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Claire Bonfils
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Journal Articles

Abstract 324: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers

Israel Matos, Yahya Ashraf, Hiba Zahreddine, Liying Gong, Amanda Baumholtz, Alex Zhou, Claire Bonfils, Aniel Moya-Torres, Yun Cui, Xiaowei Wang, Richard Wargachuk, Tiffany Cheng, Elijus Undzys, Shugang Yao, Jacynthe Linda Tolouse, Dominic Hou, Gordon Ngan, Luis daCruz, David Young
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 324.
https://doi.org/10.1158/1538-7445.AM2022-324
Published: 15 June 2022
View article titled, Abstract 324: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers
Journal Articles

Abstract LB094: KisoBody: Development and pre-clinical assessment of a novel multispecific antibody platform

Richard Wargachuk, Dominic Hou, Claire Bonfils, Nicolas Morin, Shugang Yao, Milica Krstic, Yun Cui, Jacynthe L. Toulouse, Donald Gagné, Elijus Undzys, Alex Zhou, Emily Chen, Ashwani Gupta, Luis DaCruz, David Young
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB094.
https://doi.org/10.1158/1538-7445.AM2021-LB094
Published: 01 July 2021
View article titled, Abstract LB094: KisoBody: Development and pre-clinical assessment of a novel multispecific antibody platform
Journal Articles

Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies.

Normand Beaulieu, Helene Sainte-Croix, Claire Bonfils, Michael Mannion, Stephane Raeppel, Lubo Isakovic, Stephen Claridge, Oscar Saavedra, Franck Raeppel, Arkadii Vaisburg, James Wang, Marielle Fournel, Jeffrey M. Besterman, Christiane R. Maroun
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 930.
https://doi.org/10.1158/1538-7445.AM2013-930
Published: 15 April 2013
View article titled, Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies.
Journal Articles

Abstract 1790: The combination of MGCD265, a Met/VEGFR inhibitor in clinical development, and erlotinib potently inhibits tumor growth by altering multiple pathways including glycolysis

Claire Bonfils, Normand Beaulieu, Marielle Fournel, Helene Ste-Croix, Jeffrey M. Besterman, Christiane R. Maroun
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1790.
https://doi.org/10.1158/1538-7445.AM2012-1790
Published: 15 April 2012
View article titled, Abstract 1790: The combination of MGCD265, a Met/VEGFR inhibitor in clinical development, and erlotinib potently inhibits tumor growth by altering multiple pathways including glycolysis
Journal Articles

Abstract 3610: Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR multitargeted kinase inhibitor in clinical development, in combination with taxanes

Christiane R. Maroun, Helene Ste-Croix, Normand Beaulieu, Claire Bonfils, Marielle Fournel, Isabelle Dupont, Christian Lemoyne, James Wand, Jeffrey M. Besterman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3610.
https://doi.org/10.1158/1538-7445.AM2011-3610
Published: 15 April 2011
View article titled, Abstract 3610: Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR multitargeted kinase inhibitor in clinical development, in combination with taxanes
Journal Articles

Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants

Normand Beaulieu, Isabelle Dupont, Claire Bonfils, Marja Dubay, Hélène Ste-Croix, Lubo Isakovic, Stephen Claridge, Oscar Saavedra, Franck Raeppel, Stephane Raeppel, Michael Mannion, Arkadii Vaisburg, Jeffrey M. Besterman, Christiane R. Maroun
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3609.
https://doi.org/10.1158/1538-7445.AM10-3609
Published: 15 April 2010
View article titled, Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants
Journal Articles

Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor

Marielle Fournel, Isabelle Dupont, Claire Bonfils, Marja Dubay, Hélène Ste-Croix, Carole Beaulieu, Normand Beaulieu, Christian Lemoyne, James Wang, Lubo Isakovic, Stephen Claridge, Oscar Saavedra, Franck Raeppel, Stephane Raeppel, Michael Mannion, Arkadii Vaisburg, Robert E. Martell, Jeffrey M. Besterman, Christiane R. Maroun
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3612.
https://doi.org/10.1158/1538-7445.AM10-3612
Published: 15 April 2010
View article titled, Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor
Journal Articles

Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells in vitro and in vivo

Jianhong Liu, Claire Bonfils, Marja Dubay, Hannah Nguyen, Guillermo Garcia-Manero, Allen Yang, Selina Luger, Robert Martell, Jeffrey Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 739.
Published: 01 May 2008
View article titled, Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells i<em>n vitro and in vivo</em>
Journal Articles

Induction of interleukin-6 expression by the histone deacetylase inhibitor, MGCD0103, in leukemia patients in vivo correlates with clinical efficacy

Christiane Maroun, Jianhong Liu, Ann Kalita, Marja Dubay, Claire Bonfils, Tracy-Ann Patterson, Christine Bonis, Robert Martell, Jeffrey Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1831.
Published: 01 May 2007
View article titled, Induction of interleukin-6 expression by the histone deacetylase inhibitor, MGCD0103, in leukemia patients <em>in vivo</em> correlates with clinical efficacy
Journal Articles

Induction of metallothionein-3 transcription as a pharmacodynamic biomarker for histone deacetylase inhibitor MGCD0103 in vitro and in vivo

Jianhong Liu, Claire Bonfils, Marie-Claude Trachy-Bourget, Ann Kalita, Marja Dubay, Yu Hou, Marielle Fournel, Tracy-Ann Patterson, Gregory Reid, Robert Martell, Jeffrey Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1832.
Published: 01 May 2007
View article titled, Induction of metallothionein-3 transcription as a pharmacodynamic biomarker for histone deacetylase inhibitor MGCD0103 <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Enhanced Isotype-Selectivity and Antiproliferative Activity of Thiophenyl Derivatives of Benzamide HDAC Inhibitors In Human Cancer Cells

Marielle Fournel, Oscar Moradei, Isabelle Paquin, Claire Bonfils, Marie-Claude Trachy-Bourget, Jianhong Liu, T. Pu Yan, Ai-Hua Lu, Julie Pare, Sylvain Lefebvre, Gabi Rahil, A. Robert Macleod, Arkadii Vaisburg, Jeffrey M. Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1110.
Published: 15 April 2006
View article titled, Enhanced Isotype-Selectivity and Antiproliferative Activity of Thiophenyl Derivatives of Benzamide HDAC Inhibitors In Human Cancer Cells
Journal Articles

Development of whole cell HDAC enzyme assay to analyze inhibitory activity of MGCD0103 in vitro and in vivo

Claire Bonfils, Ann Kalita, Jianhong Liu, Jeffrey M. Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 143.
Published: 01 May 2005
View article titled, Development of whole cell HDAC enzyme assay to analyze inhibitory activity of MGCD0103 i<em>n vitro</em> and i<em>n vivo</em>
Journal Articles

Specific inhibition of HDAC8 by antisenses leads to growth arrest and apoptosis of human cancer cells

Claire Bonfils, Yu Hou, Jeffrey M. Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 424.
Published: 01 May 2005
View article titled, Specific inhibition of HDAC8 by antisenses leads to growth arrest and apoptosis of human cancer cells
Journal Articles

Sulfonamide Anilides, a Novel Class of Histone Deacetylase Inhibitors, Are Antiproliferative against Human Tumors

Marielle Fournel, Marie-Claude Trachy-Bourget, P. Theresa Yan, Ann Kalita, Claire Bonfils, Carole Beaulieu, Sylvie Frechette, Silvana Leit, Elie Abou-Khalil, Soon-Hyung Woo, Daniel Delorme, A. Robert MacLeod, Jeffrey M. Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2002) 62 (15): 4325–4330.
Published: 01 August 2002
View article titled, Sulfonamide Anilides, a Novel Class of Histone Deacetylase Inhibitors, Are Antiproliferative against Human Tumors
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