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Christoph A. Klein
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Journal Articles

Abstract 1510: Cell-cell contacts regulate HER2 cellular localization and the transitions between migration and proliferation in breast cancer cells

Hedayatollah Hosseini, Saba Sameri, Shabnam Shahrivari, Carolina Fisch, Miriam Kokal, Michael Schletter, Paul Sylvester Hahn, Lisa Seider, Marisa Schübel, Durdam Das, Martin Hoffmann, Christian Werno, Kathrin Weidele, Vladan Milosevic, Arne Östman, Shamim Sarhadi, Joachim Wegener, Stefanie Michaelis, Florian Weber, Astrid Bruckmann, Ernst R. Tamm, Yuting Li, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1510.
https://doi.org/10.1158/1538-7445.AM2024-1510
Published: 22 March 2024
View article titled, Abstract 1510: Cell-cell contacts regulate HER2 cellular localization and the transitions between migration and proliferation in breast cancer cells
Journal Articles

Abstract 3692: Genomic profiling with the novel single-cell IMPACT assay reveals evidence of genetic heterogeneity among CTCs in late-stage breast cancer patients

Zbigniew T. Czyż, Clara Chaiban, Adithi Ravikumar Varadarajan, Cäcilia Köstler, Vadim Dechand, Jonas Grote, Thomas Ragg, Bernhard Polzer, Jens Warfsmann, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3692.
https://doi.org/10.1158/1538-7445.AM2024-3692
Published: 22 March 2024
View article titled, Abstract 3692: Genomic profiling with the novel single-cell IMPACT assay reveals evidence of genetic heterogeneity among CTCs in late-stage breast cancer patients
Journal Articles

Abstract 3694: Genomic profiling of single cancer cells using the novel single-cell integrated mutational profiling of actionable cancer targets (scIMPACT) assay

Clara Chaiban, Adithi Ravikumar Varadarajan, Jonas Grote, Thomas Ragg, Isabell Blochberger, Vadim Dechand, Jens Warfsmann, Christoph A. Klein, Zbigniew T. Czyż
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3694.
https://doi.org/10.1158/1538-7445.AM2024-3694
Published: 22 March 2024
View article titled, Abstract 3694: Genomic profiling of single cancer cells using the novel single-cell integrated mutational profiling of actionable cancer targets (scIMPACT) assay
Journal Articles

Abstract 3778: Comprehensive analysis of single disseminated cancer cells identifies a stem-like phenotype with strong prognostic impact

Tobias Mederer, Daniel Spitzl, Felix Elsner, Bernhard Polzer, Michael Ried, Reiner Neu, Tobias Robold, Hans-Stefan Hofmann, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3778.
https://doi.org/10.1158/1538-7445.AM2024-3778
Published: 22 March 2024
View article titled, Abstract 3778: Comprehensive analysis of single disseminated cancer cells identifies a stem-like phenotype with strong prognostic impact
Journal Articles

Abstract 4124: Patient-derived ex vivo models to test drug responses of disseminated cancer cells in various metastatic niches

Lukas Wöhrl, Catherine Botteron, Kathrin Weidele, Steffi Treitschke, Durdam Das, Melanie Werner-Klein, Martin Hoffmann, Nataša Stojanović Gužvić, Silvia Materna-Reichelt, Florian Weber, Simon Engelmann, Roman Mayr, Miodrag Gužvić, Sebastian Haferkamp, Stephan Seitz, Christoph A. Klein, Christian Werno
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4124.
https://doi.org/10.1158/1538-7445.AM2024-4124
Published: 22 March 2024
View article titled, Abstract 4124: Patient-derived ex vivo models to test drug responses of disseminated cancer cells in various metastatic niches
Journal Articles

Abstract 1504: Tumor microenvironment-mediated regulation of early dissemination and colonization in breast cancer via BAZ2A-containing remodeling complexes

