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Charles J. Link
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Journal Articles

Abstract LB355: Cryo-immune vaccination (CIV) by SYNC-T therapy: Preclinical modeling of a novel device-multidrug immunotherapeutic approach to eradicate advanced metastatic cancers

Free
James B. DuHadaway, Alexander J. Muller, Lisa D. Laury-Kleintop, U. Margaretha Wallon, Susan K. Gilmour, Marie Webster, Jason R. Williams, Gabriela R. Rossi, Mario R. Mautino, Jonathan Lewis, Charles J. Link, George C. Prendergast
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB355.
https://doi.org/10.1158/1538-7445.AM2024-LB355
Published: 05 April 2024
View articletitled, Abstract LB355: Cryo-immune vaccination (CIV) by SYNC-T therapy: Preclinical modeling of a novel device-multidrug immunotherapeutic approach to eradicate advanced metastatic cancers
Journal Articles

Abstract 6540: Regression of metastatic cancer and abscopal effects following in situ vaccination by cryosurgical tumor cell lysis and intratumoral immunotherapy: A case series

Free
Gary Onik, David Bostwick, David J. Vaughan, Donald L. Trump, Zurizaday Vega, Timothy Murphy, James Miessau, Marlene Wright-Barton, Danielle Hobbs, Charles J. Link, Jon H. Condra
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6540.
https://doi.org/10.1158/1538-7445.AM2020-6540
Published: 15 August 2020
View articletitled, Abstract 6540: Regression of metastatic cancer and abscopal effects following in situ vaccination by cryosurgical tumor cell lysis and intratumoral immunotherapy: A case series
Journal Articles

Abstract 3753: Indoximod modulates AhR-driven transcription of genes that control immune function

Free
Erik L. Brincks, James Adams, Michael Essmann, Benjamin A. Turner, Lifu Wang, Jiyuan Ke, Agnieszka Marcinowicz, Nicholas Vahanian, Charles J. Link, Mario R. Mautino
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3753.
https://doi.org/10.1158/1538-7445.AM2018-3753
Published: 01 July 2018
View articletitled, Abstract 3753: Indoximod modulates AhR-driven transcription of genes that control immune function
Journal Articles

Abstract CT004: Front-line therapy of DIPG using the IDO pathway inhibitor indoximod in combination with radiation and chemotherapy

Free
Theodore S. Johnson, Dolly Aguilera, Ahmad Al-Basheer, Robert C. Castellino, Bree R. Eaton, Natia Esiashvili, Nicholas Foreman, Ian M. Heger, Eugene P. Kennedy, Charles J. Link, William Martin, Eric K. Ring, Ramses F. Sadek, Amy Smith, Vahanian N. Vahanian, Tobey J. MacDonald, David H. Munn
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT004.
https://doi.org/10.1158/1538-7445.AM2018-CT004
Published: 01 July 2018
View articletitled, Abstract CT004: Front-line therapy of DIPG using the IDO pathway inhibitor indoximod in combination with radiation and chemotherapy
Journal Articles

Abstract 4076: A novel prodrug of indoximod with enhanced pharmacokinetic properties

Free
Mario R. Mautino, Sanjeev Kumar, Hong Zhuang, Jesse Waldo, Firoz Jaipuri, Hima Potturi, Erik Brincks, James Adams, Agnieszka Marcinowicz, Clarissa Van Allen, Nicholas Vahanian, Charles J. Link
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4076.
https://doi.org/10.1158/1538-7445.AM2017-4076
Published: 01 July 2017
View articletitled, Abstract 4076: A novel prodrug of indoximod with enhanced pharmacokinetic properties
Journal Articles

Abstract P2-15-04: A phase 1/2 study of Ad.p53 DC vaccine with indoximod immunotherapy in metastatic breast cancer

