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Journal Articles

Abstract LB114: Colon cancer preventive efficacy of ONC201 and naproxen alone or in combination in FAP relevant PIRC rat model

Venkateshwar Madka, Gopal Pathuri, Karthikkumar Venkatachalam, Srikanth Chiliveru, Yuting Zhang, Nandini Kumar, Nicole Stratton, Stanley Lightfoot, Mark S. Miller, Shizuko Sei, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB114.
https://doi.org/10.1158/1538-7445.AM2023-LB114
Published: 14 April 2023
View article titled, Abstract LB114: Colon cancer preventive efficacy of ONC201 and naproxen alone or in combination in FAP relevant PIRC rat model
Journal Articles

Abstract 5255: Effect of STAT3 inhibitors, TTI-101 and SH5-07, against bladder cancer in preclinical 3D tumor models

Surya P. Singh, Gopal Pathuri, Adam Asch, Brian Cholewa, Robert Shoemaker, Chinthalapally V. Rao, Venkateshwar Madka
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5255.
https://doi.org/10.1158/1538-7445.AM2023-5255
Published: 04 April 2023
View article titled, Abstract 5255: Effect of STAT3 inhibitors, TTI-101 and SH5-07, against bladder cancer in preclinical 3D tumor models
Journal Articles

Abstract 5003: Gene expression to copy number alterations analysis in colorectal cancers: Organ specificity of transcriptomic impact on copy number alterations

Chinthalapally V. Rao, Chao Xu, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5003.
https://doi.org/10.1158/1538-7445.AM2022-5003
Published: 15 June 2022
View article titled, Abstract 5003: Gene expression to copy number alterations analysis in colorectal cancers: Organ specificity of transcriptomic impact on copy number alterations
Journal Articles

Abstract 2783: Increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression in normal colonic mucosa with imipridone ONC201/TIC10 treatment: A potential biomarker for chemoprevention studies

Alexander G. Raufi, Arielle De La Cruz, Andrew George, Sean Hacking, Venkateshwar Madka, Varun Prabhu, Howard Safran, Lanlan Zhou, Dean Brenner, Chinthalapally V. Rao, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2783.
https://doi.org/10.1158/1538-7445.AM2022-2783
Published: 15 June 2022
View article titled, Abstract 2783: Increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression in normal colonic mucosa with imipridone ONC201/TIC10 treatment: A potential biomarker for chemoprevention studies
Journal Articles

Abstract 3181: IL-23 knockdown profoundly suppresses intestinal tumorigenesis in APCmin mice

Venkateshwar Madka, Srikanth Chiliveru, Gopal Pathuri, Janani Panneerselvam, Rajani Rai, Nicole C. Stratton, Nandini B. Kumar, Yuting Zhang, Chinthalapally V Rao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3181.
https://doi.org/10.1158/1538-7445.AM2022-3181
Published: 15 June 2022
View article titled, Abstract 3181: IL-23 knockdown profoundly suppresses intestinal tumorigenesis in APC<sup>min</sup> mice
Journal Articles

Abstract LB074: Chymostatin, a cathepsin L inhibitor, inhibits lung cancer cell proliferation and COVID-19 Mpro in vitro

Nagendra Sastry Yarla, Gopal Pathuri, Simon Terzyan, Yuting Zhang, Anil Singh, Marcus T. Scotti, Venkateshwar Madka, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB074.
https://doi.org/10.1158/1538-7445.AM2021-LB074
Published: 01 July 2021
View article titled, Abstract LB074: Chymostatin, a cathepsin L inhibitor, inhibits lung cancer cell proliferation and COVID-19 M<sup>pro</sup> <em>in vitro</em>
Journal Articles

Abstract LB225: Colon cancer preventive efficacy of licofelone and its analogue LFA-9 in PIRC rat model of FAP

Venkateshwar Madka, Nagendra S. Yarla, Gopal Pathuri, Yuting Zhang, Anh Bao, Nicole C. Stratton, Anil Singh, David L. McCormick, Altaf Mohammed, Shizuko Sei, Jennifer Fox, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB225.
https://doi.org/10.1158/1538-7445.AM2021-LB225
Published: 01 July 2021
View article titled, Abstract LB225: Colon cancer preventive efficacy of licofelone and its analogue LFA-9 in PIRC rat model of FAP
Journal Articles

Abstract 1102: Model optimization and chemoprevention of IPMN driven PDAC in KPSD4 mouse model

Gaurav Kumar, Venkateshwar Madka, Anil Singh, Nandini Kumar, Nicole Stratton, Stanley Lightfoot, Altaf Mohammed, Mark S. Miller, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1102.
https://doi.org/10.1158/1538-7445.AM2020-1102
Published: 15 August 2020
View article titled, Abstract 1102: Model optimization and chemoprevention of IPMN driven PDAC in KPSD4 mouse model
Journal Articles

Abstract 13: Aspirin and metformin combination inhibits PDAC progression and metastasis in KPC mice

Altaf Mohammed, Venkateshwar Madka, Gaurav Kumar, Anil Singh, Nicole Stratton, Stanley Lightfoot, Mark S. Miller, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 13.
https://doi.org/10.1158/1538-7445.AM2020-13
Published: 15 August 2020
View article titled, Abstract 13: Aspirin and metformin combination inhibits PDAC progression and metastasis in KPC mice
Journal Articles

Abstract 14: TRAIL inducing small molecule ONC201 prevents intestinal tumors in FAP mouse model

Chinthalapally V. Rao, Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Niklas K. Finnberg, Howard P. Safran, Jennifer Fox, Shizuko Sei, Elizabeth R. Glaze, Robert Shoemaker, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 14.
https://doi.org/10.1158/1538-7445.AM2020-14
Published: 15 August 2020
View article titled, Abstract 14: TRAIL inducing small molecule ONC201 prevents intestinal tumors in FAP mouse model
Journal Articles

Abstract 15: Hypertension drug Olmesartan medoxomil promotes colonic tumorigenesis in AOM-induced CRC rat model

Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Anil Singh, Shizuko Sei, Jennifer Fox, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 15.
https://doi.org/10.1158/1538-7445.AM2020-15
Published: 15 August 2020
View article titled, Abstract 15: Hypertension drug Olmesartan medoxomil promotes colonic tumorigenesis in AOM-induced CRC rat model
Journal Articles

Abstract 16: LTA4 hydrolase inhibitor bestatin prevents intestinal tumors in APC mutant rodent models of FAP

Venkateshwar Madka, Gopal Pathuri, Hariprasad Gali, Nandini Kumar, Nagendra Sastri Yarla, Anh Bao, Adam S. Asch, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 16.
https://doi.org/10.1158/1538-7445.AM2020-16
Published: 15 August 2020
View article titled, Abstract 16: LTA4 hydrolase inhibitor bestatin prevents intestinal tumors in APC mutant rodent models of FAP
Journal Articles

Abstract 2830: The impact of gut microbial toxins and PGE2 on IL-23 production and its role in obesity associated colorectal tumorigenesis

Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Parthasarathy Chandrakesan, Courtney W. Houchen, Dharambir K. Sanghera, Katherine T. Morris, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2830.
https://doi.org/10.1158/1538-7445.AM2020-2830
Published: 15 August 2020
View article titled, Abstract 2830: The impact of gut microbial toxins and PGE<sub>2</sub> on IL-23 production and its role in obesity associated colorectal tumorigenesis
Journal Articles

Abstract 6364: LFA-9, a dual mPGES-1 and 5-LOX inhibitor, suppresses colon cancer stemness and inflammogen-induced inflammatory response

Nagendra Sastri Yarla, Gopal Pathuri, Hariprasad Gali, Venkateshwar Madka, Janani Panneerselvam, Parthasarathy Chandrakesan, Courtney W. Houchen, Elizabeth R. Glaze, Jennifer Fox, David McCormick, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6364.
https://doi.org/10.1158/1538-7445.AM2020-6364
Published: 15 August 2020
View article titled, Abstract 6364: LFA-9, a dual mPGES-1 and 5-LOX inhibitor, suppresses colon cancer stemness and inflammogen-induced inflammatory response
Journal Articles

