1-20 of 28
Charles Sawyers
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract LB312: FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity

Free
Erik Ladewig, Abbas Nazir, Tyler Park, Vinson B. Fan, Robert Tijian, Christina Leslie, Charles Sawyers
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB312.
https://doi.org/10.1158/1538-7445.AM2025-LB312
Published: 25 April 2025
View article titled, Abstract LB312: FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Journal Articles

Abstract 1166: Lurbinectedin synergizes with selinexor by inhibiting DNA damage repair and enhancing immune cell infiltration in neuroendocrine lung and prostate tumors

Free
Esther Redin, Parvathy Manoj, Juan Qiu, Barbara de Mello, Hong Zhong, Suleyman Vural, Yingqian Zhan, Rodrigo Romero, Nicholas Socci, Richard Koche, Charles Sawyers, Elisa de Stanchina, Charles M Rudin, Alvaro Quintanal-Villalonga
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1166.
https://doi.org/10.1158/1538-7445.AM2025-1166
Published: 21 April 2025
View article titled, Abstract 1166: Lurbinectedin synergizes with selinexor by inhibiting DNA damage repair and enhancing immune cell infiltration in neuroendocrine lung and prostate tumors
Journal Articles

Abstract C006: Tumor-associated macrophages drive prostate cancer progression via IL-1β signaling

Free
Young Sun Lee, Jimmy L. Zhao, Max Land, Joseph Chan, Perianne Smith, Roshan Sharma, Sanjay Kottapalli, Linda Fong, Zhenghao Chen, Cathy Wang, Jesse Kirkpatrick, Ava Soleimany, Samir Zaidi, Kayla Lawrence, Amanda Kulick, Teng Han, Zhen Sun, Philip Watson, Anuradha Gopalan, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Ronan Chaligne, Dana Rathkopf, Michael Morris, Sangeeta Bhatia, Michael Haffner, Dana Pe'er, Charles Sawyers
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): C006.
https://doi.org/10.1158/1538-7445.TUMBODY-C006
Published: 17 November 2024
View article titled, Abstract C006: Tumor-associated macrophages drive prostate cancer progression via IL-1β signaling
Journal Articles

Abstract 1246: Erg-driven prostate cancer emerges from a basal subset of cells with luminal transcriptomic features

Free
Erik Ladewig, Weiran Feng, Christina Leslie, Charles Sawyers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1246.
https://doi.org/10.1158/1538-7445.AM2024-1246
Published: 22 March 2024
View article titled, Abstract 1246: Erg-driven prostate cancer emerges from a basal subset of cells with luminal transcriptomic features
Journal Articles

Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer

Free
Srushti Kittane, Erik Ladewig, Taibo Li, Jillian Love, Amaia Arruabarrena-Aristorena, Xinyu Guo, Mirna Sallaku, Liliana Garcia-Martinez, Ryan Blawski, Javier Carmona Sanz, Christopher Simpkins, Wanlu Chen, Bujamin Vokshi, Peihua Zhao, Nachiket Kelkar, Laura Baldino, Ingrid Kalemi, Pau Castel, Emiliano Cocco, Lluis Morey, Charles Sawyers, Hongkai Ji, Maurizio Scaltriti, Alexis Battle, Christina Leslie, Wouter Karthaus, Eneda Toska
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2024-1245
Published: 22 March 2024
View article titled, Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer
Journal Articles

Abstract 2048: Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids

Free
Erik Ladewig, Abbas Nazir, Christina Leslie, Charles Sawyers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2048.
https://doi.org/10.1158/1538-7445.AM2023-2048
Published: 04 April 2023
View article titled, Abstract 2048: Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids
Journal Articles

Abstract 1594: Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

Free
Joseph M. Chan, Wouter R. Karthaus, Manu Setty, Jillian R. Love, Samir Zaidi, Jimmy Zhao, Zi-ning Choo, Sitara Persad, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Ignas Masilionis, Linas Mazutis, Ronan Chaligne, Dana Pe'er, Charles Sawyers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1594.
https://doi.org/10.1158/1538-7445.AM2022-1594
Published: 15 June 2022
View article titled, Abstract 1594: Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition
Journal Articles

Abstract 391: Identifying molecular drivers of olaparib resistance through genome-wide sgRNA screening in prostate organoids

