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Journal Articles

Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Ya-Hui Chi, Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Mine-Hsine Wu, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiung-Tong Chen, Chuan Shih

Cancer Res (2020) 80 (16_Supplement): 1937.

https://doi.org/10.1158/1538-7445.AM2020-1937

Published: 15 August 2020

View article titled, Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Journal Articles

Abstract 4626: Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216

Ching-Chuan Kuo, Weir-Torn Jiaang, Jing-Jim Ou, Chiung-Tong Chen, Shu-Ching Hsu, Chuan Shih, Li-Mei Lin, Manwu Sun, Yi-Hsin Wang, Zih-Ting Huang, Jang-Yang Chang, Shau-Hua Ueng

Cancer Res (2019) 79 (13_Supplement): 4626.

https://doi.org/10.1158/1538-7445.AM2019-4626

Published: 01 July 2019

View article titled, Abstract 4626: Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216

Journal Articles

Abstract 3851: An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer

Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Dai-Hui Jhuo, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Po-Chu Kuo, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiun-Tong Chen, Chuan Shih, Ya-Hui Chi

Cancer Res (2019) 79 (13_Supplement): 3851.

https://doi.org/10.1158/1538-7445.AM2019-3851

Published: 01 July 2019

View article titled, Abstract 3851: An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer

Journal Articles

Abstract 4511: LY2801653 treatment increases survival of mice bearing H441 orthotopic lung tumors

Wenjuan Wu, Chen Bi, Mark T. Uhlik, Julie A. Pomeroy, Hong Gao, Kelly M. Credille, Richard A. Walgren, Chuan Shih, Jonathan M. Yingling, Wei Yang

Cancer Res (2010) 70 (8_Supplement): 4511.

https://doi.org/10.1158/1538-7445.AM10-4511

Published: 15 April 2010

View article titled, Abstract 4511: LY2801653 treatment increases survival of mice bearing H441 orthotopic lung tumors

Journal Articles

Abstract 3611: LY2801653, an orally available small molecule inhibitor of c-Met, demonstrated broad antitumor efficacy in patient derived xenograft models

Wei J. Yang, Kelly Credille, Hong Gao, Mark Uhlik, Julie Pomeroy, Richard Walgren, Chuan Shih, Steffen Baltes, Thomas Beckers, Jonathan M. Yingling

Cancer Res (2010) 70 (8_Supplement): 3611.

https://doi.org/10.1158/1538-7445.AM10-3611

Published: 15 April 2010

View article titled, Abstract 3611: LY2801653, an orally available small molecule inhibitor of c-Met, demonstrated broad antitumor efficacy in patient derived xenograft models

Journal Articles

Abstract #1752: Preclinical development of a novel, orally active cMet kinase inhibitor with potent antitumor and anti-angiogenic properties

Wei Yang, Victoria Peek, Mark Uhlik, Julie Pomeroy, Wenjuan Wu, Yuefeng Chen, Chen Bi, Jennifer Stephens, Spring Weir, Karen Huss, Kelly Credille, Boyu Zhong, Chuan Shih, Jonathan Yingling

Cancer Res (2009) 69 (9_Supplement): 1752.

Published: 01 May 2009

View article titled, Abstract #1752: Preclinical development of a novel, orally active cMet kinase inhibitor with potent antitumor and anti-angiogenic properties

Journal Articles

Caffeic acid phenethyl ester inhibits cell growth and induces apoptosis by involving caspase and mitochondrial dysfunction in pancreatic cancer

Ming-Jen Chen, Wen-Hsiung Chang, Ching-Chung Lin, Chia-Yuan Liu, Tsang-En Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Yu-Jen Chen

Cancer Res (2007) 67 (9_Supplement): 3594.

Published: 01 May 2007

View article titled, Caffeic acid phenethyl ester inhibits cell growth and induces apoptosis by involving caspase and mitochondrial dysfunction in pancreatic cancer

Journal Articles

P38 MAPK inhibitor, LY2228820, causes significant chemopotentiation of temozolomide in U87MG human glioblastoma xenografts

James Starling, Robert Campbell, Chuan Shih, Alfonso De Dios, Mary Mader, Phil Schwier, Crystal Banks, Lysiane Huber, Spring Weir, Steve Hatch, Blake Neubauer, Richard Schultz, Songqing Na, Jingyong Zhao, Bryan Anderson, Jason Johnson, Denis McCann, Greg Rener

Cancer Res (2006) 66 (8_Supplement): 575.