Free
Hatem H Soliman, Susan E Minton, Roohi Ismail-Khan, Hyo S Han, Nicholas N Vahanian, Charles J Link, Gene Kennedy, Howard Streicher, Daniel Sullivan, Scott J Antonia
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P2-15-04.
https://doi.org/10.1158/1538-7445.SABCS14-P2-15-04
Published: 01 May 2015
View articletitled, Abstract P2-15-04: A phase 1/2 study of Ad.p53 DC vaccine with indoximod immunotherapy in metastatic breast cancer
Journal Articles

Abstract 5023: Synergistic antitumor effects of combinatorial immune checkpoint inhibition with anti-PD-1/PD-L antibodies and the IDO pathway inhibitors NLG-919 and indoximod in the context of active immunotherapy

Free
Mario R. Mautino, Charles J. Link, Nicholas N. Vahanian, James T. Adams, Clarissa Van Allen, Madhav D. Sharma, Theodore S. Johnson, David Munn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5023.
https://doi.org/10.1158/1538-7445.AM2014-5023
Published: 01 October 2014
View articletitled, Abstract 5023: Synergistic antitumor effects of combinatorial immune checkpoint inhibition with anti-PD-1/PD-L antibodies and the IDO pathway inhibitors NLG-919 and indoximod in the context of active immunotherapy
Journal Articles

Abstract 1633: Novel specific- and dual- tryptophan-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO) inhibitors for tumor immunotherapy

Free
Mario R. Mautino, Richard A. Metz, Firoz Jaipuri, Jesse Waldo, Sanjeev Kumar, Agnieszka Marcinowicz-Flick, Hima Potturi, James T. Adams, Clarissa Van Allen, Nicholas N. Vahanian, Charles J. Link
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1633.
https://doi.org/10.1158/1538-7445.AM2014-1633
Published: 01 October 2014
View articletitled, Abstract 1633: Novel specific- and dual- tryptophan-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO) inhibitors for tumor immunotherapy
Journal Articles

Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy.

Free
Mario R. Mautino, Firoz A. Jaipuri, Jesse Waldo, Sanjeev Kumar, James Adams, Clarissa Van Allen, Agnieszka Marcinowicz-Flick, David Munn, Nicholas Vahanian, Charles J. Link
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 491.
https://doi.org/10.1158/1538-7445.AM2013-491
Published: 15 April 2013
View articletitled, Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy.
Journal Articles

Abstract 5507: Immunological findings in a phase II immunotherapy study using allogeneic lung cancer cells modified to express alpha(1,3)galactosyltransferase in advanced non-small cell lung cancer (NSCLC)

Free
Gabriela R. Rossi, Nicholas N. Vahanian, John C. Morris, Jay W. Ramsey, Lucinda Tennant, Charles J. Link
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5507.
https://doi.org/10.1158/1538-7445.AM2011-5507
Published: 15 April 2011
View articletitled, Abstract 5507: Immunological findings in a phase II immunotherapy study using allogeneic lung cancer cells modified to express alpha(1,3)galactosyltransferase in advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 2423: Phase I/II study of antitumor vaccination using lung cancer cells expressing murine α(1,3)galactosyltransferase (αGT) in non-small cell lung cancer (NSCLC)

Free
John C. Morris, Gabriela R. Rossi, John E. Janik, Nancy Harold, Stefania Pittaluga, Anatoli Malyguine, Susan Strobl, Lucinda Tennant, Nicholas Vahanian, Charles J. Link
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2423.
https://doi.org/10.1158/1538-7445.AM10-2423
Published: 15 April 2010
View articletitled, Abstract 2423: Phase I/II study of antitumor vaccination using lung cancer cells expressing murine α(1,3)galactosyltransferase (αGT) in non-small cell lung cancer (NSCLC)
Journal Articles

Treatment of pre-existing melanoma tumors using allogeneic vaccines expressing alpha(1,3)Gal epitopes. Efficacy and toxicology study

Free
Gabriela R. Rossi, Mario R. Mautino, Henry Lejukole, Marie Koenigsfeld, Christy Loiacono, Nicholas Vahanian, Tatiana Seregina, Charles J. Link
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 335–336.
Published: 15 April 2006
View articletitled, Treatment of pre-existing melanoma tumors using allogeneic vaccines expressing alpha(1,3)Gal epitopes. Efficacy and toxicology study
Journal Articles