Free
Kyrie Jean Pappas, Wouter Karthaus, Justin Laclair, Marco Russo, Charles Sawyers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 391.
https://doi.org/10.1158/1538-7445.AM2022-391
Published: 15 June 2022
View article titled, Abstract 391: Identifying molecular drivers of olaparib resistance through genome-wide sgRNA screening in prostate organoids
Journal Articles

Abstract 2200: Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

Free
Samir Zaidi, Jimmy Zhao, Joseph Chan, Roudier Martine, Kristine Wadosky, Anuradha Gopalan, Wouter Karthaus, Philip Watson, Lawrence True, Peter Nelson, Howard Scher, Michael Morris, Michael Haffner, David Goodrich, Dana Pe'er, Charles Sawyers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2200.
https://doi.org/10.1158/1538-7445.AM2022-2200
Published: 15 June 2022
View article titled, Abstract 2200: Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling
Journal Articles

Abstract 1728: Single cell RNA-seq analysis reveals a role of pro-inflammatory tumor-associated macrophages in driving prostate cancer progression

Free
Jimmy L. Zhao, Joseph Chan, Max Land, Perianne Smith, Anuradha Gopalan, Michael Haffner, Dana Pe'er, Charles Sawyers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1728.
https://doi.org/10.1158/1538-7445.AM2022-1728
Published: 15 June 2022
View article titled, Abstract 1728: Single cell RNA-seq analysis reveals a role of pro-inflammatory tumor-associated macrophages in driving prostate cancer progression
Journal Articles

Abstract PO-117: CHD1-loss promotes tumor heterogeneity and therapy resistance in prostate cancer

Free
Zeda Zhang, Chuanli Zhou, Xiaoling Li, Charles Sawyers, Ping Mu
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-117.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-117
Published: 03 November 2020
View article titled, Abstract PO-117: CHD1-loss promotes tumor heterogeneity and therapy resistance in prostate cancer
Journal Articles

Abstract NG06: CHD1-loss confers AR targeted therapy resistance via promoting cancer heterogeneity and lineage plasticity

Free
Zeda Zhang, Chuanli Zhou, Xiaoling Li, Spencer Barnes, Su Deng, Elizabeth Hoover, Chi-Chao Chen, Young Sun Lee, Choushi Wang, Carla Tirado, Lauren Metang, Nickolas Johnson, John Wongvipat, Kristina Navrazhina, Zhen Cao, Wassim Abida, Amaia Lujambio, Sheng Li, Vankat Malladi, Charles Sawyers, Ping Mu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG06.
https://doi.org/10.1158/1538-7445.AM2020-NG06
Published: 15 August 2020
View article titled, Abstract NG06: CHD1-loss confers AR targeted therapy resistance via promoting cancer heterogeneity and lineage plasticity
Journal Articles

Abstract 5722: Acquired stemness by luminal cells

Free
Wouter Karthaus, Matan Hofree, Danielle Choi, Eliot L. Linton, Mesruh Turkekul, Alborz Bejnood, Brett Carver, Anuhandra Gopalan, Vincent Laudone, Moshe Biton, Ojasvi Chaudhary, Ignas Masilionis, Linas Mazutis, Dana Pe'er, Aviv Regev, Charles Sawyers
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5722.
https://doi.org/10.1158/1538-7445.AM2020-5722
Published: 15 August 2020
View article titled, Abstract 5722: Acquired stemness by luminal cells
Journal Articles

Abstract 2328: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York

Free
Nicolas Robine, Fieke Froeling, Benjamin Hubert, Timothy Chu, Ashlea Chandler, Michael C. Zody, Dayna M. Oschwald, Harold E. Varmus, Charles Sawyers, David Tuveson
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2328.
https://doi.org/10.1158/1538-7445.AM2020-2328
Published: 15 August 2020
View article titled, Abstract 2328: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York
Journal Articles

Abstract 111: Tumor microenvironment derived NRG1 promotes antiandrogen resistance in prostate cancer

Free
Zeda Zhang, Wouter Karthaus, Jose Mauricio Mota, Ping Mu, Chao Wu, Wassim Abida, Eliot Linton, Young Sun Lee, Eugine Lee, Ninghui Mao, Elizabeth Adams, Danielle Choi, Dana E. Rathkopf, Brett Carver, Anuradha Gopalan, Xuejun Jiang, Philip Watson, Charles Sawyers
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 111.
https://doi.org/10.1158/1538-7445.AM2019-111
Published: 01 July 2019
View article titled, Abstract 111: Tumor microenvironment derived NRG1 promotes antiandrogen resistance in prostate cancer
Journal Articles