Published: 15 April 2006

View article titled, P38 MAPK inhibitor, LY2228820, causes significant chemopotentiation of temozolomide in U87MG human glioblastoma xenografts

Journal Articles

Effect of a selective p38-MAPK inhibitor (LY479754) on the tumor microenvironment: Implication of macrophage-derived p38α-MAPK in the growth of murine P815 mastocytoma tumors

Robert M. Campbell, Xiaohua Xin, Xiaoling Xia, Xiang Ye, Paul Lee, Richard M. Schultz, Jonathan M. Yingling, Jack R. Eastridge, Kevin Law, Bryan D. Anderson, Chuan Shih, Enrique Jambrina, Juan A. Velasco, Alfonso De Dios

Cancer Res (2005) 65 (9_Supplement): 613–614.

Published: 01 May 2005

View article titled, Effect of a selective p38-MAPK inhibitor (LY479754) on the tumor microenvironment: Implication of macrophage-derived p38α-MAPK in the growth of murine P815 mastocytoma tumors

Journal Articles

An In Vitro Tumor Model: Analysis of Angiogenic Factor Expression after Chemotherapy

Kristan Keyes, Karen Cox, Patti Treadway, Larry Mann, Chuan Shih, Margaret M. Faul, Beverly A. Teicher

Cancer Res (2002) 62 (19): 5597–5602.

Published: 01 October 2002

View article titled, An In Vitro Tumor Model: Analysis of Angiogenic Factor Expression after Chemotherapy

Journal Articles

LY231514, a Pyrrolo[2,3-d]pyrimidine-based Antifolate That Inhibits Multiple Folate-requiring Enzymes

Chuan Shih, Victor J. Chen, Lynn S. Gossett, Susan B. Gates, Warren C. MacKellar, Lillian L. Habeck, Katherine A. Shackelford, Lurane G. Mendelsohn, Daniel J. Soose, Vinod F. Patel, Sherri L. Andis, Jesse R. Bewley, Elizabeth A. Rayl, Barbara A. Moroson, G. Peter Beardsley, William Kohler, Manshan Ratnam, Richard M. Schultz

Cancer Res (1997) 57 (6): 1116–1123.

Published: 01 March 1997

View article titled, LY231514, a Pyrrolo[2,3-d]pyrimidine-based Antifolate That Inhibits Multiple Folate-requiring Enzymes

Journal Articles

Augmentation of the Therapeutic Activity of Lometrexol [(6-R)5,10-Dideazatetrahydrofolate] by Oral Folic Acid

Teresa Alati, John F. Worzalla, Chuan Shih, Jesse R. Bewley, Sidney Lewis, Richard G. Moran, Gerald B. Grindey

Cancer Res (1996) 56 (10): 2331–2335.

Published: 01 May 1996

View article titled, Augmentation of the Therapeutic Activity of Lometrexol [(6-R)5,10-Dideazatetrahydrofolate] by Oral Folic Acid

Journal Articles

A Novel Class of Monoglutamated Antifolates Exhibits Tight-binding Inhibition of Human Glycinamide Ribonucleotide Formyltransferase and Potent Activity against Solid Tumors

Lillian L. Habeck, Tracy A. Leitner, Katherine A. Shackelford, Lynn S. Gossett, Richard M. Schultz, Sherri L. Andis, Chuan Shih, Gerald B. Grindey, Laurane G. Mendelsohn

Cancer Res (1994) 54 (4): 1021–1026.

Published: 01 February 1994

View article titled, A Novel Class of Monoglutamated Antifolates Exhibits Tight-binding Inhibition of Human Glycinamide Ribonucleotide Formyltransferase and Potent Activity against Solid Tumors

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Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Abstract 4626: Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216

Abstract 3851: An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer

Abstract 4511: LY2801653 treatment increases survival of mice bearing H441 orthotopic lung tumors

Abstract 3611: LY2801653, an orally available small molecule inhibitor of c-Met, demonstrated broad antitumor efficacy in patient derived xenograft models

Abstract #1752: Preclinical development of a novel, orally active cMet kinase inhibitor with potent antitumor and anti-angiogenic properties

Caffeic acid phenethyl ester inhibits cell growth and induces apoptosis by involving caspase and mitochondrial dysfunction in pancreatic cancer

P38 MAPK inhibitor, LY2228820, causes significant chemopotentiation of temozolomide in U87MG human glioblastoma xenografts

Effect of a selective p38-MAPK inhibitor (LY479754) on the tumor microenvironment: Implication of macrophage-derived p38α-MAPK in the growth of murine P815 mastocytoma tumors

An In Vitro Tumor Model: Analysis of Angiogenic Factor Expression after Chemotherapy

LY231514, a Pyrrolo[2,3-d]pyrimidine-based Antifolate That Inhibits Multiple Folate-requiring Enzymes

Augmentation of the Therapeutic Activity of Lometrexol [(6-R)5,10-Dideazatetrahydrofolate] by Oral Folic Acid

A Novel Class of Monoglutamated Antifolates Exhibits Tight-binding Inhibition of Human Glycinamide Ribonucleotide Formyltransferase and Potent Activity against Solid Tumors

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