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Christina M. Annunziata
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Journal Articles

Abstract 2716: The O-glycan epitope targeting anti-human carcinoma monoclonal antibody (mAb) NEO-201 can also target human regulatory T cells (Tregs)

Atsushi Tanaka, Massimo Fantini, Philip M. Arlen, Christina M. Annunziata, Kwong Y. Tsang, Shimon Sakaguchi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2716.
https://doi.org/10.1158/1538-7445.AM2024-2716
Published: 22 March 2024
View article titled, Abstract 2716: The O-glycan epitope targeting anti-human carcinoma monoclonal antibody (mAb) NEO-201 can also target human regulatory T cells (Tregs)
Journal Articles

Abstract 5654: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) NEO-201 can also target human granulocytic myeloid-derived suppressor cells (gMDSCs) and regulatory T (Tregs) cells

Massimo Fantini, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5654.
https://doi.org/10.1158/1538-7445.AM2023-5654
Published: 04 April 2023
View article titled, Abstract 5654: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) NEO-201 can also target human granulocytic myeloid-derived suppressor cells (gMDSCs) and regulatory T (Tregs) cells
Journal Articles

Abstract 488: New therapeutic strategies suppressing NAD+ and ATP production in cancer metabolism specific to 3D cultured ovarian cancer cells

Kei Kudo, Brittney S. Harrington, Franklin Ning, Rahul Kamdar, Yusuke Shibuya, Soumya Korrapati, Maria Fergusson, Calen Kucera, Fantini Massimo, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 488.
https://doi.org/10.1158/1538-7445.AM2023-488
Published: 04 April 2023
View article titled, Abstract 488: New therapeutic strategies suppressing NAD<sup>+</sup> and ATP production in cancer metabolism specific to 3D cultured ovarian cancer cells
Journal Articles

Abstract 3781: NF-κB classical and alternative signaling differentially regulate miRNA expression in ovarian cancer

Rahul D. Kamdar, Brittney S. Harrington, Soumya Korrapati, Emma Attar, Nathan Wong, Carrie D. House, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3781.
https://doi.org/10.1158/1538-7445.AM2023-3781
Published: 04 April 2023
View article titled, Abstract 3781: NF-κB classical and alternative signaling differentially regulate miRNA expression in ovarian cancer
Journal Articles

Abstract 5820: NF-κB signaling regulates miRNA expression in ovarian cancer

Rahul D. Kamdar, Brittney S. Harrington, Soumya Korrapati, Nathan Wong, Carrie D. House, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5820.
https://doi.org/10.1158/1538-7445.AM2022-5820
Published: 15 June 2022
View article titled, Abstract 5820: NF-κB signaling regulates miRNA expression in ovarian cancer
Journal Articles

Abstract CT113: A phase II study of prexasertib, a cell cycle checkpoint kinase 1 (CHK1) inhibitor, in platinum-resistant recurrent high-grade serous ovarian cancer (HGSOC) with BRCA wild-type (BRCAwt)

Grant Zurcher, Ann McCoy, Brooke Solarz, Jay Nair, Min-Jung Lee, Jane B. Trepel, Christina M. Annunziata, Jung-Min Lee
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT113.
https://doi.org/10.1158/1538-7445.AM2022-CT113
Published: 15 June 2022
View article titled, Abstract CT113: A phase II study of prexasertib, a cell cycle checkpoint kinase 1 (CHK1) inhibitor, in platinum-resistant recurrent high-grade serous ovarian cancer (HGSOC) with BRCA wild-type (BRCAwt)
Journal Articles

Abstract 3577: First-in-human phase I study of intraperitoneally administered interferon-activated autologous monocytes in platinum-resistant ovarian cancer

Christopher B. Cole, Daniel S. Green, Franklin Ning, Kathryn Zoon, Lindsey B. Rosen, Steven M. Holland, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3577.
https://doi.org/10.1158/1538-7445.AM2022-3577
Published: 15 June 2022
View article titled, Abstract 3577: First-in-human phase I study of intraperitoneally administered interferon-activated autologous monocytes in platinum-resistant ovarian cancer
Journal Articles

Abstract 3188: Modulating UGDH expression in ovarian cancer tumor-initiating cells alters the tumor microenvironment

Brittney S. Harrington, Rahul Kamdar, Nathan Wong, Carrie D. House, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3188.
https://doi.org/10.1158/1538-7445.AM2022-3188
Published: 15 June 2022
View article titled, Abstract 3188: Modulating UGDH expression in ovarian cancer tumor-initiating cells alters the tumor microenvironment
Journal Articles

Abstract 4185: Targeting variant of CEACAM5 and CEACAM6 using NEO-201 and IL-15 in gynecologic cancers

Maria Pia Morelli, Massimo Fantini, Kwong Y. Tsang, Phillip Arlen, Paulette Fauceglia, Lidia Hernandez, Soumya Korrapati, Elijah Edmonson, Christopher Cole, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4185.
https://doi.org/10.1158/1538-7445.AM2022-4185
Published: 15 June 2022
View article titled, Abstract 4185: Targeting variant of CEACAM5 and CEACAM6 using NEO-201 and IL-15 in gynecologic cancers
Journal Articles

Abstract 5727: Using ChIP-seq to identify genes regulated by RelA or RelB that support ovarian cancer tumor-initiating cell (TIC) characteristics

