1-17 of 17
Christian Schnell
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 3934: Determination of the PI3Kα selective inhibitor alpelisib mechanism of action and efficacy in ER+/ PIK3CA mutant breast cancer preclinical models

Christine Fritsch, Estelle Pfister, Nicolas Ebel, Daniel Guthy, Christian Schnell, Francesco Hofmann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3934.
https://doi.org/10.1158/1538-7445.AM2018-3934
Published: 01 July 2018
View article titled, Abstract 3934: Determination of the PI3Kα selective inhibitor alpelisib mechanism of action and efficacy in ER+/ PIK3CA mutant breast cancer preclinical models
Journal Articles

Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition

Barbara Herkert, Audrey Kauffmann, Sandra Mollé, Christian Schnell, Thomas Ferrat, Hans Voshol, Janina Juengert, Hélène Erasimus, Grégory Marszalek, Malika Kazic-Legueux, Eric Billy, David Ruddy, Mark Stump, Daniel Guthy, Mitko Ristov, Keith Calkins, Sauveur-Michel Maira, William R. Sellers, Francesco Hofmann, Michael N. Hall, Saskia M. Brachmann
Journal: Cancer Research
Cancer Res (2016) 76 (2): 390–402.
https://doi.org/10.1158/0008-5472.CAN-14-3358
Published: 14 January 2016
View article titled, Maximizing the Efficacy of MAPK-Targeted Treatment in <em>PTEN</em><sup>LOF</sup><em>/BRAF</em><sup>MUT</sup> Melanoma through PI3K and IGF1R Inhibition
Open the PDF for Maximizing the Efficacy of MAPK-Targeted Treatment in <em>PTEN</em><sup>LOF</sup><em>/BRAF</em><sup>MUT</sup> Melanoma through PI3K and IGF1R Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 2058: Systematic evaluation of drug combinations in vitro and in vivo.

Marion Wiesmann, Mark Stump, Giordano Caponigro, David Duhl, Brant Firestone, Tom Gesner, Bjoern Gruenenfelder, Daniel Alexander Guthy, Jocelyn Holash, Fred King, Joseph Lehar, Christophe Leroy, Manway Liu, Lilli Petruzelli, Dale Porter, Paul McSheehy, Daniel Menezes, Anupama Reddy, Johannes Roesel, Christian Schnell, Timothy R. Smith, Markus Wartmann
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2058.
https://doi.org/10.1158/1538-7445.AM2013-2058
Published: 15 April 2013
View article titled, Abstract 2058: Systematic evaluation of drug combinations <em>in vitro</em> and <em>in vivo</em>.
Journal Articles

Abstract 3748: NVP-BYL719, a novel PI3Kalpha selective inhibitor with all the characteristics required for clinical development as an anti-cancer agent

Christine M. Fritsch, Christian Schnell, Christian Chatenay-Rivauday, Daniel A. Guthy, Alain De Pover, Markus Wartmann, Saskia Brachmann, Sauveur-Michel Maira, Alan Huang, Cornelia Quadt, Francesco Hofmann, Giorgio Caravatti
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3748.
https://doi.org/10.1158/1538-7445.AM2012-3748
Published: 15 April 2012
View article titled, Abstract 3748: NVP-BYL719, a novel PI3Kalpha selective inhibitor with all the characteristics required for clinical development as an anti-cancer agent
Journal Articles

Abstract 4466: Characterization of the pan class I PI3K inhibitor NVP-BKM120 mechanism of action across a broad range of concentrations

Saskia M. Brachmann, Julia Kleylein-Sohn, Swann Gaulis, Frederic Stauffer, Johannes Voshol, Daniel Guthy, Christopher Wilson, Alan Huang, Markus Wartmann, Thomas Bruemmendorf, Patrick Chene, Christine Fritsch, Wolfgang Hackl, Jan Cosaert, Christian Schnell, Francesco Hofmann, Michel Maira
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4466.
https://doi.org/10.1158/1538-7445.AM2011-4466
Published: 15 April 2011
View article titled, Abstract 4466: Characterization of the pan class I PI3K inhibitor NVP-BKM120 mechanism of action across a broad range of concentrations
Journal Articles

Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials

charles F. Voliva, Sabina Pecchi, Matthew Burger, Tobi Nagel, Christian Schnell, christine Fritsch, saskia Brachmann, Daniel Menezes, Mark Knapp, Kevin Shoemaker, Marion Wiesmann, kay Huh, Isabel Zaror, Marion Dorsch, William R. Sellers, Carlos Garcia-Echeverria, Michel Maira
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4498.
https://doi.org/10.1158/1538-7445.AM10-4498
Published: 15 April 2010
View article titled, Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials
Journal Articles

Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models

Michel Maira, Daniel Menezes, Sabina Pecchi, Kevin Shoemaker, Matthew Burger, christian Schnell, christine Fritsch, Saskia Brachmann, Tobi Nagel, William R. Sellers, Carlos Garcia-Echeverria, Marion Wiesmann, charles F. Voliva
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4497.
https://doi.org/10.1158/1538-7445.AM10-4497
Published: 15 April 2010
View article titled, Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models
Journal Articles

Abstract #4006: Effects of anesthesia on host and tumor physiology: impact on bioluminescence measurements when compared to conscious mice

Christian Schnell, Arnal Samuel, Welsch Axelle, Jensen Michael, Garcia-Echeverria Carlos, Cozens Robert
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4006.
Published: 01 May 2009
View article titled, Abstract #4006: Effects of anesthesia on host and tumor physiology: impact on bioluminescence measurements when compared to conscious mice
Journal Articles

Abstract #2817: Ex vivo and in vivo effects of NVP-BEZ235, a dual pan-PI3K / mTOR inhibitor, on insulin signaling and metabolic regulation.

