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Journal Articles

Abstract 5340: Novel small-molecule antagonists of the PD1/PD-L1 axis

Romain Magnez, Natascha Leleu-Chavain, Morgane Tardy, Hassiba El Bouazzati, Fréderique Klupsch, Christian Bailly, Régis Millet, Bruno Quesnel, Xavier Thuru
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5340.
https://doi.org/10.1158/1538-7445.AM2020-5340
Published: 15 August 2020
View article titled, Abstract 5340: Novel small-molecule antagonists of the PD1/PD-L1 axis
Journal Articles

Abstract 2428: Translational study of F14512, a novel vectorised epipodophyllotoxin, which demonstrates a marked activity on ovarian cancer models from patients

Benoît Thibault, Gregoire Zorza, Samuel Meignan, Nicolas Guilbaud, Christian Bailly, Jean-Pierre Delord, Bettina Couderc, Anna Kruczynski, Pierre Ferre, Jean-Philippe Annereau
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2428.
https://doi.org/10.1158/1538-7445.AM2015-2428
Published: 01 August 2015
View article titled, Abstract 2428: Translational study of F14512, a novel vectorised epipodophyllotoxin, which demonstrates a marked activity on ovarian cancer models from patients
Journal Articles

Abstract 1219: Patient-derived tumor models of resistant metastatic melanoma

Bruno Gomes, Céline ROBICHON, Arnaud Pillon, Jean-Philippe Annereau, Sandrine Pourtau, Jean-Christophe Blanchet, Aline Stennevin, Karim Bedjeguelal, Philippe Rochaix, Ignacio Garrido-Stowhas, Laurence Lamant, Nicolas Meyer, Nicolas Guilbaud, Christian Bailly, Anna Kruczynski
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1219.
https://doi.org/10.1158/1538-7445.AM2014-1219
Published: 01 October 2014
View article titled, Abstract 1219: Patient-derived tumor models of resistant metastatic melanoma
Journal Articles

Abstract 5565: Tumor targeting and enhanced efficacy of novel polyamine-cytotoxic conjugates.

Frédéric Liéby-Muller, Jean-Philippe Annereau, Viviane Brel, Frédéric Marion, Yves Guminski, Florence Redoules, Nathalie de Saint Jores, Karine André, Anna Kruczynski, Christian Bailly, Nicolas Guilbaud
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5565.
https://doi.org/10.1158/1538-7445.AM2013-5565
Published: 15 April 2013
View article titled, Abstract 5565: Tumor targeting and enhanced efficacy of novel polyamine-cytotoxic conjugates.
Journal Articles

Abstract 988: F14512, a novel vectorized topoiserase II inhibitor, bypasses MDR1 mediated resistance.

Jean Philippe Annereau, Viviane Brel, William Riquet, Laurent Créancier, Isabelle Vandenberghe, Emmanuel Fournier, Céline Robichon, Aline Stennevin, Vanessa Offrete, Laurence Lacastaigneratte, Bruno Gomes, Anna Kruczynski, Christian Bailly, Nicolas Guilbaud
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 988.
https://doi.org/10.1158/1538-7445.AM2013-988
Published: 15 April 2013
View article titled, Abstract 988: F14512, a novel vectorized topoiserase II inhibitor, bypasses MDR1 mediated resistance.
Journal Articles

Abstract 3799: Polyamine Transport System (PTS) activity and hijacking in cancer cells: New option in Head and Neck tumors treatment with the polyamine-containing drug candidate F14512

Samuel Meignan, Francois Mouawad, Amelie Dewitte, Charlotte Bertheau, Nicole Wattez, Abigaelle Gros, Eric Lartigau, Dominique Chevalier, Christian Bailly, Amelie Lansiaux
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3799.
https://doi.org/10.1158/1538-7445.AM2012-3799
Published: 15 April 2012
View article titled, Abstract 3799: Polyamine Transport System (PTS) activity and hijacking in cancer cells: New option in Head and Neck tumors treatment with the polyamine-containing drug candidate F14512
Journal Articles

Abstract 1925: Trifluoromethylated artemisinin dimers demonstrate a potent anti-cancer activity in vitro and in vivo

Jacques Fahy, Frederic Marion, Frederic Lieby-Muller, Celine Mordant, Stephane Vispe, Viviane Brel, Bruno Gomes, Jean-Philippe Annereau, Constance Chollet, Anaïs Fournial, Benoit Crousse, Daniele Bonnet-Delpon, Anna Kruczynski, Christian Bailly, Nicolas Guilbaud
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1925.
https://doi.org/10.1158/1538-7445.AM2012-1925
Published: 15 April 2012
View article titled, Abstract 1925: Trifluoromethylated artemisinin dimers demonstrate a potent anti-cancer activity in vitro and in vivo
Journal Articles

