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Journal Articles

Abstract P2-08-16: The cross-talk between nuclear p-ser294-FOXO3a and cytoplasmic MMP-2 in breast cancer survival and treatment response

Ming-Feng Hou, Sheau-Fang Yang, Yu-Chun Huang, Fang-Ming Chen, Yao-Tsung Yeh
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-08-16.
https://doi.org/10.1158/1538-7445.SABCS21-P2-08-16
Published: 15 February 2022
View article titled, Abstract P2-08-16: The cross-talk between nuclear p-ser294-FOXO3a and cytoplasmic MMP-2 in breast cancer survival and treatment response
Journal Articles

Abstract 2334: Discovery of selective inhibitors of carbamoyl phosphate synthetase I (CPS1) to modulate cancer relevant metabolic pathways

Shihua Yao, Tuong-Vi Nguyen, Alan Rolfe, Anant A. Agrawal, Jiyuan Ke, Shouyong Peng, Federico Colombo, Sean Yu, Patricia Bouchard, Jiayi Wu, Kuan-Chun Huang, Xingfeng Bao, Kiyoyuki Omoto, Anand Selvaraj, Lihua Yu, Stephanos Ioannidis, Frédéric H. Vaillancourt, Ping Zhu, Nicholas A. Larsen, David M. Bolduc
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2334.
https://doi.org/10.1158/1538-7445.AM2021-2334
Published: 01 July 2021
View article titled, Abstract 2334: Discovery of selective inhibitors of carbamoyl phosphate synthetase I (CPS1) to modulate cancer relevant metabolic pathways
Journal Articles

Abstract 592: Demonstration of E7766, a novel STING agonist, as a potent immunotherapy in BCG-insensitive non-muscle invasive bladder cancer models via intravesical administration

Kuan-Chun Huang, Chi Zhang, Kun Yu, Dae-Shik Kim, Vaishali Dixit, Renee Hukkanen, Hyeong-Wook Choi, Janna Hutz, Frank Fang, Xingfeng Bao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 592.
https://doi.org/10.1158/1538-7445.AM2020-592
Published: 15 August 2020
View article titled, Abstract 592: Demonstration of E7766, a novel STING agonist, as a potent immunotherapy in BCG-insensitive non-muscle invasive bladder cancer models via intravesical administration
Journal Articles

Abstract 3269: Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumoral administration

Kuan-Chun Huang, Atsushi Endo, Shannon McGrath, Dinesh Chandra, Jiayi Wu, Dae-Shik Kim, Diana Albu, Christy Ingersoll, Karen Tendyke, Kara Loiacono, Thomas Noland, David Verbel, Chi Zhang, Ming-Hong Hao, Mark Matijevic, Vaishali Dixit, Renee R. Hukkanen, Janna Hutz, John Wang, Frank Fang, Xingfeng Bao, Donna Kolber-Simonds, Muzaffar Akram, Nadeem Sarwar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3269.
https://doi.org/10.1158/1538-7445.AM2019-3269
Published: 01 July 2019
View article titled, Abstract 3269: Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumoral administration
Journal Articles

Abstract 4456: Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity

Atsushi ENDO, Dae-Shik Kim, Kuan-Chun Huang, Ming-Hong Hao, Steven Mathieu, Hyeong-wook Choi, Utpal Majumder, Xiaojie Zhu, Yongchun Shen, Kristen Sanders, Thomas Noland, Dinesh Chandra, Yu Chen, Karen TenDyke, Kara Loiacono, Donna Kolber-Simonds, Rongrong Jiang, Vaishali Dixit, Janna Hutz, John Wang, Xingfeng Bao, Francis Fang, Nadeem Sarwar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4456.
https://doi.org/10.1158/1538-7445.AM2019-4456
Published: 01 July 2019
View article titled, Abstract 4456: Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity
Journal Articles

Abstract 4607: Specific inhibition of PGE2-EP4 signaling by E7046 promotes anti-tumor activity of checkpoint blockade agents through boosting cytotoxic T cell activity

Diana I. Albu, David Verbel, Yuan Huang, Donna Kolber-Simonds, Zichun Wang, Xulong Wang, Zoltan Dezso, Christy Ingersoll, Kuan-Chun Huang, Janna Hutz, Mary Woodall-Jappe, Xingfeng Bao
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4607.
https://doi.org/10.1158/1538-7445.AM2017-4607
Published: 01 July 2017
View article titled, Abstract 4607: Specific inhibition of PGE<sub>2</sub>-EP4 signaling by E7046 promotes anti-tumor activity of checkpoint blockade agents through boosting cytotoxic T cell activity
Journal Articles

Abstract 4586: Intratumoral Treg cell depletion by local administration of IL-2-Diphteria toxin fusion protein E7777 induces a therapeutic and memory anti-tumor immune response in preclinical models

Diana I. Albu, Christy Ingersoll, Kuan-Chun Huang, Mary Woodall-Jappe, Xingfeng Bao
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4586.
https://doi.org/10.1158/1538-7445.AM2017-4586
Published: 01 July 2017
View article titled, Abstract 4586: Intratumoral Treg cell depletion by local administration of IL-2-Diphteria toxin fusion protein E7777 induces a therapeutic and memory anti-tumor immune response in preclinical models
Journal Articles

The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues

Gengqiang Xie, Hanqing Chen, Dongyu Jia, Zhiqiang Shu, William Hunt Palmer, Yi-Chun Huang, Xiankun Zeng, Steven X. Hou, Renjie Jiao, Wu-Min Deng
Journal: Cancer Research
Cancer Res (2017) 77 (4): 862–873.
https://doi.org/10.1158/0008-5472.CAN-16-0963
Published: 14 February 2017
View article titled, The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <em>Drosophila</em> Imaginal Tissues
Open the PDF for The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <em>Drosophila</em> Imaginal Tissues in another window
Includes: Supplementary data
Journal Articles

Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs

Diana I. Albu, Zichun Wang, Jiayi Wu, Kuan-chun Huang, Wei Li, Diana Liu, Galina Kuznetsov, Qian Chen, Xingfeng Bao, Mary Woodall-Jappe
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 275.
https://doi.org/10.1158/1538-7445.AM2015-275
Published: 01 August 2015
View article titled, Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs
Journal Articles

Abstract 2733: Antitumor activity of the PARP inhibitor E7449 in Ewing's sarcoma

Sharon McGonigle, Zhihong Chen, Jingzang Tao Miu, Kuan-Chun Huang, Donna Kolber-Simonds, Nanding Zhao, Natalie C. Twine, Qiongfang Cao, Galina Kuznetsov, Shanqin Xu, Kenichi Nomoto
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2733.
https://doi.org/10.1158/1538-7445.AM2014-2733
Published: 01 October 2014
View article titled, Abstract 2733: Antitumor activity of the PARP inhibitor E7449 in Ewing's sarcoma
Journal Articles

Abstract 899: Characterization and establishment of a drug-resistant human lung cancer model.

Kuan-Chun Huang, Judith Oestreicher, Natalie Twine, Winnie Lee, Xingfeng Bao, Sergei Agoulnik, Bruce A. Littlefield, Mary Woodall-Jappe, Kenichi Nomoto
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 899.
https://doi.org/10.1158/1538-7445.AM2013-899
Published: 15 April 2013
View article titled, Abstract 899: Characterization and establishment of a drug-resistant human lung cancer model.
Journal Articles

Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy

Rupal Ramakrishnan, Chun Huang, Hyun-Il Cho, Mark Lloyd, Joseph Johnson, Xiubao Ren, Soner Altiok, Daniel Sullivan, Jeffrey Weber, Esteban Celis, Dmitry I. Gabrilovich
Journal: Cancer Research
Cancer Res (2012) 72 (21): 5483–5493.
https://doi.org/10.1158/0008-5472.CAN-12-2236
Published: 31 October 2012
View article titled, Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy
Open the PDF for Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 5611: A synthetic lethality combination with chloroquine and rapamycin on chemosensitization

Yu-shan Wang, Yi-Chun Huang, Weng-Lam Fong, Mau-Shin Chi, Kwan-Hwa Chi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5611.
https://doi.org/10.1158/1538-7445.AM2012-5611
Published: 15 April 2012
View article titled, Abstract 5611: A synthetic lethality combination with chloroquine and rapamycin on chemosensitization
Journal Articles

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

Jue Shi, Yuan Zhou, Hsiao-Chun Huang, Timothy J. Mitchison
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4518–4526.
https://doi.org/10.1158/0008-5472.CAN-10-4336
Published: 30 June 2011
View article titled, Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL
Open the PDF for Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL in another window
Includes: Supplementary data
Journal Articles

Abstract 2054: A microRNA hypothesis for the precursor lesions of ovarian cancer

Kuan-Chun Huang, Yilan Zhou, Kathleen Hasselblatt, Junzheng Yang, Pui-Wah Choi, Wing-Ping Fong, Colleen Felmate, Michael G. Muto, Nelly Auersperg, Christopher P. Crum, Ross S. Berkowitz, Shu-Wing Ng
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2054.
https://doi.org/10.1158/1538-7445.AM10-2054
Published: 15 April 2010
View article titled, Abstract 2054: A microRNA hypothesis for the precursor lesions of ovarian cancer
Journal Articles

Abstract #3184: Platelet aggregation induced by prostate cancer cells: regulation by tissue factor, podoplanin and a novel secreted protein

Wei-Lian Tseng, Chia-Chun Huang, Chien-Ling Huang, Ju-Chien Cheng, Ching-Ping Tseng
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3184.
Published: 01 May 2009
View article titled, Abstract #3184: Platelet aggregation induced by prostate cancer cells: regulation by tissue factor, podoplanin and a novel secreted protein
Journal Articles

Serum GPC3 combination with AFP Diagnostic value for primary liver cancer

Dexi Chen, Chun Huang, Huiguo Ding, Desheng Wang
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4446.
Published: 01 May 2008
View article titled, Serum GPC3 combination with AFP Diagnostic value for primary liver cancer
Journal Articles

Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells

Kuan-Chun Huang, Wenying Zhang, Xiaoyan Ni, Ross S. Berkowitz, Samuel C. Mok, Shu-Wing Ng
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 994–995.
Published: 01 May 2005
View article titled, Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells
Journal Articles

Transcriptional and proteomic profiling of secreted and membrane proteins in ovarian cancer.

Xiaoyan Ni, Kuan-Chun Huang, Wing-Chung Ng, Shu-Kay Ng, Samuel C. Mok, Hiroaki Kataoka, Ross Berkowitz, Shu-Wing Ng
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 102.
Published: 01 May 2005
View article titled, Transcriptional and proteomic profiling of secreted and membrane proteins in ovarian cancer.
Journal Articles

p53-dependent Cell Cycle Arrests Are Preserved in DNA-activated Protein Kinase-deficient Mouse Fibroblasts

Li-chun Huang, Kristie C. Clarkin, Geoffrey M. Wahl
Journal: Cancer Research
Cancer Res (1996) 56 (13): 2940–2944.
Published: 01 July 1996
View article titled, p53-dependent Cell Cycle Arrests Are Preserved in DNA-activated Protein Kinase-deficient Mouse Fibroblasts
Open the PDF for p53-dependent Cell Cycle Arrests Are Preserved in DNA-activated Protein Kinase-deficient Mouse Fibroblasts in another window