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Christopher Winter
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Journal Articles

Abstract 2489: Sensitivity of liver cancer cell lines to B-catenin knock-down correlates with pathway activation

Zhihu (Jeff) Ding, Chaomei Shi, Lan Jiang, Tatiana Tolstykh, Hui Cao, Dinesh Bangari, Susan Ryan, Taiguang Jin, Mikhail Levit, Karl Mamaat, Qunyan Yu, Hui Qu, Joern Hopke, May Cindhuchao, Dietmar Hoffmann, Fangxian Sun, Mike Helms, Kerstin Jahn-Hofmann, Sabine Scheidler, Douglas Fang, Liang Schweizer, Jack Pollard, Christopher Winter, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2489.
https://doi.org/10.1158/1538-7445.AM2018-2489
Published: 01 July 2018
View articletitled, Abstract 2489: Sensitivity of liver cancer cell lines to B-catenin knock-down correlates with pathway activation
Journal Articles

Abstract 5550: Translational biomarkers for SAR439459, an anti-TGFβ antibody for cancer immunotherapy

Joachim Theilhaber, Jean Cavallo, Stephen L. Madden, Charlene Manning, Sherry Cao, Parminder Mankoo, Robert Pomponio, Hongjing Qu, Natalia Malkova, Gary Shapiro, Christopher Winter, Dmitri Wiederschain, Michele Sanicola-Nadel, Fangxian Sun, Tun Tun Lin, Richard C. Gregory, Jack Pollard
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5550.
https://doi.org/10.1158/1538-7445.AM2018-5550
Published: 01 July 2018
View articletitled, Abstract 5550: Translational biomarkers for SAR439459, an anti-TGFβ antibody for cancer immunotherapy
Journal Articles

Abstract 5472: Basal-like breast cancer subtype is characterized by deregulated glutamine metabolism and is sensitive to GLS inhibition

Christophe Henry, Michael Lampa, Timothy He, Beatriz Ospina, Bailin Zhang, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Jack Pollard, Adrian Francisco, Heike Arlt, Jason Reeves, Joshua Murtie, Christopher Winter, Victoria Richon, Hong Cheng, Carlos Garcia-Echeverria, Dmitri Wiederschain, Lakshmi Srinivasan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5472.
https://doi.org/10.1158/1538-7445.AM2018-5472
Published: 01 July 2018
View articletitled, Abstract 5472: Basal-like breast cancer subtype is characterized by deregulated glutamine metabolism and is sensitive to GLS inhibition
Journal Articles

Abstract 2790: The anti-TGFβ neutralizing antibody, SAR439459, blocks the immunosuppressive effects of TGFβ and inhibits the growth of syngeneic tumors in combination with anti-PD1

Richard C. Gregory, Rita Greco, Hongjing Qu, Natalia Malkova, Mikhail Levit, Keli Perron, Waldemar Racki, Fangxian Sun, Gary Shapiro, Christopher Winter, Dmitri Wiederschain, Tun Tun Lin, Jack Pollard
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2790.
https://doi.org/10.1158/1538-7445.AM2018-2790
Published: 01 July 2018
View articletitled, Abstract 2790: The anti-TGFβ neutralizing antibody, SAR439459, blocks the immunosuppressive effects of TGFβ and inhibits the growth of syngeneic tumors in combination with anti-PD1
Journal Articles

Abstract 1110: Functional genomics reveals genetic dependencies in gastric cancer

Meghana M. Kulkarni, Sushma Gurumurthy, Oleg Schmidt-Kittler, Jason Berglund, Christopher H. Hulton, David J. Wilson, David Jakubosky, Daniel Michaud, Robert E. Jones, Nicole M. Sjoblom, Russell McSweeney, Hongwei Zhou, Annapurna Venkatakrishnan, Karin J. Jensen, Jingxin Zhang, Parminder K. Mankoo, Jack Pollard, Christopher Winter, Pasi A. Jänne, Kwok-Kin Wong, Victoria M. Richon, Jessie M. English, Mark A. Bittinger
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1110.
https://doi.org/10.1158/1538-7445.AM2015-1110
Published: 01 August 2015
View articletitled, Abstract 1110: Functional genomics reveals genetic dependencies in gastric cancer
Journal Articles

