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Cheryl H. Arrowsmith
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Journal Articles

Abstract 767: Discovering the geospatial framework in glioblastoma: Uncovering hotspots for glioma stem cell hide-out and their therapeutic implications

Free
Shamini Ayyadhury, Fatemah Al Solaiman, Yuna Lee, Alyona Ivanova, Ana Nikolic, Farzaneh Aboulizadeh, Melanie Peralta, Patty Sachamitr, Michelle M. Kushida, Nicole I. Park, Fiona J. Coutinho, Owen Whitley, Panagiotis Prinos, Cheryl H. Arrowsmith, Sam Weiss, Sheila Mansouri, Gelareh Zadeh, Peter B. Dirks, Troy Ketela, H. Artee Luchman, Gary D. Bader, Trevor J. Pugh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 767.
https://doi.org/10.1158/1538-7445.AM2025-767
Published: 21 April 2025
View articletitled, Abstract 767: Discovering the geospatial framework in glioblastoma: Uncovering hotspots for glioma stem cell hide-out and their therapeutic implications
Journal Articles

Abstract 5425: Human mitochondrial ClpXP protease degrades serine phosphorylated substrates

Free
Yue Feng, Monica M. Goncalves, Yulia Jitkova, Alexander F. Keszei, Yongran Yan, Chaitra Sarathy, Jonathan St-Germain, Tristan M. Kenney, Matthew Tcheng, Vincent Trudel, Ross S. Mancini, Rahul Upadhyay, Rose Hurren, Marcela Gronda, Matthew Schultz, Kaylen Soriano, Kaitlin Lees, Neil C. Pomroy, S. Quinn W. Currie, Gilbert G. Privé, Mark A. Reed, Andrei K. Yudin, Linda Z. Penn, Cheryl H. Arrowsmith, Brian Raught, Mohammad Mazhab-Jafari, Siavash Vahidi, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5425.
https://doi.org/10.1158/1538-7445.AM2025-5425
Published: 21 April 2025
View articletitled, Abstract 5425: Human mitochondrial ClpXP protease degrades serine phosphorylated substrates
Journal Articles

Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor

Free
Stefan Gradl, Holger Steuber, Jörg Weiske, Norbert Schmees, Stephan Siegel, Detlef Stoeckigt, Clara D. Christ, Fengling Li, Shawna Organ, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Steven Kennedy, Viacheslav Trush, Masoud Vedadi, Cheryl H. Arrowsmith, Peter J. Brown, Manfred Husemann, Amaury E. Fernandez-Montalvan, Volker Badock, Marcus Bauser, Andrea Haegebarth, Ingo V. Hartung, Carlo Stresemann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2018-1646
Published: 01 July 2018
View articletitled, Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Journal Articles

LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression

Free
Yi Liang, Musaddeque Ahmed, Haiyang Guo, Fraser Soares, Junjie T. Hua, Shuai Gao, Catherine Lu, Christine Poon, Wanting Han, Jens Langstein, Muhammad B. Ekram, Brian Li, Elai Davicioni, Mandeep Takhar, Nicholas Erho, R. Jeffrey Karnes, Dianne Chadwick, Theodorus van der Kwast, Paul C. Boutros, Cheryl H. Arrowsmith, Felix Y. Feng, Anthony M. Joshua, Amina Zoubeidi, Changmeng Cai, Housheng H. He
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5479–5490.
https://doi.org/10.1158/0008-5472.CAN-17-0496
Published: 15 October 2017
View articletitled, LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression
Open the PDF for LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 3867: Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy to reactivate p53 in high-risk neuroblastoma

Free
Veronica Veschi, Zhihui Liu, Ty C. Voss, Laurent Ozbun, Berkley Gryder, Chunhua Yan, Ying Hu, Anqi Ma, Jian Jin, Sharlyn J. Mazur, Norris Lam, Barbara K. Souza, Giuseppe Giannini, Gordon L. Hager, Cheryl H. Arrowsmith, Javed Khan, Ettore Appella, Carol Thiele
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3867.
https://doi.org/10.1158/1538-7445.AM2017-3867
Published: 01 July 2017
View articletitled, Abstract 3867: Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy to reactivate p53 in high-risk neuroblastoma
Journal Articles

Abstract A44: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Free
Pawel K. Mazur, Nicolas Reynoird, Timo Stellfeld, Natasha M. Flores, Shane M. Lofgren, Scott M. Carlson, Elisabeth Brambilla, Pierre Hainaut, Ewa B. Kaznowska, Cheryl H. Arrowsmith, Purvesh Khatri, Carlo Stresemann, Or Gozani, Julien Sage
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A44.
https://doi.org/10.1158/1538-7445.PANCA16-A44
Published: 14 December 2016
View articletitled, Abstract A44: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Journal Articles

Abstract LB-179: Integrated (epi)genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors

Free
Jonathon Torchia, Shengrui Feng, King Ching Ho, Louis Letourneau, Daniel Picard, Tiffany S. Chan, Alexandre Vasiljevic, Dong Anh Khuong Quang, Brian Golbourn, Dalia Barsyte-Lovejoy, Constanze Zeller, Patrick Sin-Chan, Natalia R. Agamez, Mei Lu, Lucie Lafay-Cousin, Joseph D. Norman, Maryam Fouladi, Lindsey M. Hoffman, Stefan Rutkowski, Torsten Pietsch, Alexander R. Judkins, Eric Bouffet, James T. Rutka, Cynthia E. Hawkins, Cheryl H. Arrowsmith, Daniel De Carvalho, Nada Jabado, Annie Huang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-179.
https://doi.org/10.1158/1538-7445.AM2016-LB-179
Published: 15 July 2016
View articletitled, Abstract LB-179: Integrated (epi)genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors
Journal Articles

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Free
Yuting Sun, Jessica L. Bell, Daniel Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W.H. Wong, Rima Al-Awar, Andrew E. Tee, Pei Y. Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M. Shohet, Ygal Haupt, Johannes H. Schulte, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Karen L. MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M. Marshall, Antony Braithwaite, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5143–5154.
https://doi.org/10.1158/0008-5472.CAN-15-0423
Published: 30 November 2015
View articletitled, WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Open the PDF for WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers

Free
Lindsey I. James, Jake I. Stuckey, Brandi M. Baughman, Michael T. Perfetti, Samantha G. Pattenden, Brad M. Dickson, Jacqueline L. Norris, Gaofeng Cui, Pavel Mader, Aiping Dong, Yunxiang Mu, Scott B. Rothbart, Brian D. Strahl, Jinrong Min, Peter J. Brown, Dmitri B. Kireev, William P. Janzen, Kevin M. McBride, Mark T. Bedford, Georges Mer, Cheryl H. Arrowsmith, Stephen V. Frye
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY08-03.
https://doi.org/10.1158/1538-7445.AM2015-SY08-03
Published: 01 August 2015
View articletitled, Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers
Journal Articles

Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation

Free
Elizabeth L. Zoeller, Dalia Barsyte-Lovejoy, Peter J. Brown, Dafydd R. Owen, Cheryl H. Arrowsmith, Paula M. Vertino
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2105.
https://doi.org/10.1158/1538-7445.AM2014-2105
Published: 01 October 2014
View articletitled, Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation
Journal Articles

Abstract PR03: Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance

Free
Scott B. Rothbart, Bradley M. Dickson, Michelle S. Ong, Krzysztof Krajewski, Scott Houliston, Dmitri B. Kireev, Cheryl H. Arrowsmith, Brian D. Strahl
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): PR03.
https://doi.org/10.1158/1538-7445.CEC13-PR03
Published: 13 May 2014
View articletitled, Abstract PR03: Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance
Journal Articles

Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.”

Free
Scott B. Rothbart, Stephen M. Fuchs, Nataliya Nady, Krzysztof Krajewski, Wolfram Tempel, Sheng Xue, Aimee N. Iberg, Dalia Barsyte-Lovejoy, Jorge Y. Martinez, Mark T. Bedford, Cheryl H. Arrowsmith, Brian D. Strahl
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 993.
https://doi.org/10.1158/1538-7445.AM2012-993
Published: 15 April 2012
View articletitled, Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.”
Journal Articles

CUL7 Is a Novel Antiapoptotic Oncogene

Free
Sam S. Kim, Mary Shago, Lilia Kaustov, Paul C. Boutros, James W. Clendening, Yi Sheng, Grace A. Trentin, Dalia Barsyte-Lovejoy, Daniel Y.L. Mao, Robert Kay, Igor Jurisica, Cheryl H. Arrowsmith, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9616–9622.
https://doi.org/10.1158/0008-5472.CAN-07-0644
Published: 17 October 2007
View articletitled, CUL7 Is a Novel Antiapoptotic Oncogene
Open the PDF for CUL7 Is a Novel Antiapoptotic Oncogene in another window
Includes: Supplementary data