Miriam Kokal-Ribaudo, Nora Jahnen, Saba Sameri, Fulvia Ferrazzi, Renato Liguori, Christoph A. Klein, Gernot Längst, Hedayatollah Hosseini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1504.
https://doi.org/10.1158/1538-7445.AM2024-1504
Published: 22 March 2024
View article titled, Abstract 1504: Tumor microenvironment-mediated regulation of early dissemination and colonization in breast cancer via BAZ2A-containing remodeling complexes
Journal Articles

Abstract 2743: Molecular characterization and prognostic evaluation of disseminated cancer cell subpopulations detected in bone marrow of non-small cell lung cancer patients

Daniel Spitzl, Tobias Mederer, Julius Zank, Severin Gütter, Michael Ried, Hans-Stefan Hofmann, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2743.
https://doi.org/10.1158/1538-7445.AM2024-2743
Published: 22 March 2024
View article titled, Abstract 2743: Molecular characterization and prognostic evaluation of disseminated cancer cell subpopulations detected in bone marrow of non-small cell lung cancer patients
Journal Articles

Abstract 3709: Single cell analysis from CSF of patients with suspected leptomeningeal metastasis

Caecilia Koestler, Giancarlo Feliciello, Florian Lueke, Kathrin Weidele, Saida Zoubaa, Peter Hau, Tobias Pukrop, Markus J. Riemenschneider, Christoph A. Klein, Bernhard Polzer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3709.
https://doi.org/10.1158/1538-7445.AM2024-3709
Published: 22 March 2024
View article titled, Abstract 3709: Single cell analysis from CSF of patients with suspected leptomeningeal metastasis
Journal Articles

Abstract 3704: Whole genome and targeted proteome analysis of single cancer cells

Atieh Alyasin, Kathrin Weidele, Catherine Botteron, Christoph A. Klein, Zbigniew T. Czyż
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3704.
https://doi.org/10.1158/1538-7445.AM2024-3704
Published: 22 March 2024
View article titled, Abstract 3704: Whole genome and targeted proteome analysis of single cancer cells
Journal Articles

Abstract LB-239: A novel workflow for isolation and multi-omic profiling of DCCs derived from cerebrospinal fluid of patients with pediatric brain cancer

Zbigniew T. Czyz, Giancarlo Feliciello, Miodrag Guzvic, Thomas Schamberger, Sandra Grunewald, Selim Corbacioglu, Markus J. Riemenschneider, Bernhard Polzer, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-239.
https://doi.org/10.1158/1538-7445.AM2019-LB-239
Published: 01 July 2019
View article titled, Abstract LB-239: A novel workflow for isolation and multi-omic profiling of DCCs derived from cerebrospinal fluid of patients with pediatric brain cancer
Journal Articles

Abstract LB-312: Interleukin 6 transsignaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

Melanie Werner-Klein, Ana Grujovic, Milan Obradovic, Martin Hoffmann, Xin Lu, Stefan Kirsch, Steffi Treitschke, Cäcilia Köstler, Kathrin Weidele, Christoph Irlbeck, Catherine Botteron, Christian Werno, Bernhard Polzer, Miodrag Guzvic, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-312.
https://doi.org/10.1158/1538-7445.AM2019-LB-312
Published: 01 July 2019
View article titled, Abstract LB-312: Interleukin 6 transsignaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency
Journal Articles

Abstract 431: Semi-automated detection, isolation and molecular analysis of single disseminated melanoma cells from lymph nodes

Barbara Alberter, Sebastian Scheitler, Giancarlo Feliciello, Alberto Ferrarini, Melanie Werner-Klein, Sebastian Haferkamp, Christoph A. Klein, Bernhard Polzer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 431.
https://doi.org/10.1158/1538-7445.AM2019-431
Published: 01 July 2019
View article titled, Abstract 431: Semi-automated detection, isolation and molecular analysis of single disseminated melanoma cells from lymph nodes
Journal Articles

