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Journal Articles

Abstract 605: ABBV-101, a highly potent and selective clinical stage Bruton tyrosine kinase degrader, overcomes BTK mutation-induced resistance to BTK inhibitors

Chin Pan, Jacob Riehm, Tarikere L. Gururaja, Haiyan Li, Henry Nguyen, Yongjiao Zhai, Xiaoping Xie, Rong-Xian Ding, Rebecca Matthew, Hana Y. Hoh, Zhaozhong J. Jia, Bo Liu, Cassandra P. Shu, Claudina A. Stevenson, Christine Will, Federico Innocenti, Wissam Assaily, Lloyd T. Lam, Alexey Rivkin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 605.
https://doi.org/10.1158/1538-7445.AM2024-605
Published: 22 March 2024
View article titled, Abstract 605: ABBV-101, a highly potent and selective clinical stage Bruton tyrosine kinase degrader, overcomes BTK mutation-induced resistance to BTK inhibitors
Journal Articles

Abstract LB-237: BMS-986012, a fully human anti-fucosyl-GM1 antibody has potent in vitro and in vivo antitumor activity in preclinical models of small cell lung cancer

Bing Chen, Chin Pan, Paul Ponath, Miho Oyasu, Daniel Menezes, Pina Cardarelli
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-237.
https://doi.org/10.1158/1538-7445.AM2016-LB-237
Published: 15 July 2016
View article titled, Abstract LB-237: BMS-986012, a fully human anti-fucosyl-GM1 antibody has potent in vitro and in vivo antitumor activity in preclinical models of small cell lung cancer
Journal Articles

Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate

Daniel W. Derwin, David Passmore, Qian Zhang, Bilal Sufi, Chin Pan, Chetana Rao, Mary Huber, Sanjeev Gangwar, Pina Cardarelli, Shrikant Deshpande, Vangipuram Rangan
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-252.
https://doi.org/10.1158/1538-7445.AM2012-LB-252
Published: 15 April 2012
View article titled, Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate
Journal Articles

Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS

Mohan Srinivasan, Lourdes Thevanayagam, Indrani Chakraborty, Alasdair Bell, Shrikant Deshpande, Chin Pan, Pina M. Cardarelli, Sanjeev Gangwar, Colin Chong, Orville Cortez, David Klitzing, Jerry Jiang, Meghan Greenbaum, James Phillips
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2446.
https://doi.org/10.1158/1538-7445.AM10-2446
Published: 15 April 2010
View article titled, Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS
Journal Articles

Abstract 2578: Efficacy of anti-CD22 antibody drug-conjugates in Ramos and Raji tumor xenograft models

Chin Pan, Colin Chong, Orville Cortez, Alison Witte, Ayesha Nazeer, Chetana Rao-Naik, Mary Huber, Alice Stevens, Qian Zhang, Asna Masood, Sanjeev Gangwar, David King, Brigitte Devaux, Pina Cardarelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2578.
https://doi.org/10.1158/1538-7445.AM10-2578
Published: 15 April 2010
View article titled, Abstract 2578: Efficacy of anti-CD22 antibody drug-conjugates in Ramos and Raji tumor xenograft models
Journal Articles

Abstract 2452: Efficacy and toxicity of an anti-CD19 antibody drug conjugate

Chetana Rao, Chin Pan, Rangan Vangipuram, Mary Huber, Kavitha Vemuri, Alice Stevens, Colin Chong, Orville Cortez, Janette Sung, Dan Derwin, David Passmore, Qian Zhang, Sanjeev Gangwar, Pina Cardarelli, Shrikant Deshpande
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2452.
https://doi.org/10.1158/1538-7445.AM10-2452
Published: 15 April 2010
View article titled, Abstract 2452: Efficacy and toxicity of an anti-CD19 antibody drug conjugate
Journal Articles

Abstract #1233: Development of anti-Glypican 3 therapeutic antibodies

Li-Sheng Lu, Jon Terrett, Chin Pan, Dapeng Yao, Colin Chong, Jerry Jiang, Pina Cardarelli, Yi Wu, Haichun Huang, Tim Chen, Alasdair Bell, Mohan Srinivasan, Karla Henning
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1233.
Published: 01 May 2009
View article titled, Abstract #1233: Development of anti-Glypican 3 therapeutic antibodies
Journal Articles

Abstract #LB-150: A fully human anti-CXCR4 antibody induces apoptosis in vitro and shows anti tumor activity in vivo.

Michelle Kuhne, Tanya Mulvey, Blake Belanger, Sharline Chen, Chin Pan, Colin Chong, Jerry Jiang, Wafa Niekro, Tom Kempe, Karla Henning, Lewis Cohen, Diann Blanset, Alan Korman, Pina Cardarelli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): LB-150.
Published: 01 May 2009
View article titled, Abstract #LB-150: A fully human anti-CXCR4 antibody induces apoptosis <em>in vitro</em> and shows anti tumor activity <em>in vivo.</em>
Journal Articles

Abstract #1722: The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates

Sanjeev Gangwar, Chin Pan, Qian Zhang, Chetana Rao, Bilal Sufi, Lynae Green, David Passmore, Mary Huber, Collin Chong, Eilene Kwok, Orville Cortez, Peter Sattari, Liang Chen, Vincent Guerlavais, Vangipuram Rangan, Shrikant Deshpande, Pina Cardarelli, David King, Jon Terrett
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1722.
Published: 01 May 2009
View article titled, Abstract #1722: The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates
Journal Articles

Abstract #838: Efficacy of MDX-1110, an anti-Fucosyl-GM1 antibody in a SCLC tumor model

