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Journal Articles

Abstract 4513: Exploration degradation of intrinsically disordered protein YAP induced by PROTACs

Chen Zhou, Chunbao Sun, Liya Pi, Chenglong Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4513.
https://doi.org/10.1158/1538-7445.AM2024-4513
Published: 22 March 2024
View article titled, Abstract 4513: Exploration degradation of intrinsically disordered protein YAP induced by PROTACs
Journal Articles

Abstract 4774: Inhibition of pancreatic acinar ductal metaplasia by novel YAP/TAZ inhibitor, CV-4-26

Corey M. Perkins, Chen Zhou, Martha Campbell-Thompson, Yating Mao, Kalina R. Atanasova, Jinmai Jiang, Ranjala Ratnayake, Hendrik Luesch, Jamel Ali, Chenglong Li, Thomas D. Schmittgen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4774.
https://doi.org/10.1158/1538-7445.AM2024-4774
Published: 22 March 2024
View article titled, Abstract 4774: Inhibition of pancreatic acinar ductal metaplasia by novel YAP/TAZ inhibitor, CV-4-26
Journal Articles

Abstract 3105: Design principle of heparanase inhibitors: A combined in vitro and in silico study

Yuzhao Zhang, Meijun Xiong, Zixin Chen, Gustavo Seabra, Jun Liu, Chenglong Li, Lina Cui
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3105.
https://doi.org/10.1158/1538-7445.AM2023-3105
Published: 04 April 2023
View article titled, Abstract 3105: Design principle of heparanase inhibitors: A combined <em>in vitro</em> and <em>in silico</em> study
Journal Articles

Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells

Li Pan, Xiang Chen, Feyruz V. Rassool, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2678.
https://doi.org/10.1158/1538-7445.AM2022-2678
Published: 15 June 2022
View article titled, Abstract 2678: LLL12B, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells
Journal Articles

Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer

Elena Beketova, Shuyi Fang, Jake L. Owens, Sheng Liu, Xufeng Chen, Qingfu Zhang, Andrew M. Asberry, Xuehong Deng, Jonathan Malola, Jiaoti Huang, Chenglong Li, Roberto Pili, Bennett D. Elzey, Timothy L. Ratliff, Jun Wan, Chang-Deng Hu
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4904–4917.
https://doi.org/10.1158/0008-5472.CAN-20-1228
Published: 13 November 2020
View article titled, Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer
Open the PDF for Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract P5-05-11: Novel small molecule STAT3 inhibitors induce apoptosis and suppress cell migration and tumor growth in triple-negative breast cancer cells

Li Pan, Xiang Chen, Shengling Fu, Chenglong Li, Hui-Wen Lo, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-05-11.
https://doi.org/10.1158/1538-7445.SABCS19-P5-05-11
Published: 15 February 2020
View article titled, Abstract P5-05-11: Novel small molecule STAT3 inhibitors induce apoptosis and suppress cell migration and tumor growth in triple-negative breast cancer cells
Journal Articles

Abstract 864: Repurposing FDA-approved drug bazedoxifene as a novel inhibitor of IL-6 signaling for triple-negative breast cancer

Xiang Chen, Shengling Fu, Jilai Tian, Yang Cao, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 864.
https://doi.org/10.1158/1538-7445.AM2018-864
Published: 01 July 2018
View article titled, Abstract 864: Repurposing FDA-approved drug bazedoxifene as a novel inhibitor of IL-6 signaling for triple-negative breast cancer
Journal Articles

Abstract 186: FDA approved drug Bazedoxifene as a novel inhibitor of IL 6 and IL 11/GP130 signaling for osteosarcoma therapy

Xiaojuan Wu, Hui Xiao, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 186.
https://doi.org/10.1158/1538-7445.AM2017-186
Published: 01 July 2017
View article titled, Abstract 186: FDA approved drug Bazedoxifene as a novel inhibitor of IL 6 and IL 11/GP130 signaling for osteosarcoma therapy
Journal Articles

Abstract 1148: Bazedoxifene as a novel GP130 inhibitor for the treatment of triple-negative breast cancer

Jilai Tian, Yang Cao, Xiang Chen, Hui Xiao, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1148.
https://doi.org/10.1158/1538-7445.AM2017-1148
Published: 01 July 2017
View article titled, Abstract 1148: Bazedoxifene as a novel GP130 inhibitor for the treatment of triple-negative breast cancer
Journal Articles

Abstract 2068: Engineering of hairpin loop enhances the loading of endogenously expressed pre-miRNA into extracellular vesicles

Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Ana-Clara P. Azevedo-Pouly, Ryan E. Pavlovicz, Chenglong Li, Mitch A. Phelps, Thomas D. Schmittgen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2068.
https://doi.org/10.1158/1538-7445.AM2016-2068
Published: 15 July 2016
View article titled, Abstract 2068: Engineering of hairpin loop enhances the loading of endogenously expressed pre-miRNA into extracellular vesicles
Journal Articles

Abstract 4562: Inhibition of STAT3 signaling in human liver cancer cells using Evista

Yina Wang, Chongqiang Zhao, Haiyan Ma, Huameng Li, Jiagao Lu, Chenglong Li, Jiayuh Lin, Li Lin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4562.
https://doi.org/10.1158/1538-7445.AM2016-4562
Published: 15 July 2016
View article titled, Abstract 4562: Inhibition of STAT3 signaling in human liver cancer cells using Evista
Journal Articles

Abstract 2050: Persistent STAT3 signaling contributes to the resistance of anti cancer drugs doxorubicin and cisplatin, and MEK inhibitor AZD6244 in human sarcoma cells

Xiaojuan Wu, Hui Xiao, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2050.
https://doi.org/10.1158/1538-7445.AM2015-2050
Published: 01 August 2015
View article titled, Abstract 2050: Persistent STAT3 signaling contributes to the resistance of anti cancer drugs doxorubicin and cisplatin, and MEK inhibitor AZD6244 in human sarcoma cells
Journal Articles

Abstract 4598: GP130 as a novel therapeutic target in il-6-dependent cancers

Hui Xiao, Yang Bian, Chengguang Zhao, Li Lin, David Jou, Huameng Li, Chenglong Li, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4598.
https://doi.org/10.1158/1538-7445.AM2014-4598
Published: 01 October 2014
View article titled, Abstract 4598: GP130 as a novel therapeutic target in il-6-dependent cancers
Journal Articles

Abstract 4073: STAT3 inhibitors elicit direct anti-tumor effects against human biliary caner cell lines and limit release of immune suppressive cytokines in vitro

Jennifer Yang, Kaitlin Keenan, Thomas Mace, Tanios Bekaii-Saab, James Fuchs, Eric Schwartz, Chenglong Li, Jiayuh Lin, Pui-Kai Li, Gregory Lesinski
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4073.
https://doi.org/10.1158/1538-7445.AM2014-4073
Published: 01 October 2014
View article titled, Abstract 4073: STAT3 inhibitors elicit direct anti-tumor effects against human biliary caner cell lines and limit release of immune suppressive cytokines <em>in vitro</em>
Journal Articles

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Fengting Yan, Lapo Alinari, Mark E. Lustberg, Ludmila Katherine Martin, Hector M. Cordero-Nieves, Yeshavanth Banasavadi-Siddegowda, Selene Virk, Jill Barnholtz-Sloan, Erica Hlavin Bell, Jeffrey Wojton, Naduparambil K. Jacob, Arnab Chakravarti, Michal O. Nowicki, Xin Wu, Rosa Lapalombella, Jharna Datta, Bo Yu, Kate Gordon, Amy Haseley, John T. Patton, Porsha L. Smith, John Ryu, Xiaoli Zhang, Xiaokui Mo, Guido Marcucci, Gerard Nuovo, Chang-Hyuk Kwon, John C. Byrd, E. Antonio Chiocca, Chenglong Li, Said Sif, Samson Jacob, Sean Lawler, Balveen Kaur, Robert A. Baiocchi
Journal: Cancer Research
Cancer Res (2014) 74 (6): 1752–1765.
https://doi.org/10.1158/0008-5472.CAN-13-0884
Published: 13 March 2014
View article titled, Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
Open the PDF for Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

Paula Kroon, Paul A. Berry, Michael J. Stower, Greta Rodrigues, Vincent M. Mann, Matthew Simms, Deepak Bhasin, Somsundaram Chettiar, Chenglong Li, Pui-Kai Li, Norman J. Maitland, Anne T. Collins
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (16): 5288–5298.
https://doi.org/10.1158/0008-5472.CAN-13-0874
Published: 13 August 2013
View article titled, JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
Open the PDF for JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 3252: A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells.

Hui Xiao, Wenying Yu, Veronica R. Olson, Chenglong Li, Peter Houghton, Jiayuh Lin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3252.
https://doi.org/10.1158/1538-7445.AM2013-3252
Published: 15 April 2013
View article titled, Abstract 3252: A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells.
Journal Articles

Abstract 4637: Developing a first in class of drug to inhibit protein arginine methyltransferase 5 (PRMT5) enzyme dysregulation in glioblastoma multiforme.

Fengting Yan, Kate Gordon, Kiran Mahasenan, Mark Lustberg, Lapo Alinari, Christian T. Earl, Balveen Kaur, Chenglong Li, Robert A. Baiocchi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4637.
https://doi.org/10.1158/1538-7445.AM2013-4637
Published: 15 April 2013
View article titled, Abstract 4637: Developing a first in class of drug to inhibit protein arginine methyltransferase 5 (PRMT5) enzyme dysregulation in glioblastoma multiforme.
Journal Articles

Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia .

Somayeh S. Tarighat, Kiran Mahasenan, Danilo Perrotti, Ramiro Garzon, Michael Caligiuri, Chenglong Li, William Blum, Guido Marcucci, Robert A. Baiocchi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1128.
https://doi.org/10.1158/1538-7445.AM2013-1128
Published: 15 April 2013
View article titled, Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia .
Journal Articles

Abstract 3049: Development of novel survivin inhibitors to target mitotic machinery in cancers

James V. Cooley, Somsundaram Chettiar, In-Hee Park, Deepak Bhasin, Arnab Chakravarti, Li Pui Kai, Chenglong Li, Naduparambil K. Jacob
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3049.
https://doi.org/10.1158/1538-7445.AM2012-3049
Published: 15 April 2012
View article titled, Abstract 3049: Development of novel survivin inhibitors to target mitotic machinery in cancers