Abstract 1199: Identification of candidate regulators of genomic instability in human lung adenocarcinoma through a new cross-species in silico analysis

Chinthalapally V. Rao, Mudassir Farooqui, Yuting Zhang, Gaurav Kumar, Janani Panneerselvam, Nagendra Yarla, Adam S. Asch, Hiroshi Y. Yamada
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1199.
https://doi.org/10.1158/1538-7445.AM2019-1199
Published: 01 July 2019
View article titled, Abstract 1199: Identification of candidate regulators of genomic instability in human lung adenocarcinoma through a new cross-species <em>in silico</em> analysis
Journal Articles

Abstract 5075: Naproxen blocks spontaneous lung adenoma progression to adenocarcinoma in Kras-G12V mice

Gaurav Kumar, Venkateshwar Madka, Craig Logsdon, Anil Singh, Nicole Stratton, Stanley Lightfoot, Altaf Mohammed, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5075.
https://doi.org/10.1158/1538-7445.AM2019-5075
Published: 01 July 2019
View article titled, Abstract 5075: Naproxen blocks spontaneous lung adenoma progression to adenocarcinoma in Kras-<sup>G12V</sup> mice
Journal Articles

Abstract 5065: Pharmacological modulation of inflammation and p53 signaling synergize to prevents muscle invasive bladder cancer in-vivo

Venkateshwar Madka, Yuting Zhang, Nandini Kumar, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Adam S. Asch, Vernon E. Steele, Altaf Mohammed, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5065.
https://doi.org/10.1158/1538-7445.AM2019-5065
Published: 01 July 2019
View article titled, Abstract 5065: Pharmacological modulation of inflammation and p53 signaling synergize to prevents muscle invasive bladder cancer <em>in-vivo</em>
Journal Articles

Abstract 5079: Targeting cholecystokinin-2 receptor (CCK2R) for pancreatic ductal adenocarcinoma prevention in p48Cre/+-LSL-KrasG12D/+ mice model

Altaf Mohammed, Naveena B. Janakiram, Chen Suen, Nicole Stratton, Stanley Lightfoot, Anil Singh, Gopal Pathuri, Rebekah Ritchie, Venkateshwar Madka, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5079.
https://doi.org/10.1158/1538-7445.AM2019-5079
Published: 01 July 2019
View article titled, Abstract 5079: Targeting cholecystokinin-2 receptor (CCK2R) for pancreatic ductal adenocarcinoma prevention in p48<sup>Cre/+</sup>-LSL-Kras<sup>G12D/+</sup> mice model
Journal Articles

Abstract 1269: Diosgenin, a naturally occurring steroidal saponin, prevents colon cancer in animal models of hereditary and sporadic CRC

Venkateshwar Madka, Jayadev Raju, Gopal Pathuri, Snigdha Smriti, Anh Bao, Yuting Zhang, Nicole Stratton, Mudassir Farooqui, Stanley Lightfoot, Adam S. Asch, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1269.
https://doi.org/10.1158/1538-7445.AM2018-1269
Published: 01 July 2018
View article titled, Abstract 1269: Diosgenin, a naturally occurring steroidal saponin, prevents colon cancer in animal models of hereditary and sporadic CRC
Journal Articles

Abstract 4983: Intermittent dosing regimens of naproxen and aspirin inhibit azoxymethane-induced rat colon adenoma progression to adenocarcinoma and carcinoma invasion

Altaf Mohammed, Naveena B. Janakiram, Venkateshwar Madka, Yuting Zhang, Anil Singh, Laura Biddick, Qian Li, Stan Lightfoot, Vernon E. Steele, Ronald Lubet, Mark S. Miller, Chen S. Suen, Shizuko Sei, Chinthalapally V. Rao
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4983.
https://doi.org/10.1158/1538-7445.AM2018-4983
Published: 01 July 2018
View article titled, Abstract 4983: Intermittent dosing regimens of naproxen and aspirin inhibit azoxymethane-induced rat colon adenoma progression to adenocarcinoma and carcinoma invasion