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Charles L. Sawyers
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Journal Articles

Abstract 2004: CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation

Alvaro Quintanal-Villalonga, Fathema Uddin, Kenta Kawasaki, Esther Redin, Vidushi Durani, Amin Sabet, Wouter Karthaus, Yingqian A. Zhan, Samir Zaidi, Moniquetta Shaffer, Harsha Sridhar, Juan Qiu, Parvathy Manoj, Elisa De Stanchina, Michael C. Haffner, Charles L. Sawyers, Charles M. Rudin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2004.
https://doi.org/10.1158/1538-7445.AM2024-2004
Published: 22 March 2024
View article titled, Abstract 2004: CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation
Journal Articles

Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells

Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Ignas Masilionis, Katia Manova-Todorova, Ronan Chaligné, Elisa de Stanchina, Brett S. Carver, Yu Chen, Dong Gao, Christina S. Leslie, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): PR007.
https://doi.org/10.1158/1538-7445.PRCA2023-PR007
Published: 02 June 2023
View article titled, Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells
Journal Articles

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Jeffrey W. Tyner, Franziska Haderk, Anbarasu Kumaraswamy, Linda B. Baughn, Brian Van Ness, Song Liu, Himangi Marathe, Joshi J. Alumkal, Trever G. Bivona, Keith Syson Chan, Brian J. Druker, Alan D. Hutson, Peter S. Nelson, Charles L. Sawyers, Christopher D. Willey
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1448–1460.
https://doi.org/10.1158/0008-5472.CAN-21-3695
Published: 15 April 2022
View article titled, Understanding Drug Sensitivity and Tackling Resistance in Cancer
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Journal Articles

Abstract PO-134: Identification of the cells of origin and tumor heterogeneity in neuroendocrine prostate cancer (NEPC) by single-cell analysis

Jimmy L. Zhao, Samir Zaidi, Joseph Chan, Kristine Wadosky, Wouter Karthaus, Danielle Choi, Aura Agudelo Rivera, Anuradha Gopalan, Dana Rathkopf, Brett Carver, Wassim Abida, Howard Scher, Yu Chen, David Goodrich, Dana Pe’er, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-134.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-134
Published: 03 November 2020
View article titled, Abstract PO-134: Identification of the cells of origin and tumor heterogeneity in neuroendocrine prostate cancer (NEPC) by single-cell analysis
Journal Articles

Sanjiv “Sam” Gambhir, MD, PhD: In Memoriam (1962–2020)

Anna M. Wu, Andrei Iagaru, Harvey Herschman, Ralph Weissleder, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2020) 80 (20): 4305–4306.
https://doi.org/10.1158/0008-5472.CAN-20-2856
Published: 15 October 2020
View article titled, Sanjiv “Sam” Gambhir, MD, PhD: In Memoriam (1962–2020)
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Journal Articles

Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer

Amaia Arruabarrena-Aristorena, Jesper LV Maag, Srushti Kittane, Yanyan Cai, Jane Park, Pedram Razavi, Lorenzo Ferrando, Pier Selenica, Wouter R. Karthaus, Srinivasaraghavan Kannan, Emiliano Cocco, Sik Y. Ho, Daisylyn Senna Tan, Mirna Sallaku, Charles L. Sawyers, Jorge S. Reis-Fihlo, Chandra S. Verma, Ralf Jauch, Richard Koche, José Baselga, Eneda Toska, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2020-3439
Published: 15 August 2020
View article titled, Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
Journal Articles

Abstract 3430: The protein phosphatase 4 complex is a tumor suppressor in prostate cancer

Philip A. Watson, Kayla E. Lawrence, Tejasveeta V. Nadkarni, Taslima F. Ishmael, Eugine Lee, Aura C. Agudelo Rivera, Jillian R. Love, John Wongvipat, Ling Cai, Abbas Nazir, Phillip J. Iaquinta, Kenneth Chang, Yupu Liang, Greg J. Hannon, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3430.
https://doi.org/10.1158/1538-7445.AM2020-3430
Published: 15 August 2020
View article titled, Abstract 3430: The protein phosphatase 4 complex is a tumor suppressor in prostate cancer
Journal Articles

Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2

Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L. Sawyers, Anuradha Gopalan, Yu Chen, Brett S. Carver
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (7): 1428–1437.
https://doi.org/10.1158/0008-5472.CAN-19-1394
Published: 02 April 2020
View article titled, Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2
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Includes: Supplementary data
Journal Articles

Abstract 5128: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York

Fieke E. Froeling, Nicolas Robine, Benjamin Hubert, Michael Zody, Dayna Oschwald, Harold E. Varmus, Charles L. Sawyers, David A. Tuveson, On behalf of the NYGC P1000 Consortium
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5128.
https://doi.org/10.1158/1538-7445.AM2019-5128
Published: 01 July 2019
View article titled, Abstract 5128: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York
Journal Articles

Abstract 976: FOXA1 promotes a luminal growth program in prostate cancer

Elizabeth J. Adams, Elizabeth Hoover, Wouter R. Karthaus, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 976.
https://doi.org/10.1158/1538-7445.AM2018-976
Published: 01 July 2018
View article titled, Abstract 976: FOXA1 promotes a luminal growth program in prostate cancer
Journal Articles

Abstract LB-102: Landscape analysis of the initial data release from AACR Project GENIE

Ethan Cerami, Alexander S. Baras, Justin Guinney, Eva Lepisto, Trevor J. Pugh, Nikolaus Schultz, Thomas Stricker, Shawn M. Sweeney, Laura J. van't Veer, Gerrit A. Meijer, Fabrice Andre, Victor E. Velculescu, Kenna R. Shaw, Mia A. Levy, Philippe L. Bedard, Barrett J. Rollins, Charles L. Sawyers, on behalf of the AACR Project GENIE Consortium
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-102.
https://doi.org/10.1158/1538-7445.AM2017-LB-102
Published: 01 July 2017
View article titled, Abstract LB-102: Landscape analysis of the initial data release from AACR Project GENIE
Journal Articles

Abstract LB-103: Landscape of somatic ERBB2 Mutations: Findings from AACR GENIE and comparison to ongoing ERBB2 mutant basket study

Alison Schram, Helen H. Won, Fabrice Andre, Monica Arnedos, Funda Meric - Bernstam, Philippe L. Bedard, Kenna R. Shaw, Hugo Horlings, Christine Micheel, Ben Ho Park, Grace Mann, Alshad S. Lalani, Lillian Smyth, David B. Solit, Deborah Schrag, Mia A. Levy, Barrett J. Rollins, Mark Routbort, Charles L. Sawyers, Eva Lepisto, Michael F. Berger, David M. Hyman, on behalf of the AACR Project GENIE Consortium
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-103.
https://doi.org/10.1158/1538-7445.AM2017-LB-103
Published: 01 July 2017
View article titled, Abstract LB-103: Landscape of somatic ERBB2 Mutations: Findings from AACR GENIE and comparison to ongoing ERBB2 mutant basket study
Journal Articles

Abstract 3566: The long tail of significantly mutated genes in prostate cancer

Joshua Armenia, Stephanie Mullane, Jianjiong Gao, Debyani Chakravarty, Ritika Kundra, Franklin Huang, Celine Han, Dan Robinson, Levi A. Garraway, Peter Nelson, Mark Rubin, Mary-Ellen Taplin, Wassim Abida, Charles L. Sawyers, Arul M. Chinnaiyan, Philip W. Kantoff, Johann S. Bono, Nikolaus Schultz, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3566.
https://doi.org/10.1158/1538-7445.AM2017-3566
Published: 01 July 2017
View article titled, Abstract 3566: The long tail of significantly mutated genes in prostate cancer
Journal Articles

Abstract 1537: 3p13-14 FOXP1-SHQ1 deletion spanning multiple potential tumor suppressor genes cooperates with PTEN loss in cancer

Haley Hieronymus, Philip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1537.
https://doi.org/10.1158/1538-7445.AM2017-1537
Published: 01 July 2017
View article titled, Abstract 1537: 3p13-14 <em>FOXP1-SHQ1</em> deletion spanning multiple potential tumor suppressor genes cooperates with <em>PTEN</em> loss in cancer
Journal Articles

