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Chiung-Tong Chen
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Journal Articles

Abstract 5806: Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus

Ya-Hui Chi, Chun-Ping Chang, Teng-Kuang Yeh, Chiung-Tong Chen, Wan-Ping Wang, Yen-Ting Chen, Chia-Hua Tsai, Yan-Fu Chen, Yi-Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chen-Lung Huang, Ya-Ping Chen, Hong Zhuang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5806.
https://doi.org/10.1158/1538-7445.AM2024-5806
Published: 22 March 2024
View articletitled, Abstract 5806: Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
Journal Articles

Abstract 523: Targeting myc-amplified cancers with a novel prodrug inhibiting aurora A kinase

Ya-Hui Chi, Chun-Ping Chang, Teng-Kuang Yeh, Wan-Ping Wang, Yen-Ting Chen, Chia-Hua Tsai, Yan-Fu Chen, Yi-Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 523.
https://doi.org/10.1158/1538-7445.AM2023-523
Published: 04 April 2023
View articletitled, Abstract 523: Targeting myc-amplified cancers with a novel prodrug inhibiting aurora A kinase
Journal Articles

Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Ya-Hui Chi, Chun-Ping Chang, Yi-Yu Ke, Wen-Hsing Lin, Wan-Ping Wang, Chia-Hua Tsai, Yen-Ting Chen, Yu-Jie Su, Ming-Chun Hung, Zhong-Wei Wu, Mine-Hsine Wu, Teng-Kuang Yeh, Ching-Ping Chen, Jen-Shin Song, Chiung-Tong Chen, Chuan Shih
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1937.
https://doi.org/10.1158/1538-7445.AM2020-1937
Published: 15 August 2020
View articletitled, Abstract 1937: BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification
Journal Articles

Abstract 4626: Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216

Ching-Chuan Kuo, Weir-Torn Jiaang, Jing-Jim Ou, Chiung-Tong Chen, Shu-Ching Hsu, Chuan Shih, Li-Mei Lin, Manwu Sun, Yi-Hsin Wang, Zih-Ting Huang, Jang-Yang Chang, Shau-Hua Ueng
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4626.
https://doi.org/10.1158/1538-7445.AM2019-4626
Published: 01 July 2019
View articletitled, Abstract 4626: Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216
Journal Articles

Abstract 227: BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

Chia-Yu Hsu, Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Ching-Ping Chen, Chen-Lung Huang, Chung-Yu Huang, Min-Hsien Wang, Yu-Sheng Chao, Joe C. Shih, Teng-Kuang Yeh, Lun K. Tsou, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 227.
https://doi.org/10.1158/1538-7445.AM2019-227
Published: 01 July 2019
View articletitled, Abstract 227: BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
Journal Articles

Abstract 1664: 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo

Shau-Hua Ueng, Ching-Chuan Kuo, Shu-Yu Lin, Teng-Kuang Yeh, Jen-Shin Song, Ming-Shiu Hung, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1664.
https://doi.org/10.1158/1538-7445.AM2018-1664
Published: 01 July 2018
View articletitled, Abstract 1664: 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo
Journal Articles

Abstract 4413: Zinc-dipicolylamine directed pharmaceutical delivery system (ZAPS) as an innovative cancer drug delivery platform

Lun K. Tsou, Yu-Wei Liu, Yun-Yu Chen, Chen-Fu Lo, Teng-Kuang Yeh, Chien-Huang Wu, Kak-Shan Shia, Joe C. Shih, Brian D. Gary, Koon Y. Pak, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4413.
https://doi.org/10.1158/1538-7445.AM2015-4413
Published: 01 August 2015
View articletitled, Abstract 4413: Zinc-dipicolylamine directed pharmaceutical delivery system (ZAPS) as an innovative cancer drug delivery platform
Journal Articles

Abstract 1756: Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma

Hui-Yi Shiao, Tsu-An Hsu, Wen-Hsing Lin, Tsong-Toh Yang, Hui-Fang Hsieh, Chiung-Tong Chen, Teng-Kuang Yeh, Hsing-Pang Hsieh
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1756.
https://doi.org/10.1158/1538-7445.AM2014-1756
Published: 01 October 2014
View articletitled, Abstract 1756: Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma
Journal Articles

