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Journal Articles

Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia

Thorsten Neuß, Min-Chun Chen, Nils Wirges, Sinem Usluer, Rupert Oellinger, Svenja Lier, Michael Dudek, Tobias Madl, Martin Jastroch, Katja Steiger, Werner Schmitz, Henrik Einwächter, Roland M. Schmid
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2297–2312.
https://doi.org/10.1158/0008-5472.CAN-23-2213
Published: 15 July 2024
View article titled, Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia
Open the PDF for Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-05-10: A Carryover Effect: Antibody Drug Conjugates Constantly Provide a Substantial Improvement in Overall Survival more than in Progression-free Survival

I-Chun Chen, Ching-Hung Lin, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-05-10.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-05-10
Published: 02 May 2024
View article titled, Abstract PO4-05-10: A Carryover Effect: Antibody Drug Conjugates Constantly Provide a Substantial Improvement in Overall Survival more than in Progression-free Survival
Journal Articles

Abstract LB434: Rapid and reproducible expansion of rare tumor cells: The R3CE platform for personalized medicine

Wen-Hung Kuo, Yen-Jang Huang, Jia-Yang Chen, Yi-Chun Wu, Chia-Chun Chen, Mark D. Pegram, Ying-Chih Chang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB434.
https://doi.org/10.1158/1538-7445.AM2024-LB434
Published: 05 April 2024
View article titled, Abstract LB434: Rapid and reproducible expansion of rare tumor cells: The R<sup>3</sup>CE platform for personalized medicine
Journal Articles

Abstract 304: The role of DDR1 mediated E-cadherin stability in collective colon cancer cell migration

Hui-Chun Chen, Yu-Chun Wang, Yu-Chien Ching, Chun-Pu Cheng, Chia-En Ku, Shin-Ru Lee, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 304.
https://doi.org/10.1158/1538-7445.AM2024-304
Published: 22 March 2024
View article titled, Abstract 304: The role of DDR1 mediated E-cadherin stability in collective colon cancer cell migration
Journal Articles

Abstract 2409: Circulating differential methylation allele fraction (DMAF) strongly correlates with circulating tumor DNA (ctDNA) variant allele fraction (VAF)

Preethi Srinivasan, Tzu-Chun Chen, Ehsan Haghshenas, Misagh Kordi, Ilker Tunc, Wenching Chan, Omid Shams Solari, Joshua Babiarz, Yoshiaki Nakamura, Takayuki Yoshino, Alexey Aleshin, Trupti Kawli, Johannes G. Reiter
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2409.
https://doi.org/10.1158/1538-7445.AM2024-2409
Published: 22 March 2024
View article titled, Abstract 2409: Circulating differential methylation allele fraction (DMAF) strongly correlates with circulating tumor DNA (ctDNA) variant allele fraction (VAF)
Journal Articles

Abstract 6960: Lysosome inhibition suppress collective cell migration through caveolin-1 mediated E-cadherin stabilization in colon cancer cells

Yu-Chien Ching, Hui-Chun Chen, Yu-Chun Wang, Chun-Pu Cheng, Chia-En Ku, Shin-Ru Lee, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6960.
https://doi.org/10.1158/1538-7445.AM2024-6960
Published: 22 March 2024
View article titled, Abstract 6960: Lysosome inhibition suppress collective cell migration through caveolin-1 mediated E-cadherin stabilization in colon cancer cells
Journal Articles

Abstract 6852: Immune microenvironment profiling of pregnancy associated breast cancer: A transcriptomic and multiplex immunohistochemical analyses

I-Chun Chen, Ching-Hsuan Chen, Chia-Lang Hsu, Tzu-Pin Lu, Yen-Shen Lu, Ching-Hung Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6852.
https://doi.org/10.1158/1538-7445.AM2024-6852
Published: 22 March 2024
View article titled, Abstract 6852: Immune microenvironment profiling of pregnancy associated breast cancer: A transcriptomic and multiplex immunohistochemical analyses
Journal Articles

Abstract 4389: The role of Rab5 in epithelial growth factor stimulated E-cadherin internalization in spheroid growth of colon cancer cells

