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Journal Articles

Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer

David A. Wheeler, Scott Newman, Joy Nakitandwe, Chimene A. Kesserwan, Elizabeth M. Azzato, Michael C. Rusch, Sheila Shurtleff, Armita Bahrami, Brent Orr, Jeffery M. Klco, Dale J. Hedges, Kayla V. Hamilton, Scott G. Foy, Michael N. Edmonson, Andrew Thrasher, Jiali Gu, Lynn W. Harrison, Lu Wang, Roya Mostafavi, Manish Kubal, Jamie Maciaszek, Michael Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W. Brady, Xin Zhou, Mark Wilkinson, Delaram Rahbarinia, Jay Knight, Jian Wang, Charles G. Mullighan, Rose B. McGee, Emily A. Quinn, Elsie L. Gerhardt, Leslie M. Taylor, Regina Nuccio, Jessica M. Valdez, Stacy J. Hines-Dowell, Alberto Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W. Ellison, James R. Downing, Jinghui Zhang, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 642.
https://doi.org/10.1158/1538-7445.AM2021-642
Published: 01 July 2021
View articletitled, Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer
Journal Articles

Abstract CT146: Prognostic and therapeutic significance of leukemia subtypes in the context of risk-directed therapy based on minimal residual disease levels in pediatric acute lymphoblastic leukemia

Sima Jeha, John K. Choi, Deqing Pei, Elaine Coustan-Smith, Hiroto Inaba, Jeffrey E. Rubnitz, Raul C. Ribiero, Tanja A. Gruber, Susana C. Raimondi, Seth E. Karol, Kathryn G. Roberts, Jun J. Yang, Cheng Cheng, James R. Downing, William E. Evans, Mary V. Relling, Dario Campana, Charles G. Mullighan, Ching-Hon Pui
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT146.
https://doi.org/10.1158/1538-7445.AM2021-CT146
Published: 01 July 2021
View articletitled, Abstract CT146: Prognostic and therapeutic significance of leukemia subtypes in the context of risk-directed therapy based on minimal residual disease levels in pediatric acute lymphoblastic leukemia
Journal Articles

Abstract 2118: Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

Hongbo Yang, Hui Zhang, Yu Luan, Tingting Liu, Kathryn Roberts, Mao-xiang Qian, Bo Zhang, Wenjian Yang, Virginia Perez-Andreu, Jie Xu, Sriranga lyyanki, Da Kuang, Shalini Reshmi, Julie Gastier-Foster, Colton Smith, Ching-Hon Pui, William Evans, Stephen Hunger, Stephen Hunger, Leonidas Platanias, Mary Relling, Charles Mullighan, Mignon Loh, Feng Yue, Jun Yang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2118.
https://doi.org/10.1158/1538-7445.AM2021-2118
Published: 01 July 2021
View articletitled, Abstract 2118: Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia
Journal Articles

Abstract 2872: Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia

Benshang Li, Samuel W. Brady, Xiaotu Ma, Shuhong Shen, Yingchi Zhang, Yongjin Li, Yu Liu, Ningling Wang, Diane Flasch, Matthew Myers, Heather Mulder, Lixia Ding, Yanling Lu, Liqing Tian, Kohei Hagiwara, Ke Xu, Edgar Sioson, Tianyi Wang, Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Jiaoyang Cai, Ting-Nien Lin, Lijuan Du, Fan Yang, Michael Rusch, Michael Edmonson, John Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin Raphael, Jingyan Tang, James Downing, Bin-Bing Zhou, Ching-Hon Pui, Jun Yang, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2872.
https://doi.org/10.1158/1538-7445.AM2019-2872
Published: 01 July 2019
View articletitled, Abstract 2872: Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia
Journal Articles

Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome

Austin L. Brown, Adam J. de Smith, Michael E. Scheurer, Noah A. Kallsen, Shanna A. Peyton, Gareth E. Davies, Erik A. Ehli, Michael E. Zwick, Naomi Winick, Kelly Maloney, Anne L. Angiolillo, Reuven Schore, MIchael M. Burke, Wanda L. Salzer, Nyla A. Heerema, Andrew J. Carroll, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Elizabeth A. Raetz, Elanor Feingold, Stephanie L. Sherman, Wenjian Yang, Meenakshi Devidas, Kyle Walsh, Andrew T. DeWan, Maria S. Pombo-de-Oliveira, Jeffrey W. Taub, Daniel Sinnett, Jasmine Healy, Jillian M. Birch, Lisa F. Barcellos, Helen Hansen, Ivan Smirnov, Charles G. Mullighan, Stephen P. Hunger, Ching-Hon Pui, Mignon Loh, Joe L. Wiemels, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Mary V. Relling, Jun J. Yang, Philip J. Lupo, Karen R. Rabin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 222.
https://doi.org/10.1158/1538-7445.AM2018-222
Published: 01 July 2018
View articletitled, Abstract 222: Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome
Journal Articles

Abstract 4870: Mutational landscape and timing of resistant clone emergence in 104 Chinese pediatric patients with relapsed acute lymphoblastic leukemia

Benshang Li, Yongjin Li, Shuhong Shen, Xiaofan Zhu, Xiaotu Ma, Ningling Wang, Yanling Liu, Yu Liu, Hui Zhang, Ting-Nien Lin, Michael Rusch, Michael Edmonson, John Easton, Yingchi Zhang, Jingliao Zhang, Cheng Cheng, Jingyan Tang, James R. Downing, Ching-Hon Pui, Jun J. Yang, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4870.
https://doi.org/10.1158/1538-7445.AM2017-4870
Published: 01 July 2017
View articletitled, Abstract 4870: Mutational landscape and timing of resistant clone emergence in 104 Chinese pediatric patients with relapsed acute lymphoblastic leukemia
Journal Articles

Abstract 4884: Focal 22q11.22 deletions combined with IKZF1 alterations are associated with worse clinical outcome in acute lymphoblastic leukemia

Julia A. Meyer, Clint C. Mason, Luke Maese, Deqing Pei, Cheng Cheng, Ching-Hon Pui, Mel Greaves, Richard Aplenc, Charles G. Mulligan, Elizabeth Raetz, Rodney R. Miles, Karen R. Rabin, Joshua D. Schiffman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4884.
https://doi.org/10.1158/1538-7445.AM2017-4884
Published: 01 July 2017
View articletitled, Abstract 4884: Focal 22q11.22 deletions combined with IKZF1 alterations are associated with worse clinical outcome in acute lymphoblastic leukemia
Journal Articles

Abstract 4369: Rearrangements of the erythropoietin receptor are recurrent in Ph-like acute lymphoblastic leukemia and are sensitive to Jak2 inhibition

Ilaria Iacobucci, Kathryn G. Roberts, Yongjin Li, Jinghui Zhang, Richard C. Harvey, Debbie Payne-Turner, Marcus Valentine, Kelly McCastlain, John Easton, I-Ming Chen, Michael Rusch, Steven M. Kornblau, Marina Konopleva, Elisabeth Paietta, Jacob M. Rowe, Ching-Hon Pui, Julie M. Gastier-Foster, Shalini Reshmi, Mignon L. Loh, Cheryl Willman, James R. Downing, Stephen P. Hunger, Charles G. Mullighan
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4369.
https://doi.org/10.1158/1538-7445.AM2015-4369
Published: 01 August 2015
View articletitled, Abstract 4369: Rearrangements of the erythropoietin receptor are recurrent in Ph-like acute lymphoblastic leukemia and are sensitive to Jak2 inhibition
Journal Articles

Abstract 2033: Germline mutations in ETV6 confer risk of thrombocytopenia and acute lymphocytic leukemia

Vijai Joseph, Michael F. Walsh, Sabine Topka, Gang Wu, Rose B. McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-Hon Pui, Alberto S. Pappo, Michael Edmonson, Lauren Jacobs, Villano Danylo, Kasmintan Schrader, Pragna Gaddam, Zsofia Stadler, Michael Zhang, Polina Stepensky, Peter Steinherz, James Bussel, M Harit, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R. Downing, Kenneth Offit, Kim E. Nichols
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2033.
https://doi.org/10.1158/1538-7445.AM2015-2033
Published: 01 August 2015
View articletitled, Abstract 2033: Germline mutations in ETV6 confer risk of thrombocytopenia and acute lymphocytic leukemia
Journal Articles

Abstract CT409: Dexamethasone (dex) and asparaginase increase triglycerides during acute lymphoblastic leukemia (ALL) therapy in children

Laura B. Ramsey, Katherine M. Robinson, Jitesh D. Kawedia, Wenjian Yang, Chengcheng Liu, John C. Panetta, Sima Jeha, Deepa Bhojwani, Monika L. Metzger, Cheng Cheng, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT409.
https://doi.org/10.1158/1538-7445.AM2014-CT409
Published: 01 October 2014
View articletitled, Abstract CT409: Dexamethasone (dex) and asparaginase increase triglycerides during acute lymphoblastic leukemia (ALL) therapy in children
Journal Articles

Abstract 3083: The genetic landscape of Ph-like acute lymphoblastic leukemia

Kathryn G. Roberts, Yongjin Li, Debbie Payne-Turner, Jinghui Zhang, Richard C. Harvey, Yung-Li Yang, Guangchun Song, Jing Ma, Shann-Ching Chen, Jinjun Cheng, Natalia Santiago-Morales, Ilaria Iacobucci, Meenakshi Devidas, I-Ming Chen, Shalini Reshmi, Michael Rusch, Pankaj Gupta, Naomi J. Winick, William L. Carroll, Nyla A. Heerema, Andrew J. Carroll, Elizabeth A. Raetz, Guido Marcucci, Clara D. Bloomfield, Wendy Stock, Steven M. Kornblau, Elisabeth Paietta, Ching-Hon Pui, Sima Jeha, James Downing, Daniela S. Gerhard, Julie M. Gastier-Foster, Mignon L. Loh, Cheryl Willman, Stephen P. Hunger, Charles G. Mullighan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3083.
https://doi.org/10.1158/1538-7445.AM2014-3083
Published: 01 October 2014
View articletitled, Abstract 3083: The genetic landscape of Ph-like acute lymphoblastic leukemia
Journal Articles

Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Anna Andersson, Jing Ma, Jianmin Wang, Xiang Chen, Michael Rusch, Gang Wu, John Easton, Matthew Parker, Susana Raimondi, Linda Holmfeldt, Jared Becksfort, Pankaj Gupta, Amanda Gedman, Joy Nakitandwe, Debbie Payne-Turner, Guangchun Song, Rosemary Sutton, Nicola Venn, Albert Chetcuti, Amanda Rush, Daniel Catchpole, Jesper Heldrup, Thoas Fioretos, Charles Lu, Li Ding, Ching-Hon Pui, Sheila Shurtleff, Tanja Gruber, Charles Mullighan, Elaine Mardis, Richard Wilson, Jinghui Zhang, James Downing
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4869.
https://doi.org/10.1158/1538-7445.AM2012-4869
Published: 15 April 2012
View articletitled, Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Journal Articles

Abstract 4870: Integrated genomic analysis of hypodiploid acute lymphoblastic leukemia

Linda Holmfeldt, Ernesto Diaz-Flores, Jinghui Zhang, Debbie Payne-Turner, Anna Andersson, Shann-Ching Chen, Jared Becksfort, Jing Ma, Lei Wei, John Easton, Deqing Pei, Cheng Cheng, Ching-Hon Pui, Meenakshi Devidas, Andrew J. Carroll, Nyla A. Heerema, Julie M. Gastier-Foster, Susana C. Raimondi, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4870.
https://doi.org/10.1158/1538-7445.AM2012-4870
Published: 15 April 2012
View articletitled, Abstract 4870: Integrated genomic analysis of hypodiploid acute lymphoblastic leukemia
Journal Articles

Abstract 4867: Identification of an inv(16)-encoded CBFA2T3-GLIS2 fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project

