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Christina Leslie
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Journal Articles

Abstract 1246: Erg-driven prostate cancer emerges from a basal subset of cells with luminal transcriptomic features

Erik Ladewig, Weiran Feng, Christina Leslie, Charles Sawyers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1246.
https://doi.org/10.1158/1538-7445.AM2024-1246
Published: 22 March 2024
View articletitled, Abstract 1246: Erg-driven prostate cancer emerges from a basal subset of cells with luminal transcriptomic features
Journal Articles

Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer

Srushti Kittane, Erik Ladewig, Taibo Li, Jillian Love, Amaia Arruabarrena-Aristorena, Xinyu Guo, Mirna Sallaku, Liliana Garcia-Martinez, Ryan Blawski, Javier Carmona Sanz, Christopher Simpkins, Wanlu Chen, Bujamin Vokshi, Peihua Zhao, Nachiket Kelkar, Laura Baldino, Ingrid Kalemi, Pau Castel, Emiliano Cocco, Lluis Morey, Charles Sawyers, Hongkai Ji, Maurizio Scaltriti, Alexis Battle, Christina Leslie, Wouter Karthaus, Eneda Toska
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2024-1245
Published: 22 March 2024
View articletitled, Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer
Journal Articles

Abstract 2048: Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids

Erik Ladewig, Abbas Nazir, Christina Leslie, Charles Sawyers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2048.
https://doi.org/10.1158/1538-7445.AM2023-2048
Published: 04 April 2023
View articletitled, Abstract 2048: Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids
Journal Articles

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Erik Ladewig, Flavia Michelini, Komal Jhaveri, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G. Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina Leslie, Maurizio Scaltriti, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2269–2280.
https://doi.org/10.1158/0008-5472.CAN-22-0446
Published: 15 June 2022
View articletitled, The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Open the PDF for The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation in another window
Includes: Supplementary data
Journal Articles

Abstract LB-263: Pancreatic cancer prognosis is predicted by chromatin accessibility microarray

Surajit Dhara, Sagar Chhangawala, Himanshu Chintalapudi, Alexandra L. Massa, Victoria Aveson, Gokce Askan, Liguo Zhang, Remy Nicolle, Alvin P. Makohon-Moore, Smrita Sinha, Jiang Gui, Richard Moffitt, Kenneth H. Yu, Vinod Balachandran, Rohit Chandwani, Christina Leslie, Steven D. Leach
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-263.
https://doi.org/10.1158/1538-7445.AM2020-LB-263
Published: 15 August 2020
View articletitled, Abstract LB-263: Pancreatic cancer prognosis is predicted by chromatin accessibility microarray
Journal Articles

Abstract 3384: Genome-wide epigenetic and transcriptional comparison of CD8 T cell functional states between mouse models of cancer and chronic viral infection

Yuri Pritykin, Christina Leslie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3384.
https://doi.org/10.1158/1538-7445.AM2019-3384
Published: 01 July 2019
View articletitled, Abstract 3384: Genome-wide epigenetic and transcriptional comparison of CD8 T cell functional states between mouse models of cancer and chronic viral infection
Journal Articles

Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers

Erik Ladewig, Lauren Fairchild, Maurizio Scaltriti, Christina Leslie, Eneda Toska, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4346.
https://doi.org/10.1158/1538-7445.AM2019-4346
Published: 01 July 2019
View articletitled, Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers
Journal Articles

Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

Hatice Ulku Osmanbeyoglu, Fumiko Shimizu, Angela Rynne-Vidal, Tsz-Lun Yeung, Petar Jelinic, Samuel C. Mok, Gabriela Chiosis, Douglas A. Levine, Christina Leslie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3370.
https://doi.org/10.1158/1538-7445.AM2019-3370
Published: 01 July 2019
View articletitled, Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers
Journal Articles

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

Eneda Toska, Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Jordan Otto, Yanyan Cai, Carmen Chan, Drew R. D' Avino, Clayton Collings, Ross L. Levine, Maurizo Scaltriti, Jorge S. Reis-Filho, Cigall Kadoch, Christina Leslie, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 949.
https://doi.org/10.1158/1538-7445.AM2019-949
Published: 01 July 2019
View articletitled, Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer
Journal Articles

Abstract LB-238: Genome wide cis-regulatory elements accessibility signature predicts early recurrence of the treatment-naïve resected subset of PDAC: A new paradigm for precision oncology

Surajit Dhara, Sagar Chhangawala, Gokce Askan, Zhang Liguo, Smrita Sinha, Danielle Glassman, Kenneth Yu, Vinod Balachandran, Christina Leslie, Steven Leach
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-238.
https://doi.org/10.1158/1538-7445.AM2018-LB-238
Published: 01 July 2018
View articletitled, Abstract LB-238: Genome wide cis-regulatory elements accessibility signature predicts early recurrence of the treatment-naïve resected subset of PDAC: A new paradigm for precision oncology
Journal Articles

Abstract 282: Inferring transcriptional regulatory programs in gynecological cancers

Hatice U. Osmanbeyoglu, Petar Jelinic, Douglas Douglas, Christina Leslie
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 282.
https://doi.org/10.1158/1538-7445.AM2018-282
Published: 01 July 2018
View articletitled, Abstract 282: Inferring transcriptional regulatory programs in gynecological cancers
Journal Articles

Abstract B37: RNAi and CRISPR/Cas9-based in vivo models for drug discovery

Prem K. Premsrirut, Chia-Lin Wang, Yu-ting Yang, Rafii Pelossof, Christina Leslie, Christof Fellmann, Lukas Dow, Johannes Zuber, Scott Lowe
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): B37.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-B37
Published: 14 May 2018
View articletitled, Abstract B37: RNAi and CRISPR/Cas9-based in vivo models for drug discovery
Journal Articles

Abstract LB-010: Modeling the impact of mutations in ubiquitin pathway genes across human cancers

Hatice U. Osmanbeyoglu, Christina Leslie
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-010.
https://doi.org/10.1158/1538-7445.AM2017-LB-010
Published: 01 July 2017
View articletitled, Abstract LB-010: Modeling the impact of mutations in ubiquitin pathway genes across human cancers
Journal Articles

Abstract 781: Modeling the impact of somatic alterations across human cancers

Hatice U. Osmanbeyoglu, Eneda Toska, José Baselga, Christina Leslie
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 781.
https://doi.org/10.1158/1538-7445.AM2016-781
Published: 15 July 2016
View articletitled, Abstract 781: Modeling the impact of somatic alterations across human cancers
Journal Articles

Abstract 4078: KRAS mutation status is associated with stromal inactivation in colorectal cancer and predicts poor response to neoadjuvant chemoradiotherapy

Raphael Pelossof, Moshe Elkatebts, Oliver Chow, Lauren Fairchild, Kevin O’Rourke, Jesse J. Smith, Chin-Tung Chen, Samuel Brook, Maurizio Scaltriti, Jinru Shia, Philip Paty, Christina Leslie, Scott Lowe, Jose Baselga, Julio Garcia-Aguilar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4078.
https://doi.org/10.1158/1538-7445.AM2016-4078
Published: 15 July 2016
View articletitled, Abstract 4078: KRAS mutation status is associated with stromal inactivation in colorectal cancer and predicts poor response to neoadjuvant chemoradiotherapy
Journal Articles

Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer

Eneda Toska, Hatice Osmanbeyoglu, Moshe Elkabets, Carmen Chan, Pau Castel, Maura Dickler, Scott Armstrong, Christina Leslie, Maurizio Scaltriti, Baselga José
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 885.
https://doi.org/10.1158/1538-7445.AM2016-885
Published: 15 July 2016
View articletitled, Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer
Journal Articles

Abstract IA18: A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks

Lisa Sevenich, Robert Bowman, Steve Mason, Daniela Quail, Franck Rapaport, Benelita Elie, Edi Brogi, Priscilla Brastianos, William Hahn, Leslie Holsinger, Joan Massagué, Christina Leslie, Johanna A. Joyce
Journal: Cancer Research
Cancer Res (2015) 75 (1_Supplement): IA18.
https://doi.org/10.1158/1538-7445.CHTME14-IA18
Published: 12 January 2015
View articletitled, Abstract IA18: A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks
Journal Articles

Abstract 2844: Systems biology analysis of tumor and stromal genes in different metastatic microenvironments

Lisa Sevenich, Steve Mason, Franck Rapaport, Joan Massague, Christina Leslie, Johanna Joyce
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2844.
https://doi.org/10.1158/1538-7445.AM2011-2844
Published: 15 April 2011
View articletitled, Abstract 2844: Systems biology analysis of tumor and stromal genes in different metastatic microenvironments