Christian Schnell, Saskia Brachmann, Samuel Arnal, Christine Fritsch, Carlos Garcia-Echeverria, Michel Sauveur-Maira
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2817.
Published: 01 May 2009
View article titled, Abstract #2817: <em>Ex vivo</em> and <em>in v</em>ivo effects of NVP-BEZ235, a dual pan-PI3K / mTOR inhibitor, on insulin signaling and metabolic regulation.
Journal Articles

Integrative approaches to investigate the molecular basis of the in vivo activity of NVP-BEZ235, a dual pan-PI3K / mTOR inhibitor

Estelle Marrer, Sauveur-Michel Maira, Carlos Garcia-Echeverria, Christian Schnell
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 215.
Published: 01 May 2008
View article titled, Integrative approaches to investigate the molecular basis of the <em>in vivo</em> activity of NVP-BEZ235, a dual pan-PI3K / mTOR inhibitor
Journal Articles

Efficacy of the HSP90 inhibitor NVP-AUY922 correlates with decreased vessel permeability and reduced interstitial fluid pressure

Michael Jensen, Christian Schnell, Paul McSheehy, Joseph Schoepfer, Josef Brueggen, Cornelia Quadt, Robert Cozens, Carlos Garcia-Echeverria, Patrick Chene
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2452.
Published: 01 May 2008
View article titled, Efficacy of the HSP90 inhibitor NVP-AUY922 correlates with decreased vessel permeability and reduced interstitial fluid pressure
Journal Articles

Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics

Patrizia Sini, Ivana Samarzija, Fabienne Baffert, Amanda Littlewood-Evans, Christian Schnell, Andreas Theuer, Sven Christian, Anja Boos, Holger Hess-Stumpp, John A. Foekens, Buddy Setyono-Han, Jeanette Wood, Nancy E. Hynes
Journal: Cancer Research
Cancer Res (2008) 68 (5): 1581–1592.
https://doi.org/10.1158/0008-5472.CAN-06-4685
Published: 03 March 2008
View article titled, Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics
Open the PDF for Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics in another window
Includes: Supplementary data
Journal Articles

Biochemical, cellular and in vivo profiling of a new PI3K inhibitor from the imidazoquinoline series

Frederic Stauffer, Carlos Garcia-Echeverria, Pascal Furet, Christian Schnell, Stephan Ruetz, Michel Maira, Christine FRITSCH
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 269.
Published: 01 May 2007
View article titled, Biochemical, cellular and in vivo profiling of a new PI3K inhibitor from the imidazoquinoline series
Journal Articles

Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization

Kenneth LaMontagne, Amanda Littlewood-Evans, Christian Schnell, Terence O'Reilly, Lorenza Wyder, Teresa Sanchez, Beatrice Probst, Jeannene Butler, Alexander Wood, Gene Liau, Eric Billy, Andreas Theuer, Timothy Hla, Jeanette Wood
Journal: Cancer Research
Cancer Res (2006) 66 (1): 221–231.
https://doi.org/10.1158/0008-5472.CAN-05-2001
Published: 05 January 2006
View article titled, Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization
Open the PDF for Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization in another window
Journal Articles

Characterization of the effects of a small molecular weight inhibitor on IGF-I induced angiogenesis

Christian Schnell, Georg Martiny-Baron, Jeanette Wood, Francesco Hofmann, Hansgeorg Capraro, Doriano Fabbro, Pascal Furet, Carlos Garcia-Echeverria, Jurgen Mestan, Thomas Meyer, Mark A. Pearson
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 358.
Published: 01 May 2005
View article titled, Characterization of the effects of a small molecular weight inhibitor on IGF-I induced angiogenesis
Journal Articles

PTK787/ZK222584, a VEGFR tyrosine kinase inhibitor, effectively targets immature vessels in an orthotopic melanoma model

Amanda J. Littlewood-Evans, Christian Schnell, Beatrice Probst, Hans Peter Mueller, Marina Maurer, Andreas Theuer, Georg Martiny-Baron, Jeanette Wood
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 596.
Published: 01 April 2004
View article titled, PTK787/ZK222584, a VEGFR tyrosine kinase inhibitor, effectively targets immature vessels in an orthotopic melanoma model
Journal Articles

PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration

Jeanette M. Wood, Guido Bold, Elizabeth Buchdunger, Robert Cozens, Stefano Ferrari, Jörg Frei, Francesco Hofmann, Jürgen Mestan, Helmut Mett, Terence O’Reilly, Elke Persohn, Johannes Rösel, Christian Schnell, David Stover, Andreas Theuer, Harry Towbin, Fritz Wenger, Kathie Woods-Cook, Andreas Menrad, Gerhard Siemeister, Michael Schirner, Karl-Heinz Thierauch, Martin R. Schneider, Joachim Drevs, Georg Martiny-Baron, Frank Totzke, Dieter Marmé
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2178–2189.
Published: 01 April 2000
View article titled, PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration
Open the PDF for PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration in another window