Yu-Chun Wang, Yu-Chien Ching, Hui-Chun Chen, Chun-Pu Cheng, Chia-En Ku, Shin-Ru Lee, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4389.
https://doi.org/10.1158/1538-7445.AM2024-4389
Published: 22 March 2024
View article titled, Abstract 4389: The role of Rab5 in epithelial growth factor stimulated E-cadherin internalization in spheroid growth of colon cancer cells
Journal Articles

Abstract 5717: CDK4 inhibition suppresses Rab11 mediated collective cell migration in colon cancer cells

Chun Pu Cheng, Chia-En Ku, Shin-Ru Lee, Yu-Chun Wang, Yu-Chien Ching, Hui-Chun Chen, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5717.
https://doi.org/10.1158/1538-7445.AM2024-5717
Published: 22 March 2024
View article titled, Abstract 5717: CDK4 inhibition suppresses Rab11 mediated collective cell migration in colon cancer cells
Journal Articles

Abstract CT141: Combination of hormone therapy, GnRH agonist, and immunotherapy enhance immune activation in premenopausal ER+/HER2- metastatic breast cancer patients: Results of biomarker analysis from a pilot phase II study

I-Chun Chen, Ching-Hung Lin, Dwan-Ying Chang, Tom Wei-Wu Chen, Ming-Yang Wang, Wei-Li Ma, Yi-Ting Lin, Shu-Min Huang, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT141.
https://doi.org/10.1158/1538-7445.AM2023-CT141
Published: 14 April 2023
View article titled, Abstract CT141: Combination of hormone therapy, GnRH agonist, and immunotherapy enhance immune activation in premenopausal ER+/HER2- metastatic breast cancer patients: Results of biomarker analysis from a pilot phase II study
Journal Articles

Abstract 3032: A novel deep learning pipeline for early detection of colorectal cancer and colorectal adenoma using gut microbiome data

Nai-Shun Liao, Yuan-Mao Hung, Yi-Jian Tsai, Nam Nhut Phan, Pei-Chun Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Tzu-Pin Lu, Eric Y. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3032.
https://doi.org/10.1158/1538-7445.AM2023-3032
Published: 04 April 2023
View article titled, Abstract 3032: A novel deep learning pipeline for early detection of colorectal cancer and colorectal adenoma using gut microbiome data
Journal Articles

Abstract 1225: the existence, characteristics and underlying regulators of spontaneous epithelial-mesenchymal transition from a monophasic metaplastic squamous carcinoma patient-derived cancer cell model

Huang-Chun Lien, Hui-Chieh Yu, Tom Wei-Wu Chen, I-Chun Chen, Chiao Lo, Ling-Chun Yeh, Li-Ping Hsiao, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1225.
https://doi.org/10.1158/1538-7445.AM2023-1225
Published: 04 April 2023
View article titled, Abstract 1225: the existence, characteristics and underlying regulators of spontaneous epithelial-mesenchymal transition from a monophasic metaplastic squamous carcinoma patient-derived cancer cell model
Journal Articles

Abstract 5326: Comparison of CAR-T cell-mediated cytotoxicity assays with suspension tumor cells using high-throughput plate-based image cytometry method

Leo Li-Ying Chan, Yu-Jun Sun, Yi-Chun Chen, Wei-Kai Hua, Sariena Chiung-Yuan Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5326.
https://doi.org/10.1158/1538-7445.AM2023-5326
Published: 04 April 2023
View article titled, Abstract 5326: Comparison of CAR-T cell-mediated cytotoxicity assays with suspension tumor cells using high-throughput plate-based image cytometry method
Journal Articles

Abstract 3344: Early detection biomarkers of LncRNA H19 genotypes for determining childhood leukemia susceptibility

Chia-Wen Tsai, Wen-Shin Chang, Chao-Chun Chen, Pei-Chen Hsu, Yun-Chi Wang, Jen-Sheng Pei, Da-Tian Bau
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3344.
https://doi.org/10.1158/1538-7445.AM2023-3344
Published: 04 April 2023
View article titled, Abstract 3344: Early detection biomarkers of LncRNA H19 genotypes for determining childhood leukemia susceptibility
Journal Articles

Abstract P4-01-34: Benefits Provided by Antibody Drug Conjugates in Overall Survival Outweighs those in Progression-free Survival for Metastatic Breast Cancer: A Class Effect