Abstract 3527: YYEI motif is critical to oncogenicity of 14-3-3 proteins

Wen-Hsin Chang, Ching-Hsien Chen, Qi-Sheng Hong, Jian-Wei Chen, Sung-Liang Yu, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3527.
https://doi.org/10.1158/1538-7445.AM2014-3527
Published: 01 October 2014
View articletitled, Abstract 3527: YYEI motif is critical to oncogenicity of 14-3-3 proteins
Journal Articles

DBPR204, a tubulin-binding agent orally active against human colorectal tumor xenografts in nude mice

Heng-Liang Lin, Ching-Ping Chen, Yu-Kang Lo, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1390–1391.
Published: 01 May 2005
View articletitled, DBPR204, a tubulin-binding agent orally active against human colorectal tumor xenografts in nude mice
Journal Articles

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

Ching-Chuan Kuo, Hsing-Pang Hsieh, Wen-Yu Pan, Ching-Ping Chen, Jing-Ping Liou, Shiow-Ju Lee, Yi-Ling Chang, Li-Tzong Chen, Chiung-Tong Chen, Jang-Yang Chang
Journal: Cancer Research
Cancer Res (2004) 64 (13): 4621–4628.
https://doi.org/10.1158/0008-5472.CAN-03-3474
Published: 01 July 2004
View articletitled, BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo
Open the PDF for BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo in another window
Journal Articles

Involvement of phosphatidylinositol 3-kinase α (PI3K-α) in gastric cancer metastasis in mice

Heng-Liang Lin, Chiung-Tong Chen
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 299.
Published: 01 April 2004
View articletitled, Involvement of phosphatidylinositol 3-kinase α (PI3K-α) in gastric cancer metastasis in mice
Journal Articles

Anti-cancer activity of N-heterocyclic indolyl glyoxylamides

Jiunn Jye Chuu, Chiung Tong Chen
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1185.
Published: 01 April 2004
View articletitled, Anti-cancer activity of N-heterocyclic indolyl glyoxylamides
Journal Articles

BPR0L075, a novel synthetic indole compound with anti-mitotic activity in multidrug-sensitive and -resistant human tumor cell lines, and exerts effective antitumoral activity in vivo

Ching-Chuan Kuo, Hsing-Pang Hsieh, Wen-Yu Pan, Jing-Ping Liou, Li-Tzong Chen, Chiung-Tong Chen, Jang-Yang Chang
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1254–1255.
Published: 01 April 2004
View articletitled, BPR0L075, a novel synthetic indole compound with anti-mitotic activity in multidrug-sensitive and -resistant human tumor cell lines, and exerts effective antitumoral activity in vivo
Journal Articles

Androgen-dependent and -independent Human Prostate Xenograft Tumors as Models for Drug Activity Evaluation

Chiung-Tong Chen, Yuebo Gan, Jessie L-S. Au, M. Guillaume Wientjes
Journal: Cancer Research
Cancer Res (1998) 58 (13): 2777–2783.
Published: 01 July 1998
View articletitled, Androgen-dependent and -independent Human Prostate Xenograft Tumors as Models for Drug Activity Evaluation
Open the PDF for Androgen-dependent and -independent Human Prostate Xenograft Tumors as Models for Drug Activity Evaluation in another window
Journal Articles

Pharmacodynamics of Immediate and Delayed Effects of Paclitaxel: Role of Slow Apoptosis and Intracellular Drug Retention

Jessie L-S. Au, Dong Li, Yuebo Gan, Xiang Gao, Andrew L. Johnson, Jeffrey Johnston, Nancy J. Millenbaugh, Seong H. Jang, Hyo-Jeong Kuh, Chiung-Tong Chen, M. Guillaume Wientjes
Journal: Cancer Research
Cancer Res (1998) 58 (10): 2141–2148.
Published: 01 May 1998
View articletitled, Pharmacodynamics of Immediate and Delayed Effects of Paclitaxel: Role of Slow Apoptosis and Intracellular Drug Retention
Open the PDF for Pharmacodynamics of Immediate and Delayed Effects of Paclitaxel: Role of Slow Apoptosis and Intracellular Drug Retention in another window