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Journal Articles

Abstract 6051: Opposing function of USP5 in MRE11 endonuclease activity to evade anti-tumor immunity

Free
Chuan-Chun Lee, Wan-Rong Wu, Liang-Chih Liu, Ting-Yi Liao, You-Zhe Lin, Fang-Ying Lin, Yi-Chun Shen, Feng-Chi Chung, Yuan-Liang Wang, Chih-Hao Lu, Wei-Chung Cheng, Wei-Chao Chang, Yi-Chuan Li, Chih-Tung Lin, Chung-Yu Chen, Sheng-Wen Chen, Hsin-An Shih, Steven Lin, I-Wen Chou, Chen-Yuan Lin, Chang-Feng Chiu, Shao-Chun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6051.
https://doi.org/10.1158/1538-7445.AM2025-6051
Published: 21 April 2025
View articletitled, Abstract 6051: Opposing function of USP5 in MRE11 endonuclease activity to evade anti-tumor immunity
Journal Articles

Abstract A029: Evaluating and interpreting scGPT: A foundation model for single-cell biology in real-world cancer clinical trial data

Free
Runzi Tan, Haotian Cui, Bo Wang, Kimberly Perez, Andressa Dias Costa, Alexander Jordan, Thomas Karacic, Dalia Elganainy, Dan Y Gui, Suryun Kim, Chen Yuan, Morgan Truitt, Michael Downes, Ronald Evans, Tae Gyu Oh, Peter O’Dwyer, Andrew Aguirre, Jonathan A Nowak, Brian Wolpin, Simona Cristea
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A029.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A029
Published: 15 September 2024
View articletitled, Abstract A029: Evaluating and interpreting scGPT: A foundation model for single-cell biology in real-world cancer clinical trial data
Journal Articles

Abstract PR-21: Temporal stability and chemotherapy responsiveness of classical and basal transcriptional subtypes of pancreatic cancer

Free
Harshabad Singh, Joanne Xiu, Kevin Kapner, Chen Yuan, Raja R Narayan, Matthew Oberley, Alex Farrell, Rishi Surana, Brandon M Huffmann, Kimberly J Perez, James M Cleary, Alexander C Jordan, Andressa Dias Costa, Hannah L Williams, Srivatsan Raghavan, Benjamin Weinberg, Michael J Pishvaian, Rachna T Shroff, Sanjay Goel, Stephanie K Dougan, Jonathan Nowak, David Spetzler, George Sledge, Brian M Wolpin, Andrew J Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-21.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-21
Published: 15 September 2024
View articletitled, Abstract PR-21: Temporal stability and chemotherapy responsiveness of classical and basal transcriptional subtypes of pancreatic cancer
Journal Articles

Abstract A035: Stromal composition, fibroblast heterogeneity and spatial organization in pancreatic adenocarcinoma

Free
Dalia Elganainy, Andressa Dias Costa, Alexander Jordan, Suryun Kim, Sara A. Väyrynen, Hannah L. Williams, Chen Yuan, Douglas A. Rubinson, Kimberly Perez, Harshabad Singh, Richard F. Dunne, Thomas E. Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A035.
https://doi.org/10.1158/1538-7445.PANCA2023-A035
Published: 16 January 2024
View articletitled, Abstract A035: Stromal composition, fibroblast heterogeneity and spatial organization in pancreatic adenocarcinoma
Journal Articles

Abstract 5220: Prediagnostic vitamin D status and colorectal cancer survival by vitamin D-binding protein isoforms in the US cohorts

Free
Hanseul Kim, Chen Yuan, Long H. Nguyen, Kimmie Ng, Edward L. Giovannucci
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5220.
https://doi.org/10.1158/1538-7445.AM2023-5220
Published: 04 April 2023
View articletitled, Abstract 5220: Prediagnostic vitamin D status and colorectal cancer survival by vitamin D-binding protein isoforms in the US cohorts
Journal Articles

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

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Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 441–455.
https://doi.org/10.1158/0008-5472.CAN-22-3050
Published: 03 February 2023
View articletitled, Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Open the PDF for Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Abstract A001: Clinical-genomic analysis of KRAS wild-type pancreatic cancer confirms alternative targetable drivers and provides insight for age and risk related clinical stratification

Free
Harshabad Singh, Rachel B. Keller, Kevin S. Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Eizabeth Cohen, Michael Tolstorukov, Emma Hill, Elizabeth Andrews, Lauren K. Brais, Annacarolina Da Silva, Kimberly Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Michael H. Rosenthal, Jason L. Hornick, Valentina Nardi, Yvonne Li, Hersh Gupta, Andrew Cherniack, Mathew L. Meyerson, James M. Cleary, Jonathan A. Nowak, Brian M. Wolpin, Andrew A. Aguirre
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A001.
https://doi.org/10.1158/1538-7445.PANCA22-A001
Published: 15 November 2022
View articletitled, Abstract A001: Clinical-genomic analysis of KRAS wild-type pancreatic cancer confirms alternative targetable drivers and provides insight for age and risk related clinical stratification
Journal Articles

Abstract 5934: Weight loss and subsequent cancer diagnosis: A prospective cohort study

Free
Qiao-Li Wang, Ana Babic, Michael H. Rosenthal, Alice A. Lee, Yin Zhang, Xuehong Zhang, Mingyang Song, Leandro F. Rezende, Dong Hoon Lee, Leah Biller, Kimmie Ng, Andrew T. Chan, Meir J. Stampfer, Edward L. Giovannucci, Peter Kraft, Chen Yuan, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5934.
https://doi.org/10.1158/1538-7445.AM2022-5934
Published: 15 June 2022
View articletitled, Abstract 5934: Weight loss and subsequent cancer diagnosis: A prospective cohort study
Journal Articles

Abstract 5891: The age-dependent association of risk factors with pancreatic cancer

Free
Chen Yuan, Jihye Kim, Qiao-Li Wang, Alice A. Lee, Ana Babic, PanScan/PanC4 I-III Consortium, Laufey T. Amundadottir, Alison P. Klein, Donghui Li, Marjorie L. McCullough, Gloria M. Petersen, Harvey A. Risch, Rachael Z. Stolzenberg-Solomon, Kimberly Perez, Kimmie Ng, Edward L. Giovannucci, Meir J. Stampfer, Peter Kraft, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5891.
https://doi.org/10.1158/1538-7445.AM2022-5891
Published: 15 June 2022
View articletitled, Abstract 5891: The age-dependent association of risk factors with pancreatic cancer
Journal Articles

Abstract LB550: AI predicts risk of pancreatic cancer from disease trajectories using real-world electronic health records (EHRs) from Denmark and the USA

Free
Davide Placido, Bo Yuan, Jessica X. Hjaltelin, Amalie D. Haue, Piotr J. Chmura, Chen Yuan, Jihye Kim, Renato Umeton, Gregory Antell, Alexander Chowdhury, Alexandra Franz, Lauren Brais, Elizabeth Andrews, Debora S. Marks, Aviv Regev, Peter Kraft, Brian M. Wolpin, Michael Rosenthal, Søren Brunak, Chris Sander
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB550.
https://doi.org/10.1158/1538-7445.AM2022-LB550
Published: 15 June 2022
View articletitled, Abstract LB550: AI predicts risk of pancreatic cancer from disease trajectories using real-world electronic health records (EHRs) from Denmark and the USA
Journal Articles

Abstract 28: New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis

Free
Hongmei Zeng, Chen Yuan, Jakub Morze, Ruiying Fu, Kai Wang, Liang Wang, Feng Sun, John S. Ji, Edward L. Giovannucci, Mingyang Song
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 28.
https://doi.org/10.1158/1538-7445.AM2022-28
Published: 15 June 2022
View articletitled, Abstract 28: New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis
Journal Articles

Abstract 840: Gallstones and risk of cancers of the liver, biliary tract, and pancreas: A prospective study within two U.S. cohorts

Free
Xiao Luo, wanshui yang, Amit Joshi, Kana Wu, Tracey Simon, Chen Yuan, Lina Jin, Lu Long, Mi Na Kim, Chun-Han Lo, Xing Liu, Thomas A. Abrams, Brian M. Wolpin, Andrew T. Chan, Edward L. Giovannucci, Xuehong Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 840.
https://doi.org/10.1158/1538-7445.AM2021-840
Published: 01 July 2021
View articletitled, Abstract 840: Gallstones and risk of cancers of the liver, biliary tract, and pancreas: A prospective study within two U.S. cohorts
Journal Articles

Abstract IA-11: An exception to the rule: A coding functional variant at a pancreatic cancer GWAS locus

Free
Ashley Jermusyk, Jun Zhong, Naomi Gordon, Katelyn Connelly, Sumeth Perera, Ehssan Abdolalizadeh, Tongwu Zhang, Aidan O'Brien, Jason Hoskins, Irene Collins, Daina Eiser, Chen Yuan, Harvey Risch, Eric J. Jacobs, Donghui Li, Mengmeng Du, Rachael Stolzenberg-Solomon, Alison P. Klein, Jill P. Smith, Brian M. Wolpin, Stephen J. Chanock, Jianxin Shi, Gloria M. Petersen, Christopher Westlake, Laufey T. Amundadottir
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): IA-11.
https://doi.org/10.1158/1538-7445.PANCA20-IA-11
Published: 13 November 2020
View articletitled, Abstract IA-11: An exception to the rule: A coding functional variant at a pancreatic cancer GWAS locus
Journal Articles

Abstract PO-013: MTAP protein expression is lost in nearly one-third of primary pancreatic cancers and is associated with sensitivity to MAT2A inhibition in patient-derived organoid models

Free
Sara A. Väyrynen, Annan Yang, Junning Wang, Jinming Zhang, Kristen Lowder, Kevin S. Kapner, Tim Bosse, Sri Raghavan, Andressa Dias Costa, Hannah Williams, Chen Yuan, Ashley Pelton, Vicente Morales-Oyarvide, Douglas A. Rubinson, Lauren Brais, Emma Reilly, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Brian M. Wolpin, Jonathan A Nowak, Andrew J Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-013.
https://doi.org/10.1158/1538-7445.PANCA20-PO-013
Published: 13 November 2020
View articletitled, Abstract PO-013: MTAP protein expression is lost in nearly one-third of primary pancreatic cancers and is associated with sensitivity to MAT2A inhibition in patient-derived organoid models
Journal Articles

Abstract PR-006: Spatially resolved, single cell assessment of pancreatic ductal adenocarcinoma expression subtypes reveals mixed and hybrid basal-classical marker expression with prognostic significance and discrete spatial localization

Free
Hannah L. Williams, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin Kapner, Sara Vayrynen, Andressa Dias Costa, Chen Yuan, Mai Chan Lau, Vicente Morales-Oyarvide, Douglas Rubinson, Lauren Brais, Emma Reilly, Margaret Kozak, David Linehan, Richard Dunne, Daniel Chang, Albert Koong, Aram Hezel, William C. Hahn, Alek K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M Wolpin
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-006.
https://doi.org/10.1158/1538-7445.PANCA20-PR-006
Published: 13 November 2020
View articletitled, Abstract PR-006: Spatially resolved, single cell assessment of pancreatic ductal adenocarcinoma expression subtypes reveals mixed and hybrid basal-classical marker expression with prognostic significance and discrete spatial localization
Journal Articles

Abstract PR-001: Neoadjuvant therapy is associated with altered composition of immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer

Free
Andressa Dias Costa, Sara Väyrynen, Akhil Chawla, Jinming Zhang, Juha P. Väyrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Douglas A. Rubinson, Thomas E. Clancy, Lauren K. Brais, Emma Reilly, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-001.
https://doi.org/10.1158/1538-7445.PANCA20-PR-001
Published: 13 November 2020
View articletitled, Abstract PR-001: Neoadjuvant therapy is associated with altered composition of immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer
Journal Articles

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Free
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, John M. Krill-Burger, Andrew L. Hong, Guillaume Kugener, Jeremie Kalfon, Annan Yang, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Federica Piccioni, Brian M. Wolpin, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-053.
https://doi.org/10.1158/1538-7445.AM2020-LB-053
Published: 15 August 2020
View articletitled, Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4
Journal Articles

Abstract 3297: Prediagnostic circulating concentrations of vitamin D binding protein and survival among colorectal cancer patients

Free
Chen Yuan, Mingyang Song, Brian M. Wolpin, Jeffrey A. Meyerhardt, Shuji Ogino, Bruce W. Hollis, Andrew T. Chan, Charles S. Fuchs, Kana Wu, Molin Wang, Stephanie A. Smith-Warner, Edward L. Giovannucci, Kimmie Ng
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3297.
https://doi.org/10.1158/1538-7445.AM2019-3297
Published: 01 July 2019
View articletitled, Abstract 3297: Prediagnostic circulating concentrations of vitamin D binding protein and survival among colorectal cancer patients
Journal Articles

Abstract 4945: Absolute risk prediction models for pancreatic cancer

Free
Jihye Kim, Chen Yuan, Ana Babic, Ying Bao, Lauren K. Brais, Marisa W. Welch, Meir Stampfer, Edward L. Giovannucci, Howard D. Sesso, JoAnn E. Manson, Charles S. Fuchs, Brian M. Wolpin, Peter Kraft
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4945.
https://doi.org/10.1158/1538-7445.AM2018-4945
Published: 01 July 2018
View articletitled, Abstract 4945: Absolute risk prediction models for pancreatic cancer
Journal Articles

Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms

Free
Ana Babic, Ying Bao, Zhi Rong Qian, Chen Yuan, Edward L. Giovannucci, Hugues Aschard, Peter Kraft, Laufey T. Amundadottir, Rachael Stolzenberg-Solomon, Vicente Morales-Oyarvide, Kimmie Ng, Meir J. Stampfer, Shuji Ogino, Julie E. Buring, Howard D. Sesso, John Michael Gaziano, Nader Rifai, Michael N. Pollak, Matthew L. Anderson, Barbara B. Cochrane, Juhua Luo, JoAnn E. Manson, Charles S. Fuchs, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2016) 76 (24): 7160–7167.
https://doi.org/10.1158/0008-5472.CAN-16-1699
Published: 15 December 2016
View articletitled, Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms
Open the PDF for Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms in another window
Includes: Supplementary data