Abstract 2727: The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin

Free
Kirsten Kubler, Rosa Karlic, Nicholas J. Haradhvala, Kyungsik Ha, Jaegil Kim, Maja Kuzman, Wei Jiao, Sitanshu Gakkhar, Kent W. Mouw, Lior Z. Braunstein, Olivier Elemento, Andrew V. Biankin, Ilse Rooman, Mendy Miller, Christopher D. Nogiec, Edward Curry, Mari Mino-Kenudson, Leif W. Ellisen, Robert Brown, Alexander Gusev, Cristian Tomasetti, Hong-Gee Kim, Hwajin Lee, Kristian Vlahovicek, Charles Sawyers, Katherine A. Hoadley, Edwin Cuppen, Amnon Koren, Peter F. Arndt, David N. Louis, Lincoln Stein, William D. Foulkes, Paz Polak, Gad Getz
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2727.
https://doi.org/10.1158/1538-7445.AM2019-2727
Published: 01 July 2019
View article titled, Abstract 2727: The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin
Journal Articles

Abstract 5287: Heterogeneity of mutation calling and annotation: a survey of cancer next-generation sequencing initiatives by the Global Alliance for Genomics and Health (GA4GH)

Free
Daniel J. Vis, Jeremy Lewin, Lillian Siu, Rachel Liao, Jean Claude Zenklusen, Fabien Calvo, Edit Szepessy, Ana Vivancos, Valtteri Wirta, Subha Madhavan, Keunchil Park, Daniel Tan, Janessa Laskin, Melissa Brammer, Emmanuel Dias-Neto, Anthony Tolcher, Thomas J. Hudson, Charles Sawyers, Mark Lawler, Emile E. Voest
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5287.
https://doi.org/10.1158/1538-7445.AM2016-5287
Published: 15 July 2016
View article titled, Abstract 5287: Heterogeneity of mutation calling and annotation: a survey of cancer next-generation sequencing initiatives by the Global Alliance for Genomics and Health (GA4GH)
Journal Articles

Abstract LB-276: The identification and characterization of prostate adenocarcinoma tumor initiating cells

Free
Supreet Agarwal, Paul Hynes, Ross Lake, Lei Fang, Heather Tillman, Mike Beshiri, Keith Jansson, Wouter Karthaus, Philip Iaquinta, Charles Sawyers, Kathleen Kelly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-276.
https://doi.org/10.1158/1538-7445.AM2016-LB-276
Published: 15 July 2016
View article titled, Abstract LB-276: The identification and characterization of prostate adenocarcinoma tumor initiating cells
Journal Articles

Abstract 1832: Large variations in clinical and ethical aspects of genomic sequencing initiatives: A Global Alliance for Genomics and Health (GA4GH) survey

Free
Jeremy Lewin, Daniel J. Vis, Mark Lawler, Rachel Liao, Mao Mao, Bin Tean Teh, William Sellers, Robyn Ward, Anamaria Aranha Camargo, Fabrice Andre, Richard Schilsky, Denis Lacombe, Tatsuhiro Shibata, Stephen Fox, Christophe Le Tourneau, William S. Dalton, Bartha Maria Knoppers, Charles Sawyers, Emile E. Voest, Lillian L. Siu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1832.
https://doi.org/10.1158/1538-7445.AM2016-1832
Published: 15 July 2016
View article titled, Abstract 1832: Large variations in clinical and ethical aspects of genomic sequencing initiatives: A Global Alliance for Genomics and Health (GA4GH) survey
Journal Articles

Abstract LB-018: Loss of function mutations of an ETS repressor expand the ETS positive subset of prostate cancer

Free
Rohit Bose, Wassim Abida, Wouter Karthaus, Joshua Armenia, Phillip Iaquinta, John Wongvipat, Michael Doran, Haley Hieronymus, Philip Watson, Patrick Sullivan, Yupu Liang, Nikolaus Schultz, Charles Sawyers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-018.
https://doi.org/10.1158/1538-7445.AM2016-LB-018
Published: 15 July 2016
View article titled, Abstract LB-018: Loss of function mutations of an ETS repressor expand the ETS positive subset of prostate cancer