Abstract 2170: Rb1 suppresses prostate cancer metastasis and lineage plasticity underlying castration resistance

Sheng-Yu Ku, Spencer Rosario, Yanqing Wang, Ping Mu, Mukund Seshadri, Zachary Goodrich, Maxwell Goodrich, David P. Labbé, Eduardo Cortez Gomez, Jianmin Wang, Henry W. Long, Bo Xu, Myles Brown, Massimo Loda, Charles L. Sawyers, Leigh Ellis, David G. Goodrich
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2170.
https://doi.org/10.1158/1538-7445.AM2017-2170
Published: 01 July 2017
View article titled, Abstract 2170: <em>Rb1</em> suppresses prostate cancer metastasis and lineage plasticity underlying castration resistance
Journal Articles

Abstract 4165: SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 and RB1 deficient prostate cancer

Ping Mu, Zeda Zhang, Matteo Benelli, Wouter Karthaus, Elizebeth Hoover, Chi-Chao Chen, John Wongvipat, Sheng-Yu Ku, Dong Gao, Zhen Cao, Neel Shah, Elizabeth Adams, Wassim Abida, Philip Watson, Davide Prandi, Chun-Hao Huang, Elisa de Stanchina, Scott Lowe, Leigh Ellis, Himisha Beltran, Mark Rubin, David Goodrich, Francesca Demichelis, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4165.
https://doi.org/10.1158/1538-7445.AM2017-4165
Published: 01 July 2017
View article titled, Abstract 4165: <em>SOX2</em> promotes lineage plasticity and antiandrogen resistance in <em>TP53</em> and <em>RB1</em> deficient prostate cancer
Journal Articles

Abstract 238: Androgen insensitivity syndrome germline loss-of-function mutations in the androgen receptor that acquire somatic gain-of-function in prostate cancer

Philip A. Watson, Minna D. Balbas, Zeda Zhang, Taslima F. Ishmael, Kayla E. Lawrence, John Wongvipat, Sophie D. Sawyers, Yi-Mi Wu, Dan Robinson, Yang Shen, Arul M. Chinnaiyan, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 238.
https://doi.org/10.1158/1538-7445.AM2016-238
Published: 15 July 2016
View article titled, Abstract 238: Androgen insensitivity syndrome germline loss-of-function mutations in the androgen receptor that acquire somatic gain-of-function in prostate cancer
Journal Articles

Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making

Wassim Abida, Michael F. Walsh, Joshua Armenia, Joseph Vijai, Anuradha Gopalan, Ryan Brennan, Kristen Curtis, Maria Arcila, Daniel Danila, Angela Arnold, Dana Rathkopf, Michael J. Morris, Mark Robson, Susin Slovin, David Hyman, Jeremy Durack, Stephen B. Solomon, Herbert A. Vargas, Barry Taylor, Victor Reuter, David Solit, Michael F. Berger, Kenneth Offit, Charles L. Sawyers, Nikolaus Schultz, Howard I. Scher
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-070.
https://doi.org/10.1158/1538-7445.AM2016-LB-070
Published: 15 July 2016
View article titled, Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making
Journal Articles

Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation

Daniel E. Spratt, Michael J. Evans, Brian J. Davis, Michael G. Doran, Man Xia Lee, Neel Shah, John Wongvipat, Kathryn E. Carnazza, George G. Klee, William Polkinghorn, Donald J. Tindall, Jason S. Lewis, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2015) 75 (22): 4688–4696.
https://doi.org/10.1158/0008-5472.CAN-15-0892
Published: 15 November 2015
View article titled, Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation
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Includes: Supplementary data
Journal Articles

Abstract 4774: The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling

Sarit Schwartz, Brett S. Carver, John Wongvipat, Vanessa Rodrik-Outmezguine, Elisa D. Stanchina, Cath Trigwell, Simon Barry, Jose Baselga, Sarat Chandarlapaty, Howard I. Scher, Charles L. Sawyers, Neal Rosen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4774.
https://doi.org/10.1158/1538-7445.AM2014-4774
Published: 01 October 2014
View article titled, Abstract 4774: The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling