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Christopher A. Bristow
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Journal Articles

Abstract LB079: Pancreatic clonal replica tumors display functional heterogeneity in response to KRAS pharmacological inhibition and reveal unique epigenetic vulnerabilities to overcome resistance

Hengyu Lyu, Rosalba Minelli, Charles E. Deckard, Sahil Seth, Justin Huang, Hong Jiang, Michael D. Peoples, Meggie Lam, Christopher A. Bristow, Daniel Gerlach, Ulrike Tontsch-Grunt, Chieh-Yuan Li, I-Lin Ho, Christopher P. Vellano, Marco H. Hofmann, Timothy P. Heffernan, Joseph R. Marszalek, Andrea Viale, Alessandro Carugo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB079.
https://doi.org/10.1158/1538-7445.AM2022-LB079
Published: 15 June 2022
View articletitled, Abstract LB079: Pancreatic clonal replica tumors display functional heterogeneity in response to KRAS pharmacological inhibition and reveal unique epigenetic vulnerabilities to overcome resistance
Journal Articles

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer

Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5572–5581.
https://doi.org/10.1158/0008-5472.CAN-20-3242
Published: 01 November 2021
View articletitled, Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
Open the PDF for Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya'an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4054–4065.
https://doi.org/10.1158/0008-5472.CAN-20-3792
Published: 01 August 2021
View articletitled, Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Open the PDF for Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 1102: Integrated approach towards defining mechanism based combinations to guide clinical development of glutaminase inhibitors

Jeffrey J. Kovacs, Nakia D. Spencer, Christopher A. Bristow, Alessandro Carugo, Virginia Giluiani, Meredith A. Miller, Angela Harris, Ningping Feng, Michael L. Soth, Kang Le, Elisa de Stanchina, Charles M. Rudin, Giulio Draetta, Timothy A. Yap, Philip Jones, Timothy Heffernan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1102.
https://doi.org/10.1158/1538-7445.AM2021-1102
Published: 01 July 2021
View articletitled, Abstract 1102: Integrated approach towards defining mechanism based combinations to guide clinical development of glutaminase inhibitors
Journal Articles

Abstract 87: Asparagine synthetase (ASNS) expression predicts response to the GLS1 inhibitor IPN60090 in ovarian cancer through selective modulation of redox homeostasis

Nakia D. Spencer, Christopher A. Bristow, Virginia Giulani, Meredith A. Miller, Alessandro Carugo, Angela L. Harris, Rosalba Minelli, Ningpeng Feng, Qing Chang, Michael J. Soth, Kang Le, John N. Weinstein, Philip L. Lorenzi, Jinsong Liu, Wei-Lien Wang, Timothy A. Yap, Giulio Draetta, Philip Jones, Timothy P. Heffernan, Jeffrey J. Kovacs
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 87.
https://doi.org/10.1158/1538-7445.AM2021-87
Published: 01 July 2021
View articletitled, Abstract 87: Asparagine synthetase (ASNS) expression predicts response to the GLS1 inhibitor IPN60090 in ovarian cancer through selective modulation of redox homeostasis
Journal Articles

Abstract 985: BI 905711 selectively induces apoptosis and anti-tumor response in TRAILR2/CDH17- expressing pancreatic cancer models

Jing Han, Annette A. Machado, Mikhila Mahendra, Joseph R. Daniele, Christopher A. Bristow, Justin Kwang-Lay Huang, Alessandro Carugo, Robert A. Mullinax, Benjamin J. Bivona, Ningping Feng, Poojabahen Gandhi, Norbert Schweifer, Paolo Maria Chetta, Juan Manuel Garcia-Martinez, Frank Hilberg, Christopher P. Vellano, Timothy P. Heffernan, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 985.
https://doi.org/10.1158/1538-7445.AM2021-985
Published: 01 July 2021
View articletitled, Abstract 985: BI 905711 selectively induces apoptosis and anti-tumor response in TRAILR2/CDH17- expressing pancreatic cancer models
Journal Articles

Abstract 619: Integrated multi-platform profiling of early-stage non-small cell lung cancer identifies relationship between disease recurrence and decreased native immune response in treatment-naïve resected NSCLC

Neal Akhave, Stephanie Schmidt, Alexandre Reuben, Tina Cascone, Jianhua Zhang, Jun Li, Junya Fujimoto, Lauren A. Byers, Beatriz Sanchez-Espiridion, Lixia Diao, Jing Wang, Lorenzo Federico, Marie-Andree Forget, Daniel J. McGrail, Annikka Weissferdt, Shiaw-Yih Lin, Younghee Lee, Carmen Behrens, Ignacio I. Wistuba, Andrew Futreal, Ara Vaporciyan, Boris Sepesi, John V. Heymach, Chantale Bernatchez, Cara Haymaker, Jianjun Zhang, Christopher A. Bristow, Marcelo V. Negrao, Don L. Gibbons
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 619.
https://doi.org/10.1158/1538-7445.AM2021-619
Published: 01 July 2021
View articletitled, Abstract 619: Integrated multi-platform profiling of early-stage non-small cell lung cancer identifies relationship between disease recurrence and decreased native immune response in treatment-naïve resected NSCLC
Journal Articles

Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics

Sanjana Srinivasan, Johnathon Rose, Wantong Yao, Sahil Seth, Michael Peoples, Annette Machado, Chieh-Yuan Li, I Lin Ho, Jaewon J. Lee, Paola A. Guerrera, Eiru Kim, Mustafa Syed, Joseph Daniele, Angela K. Deem, Michael Kim, Christopher A. Bristow, Eugene Koay, Giannicola Genovese, Andrea Viale, Timothy P. Heffernan, Anirban Maitra, Traver Hart, Alessandro Carugo, Giulio Draetta
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2136.
https://doi.org/10.1158/1538-7445.AM2021-2136
Published: 01 July 2021
View articletitled, Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics
Journal Articles

Abstract 2338: The GLS1 inhibitor IPN60090 enhances antitumor immune response through metabolic reprogramming of T cells and impacts on the tumor microenvironment

Erika Suzuki, Jennifer Molina, Nakia D. Spencer, Christopher A. Bristow, Angela L. Harris, Ningping Feng, Mikhila Mahendra, Sonal Gera, Michael J. Soth, Kang Le, Timothy A. Yap, Giulio Draetta, Philip Jones, Timothy P. Heffernan, Jeffrey J. Kovacs
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2338.
https://doi.org/10.1158/1538-7445.AM2021-2338
Published: 01 July 2021
View articletitled, Abstract 2338: The GLS1 inhibitor IPN60090 enhances antitumor immune response through metabolic reprogramming of T cells and impacts on the tumor microenvironment
Journal Articles

Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress

Hideo Tomihara, Federica Carbone, Luigi Perelli, Justin K. Huang, Melinda Soeung, Johnathon L. Rose, Frederick S. Robinson, Yonathan Lissanu Deribe, Ningping Feng, Mitsunobu Takeda, Akira Inoue, Edoardo Del Poggetto, Angela K. Deem, Anirban Maitra, Pavlos Msaouel, Nizar M. Tannir, Giulio F. Draetta, Andrea Viale, Timothy P. Heffernan, Christopher A. Bristow, Alessandro Carugo, Giannicola Genovese
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (2): 332–343.
https://doi.org/10.1158/0008-5472.CAN-19-3922
Published: 15 January 2021
View articletitled, Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress
Open the PDF for Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress in another window
Includes: Supplementary data
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View articletitled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma

Carla Mottini, Hideo Tomihara, Diego Carrella, Alessia Lamolinara, Manuela Iezzi, Justin K. Huang, Carla A. Amoreo, Simonetta Buglioni, Isabella Manni, Frederick S. Robinson, Rosalba Minelli, Ya'an Kang, Jason B. Fleming, Michael P. Kim, Christopher A. Bristow, Daniela Trisciuoglio, Antonella Iuliano, Donatella Del Bufalo, Diego Di Bernardo, Davide Melisi, Giulio F. Draetta, Gennaro Ciliberto, Alessandro Carugo, Luca Cardone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5612–5625.
https://doi.org/10.1158/0008-5472.CAN-19-0187
Published: 01 November 2019
View articletitled, Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma
Open the PDF for Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 277: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma

Virginia Giuliani, Alessandro Carugo, Meredith Miller, Lionel Sanz, Chiu-Yi Liu, Christopher A Bristow, Erika Suzuki, Caleb A Class, Stella R. Hartono, Guang Gao, Ningping Feng, Jason P Gay, Bhavatarini Vangamudi, Joseph R Marszalek, Jeffrey Kovacs, Maria Emilia Di Francesco, Frederic Chedin, Philip Jones, Giulio Draetta, Timothy Heffernan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 277.
https://doi.org/10.1158/1538-7445.AM2019-277
Published: 01 July 2019
View articletitled, Abstract 277: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells

Joseph R. Marszalek, Sahil Seth, Denise Corti, Qi Zhang, Gloria V. Echeverria, Lina Han, Yuting Sun, Jennifer Molina, Sonal Gera, Edward Chang, Tin O. Khor, Mikhila Mahendra, Ningping Feng, Jason P. Gay, Timothy McAfoos, Virginia Giuliani, Xi Shi, Sabrina Jeter-Jones, Sarah Loponte, Chieh-Yuan Li, Christopher A. Bristow, Maria Emilia Di Francesco, Helen Piwnica-Worms, Marina Konopleva, Alessandro Carugo, Andrea Viale, Philip Jones, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2856.
https://doi.org/10.1158/1538-7445.AM2018-2856
Published: 01 July 2018
View articletitled, Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Journal Articles

Abstract 415: In vivo shRNA library screening to identify novel targets for head and neck squamous cell carcinoma

Curtis R. Pickering, Tongxin Xie, Manish Kumar, Ramya L. Parimi, Liang P. Yang, Jiping Wang, Sahil Seth, Christopher A. Bristow, Alessandro Carugo, Frederick S. Robinson, Giulio F. Draetta, Heath Skinner, Mitchell J. Frederick, Jeffrey N. Myers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 415.
https://doi.org/10.1158/1538-7445.AM2017-415
Published: 01 July 2017
View articletitled, Abstract 415: In vivo shRNA library screening to identify novel targets for head and neck squamous cell carcinoma