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Clarence Yapp
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Journal Articles

Abstract 7152: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer

Free
Alexander P. Gottlieb, Gregory J. Baker, Jia-Ren Lin, Ricardo Pastorello, Yu-An Chen, Tuulia Vallius, Janae Davis, Clarence Yapp, Sarah E. Church, Eric Miller, Anniina Farkkila, Shaveta Vinayak, Melinda L. Telli, Sara M. Tolaney, Filipa Lynce, Joan S. Brugge, Alan D'Andrea, Geoffrey Shapiro, Sandro Santagata, Peter K. Sorger, Elizabeth A. Mittendorf, Jennifer L. Guerriero
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7152.
https://doi.org/10.1158/1538-7445.AM2025-7152
Published: 21 April 2025
View articletitled, Abstract 7152: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer
Journal Articles

Abstract LB311: Multimodal spatial profiling reveals the emergence of an immune suppressive microenvironment at the initial stages of high-grade serous ovarian cancer development

Free
Tanjina Kader, Jia-Ren Lin, Shannon Coy, Clemens Hug, Yu-An Chen, Roxanne J. Pelletier, Mariana Leon, John Lee, Yi-Lin Xu, Clarence Yapp, Natalie Shih, Gabriel Mingo, Euihye Jung, Srishti Rathore, Judith Agudo, Charles Drescher, Peter K. Sorger, Ronny Drapkin, Sandro Santagata
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB311.
https://doi.org/10.1158/1538-7445.AM2024-LB311
Published: 05 April 2024
View articletitled, Abstract LB311: Multimodal spatial profiling reveals the emergence of an immune suppressive microenvironment at the initial stages of high-grade serous ovarian cancer development
Journal Articles

Abstract 2593: Spatial multi-omics profiling of tumor cell phenotypes in primary cutaneous melanoma at single-cell resolution

Free
Tuulia Vallius, Edward Novikov, Ajit Nirmal Johnson, Shi Yingxiao, Roxanne Pelletier, Shishir Pant, Zoltan Maliga, Alyce Chen, Clarence Yapp, Sabrina Chan, Christine Lian, George F. Murphy, Sandro Santagata, Peter Sorger
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2593.
https://doi.org/10.1158/1538-7445.AM2024-2593
Published: 22 March 2024
View articletitled, Abstract 2593: Spatial multi-omics profiling of tumor cell phenotypes in primary cutaneous melanoma at single-cell resolution
Journal Articles

Abstract A028: Multi-modal digital pathology by sequential acquisition and joint analysis of highly multiplexed immunofluorescence and hematoxylin and eosin images

Free
Jia-Ren Lin, Yu-An Chen, Daniel Campton, Jeremy Cooper, Shannon Coy, Clarence Yapp, Erin McCarty, Keith L. Ligon, Steven Reese, Tad George, Sandro Santagata, Peter Sorger
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): A028.
https://doi.org/10.1158/1538-7445.CRC22-A028
Published: 01 December 2022
View articletitled, Abstract A028: Multi-modal digital pathology by sequential acquisition and joint analysis of highly multiplexed immunofluorescence and hematoxylin and eosin images
Journal Articles

Abstract LB056: The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution

Free
Ajit Johnson Nirmal, Zoltan Maliga, Tuulia Vallius, Brian Quattrochi, Alyce Chen, Connor Jacobson, Roxanne Pelletier, Clarence Yapp, Raquel Arias-Camison, Yu-An Chen, Christine Lian, George F. Murphy, Sandro Santagata, Peter K. Sorger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB056.
https://doi.org/10.1158/1538-7445.AM2022-LB056
Published: 15 June 2022
View articletitled, Abstract LB056: The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Journal Articles

Abstract P2-07-13: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer

Free
Jennifer L Guerriero, Gregory J Baker, Jia-Ren Lin, Yu-An Chen, Ricardo Pastorello, Tuulia Vallius, Janae Davis, Clarence Yapp, Sarah E Church, Eric Miller, Anniina Färkkilä, Shaveta Vinayak, Melinda L Telli, Giulia Fulci, Alan D'Andrea, Geoffrey I Shapiro, Sara M Tolaney, Sandro Santagata, Peter K Sorger, Elizabeth A Mittendorf
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-07-13.
https://doi.org/10.1158/1538-7445.SABCS21-P2-07-13
Published: 15 February 2022
View articletitled, Abstract P2-07-13: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer
Journal Articles

Abstract 2168: A growth rate corrected metric for cytotoxic co-culture systems

Free
Johannes Christian Melms, Clarence Yapp, Caitlin Elizabeth Mills, Peter Sorger, Benjamin Izar
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2168.
https://doi.org/10.1158/1538-7445.AM2020-2168
Published: 15 August 2020
View articletitled, Abstract 2168: A growth rate corrected metric for cytotoxic co-culture systems
Journal Articles

Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity

Available to Purchase
Johannes C. Melms, Sreeram Vallabhaneni, Caitlin E. Mills, Clarence Yapp, Jia-Yun Chen, Eugenio Morelli, Patricia Waszyk, Sushil Kumar, Derrick Deming, Nienke Moret, Steven Rodriguez, Kartik Subramanian, Meri Rogava, Adam N.R. Cartwright, Adrienne Luoma, Shaolin Mei, Titus J. Brinker, David M. Miller, Alexander Spektor, Dirk Schadendorf, Nicolo Riggi, Kai W. Wucherpfennig, Peter K. Sorger, Benjamin Izar
Journal: Cancer Research
Cancer Res (2020) 80 (4): 798–810.
https://doi.org/10.1158/0008-5472.CAN-19-2330
Published: 14 February 2020
View articletitled, Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity
Open the PDF for Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity in another window
Includes: Multimedia, Supplementary data
Journal Articles

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Free
Sarah Picaud, Oleg Fedorov, Angeliki Thanasopoulou, Katharina Leonards, Katherine Jones, Julia Meier, Heidi Olzscha, Octovia Monteiro, Sarah Martin, Martin Philpott, Anthony Tumber, Panagis Filippakopoulos, Clarence Yapp, Christopher Wells, Ka Hing Che, Andrew Bannister, Samuel Robson, Umesh Kumar, Nigel Parr, Kevin Lee, Dave Lugo, Philip Jeffrey, Simon Taylor, Matteo L. Vecellio, Chas Bountra, Paul E. Brennan, Alison O'Mahony, Sharlene Velichko, Susanne Müller, Duncan Hay, Danette L. Daniels, Marjeta Urh, Nicholas B. La Thangue, Tony Kouzarides, Rab Prinjha, Jürg Schwaller, Stefan Knapp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (23): 5106–5119.
https://doi.org/10.1158/0008-5472.CAN-15-0236
Published: 30 November 2015
View articletitled, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Open the PDF for Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy in another window
Includes: Supplementary data