Tanja A. Gruber, Amanda L. Gedman, Huy Ta, Jinghui Zhang, Cary Koss, Suresh Marada, Shann-Ching Chen, Xiaoping Su, Stacey Ogden, Vedant Gupta, Anna Andersson, Stanley Pounds, Lei Shi, John Easton, Jianmin Wang, Michael Rusch, Li Ding, Giovanni Cazzaniga, Andrea Biondi, Steven Kornblau, Farhad Ravandi-Kashani, Hagop Kantarjian, Stephen D. Nimer, Konstanze Doehner, Hartmut Doehner, Timothy J. Ley, Paola Ballerini, Thomas Mercher, Sheila Shurtleff, Lee-Yung Shih, Der-Cherng Liang, Jeffrey Rubnitz, Ching-Hon Pui, Elaine Mardis, Richard K. Wilson, James R. Downing
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4867.
https://doi.org/10.1158/1538-7445.AM2012-4867
Published: 15 April 2012
View articletitled, Abstract 4867: Identification of an inv(16)-encoded CBFA2T3-GLIS2 fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project
Journal Articles

Abstract #2912: A mathematical model of intracellular methotrexate accumulation and the inhibition of folate pathway enzymes in acute lymphoblastic leukemia

John Panetta, Alex Sparreboom, Ching-Hon Pui, Mary Relling, William Evans
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2912.
Published: 01 May 2009
View articletitled, Abstract #2912: A mathematical model of intracellular methotrexate accumulation and the inhibition of folate pathway enzymes in acute lymphoblastic leukemia
Journal Articles

Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine Pharmacodynamics

Christine Hartford, Erick Vasquez, Matthias Schwab, Mathew J. Edick, Jerold E. Rehg, Gerard Grosveld, Ching-Hon Pui, William E. Evans, Mary V. Relling
Journal: Cancer Research
Cancer Res (2007) 67 (10): 4965–4972.
https://doi.org/10.1158/0008-5472.CAN-06-3508
Published: 17 May 2007
View articletitled, Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine Pharmacodynamics
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Journal Articles

Differential expression of apoptosis genes in MSH2-deficient human acute lymphoblastic leukemia (ALL) cells.

Natalia Krynetskaia, Weinan Du, Meyling Cheok, Deqing Pei, John Panetta, Cheng Cheng, Dario Campana, Eugene Krynetski, James Downing, Ching-Hon Pui, William Evans
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 568–569.
Published: 01 April 2004
View articletitled, Differential expression of apoptosis genes in MSH2-deficient human acute lymphoblastic leukemia (ALL) cells.
Journal Articles

Phase I Clinical Trial of Orally Administered 4-Demethoxydaunorubicin (Idarubicin) with Pharmacokinetic and in Vitro Drug Sensitivity Testing in Children with Refractory Leukemia

Ching-Hon Pui, Siebold S. N. de Graaf, Lois W. Dow, John H. Rodman, William E. Evans, Bruce S. Alpert, Sharon B. Murphy
Journal: Cancer Research
Cancer Res (1988) 48 (18): 5348–5352.
Published: 01 September 1988
View articletitled, Phase I Clinical Trial of Orally Administered 4-Demethoxydaunorubicin (Idarubicin) with Pharmacokinetic and in Vitro Drug Sensitivity Testing in Children with Refractory Leukemia
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Journal Articles

Failure of Late Intensification Therapy to Improve a Poor Result in Childhood Lymphoblastic Leukemia

Ching-Hon Pui, Rhomes J. A. Aur, W. Paul Bowman, Gary V. Dahl, Richard K. Dodge, Stephen L. George, Judith Ochs, David K. Kalwinsky, Minnie Abromowitch, H. Omar Hustu, Joseph V. Simone
Journal: Cancer Research
Cancer Res (1984) 44 (8): 3593–3598.
Published: 01 August 1984
View articletitled, Failure of Late Intensification Therapy to Improve a Poor Result in Childhood Lymphoblastic Leukemia
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Journal Articles

Glucocorticoid Receptors in Childhood Acute Lymphocytic Leukemia

Mark E. Costlow, Ching-Hon Pui, Gary V. Dahl
Journal: Cancer Research
Cancer Res (1982) 42 (11): 4801–4806.
Published: 01 November 1982
View articletitled, Glucocorticoid Receptors in Childhood Acute Lymphocytic Leukemia
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