Bingliang Chen, Alison Witte, James Phillips, Jenny Chang, Meghan Greenbaum, Orville Cortez, Chin Pan, Jon Terrett, Pina Cardarelli
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 838.
Published: 01 May 2009
View article titled, Abstract #838: Efficacy of MDX-1110, an anti-Fucosyl-GM1 antibody in a SCLC tumor model
Journal Articles

Ptk7 as a direct and tumor stroma target in multiple solid malignancies

Jonathan Terrett, Vidusha Devasthali, Chin Pan, Sanjeev Gangwar, David King, Lisheng Lu, Pina Cardarelli, Orville Cortez, Colin Ching, Rory Dai, Chetana Rao-Naik, Mary Huber, Sarah Pogue, Rozanne Lee, David Passmore, Haichun Huang, Vangipuram Rangan, Allen Zhang, Bilal Sufi, Vincent Guerlavais, Liang Chen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1526.
Published: 01 May 2008
View article titled, Ptk7 as a direct and tumor stroma target in multiple solid malignancies
Journal Articles

Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

Chin Pan, Jonathan Terrett, Chetana Rao, Colin Chong, Rory Dai, Eilene Kwok, Mary Huber, Liang Chen, Alan Zhang, Sufi Bilal, Charlie Cong, Rangan Vangipuram, David Passmore, Shrikant Deshpande, Sanjeev Gangwar, Pina Cardarelli, David King
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4062.
Published: 01 May 2008
View article titled, Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)
Journal Articles

Mechanism of activation of a human anti-cd70 antibody-mgba conjugate and efficacy in a nude rat model of renal carcinoma

David King, Jon Terrett, Pina Cardarelli, Chin Pan, Chetana Rao, Sanjeev Gangwar, Shrikant Deshpande, Rangan Vangipuram, David Passmore, Jean Francois Mirjolet, Francis Bichat
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4057.
Published: 01 May 2008
View article titled, Mechanism of activation of a human anti-cd70 antibody-mgba conjugate and efficacy in a nude rat model of renal carcinoma
Journal Articles

Efficacy and safety of a human anti-CD70 antibody-MGBA conjugate

Pina Cardarelli, David King, Jon Terrett, Sanjeev Gangwar, Lewis Cohen, Chin Pan, Chetana Rao, Shrikant Deshpande, Rangan Vangipuram, David Passmore, Diann Blanset
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4061.
Published: 01 May 2008
View article titled, Efficacy and safety of a human anti-CD70 antibody-MGBA conjugate
Journal Articles

Efficacy study of anti-CD19 antibody drug-conjugates in Raji tumor xenograft and systemic model

Chetana Rao, Chin Pan, Mary Huber, Peter Sattari, Colin Chong, Rory Dai, Carol Soderberg, Liang Chen, Vincent Guerlavais, Kilian Horgan, Allen Zhang, Bilal Sufi, Haichun Huang, Haibin Chen, Sanjeev Gangwar, Pina Cardarelli, David King
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4104.
Published: 01 May 2007
View article titled, Efficacy study of anti-CD19 antibody drug-conjugates in Raji tumor xenograft and systemic model
Journal Articles

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

Jonathan Terrett, Sanjeev Gangwar, Chetana Rao-Naik, Chin Pan, Vincent Guerlavais, Mary Huber, Colin Chong, Lynae Green, Pina Cardarelli, David King, Shrikant Deshpande, Vangipuram Rangan, Marco Coccia, Lisheng Lu, David Passmore, Diann Blansett, Rory Dai, Bilal Sufi, Qian Zhang, Liang Chen, Carol Soderberg, Eilene Kwok, Killian Horgan, Orville Cortez, Peter Sattari
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4112.
Published: 01 May 2007
View article titled, Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures
Journal Articles

Human antibody conjugates of DNA minor groove-binding alkylating agents with single dose efficacy in xenograft models which retain activity in drug resistant cells

Chin Pan, Sanjeev Gangwar, Liang Chen, Chetana Rao, Mary Huber, Peter Sattari, Mary Do, Rory Dai, Colin Chong, Carol Soderberg, Hao Li, Bilal Sufi, Sharon Boyd, Haichun Huang, Haibin Chen, Vincent Guerlavais, Killian Horgan, Nik Sharkov, Pina Cardarelli, David J. King
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 277.
Published: 15 April 2006
View article titled, Human antibody conjugates of DNA minor groove-binding alkylating agents with single dose efficacy in xenograft models which retain activity in drug resistant cells
Journal Articles

CD70 antibody based drugs: two different mechanisms of action for the treatment of multiple cancer types

Jonathan A. Terrett, Chin Pan, Sanjeev Gangwar, Lisheng Lu, Liang Chen, Chetana Rao, Mary Huber, Peter Sattari, Mary Do, Rory Dai, Colin Chong, Carol Soderberg, Hao Li, Bilal Sufi, Sharon Boyd, Haichun Huang, Jun Zhang, Erika Meaddough, Vincent Guerlavais, Killian Horgan, Nick Sharkov, Pina Cardarelli, David King, Dapeng Yao, Sarah Pogue
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 470.
Published: 15 April 2006
View article titled, CD70 antibody based drugs: two different mechanisms of action for the treatment of multiple cancer types
Journal Articles

CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10+ Tumors

Chin Pan, Pina M. Cardarelli, Matthew H. Nieder, Lesley B. Pickford, Sanjeev Gangwar, David J. King, Geoffrey T. Yarranton, Dana Buckman, William Roscoe, Fengmin Zhou, Adam Salles, Tseng-Hui Chen, Killian Horgan, Yi-Hong Wang, Thi Nguyen, Christopher R. Bebbington
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5526–5531.
Published: 18 September 2003
View article titled, CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10<sup>+</sup> Tumors
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