Abstract 2747: Synergistic antileukemic activity of F14512 in combination with AraC

Isabelle Vandenberghe-Huez, Arnaud Pillon, Laurent Créancier, Bruno Gomes, Jean-Philippe Annereau, Emmanuel Fournier, Viviane Brel, Valérie Cartron, Nathalie Chansard, Sandrine Pourtau, Sabine Roy, Jean-Christophe Blanchet, Jérôme Verdier, Caroline Dejean, Christel Ricome, Vanessa Offrete, Stéphane Gras, Karine André, Yves Guminski, Christian Bailly, Nicolas Guilbaud, Anna Kruczynski
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2747.
https://doi.org/10.1158/1538-7445.AM2012-2747
Published: 15 April 2012
View article titled, Abstract 2747: Synergistic antileukemic activity of F14512 in combination with AraC
Journal Articles

Abstract 3518: In vitro and in vivo synergistic effects of F14512, a novel targeted cytotoxic agent in phase I clinical study, in combination with other anticancer drugs

Isabelle Vandenberghe, Jean-Philippe Annereau, Viviane Brel, Stéphane Vispe, Jean-Marc Barret, Bruno GOMES, Vanessa Offrete, Karine Andre, Sabine Roy, Caroline Castano, Fiona Celestin, Yves Guminski, Thierry Imbert, Anna Kruczynski, Nicolas Guilbaud, Christian Bailly
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3518.
https://doi.org/10.1158/1538-7445.AM2011-3518
Published: 15 April 2011
View article titled, Abstract 3518: In vitro and in vivo synergistic effects of F14512, a novel targeted cytotoxic agent in phase I clinical study, in combination with other anticancer drugs
Journal Articles

Abstract 4571: 515H7, a novel anti-CXCR4 antibody: In vitro efficacy on CXCR4-associated signaling pathways and in vivo anti-tumor activity

Nathalie Corvaia, Sven Berger, Thierry Wurch, Nicolas Boute, Matthieu Broussas, Charlotte Beau-Larvor, Barbara Akla, Alain Robert, Jean-François Haeuw, Liliane Goetsch, Christian Bailly, Christine Klinguer-Hamour
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4571.
https://doi.org/10.1158/1538-7445.AM2011-4571
Published: 15 April 2011
View article titled, Abstract 4571: 515H7, a novel anti-CXCR4 antibody: In vitro efficacy on CXCR4-associated signaling pathways and in vivo anti-tumor activity
Journal Articles

Abstract 3261: Novel hemisynthetic derivatives of Amaryllidaceae alkaloids exert antitumor activity on xenograft melanoma models

Jean-Philippe Annereau, Frédéric Marion, Emmanuel Fournier, Isabelle Vandenberghe, Stéphane Vispé, Isabelle Pouny, François Sautel, Yannick Aussagues, Frédéric Ausseil, Bruno Gomes, Jacques Fahy, Christian Bailly, Anna Kruczynski, Nicolas Guilbaud
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3261.
https://doi.org/10.1158/1538-7445.AM2011-3261
Published: 15 April 2011
View article titled, Abstract 3261: Novel hemisynthetic derivatives of Amaryllidaceae alkaloids exert antitumor activity on xenograft melanoma models
Journal Articles

Abstract 4580: A novel role for Junctional Adhesion Molecule-A (JAM-A) in tumor proliferation: modulation by a humanized anti-JAM-A monoclonal antibody

Liliane Goetsch, Jean-François Haeuw, Matthieu Broussas, Thierry Wurch, Charlotte Beau-Larvor, Alain Robert, Christian Bailly, Nathalie Corvaia
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4580.
https://doi.org/10.1158/1538-7445.AM2011-4580
Published: 15 April 2011
View article titled, Abstract 4580: A novel role for Junctional Adhesion Molecule-A (JAM-A) in tumor proliferation: modulation by a humanized anti-JAM-A monoclonal antibody
Journal Articles

Abstract 5461: Novel antitumor amino-pancratistatin derivatives inhibitors of protein and DNA synthesis

Frederic Marion, Jean-Philippe Annereau, Stephane Vispe, Isabelle Vandenberghe, Florence Redoules, Aline Stennevin, Stephane Gras, Sabine Roy, Caroline Castano, Anna Kruczynski, Jean-Marc Barret, Nicolas Guilbaud, Christian Bailly, Jacques Fahy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5461.
https://doi.org/10.1158/1538-7445.AM10-5461
Published: 15 April 2010
View article titled, Abstract 5461: Novel antitumor amino-pancratistatin derivatives inhibitors of protein and DNA synthesis
Journal Articles

Abstract 2448: h224G11, a humanized whole antibody targeting the c-Met receptor, induces c-Met down-regulation and triggers ADCC functions