Abstract 3051: Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Kathryn Harper, Maria Soledad Sosa, David Entenberg, Hedayatollah Hosseini, Julie Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger Davis, Eduardo Farias, John Condeelis, Christoph A. Klein, Julio A. Aguirre-Ghiso
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3051.
https://doi.org/10.1158/1538-7445.AM2017-3051
Published: 01 July 2017
View article titled, Abstract 3051: Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Journal Articles

Abstract 1551: High-resolution parallel analysis of genome and transcriptome of single disseminated prostate cancer cells

Stefan Kirsch, Urs Lahrmann, Miodrag Guzvic, Zbigniew T. Czyz, Giancarlo Feliciello, Bernhard Polzer, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1551.
https://doi.org/10.1158/1538-7445.AM2016-1551
Published: 15 July 2016
View article titled, Abstract 1551: High-resolution parallel analysis of genome and transcriptome of single disseminated prostate cancer cells
Journal Articles

Abstract 472: A digital sorting-based detection and isolation assay for single disseminated cancer cells from lymph nodes of melanoma patients

Sebastian Scheitler, Kathrin Weidele, Barbara Alberter, Christian Werno, Christoph A. Klein, Bernhard Polzer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 472.
https://doi.org/10.1158/1538-7445.AM2016-472
Published: 15 July 2016
View article titled, Abstract 472: A digital sorting-based detection and isolation assay for single disseminated cancer cells from lymph nodes of melanoma patients
Journal Articles

Abstract 371: Longitudinal genetic characterization of circulating tumor cells in metastatic breast cancer patients

Valeria Sero, Francesca De Luca, Anna Doffini, Francesca Galardi, Marta Pestrin, Zbignew T. Czyz, Genny Buson, Giulia Bregola, Chiara Bolognesi, Francesca Fontana, Gianni Medoro, Bernhard Polzer, Angelo Di Leo, Christoph A. Klein, Nicolo Manaresi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 371.
https://doi.org/10.1158/1538-7445.AM2015-371
Published: 01 August 2015
View article titled, Abstract 371: Longitudinal genetic characterization of circulating tumor cells in metastatic breast cancer patients
Journal Articles

Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes

Miodrag Gužvić, Bernhard Braun, Roman Ganzer, Maximilian Burger, Michael Nerlich, Sebastian Winkler, Melanie Werner-Klein, Zbigniew T. Czyż, Bernhard Polzer, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7383–7394.
https://doi.org/10.1158/0008-5472.CAN-14-0934
Published: 14 December 2014
View article titled, Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes
Open the PDF for Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes in another window
Includes: Supplementary data
Journal Articles

Abstract A63: Identification and molecular characterization of single disseminated metastasis progenitor cells in prostate cancer: The significance of EpCAM-positive cells

Miodrag Gužvić, Bernhard Polzer, Roman Ganzer, Dorothea Weckermann, Bernhard Braun, Inka Appel, Matthias Maneck, Wolfgang Wieland, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): A63.
https://doi.org/10.1158/1538-7445.PRCA2012-A63
Published: 09 May 2013
View article titled, Abstract A63: Identification and molecular characterization of single disseminated metastasis progenitor cells in prostate cancer: The significance of EpCAM-positive cells
Journal Articles

Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma

Christoph A. Klein, Nikolas H. Stoecklein
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5285–5288.
https://doi.org/10.1158/0008-5472.CAN-08-4586
Published: 01 July 2009
View article titled, Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma
Open the PDF for Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma in another window
Journal Articles

BAC array analysis of single disseminated tumor cells from bone marrow of breast cancer patients

Christine Fuhrmann, Oleg Schmidt-Kittler, Karina Petat-Dutter, Nikolas H. Stoecklein, Christian Vay, Kerstin Bockler, Christoph A. Klein
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 986.
Published: 15 April 2006
View article titled, BAC array analysis of single disseminated tumor cells from bone marrow of breast cancer patients