Effective Treatment of Preexisting Melanoma with Whole Cell Vaccines Expressing α(1,3)-Galactosyl Epitopes

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Gabriela R. Rossi, Mario R. Mautino, Robert C. Unfer, Tatiana M. Seregina, Nicholas Vahanian, Charles J. Link
Journal: Cancer Research
Cancer Res (2005) 65 (22): 10555–10561.
https://doi.org/10.1158/0008-5472.CAN-05-0627
Published: 15 November 2005
View articletitled, Effective Treatment of Preexisting Melanoma with Whole Cell Vaccines Expressing α(1,3)-Galactosyl Epitopes
Open the PDF for Effective Treatment of Preexisting Melanoma with Whole Cell Vaccines Expressing α(1,3)-Galactosyl Epitopes in another window
Journal Articles

Novel vaccine immunotherapy for B-cell malignancies using adenoviral delivery of αGalactosyltransferase gene

Free
Robert C. Unfer, Elena Mitrofanova, Gabriela Rossi, James Wooldridge, George Weiner, Charles J. Link
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 816.
Published: 01 May 2005
View articletitled, Novel vaccine immunotherapy for B-cell malignancies using adenoviral delivery of αGalactosyltransferase gene
Journal Articles

In vivo efficacy of rat NIS-mediated cancer therapy at significantly lower radioactive iodine levels

Free
Charles J. Link, Jr., Robert Unfer, Elena Mitrofanova
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 344–345.
Published: 01 May 2005
View articletitled, In vivo efficacy of rat NIS-mediated cancer therapy at significantly lower radioactive iodine levels
Journal Articles

The classical complement pathway-mediated mechanism kills breast cancer cells expressing αGal epitopes

Free
Robert C. Unfer, Elena Mitrofanova, Serguei Kisselev, Charles J. Link
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 274.
Published: 01 April 2004
View articletitled, The classical complement pathway-mediated mechanism kills breast cancer cells expressing αGal epitopes
Journal Articles

Cloning and analysis of the promoter of an ovarian cancer-specific gene NBR1

Free
Hsi-Chou Liu, Charles J. Link
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 219.
Published: 01 April 2004
View articletitled, Cloning and analysis of the promoter of an ovarian cancer-specific gene NBR1
Journal Articles

Iron chelators increase the genomic stability of ataxia-telangeictasia cells.

Free
Rodney E. Shackelford, Ryan Manuszak, Daniel Hellrung, Charles J. Link, Jr., Suming Wang
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 881–882.
Published: 01 April 2004
View articletitled, Iron chelators increase the genomic stability of ataxia-telangeictasia cells.
Journal Articles

Immunity to the α(1,3)Galactosyl Epitope Provides Protection in Mice Challenged with Colon Cancer Cells Expressing α(1,3)Galactosyl-transferase: A Novel Suicide Gene for Cancer Gene Therapy

Available to Purchase
Robert C. Unfer, Daniel Hellrung, Charles J. Link, Jr.
Journal: Cancer Research
Cancer Res (2003) 63 (5): 987–993.
Published: 01 March 2003
View articletitled, Immunity to the α(1,3)Galactosyl Epitope Provides Protection in Mice Challenged with Colon Cancer Cells Expressing α(1,3)Galactosyl-transferase: A Novel Suicide Gene for Cancer Gene Therapy
Open the PDF for Immunity to the α(1,3)Galactosyl Epitope Provides Protection in Mice Challenged with Colon Cancer Cells Expressing α(1,3)Galactosyl-transferase: A Novel Suicide Gene for Cancer Gene Therapy in another window
Journal Articles

Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symporter Gene

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Robert B. Mandell, Leisa Z. Mandell, Charles J. Link, Jr.
Journal: Cancer Research
Cancer Res (1999) 59 (3): 661–668.
Published: 01 February 1999
View articletitled, Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symporter Gene
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