Liliane Goetsch, Matthieu Broussas, Stéphanie Fabre-Lafay, Alain Robert, Anne-Marie Lepecquet, Alexandra Gonzalez, Thierry Wurch, Christian Bailly, Nathalie Corvaia
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2448.
https://doi.org/10.1158/1538-7445.AM10-2448
Published: 15 April 2010
View article titled, Abstract 2448: h224G11, a humanized whole antibody targeting the c-Met receptor, induces c-Met down-regulation and triggers ADCC functions
Journal Articles

Abstract #3771: Triptolide inhibits RNA polymerase I and II-dependent transcription leading predominantly to downregulation of short half-life RNAs

Stéphane Vispé, Stéphane Gras, Natacha Novosad, Luc DeVries, Fabrice Lestienne, Didier Cussac, David Hobson, Jesper Svejstrup, Jérome Verdier, Laurent Créancier, Aline Stennevin, Jean-Philippe Annereau, Emeline Cros, Dumontet Charles, Nicolas Guilbaud, Jean-Marc Barret, Christian Bailly
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3771.
Published: 01 May 2009
View article titled, Abstract #3771: Triptolide inhibits RNA polymerase I and II-dependent transcription leading predominantly to downregulation of short half-life RNAs
Journal Articles

Abstract #1701: Potent antitumor effect of F14512, a novel targeted cytotoxic agent, in an orthotopic glioblastoma model, as evaluated with non invasive optical imaging using in vivo bioluminescence spectral properties

Arnaud Pillon, Sabrina Pesnel, Bruno Gomes, Christel Ricome, Yoann Menon, Jean-Christophe Blanchet, Laurent Creancier, Jean-Marc Barret, Nicolas Guilbaud, Anna Kruczynski, Stéphanie Lerondel, Alain Le Pape, Christian Bailly
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1701.
Published: 01 May 2009
View article titled, Abstract #1701: Potent antitumor effect of F14512, a novel targeted cytotoxic agent, in an orthotopic glioblastoma model, as evaluated with non invasive optical imaging using <em>in vivo</em> bioluminescence spectral properties
Journal Articles

Abstract #835: First bivalent fully antagonist anti-c-Met antibody targeting the c-Met receptor: I) in vitro mechanism of action

Nathalie Corvaïa, Alexandra Gonzalez, Nicolas Boute, Charlotte Beau-Larvor, Stéphanie Fabre-Lafay, Fabien Géronimi, Matthieu Broussas, Anne-Marie Lepecquet, Alain Robert, Thierry Wurch, Jean-François Haeuw, Christian Bailly, Liliane Goetsch
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 835.
Published: 01 May 2009
View article titled, Abstract #835: First bivalent fully antagonist anti-c-Met antibody targeting the c-Met receptor: I) <em>in vitro</em> mechanism of action
Journal Articles

Abstract #2792: First bivalent fully antagonist anti-c-Met antibody targeting the c-Met receptor: II) in vivo activity

Liliane Goetsch, Anne-Marie Lepecquet, Fabien Géronimi, Alexandra Gonzalez, Alain Robert, Stéphane Chenu, Jean-Claude Corbière, Christian Bailly, Nathalie Corvaïa
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2792.
Published: 01 May 2009
View article titled, Abstract #2792: First bivalent fully antagonist anti-c-Met antibody targeting the c-Met receptor: II) <em>in vivo</em> activity
Journal Articles

F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System

Jean-Marc Barret, Anna Kruczynski, Stéphane Vispé, Jean-Philippe Annereau, Viviane Brel, Yves Guminski, Jean-Guy Delcros, Amélie Lansiaux, Nicolas Guilbaud, Thierry Imbert, Christian Bailly
Journal: Cancer Research
Cancer Res (2008) 68 (23): 9845–9853.
https://doi.org/10.1158/0008-5472.CAN-08-2748
Published: 01 December 2008
View article titled, F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System
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Includes: Supplementary data
Journal Articles

F14512, a novel antitumor agent targeted to tumors expressing a high level of the polyamine transport system

Isabelle Vandenberghe-Huez, Viviane Brel, Jean-Philippe Annereau, Nathalie Chansard, Aline Stennevin, Karine Andre, Vanessa Tillement, Sabine roy, Marie-Laure Marionneau, Sandrine Pourtau, Vanessa Offrete, Caroline Castano, Valerie Cartron, Arnaud Pillon, Sabrina Pesnel, Alain Le Pape, Yves Guminski, Thierry Imbert, Jean-Marc Barret, Anna Kruczynski, Nicolas Guilbaud, Christian Bailly
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1595.
Published: 01 May 2008
View article titled, F14512, a novel antitumor agent targeted to tumors expressing a high level of the polyamine transport system