I-Chun Chen, Ching-Hung Lin, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-01-34.
https://doi.org/10.1158/1538-7445.SABCS22-P4-01-34
Published: 01 March 2023
View article titled, Abstract P4-01-34: Benefits Provided by Antibody Drug Conjugates in Overall Survival Outweighs those in Progression-free Survival for Metastatic Breast Cancer: A Class Effect
Journal Articles

Abstract 2438: Determining the role of non-mutated C-Raf kinase in metastatic disease

Lisa H. Ta, Janai R. Carr-Ascher, Weixian Deng, Brandon L. Tsai, Wendy Tran, Donny Gun, Donghui Cheng, Jihui Sha, Yeonjoo Hwang, John W. Phillips, Matthew B. Obusan, Nathanael J. Bangayan, Miyako Noguchi, Zhiyuan Mao, Chia-Chun Chen, Liang Wang, Grigor Varuzhanyan, John D. Gordon, James W. Wohlschlegel, Owen N. Witte
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2438.
https://doi.org/10.1158/1538-7445.AM2022-2438
Published: 15 June 2022
View article titled, Abstract 2438: Determining the role of non-mutated C-Raf kinase in metastatic disease
Journal Articles

Abstract 789: Elucidating transcriptional dynamics in neuroendocrine differentiation of advanced prostate cancer

Chia-Chun Chen, Kai Song, Wendy Tran, Matthew Obusan, Tyler Sugimoto, Katherine Sheu, Donghui Cheng, Grigor Varuzhanyan, Liang Wang, Lisa Ta, Zhiyuan Mao, Nathanael Bangayan, Jung-Wook Park, Thomas Graerber, Owen Witte
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 789.
https://doi.org/10.1158/1538-7445.AM2022-789
Published: 15 June 2022
View article titled, Abstract 789: Elucidating transcriptional dynamics in neuroendocrine differentiation of advanced prostate cancer
Journal Articles

Abstract CT031: TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)– Exploration of genomic loss of heterozygosity (gLOH) and potential associations with antitumor activity

Johann S. de Bono, Niven Mehra, A. Douglas Laird, Elena Castro, Philippe Barthelemy, Remy Delva, Giorgio V. Scagliotti, Marco Maruzzo, Adam Stirling, Jean-Pascal Machiels, Herlinde Dumez, Vincent Renard, Julia F. Hopkins, Lee A. Albacker, Hsiang-Chun Chen, Cynthia G. Healy, Jijumon Chelliserry, Tanya Dorff, Karim Fizazi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT031.
https://doi.org/10.1158/1538-7445.AM2022-CT031
Published: 15 June 2022
View article titled, Abstract CT031: TALAPRO-1: Talazoparib monotherapy in metastatic castration-resistant prostate cancer (mCRPC) with tumor DNA damage response alterations (DDRm)– Exploration of genomic loss of heterozygosity (gLOH) and potential associations with antitumor activity
Journal Articles

Abstract P2-10-09: Oxysterol profiling in breast adipose tissue identifies brassicasterol and 24-hydroxycholesterol as breast cancer risk predictors

I-Chun Chen, Wen-Hung Kuo, Fu-Chang Hu, Ming-Yang Wang, Yen-Shen Lu, Dieter Lütjohann, Ching-Hung Lin
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-10-09.
https://doi.org/10.1158/1538-7445.SABCS21-P2-10-09
Published: 15 February 2022
View article titled, Abstract P2-10-09: Oxysterol profiling in breast adipose tissue identifies brassicasterol and 24-hydroxycholesterol as breast cancer risk predictors
Journal Articles

Abstract P2-01-09: Clinical impact of ESR1 mutation ctDNA on survival outcome is dependent on PI3KCA/TP53 ctDNA mutation status

Tom Wei-Wu Chen, Wen Hsiao, Ming-Shen Dai, Ching-Hung Lin, Dwang-Ying Chang, I-Chun Chen, Ming-Yang Wang, Ling-Yi Huang, Shu-Han Chang, Shu-Min Huang, Ann-Lii Cheng, Kien Thiam Tan, Yen-Shen Lu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-01-09.
https://doi.org/10.1158/1538-7445.SABCS21-P2-01-09
Published: 15 February 2022
View article titled, Abstract P2-01-09: Clinical impact of ESR1 mutation ctDNA on survival outcome is dependent on PI3KCA/TP53 ctDNA mutation status