Emily M. Mu, Samuel F. Gilbert, Mikella Robinson, Jacqueline Lara, Omar Lujano-Olazaba, Christina M. Annunziata, Carrie D. House
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5727.
https://doi.org/10.1158/1538-7445.AM2022-5727
Published: 15 June 2022
View article titled, Abstract 5727: Using ChIP-seq to identify genes regulated by RelA or RelB that support ovarian cancer tumor-initiating cell (TIC) characteristics
Journal Articles

Abstract 3582: Drugs targeting ovarian cancer tumor-initiating cells enhance oxidative stress and prevent disease recurrence

Brittney S. Harrington, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3582.
https://doi.org/10.1158/1538-7445.AM2020-3582
Published: 15 August 2020
View article titled, Abstract 3582: Drugs targeting ovarian cancer tumor-initiating cells enhance oxidative stress and prevent disease recurrence
Journal Articles

Abstract 4534: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) can enhance NK activity and target immunosuppressive regulatory T cells

Massimo Fantini, Maria Pia Morelli, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4534.
https://doi.org/10.1158/1538-7445.AM2020-4534
Published: 15 August 2020
View article titled, Abstract 4534: A therapeutic humanized anti-carcinoma monoclonal antibody (mAb) can enhance NK activity and target immunosuppressive regulatory T cells
Journal Articles

Abstract 3947: Mechanisms of action of a neoantigen-targeting antibody NEO-201

Philip Martin Arlen, Massimo Fantini, Justin David, Christina M. Annunziata, Kwong Y. Tsang, Pia Morelli
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3947.
https://doi.org/10.1158/1538-7445.AM2019-3947
Published: 01 July 2019
View article titled, Abstract 3947: Mechanisms of action of a neoantigen-targeting antibody NEO-201
Journal Articles

Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Jialing Zhang, Tony Chen, Xinping Yang, Hui Cheng, Stephan S. Späth, Paul E. Clavijo, Jianhong Chen, Christopher Silvin, Natalia Issaeva, Xiulan Su, Wendell G. Yarbrough, Christina M. Annunziata, Zhong Chen, Carter Van Waes
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4613–4626.
https://doi.org/10.1158/0008-5472.CAN-17-0642
Published: 14 August 2018
View article titled, Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers
Open the PDF for Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 3821: The neoantigen-targeting antibody NEO-201 enhances NK cell-dependent killing of tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway

Justin M. David, Massimo Fantini, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3821.
https://doi.org/10.1158/1538-7445.AM2018-3821
Published: 01 July 2018
View article titled, Abstract 3821: The neoantigen-targeting antibody NEO-201 enhances NK cell-dependent killing of tumor cells through blockade of the inhibitory CEACAM5/CEACAM1 immune checkpoint pathway
Journal Articles

Abstract 167: Targeting the NF-kappaB pathway with bardoxolone methyl to inhibit ovarian cancer spheroid formation

Michelle K. Ozaki, Carrie D. House, Krystyna Mazan-Mamczarz, Madhu Lal-Nag, Craig Thomas, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 167.
https://doi.org/10.1158/1538-7445.AM2018-167
Published: 01 July 2018
View article titled, Abstract 167: Targeting the NF-kappaB pathway with bardoxolone methyl to inhibit ovarian cancer spheroid formation
Journal Articles

Abstract 619: ALT-803 enhances antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by NEO-201 against human carcinoma cells

Massimo Fantini, Justin M. David, Hing C. Wong, Christina M. Annunziata, Philip M. Arlen, Kwong Yok Tsang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 619.
https://doi.org/10.1158/1538-7445.AM2018-619
Published: 01 July 2018
View article titled, Abstract 619: ALT-803 enhances antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by NEO-201 against human carcinoma cells
Journal Articles

Abstract 5470: IKK-epsilon supports anchorage independent growth via alternative NF-kB signaling in triple-negative breast cancer

Carrie D. House, Valentina Grajales, Michelle Ozaki, Elizabeth Jordan, Helmae Wubneh, Danielle Kimble, Marianne Kim, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5470.
https://doi.org/10.1158/1538-7445.AM2018-5470
Published: 01 July 2018
View article titled, Abstract 5470: IKK-epsilon supports anchorage independent growth via alternative NF-kB signaling in triple-negative breast cancer
Journal Articles

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem–like Cells

Carrie D. House, Elizabeth Jordan, Lidia Hernandez, Michelle Ozaki, Jana M. James, Marianne Kim, Michael J. Kruhlak, Eric Batchelor, Fathi Elloumi, Margaret C. Cam, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6927–6940.
https://doi.org/10.1158/0008-5472.CAN-17-0366
Published: 14 December 2017
View article titled, NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH<sup>+</sup> Cancer Stem–like Cells
Open the PDF for NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH<sup>+</sup> Cancer Stem–like Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 3025: Preclinical characterization of a novel monoclonal antibody targeting a neo-antigen expressed in ovarian and GI malignancies

Kristen Zeligs, Philip M. Arlen, Kwong Tsang, Lidia Hernandez, Massimo Fantini, Christina M. Annunziata
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3025.
https://doi.org/10.1158/1538-7445.AM2017-3025
Published: 01 July 2017
View article titled, Abstract 3025: Preclinical characterization of a novel monoclonal antibody targeting a neo-antigen expressed in ovarian and GI malignancies