, Clint Mitchell, Mohamed Rahmani, Margaret Park, Steven Grant, Paul Dent, Andrew Thorburn, Roland Reinehr
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1849.
Published: 01 May 2009
View article titled, Abstract #1849: Knock down of BCL-2 family protein expression enhances HDACI+sorafenib toxicity in tumor cells.
Journal Articles

Abstract #1846: Sorafenib and Vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms

Teneille Walker, Clint Mitchell, Guo Zhang, Martin Graf, Mohamed Rahmani, Christina Voelkel-Johnson, Margaret Park, Steven Grant, Paul Dent
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1846.
Published: 01 May 2009
View article titled, Abstract #1846: Sorafenib and Vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms
Journal Articles

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2009) 69 (1): 143–150.
https://doi.org/10.1158/0008-5472.CAN-07-6656
Published: 31 December 2008
View article titled, Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance
Open the PDF for Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance in another window
Journal Articles

MEK1/2 inhibitors and 17AAG synergize to kill human hepatoma cells in vitro via suppression of c-FLIP-s levels and activation of the extrinsic apoptosis pathway

Adly Yacoub, Guo Zhang, Margaret PARK, Hossein Hamed, Clint Mitchell, Mohammed Rhamani, Shigang Lin, David Curiel, Michael Hagan, Paul Fisher, Steven Grant, Paul Dent
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4011.
Published: 01 May 2008
View article titled, MEK1/2 inhibitors and 17AAG synergize to kill human hepatoma cells <em>in vitro</em> via suppression of c-FLIP-s levels and activation of the extrinsic apoptosis pathway