Abstract 5448: PTK7 as a potential therapeutic target in ovarian cancer

Zhihu Ding, Amanda Lennon, Keli Perron, David Harper, Hui Su, Meredith Wolfram, Joshua Murtie, Stuart Licht, Jason Pinckney, Helene Simonds-Mannes, Kimberly Bishop, Julie-Ann Gavigan, Dinesh Bangari, Maureen Magnay, William Weber, David Reczek, William Brondyk, Vicky Drewett, Marc Trombe, Dietmar Hoffmann, Raffaele Baffa, Serena Silver, Victoria Richon, Christopher Winter, Venkat Reddy, Richard C. Gregory
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5448.
https://doi.org/10.1158/1538-7445.AM2014-5448
Published: 01 October 2014
View articletitled, Abstract 5448: PTK7 as a potential therapeutic target in ovarian cancer
Journal Articles

Abstract LB-324: First isoform selective inhibitor of FGFR4 for the treatment of genomically defined patients with hepatocellular carcinoma

Margit Hagel, Chandra Miduturu, Mike Sheets, Weifan Weng, Nooreen Rubin, Neil Bifulco, Lucian DiPietro, Joseph Kim, Natasja Brooijmans, Nicolas Stransky, Christopher Winter, Christoph Lengauer, Timothy Guzi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-324.
https://doi.org/10.1158/1538-7445.AM2014-LB-324
Published: 01 October 2014
View articletitled, Abstract LB-324: First isoform selective inhibitor of FGFR4 for the treatment of genomically defined patients with hepatocellular carcinoma
Journal Articles

Abstract LB-303: Anti-IGF1R therapy with dalotuzumab is efficacious in pre-clinical models of erlotinib refractory NSCLC

Youyuan Xu, Sharda Jha, Kara Sykes, Cloud P. Paweletz, Michael Nebozhyn, Igor Feldman, andrey Loboda, john Reilly, Christopher Winter, Theresa Zhang, Sriram Sathyanarayanan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-303.
https://doi.org/10.1158/1538-7445.AM10-LB-303
Published: 15 April 2010
View articletitled, Abstract LB-303: Anti-IGF1R therapy with dalotuzumab is efficacious in pre-clinical models of erlotinib refractory NSCLC
Journal Articles

Abstract 3478: PI3K suppression by the mTOR inhibitor ridaforolimus and the AKT inhibitor MK-2206 is associated with enhanced anti-tumor activity and hyperglycemia in preclinical models

Marlene C. Artime, Samuel Blackman, Scot Ebbinghaus, Ray Lee, Alessandra Di Bacco, Diana Gargano, Theresa Zhang, Nagaraja Muniappa, Punam Sandhu, Gail Gitzlaff, Cynthia Chavez-Eng, James Watters, Melissa Chenard, Edwin Clark, Christopher Winter, Brian B. Haines
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3478.
https://doi.org/10.1158/1538-7445.AM10-3478
Published: 15 April 2010
View articletitled, Abstract 3478: PI3K suppression by the mTOR inhibitor ridaforolimus and the AKT inhibitor MK-2206 is associated with enhanced anti-tumor activity and hyperglycemia in preclinical models
Journal Articles

Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model

Clay L. Efferson, Christopher T. Winkelmann, Christopher Ware, Timothy Sullivan, Saverio Giampaoli, Jennifer Tammam, Shailendra Patel, Giuseppe Mesiti, John F. Reilly, Raymond E. Gibson, Carolyn Buser, Timothy Yeatman, Domenico Coppola, Christopher Winter, Edwin A. Clark, Giulio F. Draetta, Peter R. Strack, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2010) 70 (6): 2476–2484.
https://doi.org/10.1158/0008-5472.CAN-09-3114
Published: 14 March 2010
View articletitled, Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model
Open the PDF for Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model in another window
Includes: Supplementary data
Journal Articles

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

James W. Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy Kohl, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8949–8957.
https://doi.org/10.1158/0008-5472.CAN-09-1544
Published: 30 November 2009
View articletitled, De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model
Open the PDF for De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model in another window
Includes: Supplementary data
Journal Articles

Abstract #2809: Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity

Sriram Sathyanarayanan, Sharda Jha, Richard Klinghoffer, Youyuan Xu, Mark Bittinger, Jason Frazier, Alessandra Di Bacco, Michael Chastain, Astrid Kral, Nancy Kohl, Brian Haines, Katharine Yen, Shailaja Kasibhatla, Christopher Winter
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2809.
Published: 01 May 2009
View articletitled, Abstract #2809: Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity