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Journal Articles

Abstract 1520: A novel cluster of cytolytic alpha/beta TCR+CD4−CD8−T cells originating from CD8+T cells with potent innate-like T cell killing ability: implicating adoptive T cell transfer therapy for hepatocellular carcinoma

Cheng-Heng Wu, Te-Wei Tseng, Chen-Yang Huang, Ping-Hsun Ou, Yi-Chen Lin, Pin-Jung Chen, Po-Ting Lin, Chan-Keng Yang, Wei Teng, Tsung-Han Wu, Yung-Chang Lin, Chun-Yen Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1520.
https://doi.org/10.1158/1538-7445.AM2024-1520
Published: 22 March 2024
View articletitled, Abstract 1520: A novel cluster of cytolytic alpha/beta TCR+CD4−CD8−T cells originating from CD8+T cells with potent innate-like T cell killing ability: implicating adoptive T cell transfer therapy for hepatocellular carcinoma
Journal Articles

Abstract 3161: Novel gene signature for predicting aggressive type of bladder cancer and the associated therapeutic strategies

Jim Jinn-Chyuan Sheu, Chung Chang, Bo-Chen Lin, Tritium Hwang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3161.
https://doi.org/10.1158/1538-7445.AM2023-3161
Published: 04 April 2023
View articletitled, Abstract 3161: Novel gene signature for predicting aggressive type of bladder cancer and the associated therapeutic strategies
Journal Articles

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2023) 83 (6): 922–938.
https://doi.org/10.1158/0008-5472.CAN-21-3052
Published: 15 March 2023
View articletitled, Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
Open the PDF for Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 5397: Gene signatures for predicting patients with aggressive type of bladder cancer and shorter survivals

Jim Jinn-Chyuan Sheu, Bo-Chen Lin, Oscar Yang, Chung Chang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5397.
https://doi.org/10.1158/1538-7445.AM2022-5397
Published: 15 June 2022
View articletitled, Abstract 5397: Gene signatures for predicting patients with aggressive type of bladder cancer and shorter survivals
Journal Articles

Abstract PD10-04: Phase Ib/II open-label, randomized trial of atezolizumab (atezo) with ipatasertib (ipat) and fulvestrant (fulv) vs control in MORPHEUS-HR+ breast cancer (M-HR+ BC) and atezo with ipat vs control in MORPHEUS triple negative breast cancer (M-TNBC)

Sara A. Hurvitz, Valentina Boni, Elizabeth Comen, Seock-Ah Im, Kyung Hae Jung, Sung-Bae Kim, Keun Seok Lee, Sherene Loi, Hope S. Rugo, Amir Sonnenblick, Melinda L. Telli, Kelly DuPree, Marcella Fasso, Ya-Chen Lin, Mina Nikanjam, Frauke Schimmoller, Xiaosong Zhang, Jing Zhu, Peter Schmid
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD10-04.
https://doi.org/10.1158/1538-7445.SABCS21-PD10-04
Published: 15 February 2022
View articletitled, Abstract PD10-04: Phase Ib/II open-label, randomized trial of atezolizumab (atezo) with ipatasertib (ipat) and fulvestrant (fulv) vs control in MORPHEUS-HR+ breast cancer (M-HR+ BC) and atezo with ipat vs control in MORPHEUS triple negative breast cancer (M-TNBC)
Journal Articles

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (5): 1216–1229.
https://doi.org/10.1158/0008-5472.CAN-20-0652
Published: 01 March 2021
View articletitled, A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
Open the PDF for A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma

Li Peng, Xiaoqing Yuan, Zhen Chen, Chaoyang Zhang, Duanqing Tian, Dong Yin, De-Chen Lin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4686.
https://doi.org/10.1158/1538-7445.AM2020-4686
Published: 15 August 2020
View articletitled, Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma
Journal Articles

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shaoyan Hu, Li-Yan Xu, En-Min Li, Yanbing Ding, Samuel J. Klempner, Simon A. Gayther, Benjamin P. Berman, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (13): 2722–2736.
https://doi.org/10.1158/0008-5472.CAN-20-0390
Published: 02 July 2020
View articletitled, Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
Open the PDF for Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling

Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding, Anand Mayakonda, Nachiyappan Venkatachalam, Mei-Shi Yeo, Tiago C. Silva, Jin-Fen Xiao, Ngan B. Doan, Jonathan W. Said, Xue-Bin Ran, Si-Qin Zhou, Pushkar Dakle, Pavithra Shyamsunder, Angele Pei-Fern Koh, Ruby Yun-Ju Huang, Benjamin P. Berman, Soo-Yong Tan, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2020) 80 (2): 219–233.
https://doi.org/10.1158/0008-5472.CAN-18-2796
Published: 15 January 2020
View articletitled, RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling
Open the PDF for RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling in another window
Includes: Supplementary data
Journal Articles

Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma

Rui You, You-Ping Liu, De-Chen Lin, Qing Li, Tao Yu, Xiong Zou, Mei Lin, Xiao-Long Zhang, Gui-Ping He, Qi Yang, Yi-Nuan Zhang, Yu-Long Xie, Rou Jiang, Chen-Yan Wu, Chao Zhang, Cheng Cui, Jing-Qi Wang, Yue Wang, Ai-Hua Zhuang, Gui-Fang Guo, Yi-Jun Hua, Rui Sun, Jing-Ping Yun, Zhi-Xiang Zuo, Ze-Xian Liu, Xiao-Feng Zhu, Tie-Bang Kang, Chao-Nan Qian, Hai-Qiang Mai, Ying Sun, Mu-Sheng Zeng, Lin Feng, Yi-Xin Zeng, Ming-Yuan Chen
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5930–5943.
https://doi.org/10.1158/0008-5472.CAN-18-3845
Published: 02 December 2019
View articletitled, Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
Open the PDF for Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma in another window
Includes: Supplementary data
Journal Articles

Use of Natural Language Processing to Extract Clinical Cancer Phenotypes from Electronic Medical Records

Guergana K. Savova, Ioana Danciu, Folami Alamudun, Timothy Miller, Chen Lin, Danielle S. Bitterman, Georgia Tourassi, Jeremy L. Warner
Journal: Cancer Research
Cancer Res (2019) 79 (21): 5463–5470.
https://doi.org/10.1158/0008-5472.CAN-19-0579
Published: 01 November 2019
View articletitled, Use of Natural Language Processing to Extract Clinical Cancer Phenotypes from Electronic Medical Records
Open the PDF for Use of Natural Language Processing to Extract Clinical Cancer Phenotypes from Electronic Medical Records in another window
Journal Articles

Abstract 2939: Developing new therapeutic strategy to bladder cancer by targeting CK1 delta

Yu-Chen Lin, Mei-chuan Chen, Jing-Ping Liou, Chun-Han Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2939.
https://doi.org/10.1158/1538-7445.AM2019-2939
Published: 01 July 2019
View articletitled, Abstract 2939: Developing new therapeutic strategy to bladder cancer by targeting CK1 delta
Journal Articles

Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma

Li Peng, Binyuan Jiang, Xiaoqing Yuan, Yuntan Qiu, Jiangyun Peng, Yongsheng Huang, Chaoyang Zhang, Yin Zhang, Zhaoyu Lin, Jinsong Li, Weicheng Yao, Weixi Deng, Yaqin Zhang, Meng Meng, Xi Pan, Chunquan Li, Dong Yin, Xinyu Bi, Guancheng Li, De-Chen Lin
Journal: Cancer Research
Cancer Res (2019) 79 (3): 572–584.
https://doi.org/10.1158/0008-5472.CAN-18-0367
Published: 01 February 2019
View articletitled, Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma
Open the PDF for Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5339: Epigenetic silencing of ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment

Michael WY Chan, Hsiao-Yen Hsieh, Yeong-Chin Jou, Chun-Liang Tung, Yuh-Shyan Tsai, Yuan-Hung Wang, Chen-Lin Chi, Ru-Inn Lin, Shih-Kai Hung, Yu-Ming Chuang, Shu-Fen Wu, Chin Li, Cheng-Huang Shen, Cheng-Da Hsu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5339.
https://doi.org/10.1158/1538-7445.AM2018-5339
Published: 01 July 2018
View articletitled, Abstract 5339: Epigenetic silencing of ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment
Journal Articles

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma

Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W. Tyner, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6614–6626.
https://doi.org/10.1158/0008-5472.CAN-17-1143
Published: 30 November 2017
View articletitled, Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
Open the PDF for Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma in another window
Includes: Supplementary data
Journal Articles

DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records

Guergana K. Savova, Eugene Tseytlin, Sean Finan, Melissa Castine, Timothy Miller, Olga Medvedeva, David Harris, Harry Hochheiser, Chen Lin, Girish Chavan, Rebecca S. Jacobson
Journal: Cancer Research
Cancer Res (2017) 77 (21): e115–e118.
https://doi.org/10.1158/0008-5472.CAN-17-0615
Published: 01 November 2017
View articletitled, DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records
Open the PDF for DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma

Ye Chen, Liang Xu, Marina Dutra-Clarke, Anand Mayakonda, De-Chen Lin, Lynnette Koh, Yuk Kien Chong, Edwin Sandanaraj, Vikas Madan, Henry Yang, Ngan Doan, Jonathan W. Said, William H. Yong, Markus Müschen, Beng Ti Ang, Carol Tang, Joshua J. Breunig, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1524.
https://doi.org/10.1158/1538-7445.AM2017-1524
Published: 01 July 2017
View articletitled, Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma
Journal Articles

Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
View articletitled, Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target
Journal Articles

Abstract 2733: Comparison of copy number aberrations (CNAs) between plasma cell free DNA (cfDNA) and tissue DNA in metastatic castrate resistant prostate cancer (mCRPC)

Chiang-Ching Huang, Meijun Du, Liguo Wang, Yen-chen Lin, Hua Huang, Liewei Wang, Liang Wang, Manish Kohli
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2733.
https://doi.org/10.1158/1538-7445.AM2017-2733
Published: 01 July 2017
View articletitled, Abstract 2733: Comparison of copy number aberrations (CNAs) between plasma cell free DNA (cfDNA) and tissue DNA in metastatic castrate resistant prostate cancer (mCRPC)
Journal Articles

Abstract 798: Label-free enrichment and detection of circulating tumor cells in metastatic breast cancer patients show 82% of cohorts have detectable targets

Yu-Jen Chang, Chen-Lin Chen, Wei-Fan Hsu, Meng-Ze Li, Wei-Yuan Ma, Ken-Chao Chen, Guan-Syuan Huang, Wai-Sang Wong, Jhan-Yu Syu, Thomas, Yo-Yan Huang, Ching-Hung Lin, Andrew M. Wo, Chiun-Sheng Huang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 798.
https://doi.org/10.1158/1538-7445.AM2017-798
Published: 01 July 2017
View articletitled, Abstract 798: Label-free enrichment and detection of circulating tumor cells in metastatic breast cancer patients show 82% of cohorts have detectable targets